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Wound Tissues (wound + tissue)

Distribution by Scientific Domains
Medical Sciences75%

Selected Abstracts

Delivery of a Growth Factor Fusion Protein Having Collagen-Binding Activity to Wound Tissues

ARTIFICIAL ORGANS, Issue 2 2003
Tetsuya Ishikawa
Abstract: Recently, we established a collagen-binding growth factor consisting of epidermal growth factor and the fibronectin collagen-binding domain (FNCBD-EGF). FNCBD-EGF is a biologically active fusion protein that could stably bind to collagen materials, and exert its growth factor activity even after collagen binding. In this study, we investigated the concept that FNCBD moiety with high collagen affinity may enhance the effective local concentration of EGF at the site of administration in the following tissues: skin wounds, catheter-injured arteries, and hind limb muscles. In an animal model of impaired wound healing, application of FNCBD-EGF in combination with collagen gel induced granulation tissue formation in the wounds due to its sustained retention. In the injured artery, infused FNCBD-EGF remained bound to collagen exposed on the injured tissues even after blood circulation was restored. Injection of the fusion protein into the hind limbs revealed that our delivery system was effective for direct administration to muscular tissue. [source]

Caffeic acid phenetyl ester accelerates cutaneous wound healing in a rat model and decreases oxidative stress

CLINICAL & EXPERIMENTAL DERMATOLOGY, Issue 6 2007
G. Serarslan
Summary Background., Cutaneous injury causes a depression in antioxidant status, as reactive oxygen species (ROS) are produced in response to injury., Aim., To determine the effects of caffeic acid phenethyl ester (CAPE), an antioxidant and anti-inflammatory agent, on wound healing in rats. Methods., In total, 40 male rats were divided into two groups: one group treated with CAPE (n = 20) and a second untreated control group (n = 20). A linear full-thickness incision was performed on the back of each rat and sutured. After incision, CAPE was given to the treatment group and saline to the control group. On days 1, 3, 7 and 14, five animals in each group were killed, and wound tissues dissected for biochemical and histopathological analysis. Results., Wound tissues showed a significant increase in glutathione and nitric oxide levels, and a significant decrease in malondialdehyde levels and superoxide dismutase levels in the CAPE group compared with the control group. Histopathology of the wound tissues displayed rapid epithelium development in the CAPE group compared with the control group. Conclusion., This study has demonstrated that CAPE partly accelerates full-thickness wound healing by its antioxidant and ROS-scavenging capabilities. [source]

Lebensspuren holzzerstörender Organismen an fossilen Hölzern aus dem Tertiär der Insel Lesbos, Griechenland

FOSSIL RECORD-MITTEILUNGEN AUS DEM MUSEUM FUER NATURKUNDE, Issue 1 2001
Herbert Süss
Abstract Lebensspuren (Schadbilder) holzzerstörender Organismen an fossilen Holzresten aus dem Untermiozän von Lesbos (Griechenland) werden beschrieben. Von pflanzlichen Holzzerstörern konnten Bakterien, imperfekte Pilze, Weiß- und Braunfäulepilze und in das Holz eingewachsene Wurzeln nachgewiesen werden. Von tierischen Holzzerstörern wurden Termitenfraß, durch Pflanzensauger (Homopteren) verursachtes Wundgewebe, Larvenfraß der Kambium-Minierfliege Palaeophytobia (Agromyzidae, Diptera) und Fraßgänge mit Koprolithen verschiedener Käferarten (Anobiiden?) und Milben (Acari) gefunden. Außerdem werden durch Kristallisationsvorgänge im Holz verursachte kugelförmige Gebilde beschrieben. Traces of wood destroying organisms on fossil wood from the Lower Miocene of Lesbos (Greece) are described. Among nonanimal wood destroyers evidence is presented of bacteria, Fungi imperfecti, whiterot and brownrot fungus and penetrating roots. Animal wood destroyers include termite feeding traces, wound tissues produced by plant suckers (Homoptera), larval feeding traces of the cambium miner Palaeophytobia (Agromyzidae, Diptera) and feeding channels, with coprolites, of several beetle species (Anobiidae?) and Mites (Acari). In addition globe-like structures produced in the wood through crystallization processes are described. [source]

Caffeic acid phenetyl ester accelerates cutaneous wound healing in a rat model and decreases oxidative stress

CLINICAL & EXPERIMENTAL DERMATOLOGY, Issue 6 2007
G. Serarslan
Summary Background., Cutaneous injury causes a depression in antioxidant status, as reactive oxygen species (ROS) are produced in response to injury., Aim., To determine the effects of caffeic acid phenethyl ester (CAPE), an antioxidant and anti-inflammatory agent, on wound healing in rats. Methods., In total, 40 male rats were divided into two groups: one group treated with CAPE (n = 20) and a second untreated control group (n = 20). A linear full-thickness incision was performed on the back of each rat and sutured. After incision, CAPE was given to the treatment group and saline to the control group. On days 1, 3, 7 and 14, five animals in each group were killed, and wound tissues dissected for biochemical and histopathological analysis. Results., Wound tissues showed a significant increase in glutathione and nitric oxide levels, and a significant decrease in malondialdehyde levels and superoxide dismutase levels in the CAPE group compared with the control group. Histopathology of the wound tissues displayed rapid epithelium development in the CAPE group compared with the control group. Conclusion., This study has demonstrated that CAPE partly accelerates full-thickness wound healing by its antioxidant and ROS-scavenging capabilities. [source]