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Zinc Levels (zinc + level)

Distribution by Scientific Domains

Medical Sciences	60%
Life Sciences	25%
Earth and Environmental Science	10%

Kinds of Zinc Levels

serum zinc level

Selected Abstracts

Zinc, a regulator of islet function and glucose homeostasis

DIABETES OBESITY & METABOLISM, Issue 2009
N. Wijesekara
It is well known that zinc is required in pancreatic ,-cells in the process of insulin biosynthesis and the maturation of insulin secretory granules. In fact, the zinc level in pancreatic islets is amongst the highest in the body and reduction in its levels in the pancreas has been associated with diabetes. High concentrations of zinc can also be toxic because of enhanced oxidative damage. The link between zinc, diabetes and islet dysfunction has recently been reiterated by genomewide association studies that identified an islet cell membrane zinc transporter, SLC30A8 (ZnT8), as one of the risk loci for type 2 diabetes. Here we explore the importance of both zinc and ZnT8 to islet biology and whole body glucose homeostasis. [source]

Haematological, hepatic and renal alterations after repeated oral or intraperitoneal administration of monoisoamyl DMSA.

JOURNAL OF APPLIED TOXICOLOGY, Issue 6 2002

Abstract Monoisoamyl 2,3-dimercaptosuccinic acid (MiADMSA), a vicinal thiol chelator, is gaining recognition recently as a better chelator than meso 2,3-dimercaptosuccinic acid (DMSA) in decreasing heavy metal burden in tissues because of its lipophilic character. There is, however, little information available on the toxicological properties of this chelator after repeated administration in animals. In the present study, we investigated the dose-dependent effect of MiADMSA on various biochemical parameters suggestive of alterations in haem biosynthesis and hepatic, renal and brain oxidative stress after 21 days of repeated intraperitoneal (i.p.) or oral (p.o.) administration to rats. The concentration of essential metals in blood and soft tissues was determined along with histopathological observations of hepatic and renal tissues. The results suggest that MiADMSA administration had no effect on blood ,-aminolevulinic acid dehydratase activity. However, an increase in zinc protoporphyrin and a decrease in haemoglobin levels were noted in animals given MiADMSA i.p. A moderate increase in serum alkaline phosphatase suggested mild hepatotoxicity at the highest dose (100 mg kg,1, i.p.). This was confirmed by histopathological examinations, which identified basophilic stippling, granulation of the cytoplasm, haemorrhage and congestion. At the highest dose, levels of hepatic thiobarbituric acid reactive substance and oxidized glutathione were increased above those of control values. Levels of hepatic reduced glutathione were decreased. Taken together, these observations point to oxidative stress. In animals administered MiADMSA i.p. there was an increase in the brain malondialdehyde levels at the two higher doses (50 and 100 mg kg,1). Essential metal status revealed a significant effect of MiADMSA (p.o.) in increasing blood zinc while significantly decreasing the kidney zinc level. The most significant adverse effect of MiADMSA was on copper concentration, which showed significant depletion from almost all major organs. Magnesium levels in blood decreased but increased in liver of MiADMSA-administered rats. Histopathological observations of liver and kidneys suggest few moderate lesions. It can be concluded that repeated administration of MiADMSA is compromised with some mild toxic effect, particularly the loss of copper. The effects during oral administration are comparatively less pronounced than by the i.p. route. Copyright © 2002 John Wiley & Sons, Ltd. [source]

Zinc deficiency may be a cause of burning mouth syndrome as zinc replacement therapy has therapeutic effects

