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Benign Multiple Sclerosis (benign + multiple_sclerosis)
Selected AbstractsBenign multiple sclerosis: a need for a consensusACTA NEUROLOGICA SCANDINAVICA, Issue 2010S. B. Glad Glad SB, Aarseth JH, Nyland H, Riise T, Myhr K-M. Benign multiple sclerosis: a need for a consensus. Acta Neurol Scand: 2010: 122 (Suppl. 190): 44,50. © 2010 John Wiley & Sons A/S. Objectives,,, To investigate the impact of different definitions on the frequency of benign multiple sclerosis (MS) in patients with a long follow-up, and to study the presence of non-motor symptoms and employment across the definitions. Materials and methods,,, All patients alive (n = 188) with disease onset during 1976,1986 in Hordaland County, Norway, were clinically examined including the Expanded Disability Status Scale (EDSS) in 2003. Non-motor symptoms which included depression, cognitive impairment, fatigue and pain, and employment status were also registered. Three definitions of benign MS were used based on the following EDSS cut-off values: 2.0, 3.0 and 4.0. Two additional definitions were added using an EDSS ,4.0 and incorporating either full-time or full- and part-time employment status. Results,,, The frequency of benign MS increased from 14.5% for EDSS ,2.0 to 40.8% for EDSS ,4.0, but was only 12.3% for the definition based on full-time employment. Patients with an EDSS ,2.0 had markedly less non-motor symptoms and lower unemployment rates than the other groups. Conclusions,,, An EDSS score ,2.0 with at least 10 years of disease duration seems to be the most appropriate criterion in identifying patients with benign MS. [source] Clinical implications of benign multiple sclerosis: A 20-year population-based follow-up studyANNALS OF NEUROLOGY, Issue 2 2004MRCPI, Sean J. Pittock MD In 2001, we followed up all patients from the 1991 Olmsted County Multiple Sclerosis (MS) prevalence cohort. We found that the longer the duration of MS and the lower the disability, the more likely a patient is to remain stable and not progress. This is particularly powerful for patients with benign MS with Expanded Disability Status Scale score of 2 or lower for 10 years or longer who have a greater than 90% chance of remaining stable. This is important because these patients represent 17% of the entire prevalence cohort. These data should assist in the shared therapeutic decision-making process of whether to start immunomodulatory medications. Ann Neurol 2004;56:303,306 [source] Benign multiple sclerosis: a need for a consensusACTA NEUROLOGICA SCANDINAVICA, Issue 2010S. B. Glad Glad SB, Aarseth JH, Nyland H, Riise T, Myhr K-M. Benign multiple sclerosis: a need for a consensus. Acta Neurol Scand: 2010: 122 (Suppl. 190): 44,50. © 2010 John Wiley & Sons A/S. Objectives,,, To investigate the impact of different definitions on the frequency of benign multiple sclerosis (MS) in patients with a long follow-up, and to study the presence of non-motor symptoms and employment across the definitions. Materials and methods,,, All patients alive (n = 188) with disease onset during 1976,1986 in Hordaland County, Norway, were clinically examined including the Expanded Disability Status Scale (EDSS) in 2003. Non-motor symptoms which included depression, cognitive impairment, fatigue and pain, and employment status were also registered. Three definitions of benign MS were used based on the following EDSS cut-off values: 2.0, 3.0 and 4.0. Two additional definitions were added using an EDSS ,4.0 and incorporating either full-time or full- and part-time employment status. Results,,, The frequency of benign MS increased from 14.5% for EDSS ,2.0 to 40.8% for EDSS ,4.0, but was only 12.3% for the definition based on full-time employment. Patients with an EDSS ,2.0 had markedly less non-motor symptoms and lower unemployment rates than the other groups. Conclusions,,, An EDSS score ,2.0 with at least 10 years of disease duration seems to be the most appropriate criterion in identifying patients with benign MS. [source] | ||||||||||