JOURNAL OF ORAL PATHOLOGY & MEDICINE, Issue 9 2010
Gye Song Cho
J Oral Pathol Med (2010) 39: 722,727 Background:, Zinc is known to play an important role for growth and development, the immune response, neurological function, and reproduction. Although the etiology of burning mouth syndrome (BMS) is unknown, zinc deficiency may be implicated in the pathogenesis of BMS. The aim of this study was to demonstrate a causal relationship between zinc deficiency and BMS and to assess whether zinc replacement is an effective therapy for BMS. Methods:, Serum zinc level was evaluated in 276 patients with BMS. To assess the therapeutic effect of zinc replacement, patients with zinc deficiency were administered a zinc supplement (14.1 mg/day). Pain intensity 6 months after zinc replacement was evaluated using an 11-point numerical scale. We also developed an animal model of zinc deficiency to assess the effects of zinc deficiency on the oral mucosa. Results:, Of the 276 patients with BMS, 74 (26.8%) had low serum zinc levels. Zinc replacement therapy lowered the mean numerical pain scale in these patients from 8.1 to 4.1, compared with a mean decrease from 7.7 to 6.7 in a control group (P = 0.004). In our animal model of zinc deficiency, the main pathologic findings were hyperkeratinization and increased mitosis on the dorsum of the tongue, although there were no gross oral mucosal lesions. Conclusions:, Zinc deficiency might play a role in some patients with BMS. In such patients, appropriate zinc replacement therapy is effective in relieving symptoms. [source]

Serum zinc levels in children with acute gastroenteritis

PEDIATRICS INTERNATIONAL, Issue 3 2007
AKGÜN ÖLMEZ
Abstract Background: The aim of the present study was to determine the serum zinc levels on admission and 7,10 days after clinical recovery from acute gastroenteritis of <8 days' duration. Methods: This prospective study included 82 infants aged 2,24 months who had no associated bacterial infection, chronic disease, prior antibiotic use, moderate or severe malnutrition or dysentery. Forty-one healthy children formed the control group. Results: The mean serum zinc level on admission (Zn1) was 11.85 ± 2.83 ,mol/L and at 7,10 days after recovery (Zn2) was 10.92 ± 2.17 ,mol/L; mean serum zinc level of the control group was 11.81 ± 3.45 ,mol/L. Zn2 was significantly lower than Zn1, but there was no statistical difference between the mean of the control group and Zn1 and Zn2. When dehydrated patients were excluded from the patient group, Zn1 and Zn2 did not differ. Although asymptomatic, 39% of the control group had low zinc. Serum zinc levels were not affected by sex, age, clinical characteristics of the patients or severity of gastroenteritis. Conclusion: Serum zinc levels of the patients admitted with acute gastroenteritis without any other disease and without moderate or severe malnutrition were not affected by disease state. Gastroenteritis did not further decrease serum zinc levels in patients with asymptomatic or subclinical zinc deficiency. [source]

Evaluation of zinc level in skin of patients with necrolytic acral erythema

BRITISH JOURNAL OF DERMATOLOGY, Issue 3 2010
H.A.M. Moneib
Summary Background, Necrolytic acral erythema (NAE) is considered a cutaneous sign of hepatitis C virus infection. Its exact pathogenesis is still not fully understood, with some reports about decreased serum zinc levels but none about its level in the skin. Objectives, To assess skin (lesional and perilesional) and serum zinc levels in patients with NAE and compare them with levels in control subjects. Methods, Fifteen patients with NAE and 10 healthy controls were included in this study. Assessment of zinc level, in serum by graphite furnace atomic absorption spectrophotometry and in lesional and perilesional skin biopsies by flame atomic absorption spectrometry, was done in all subjects. Re-evaluation of serum and lesional skin zinc level was done after oral zinc treatment. Results, Mean ± SD zinc levels were significantly lower in patients (serum 0·44 ± 0·13 mg L,1; lesional skin 42·6 ± 18·9 mg L,1; perilesional skin 32·5 ± 17·2 mg L,1) than controls (serum 1·17 ± 0·29 mg L,1; skin 100·1 ± 2·77 mg L,1), with a positive correlation between lesional and perilesional skin zinc (r = 0·91, P < 0·01). Oral zinc supplementation significantly increased serum and skin zinc levels (by 159% and 4%, respectively; P < 0·05). Conclusions, NAE is associated with decreased serum and skin zinc levels. Oral zinc supplementation corrects decreased levels of plasma and skin zinc much earlier than the desired clinical benefits appear. [source]

Additional dietary zinc for weaning piglets is associated with elevated concentrations of serum IGF-I

JOURNAL OF ANIMAL PHYSIOLOGY AND NUTRITION, Issue 9-10 2004
D. Carlson
Summary Two experiments were performed in order to study how weaning and post-weaning dietary zinc level affect serum IGF-I. Further, whether the growth-enhancing effect of 2500 ppm of dietary zinc (Zn2500) and/or 175 ppm of dietary copper (Cu175) in post-weaning diets is associated with elevated serum IGF-I levels in piglets was studied. Experiment 1 included 54 piglets (six litters of nine piglets). One piglet from every litter was assigned to a control group (blood sampled 1 day before weaning). At weaning the remaining eight piglets from every litter were allocated randomly to four dietary treatments with increasing zinc inclusions (Zn100, Zn250, Zn1000, Zn2500). In exp. 2, 48 piglets (six litters of eight piglets) were allocated to four dietary treatments (Zn100, Zn100Cu175, Zn2500, Zn2500Cu175). All piglets in exp. 1 were blood sampled at ,1, 1,2, 5,6 or 14,15 days after weaning and in exp. 2 blood samples were taken from all pigs 5,7 days after weaning. Feed intake was recorded per pen (two piglets) and weight gain was recorded for every piglet. Just after weaning feed intake was very low, piglets lost weight and serum IGF-I decreased in exp. 1. However, the piglets fed 2500 ppm of zinc reached pre-weaning levels of serum IGF-I at 14,15 days post-weaning, whereas piglets receiving lower zinc levels showed no changes in serum IGF-I. In exp. 2, additional dietary zinc in weaning diets for piglets was found to be associated with increased feed intake, improved growth rate and increased serum IGF-I. High levels of dietary copper did not affect any of these measurements. Zinc-induced rise in serum IGF-I was partly due to increased feed intake. After correcting for differences in feed intake, zinc significantly increased serum IGF-I. However, to completely separate effects of feed intake from effects of zinc status, pair-feeding should be considered in future studies. [source]

Zinc deficiency may be a cause of burning mouth syndrome as zinc replacement therapy has therapeutic effects

Serum zinc levels in children with acute gastroenteritis

Serological levels of zinc, copper and iron elements among Giardia lamblia infected children in Turkey

PEDIATRICS INTERNATIONAL, Issue 3 2002
Pelin Ertan
Abstract Background: Giardiasis, an intestinal protozoan infection caused by Giardia lamblia, is common in Turkey, especially among children aged between 2- and 14-years-old. Effects of giardiasis on serological levels of zinc, copper and iron elements were assessed in this study. Methods: A total of 45 children, aged between 2- and 14-years-old, who were admitted to the Pediatrics Department of Celal Bayar University Medical School with gastrointestinal complaints and diagnosed as having giardiasis by stool examinations in the Parasitology Department, were enrolled as the study group (SG). The control group (CG) consisted of 45 age-matched healthy children. Serological levels of zinc, copper and iron were measured by atomic absorption spectrophotometer in all samples. Results: As a result of the study, serum zinc levels were 67.43 ± 17.72 µg/dL and 145.20 ± 9.13 µg/dL, copper levels were 198.45 ± 39.14 µg/dL and 150 ± 21.14 µg/dL and iron levels were 87.98 ± 18.31 µg/dL and 160.45 ± 45.40 µg/dL, in SG and CG, respectively. When compared separately as SG and CG, there was a statistically significant difference between the serological levels of all these elements. Conclusion: These results revealed that giardiasis increased the serological levels of copper, like other infectious agents. However, zinc and iron levels decreased during giardiasis due to malabsorption. [source]

Maternal diets, nutritional status, and zinc in contemporary Mexican infants' teeth: Implications for reconstructing paleodiets

AMERICAN JOURNAL OF PHYSICAL ANTHROPOLOGY, Issue 3 2009
Alexis E. Dolphin
Abstract Despite attempts to use zinc (Zn) concentrations in hard tissues to comment upon the degree of carnivory in past populations, zinc has yielded inconsistent trophic level effects. The question of what, if anything, zinc in human enamel reveals regarding past diets is the focus of this research. We test whether the zinc content of deciduous tooth enamel from contemporary Mexican infants varies by maternal dietary variables such as zinc intake, proportion of animal products consumed, and dietary components that are known to impact zinc absorption. Deciduous teeth were collected from former participants in a longitudinal study of maternal and infant diet and function in highland Mexico. The Zn/Ca ratios of both prenatal and postnatal regions of 37 anterior teeth representing 26 individuals were assessed via laser ablation,inductively coupled plasma,mass spectrometry. Maternal dietary data collected during lactation were not correlated with zinc levels in the early postnatal enamel of infants' teeth, which were forming at the same time. In the case of prenatal enamel, zinc values were correlated with the consumption of foods known to influence Zn bioavailability, most notably tortillas (P = 0.008; r = 0.510), but not with meat consumption. Unexpectedly, women who consumed diets with poor zinc bioavailability during pregnancy gave birth to infants whose prenatal enamel demonstrated the highest Zn/Ca ratios, possibly due to enhanced zinc absorption during pregnancy for those mothers suffering most from long-term micronutrient deficiency. These results would suggest that zinc is not a reliable trophic level indicator. Am J Phys Anthropol, 2009. © 2009 Wiley-Liss, Inc. [source]

Effects of dietary zinc levels on growth, serum zinc, haematological parameters and tissue trace elements of soft-shelled turtles, Pelodiscus sinensis

AQUACULTURE NUTRITION, Issue 3 2010
S.-C. HUANG
Abstract A 10-week feeding trial was conducted to evaluate the effects of dietary zinc (Zn) contents on the growth, tissue trace element contents and serum Zn levels in soft-shelled turtles, Pelodiscus sinensis. Juvenile soft-shelled turtles approximately 4.8 g in body weight were fed casein-based diets containing seven levels of Zn (14, 23, 32, 43, 58, 87 and 100 mg kg,1) for 10 weeks. There were no significant differences (P > 0.05) in weight gain (WG), feed conversion ratio (FCR) or protein efficiency ratio (PER) among the dietary treatments. However, Zn concentrations in the liver, serum and carapace of turtles fed the basal diet containing 14 mg Zn kg,1 were the lowest among all groups. Zn contents in the liver, serum and carapace increased when dietary Zn increased up to a dietary Zn level of approximately 43 mg kg,1. Beyond this dietary level, tissue Zn contents were relatively constant. Carapace iron (Fe), selenium (Se) in hard tissues and haemoglobin concentrations decreased when dietary Zn increased. Dietary Zn requirements of juvenile soft-shelled turtles derived from regression modelling using the liver, serum, carapace and bone Zn contents as indicators were 42, 39, 35 and 46 mg Zn kg,1, respectively. [source]

Evaluation of zinc supplementation in European sea bass (Dicentrarchus labrax) juvenile diets

AQUACULTURE RESEARCH, Issue 9 2010
Eleni Fountoulaki
Abstract This study aimed to investigate the effect of increased zinc dietary levels on the growth performance, feed utilization, immune status and induced wound healing in European sea bass (Dicentrarchus labrax). Fish weighing 10 g were fed five diets containing organic zinc at 30, 70, 110 and 150 mg kg,1 diet and one inorganic zinc source (zinc oxide) at 150 mg kg,1 diet for a period of 12 weeks. No significant (P>0.05) differences were found in the growth performance parameters (final weight, specific growth rate), immunological indices tested (respiratory burst activity in whole blood) and the wound-healing process. Zinc accumulation in the skin, vertebrae and liver increased significantly (P<0.01) with increased dietary zinc levels but not in muscle. The highest zinc concentrations were obtained in skin tissue, followed by vertebrae, liver and muscle tissue. Using the concentration of zinc in skin as a response criterion, broken-line analysis showed that the supplementation of 148 mg organic Zn kg,1 diet seemed to be the optimum dietary zinc supplementation level for sea bass juveniles. [source]

Changes in zinc uptake in response to ascorbic acid and folic acid in rat liver slices under normal and oxidative stress conditions

BIOFACTORS, Issue 1 2007
R.S. Tupe
Abstract Zinc plays a dual role, as an integral part of metabolic machinery and in defense against reactive oxygen species. Hepatocytes are important sites for zinc metabolism for synthesis of zinc metalloproteins and maintaining its homeostasis. However, the factors influencing post absorptive zinc metabolism under normal and oxidative stress (OS) conditions are not well understood. Using rat liver slices, we conducted a series of four in vitro zinc uptake experiments to study influence of ascorbic acid and folic acid in normal and oxidative stress conditions with Zn concentrations representing deficient to excess states (7.7,30.7 millimole/L). Zinc uptakes under OS at these four zinc levels were lower than the normal conditions. Folic acid showed significant inhibitory effect on zinc uptake under both normal and OS conditions in a dose response manner. Nevertheless, dose response of ascorbic acid at four zinc levels indicated its marked enhancing effect under OS condition. Differences in zinc uptake trend lines between the normal and OS conditions for interaction of both the vitamins narrowed down as the zinc levels increased. Our results suggest that folic acid causes inhibitory effect, while ascorbic acid may be protective in OS with reference to zinc uptake. [source]

Analysis of calcium, magnesium, and zinc levels in hair of healthy students.

BIOFACTORS, Issue 1-2 2000
Screening of calcium or magnesium deficiency hazard
No abstract is available for this article. [source]

Evaluation of zinc level in skin of patients with necrolytic acral erythema

The relation between reduced serum melatonin levels and zinc in rats with induced hypothyroidism

CELL BIOCHEMISTRY AND FUNCTION, Issue 1 2008
Muaz Belviranli
Abstract The objective of the study was to explore the changes in melatonin and zinc levels in rats with induced hypothyroidism. Thirty adult male rats used in the study were allocated to three groups with equal numbers. Group 1: General control group which was not subjected to any procedure. Group 2: Sham-hypothyroidism group to which was administered 10,mg,kg,1 intraperitoneal (i.p.) physiologic saline (0.09% NaCl) for 4 weeks. Group 3: Hypothyroidism group which was supplemented with intraperitoneal 10,mg,kg,1 propylthiouracil (PTU) for 4 weeks. Blood samples collected from all animals at the end of the study by decapitation were analysed for serum Total T4 (TT4), Total T3 (TT3), Free T4 (FT4), Free T3 (FT3) (ELISA) as well as for melatonin (RIA) hormones and zinc levels (atomic emission). Comparison of the study groups in terms of thyroid hormones, melatonin and zinc levels showed that TT4, TT3, FT4, FT3, melatonin and zinc levels in group 3 were lower than those in groups 1 and 2 (,p,<,0.01). These parameters were not different in groups 1 and 2. The results of the study demonstrate that PTU supplementation for 4 weeks results in a significant inhibition in both melatonin and zinc levels. Inhibited melatonin levels may result from the decrease in zinc levels. Copyright © 2006 John Wiley & Sons, Ltd. [source]

Serum zinc levels in Iranian patients with acne

CLINICAL & EXPERIMENTAL DERMATOLOGY, Issue 7 2009
S. Nasiri
No abstract is available for this article. [source]