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Selected AbstractsA new endoscopic technique for suspension of esophageal prosthesis for refractory caustic esophageal stricturesDISEASES OF THE ESOPHAGUS, Issue 3 2008E. Ancona SUMMARY., There is no clear consensus concerning the best endoscopic treatment of benign refractory esophageal strictures due to caustic ingestion. Different procedures are currently used: frequent multiple dilations, retrievable self-expanding stent, nasogastric intubation and surgery. We describe a new technique to fix a suspended esophageal silicone prosthesis to the neck in benign esophageal strictures; this permits us to avoid the frequent risk of migration of the expandable metallic or plastic stents. Under general anesthesia a rigid esophagoscope was placed in the patient's hypopharynx. Using transillumination from the optical device, the patient's neck was pierced with a needle. A n.0 monofilament surgical wire was pushed into the needle, grasped by a standard foreign body forceps through the esophagoscope and pulled out of the mouth (as in percutaneous endoscopic gastrostomy procedure). After tying the proximal end of the silicone prosthesis with the wire, it was placed through the strictures under endoscopic view. This procedure was successfully utilized in four patients suffering from benign refractory esophageal strictures due to caustic ingestion. The prosthesis and its suspension from the neck were well-tolerated until removal (mean duration 4 months). A postoperative transitory myositis was diagnosed in only one patient. One of the most frequent complications of esophageal prostheses in refractory esophageal strictures due to caustic ingestion is distal migration. Different solutions were proposed. For example the suspension of a wire coming from the nose and then fixed behind the ear. This solution is not considered optimal because of patient complaints and moreover the aesthetic aspect is compromised. The procedure we utilized in four patients utilized the setting of a silicone tube hanging from the neck in a way similar to that of endoscopic pharyngostomy. This solution is a valid alternative both for quality of life and for functional results. [source] THE EFFECT OF ALTERNATIVE PREY ON THE DYNAMICS OF IMPERFECT BATESIAN AND MÜLLERIAN MIMICRIESEVOLUTION, Issue 6 2004Leena Lindström Abstract Both Batesian and Müllerian mimicries are considered classical evidence of natural selection where predation pressure has, at times, created a striking similarity between unrelated prey species. Batesian mimicry, in which palatable mimics resemble unpalatable aposematic species, is parasitic and only beneficial to the mimics. By contrast, in classical Müllerian mimicry the cost of predators' avoidance learning is shared between similar unpalatable co-mimics, and therefore mimicry benefits all parties. Recent studies using mathematical modeling have questioned the dynamics of Müllerian mimicry, suggesting that fitness benefits should be calculated in a way similar to Batesian mimicry; that is, according to the relative unpalatability difference between co-mimics. Batesian mimicry is very sensitive to the availability of alternative prey, but the effects of alternative prey for Müllerian dynamics are not known and experiments are rare. We designed two experiments to test the effect of alternative prey on imperfect Batesian and Müllerian mimicry complexes. When alternative prey were scarce, imperfect Batesian mimics were selected out from the population, but abundantly available alternative prey relaxed selection against imperfect mimics. Birds learned to avoid both Müllerian models and mimics irrespective of the availability of alternative prey. However, the rate of avoidance learning of models increased when alternative prey were abundant. This experiment suggests that the availability of alternative prey affects the dynamics of both Müllerian and Batesian mimicry, but in different ways. [source] Biophysical characterization of synthetic rhamnolipidsFEBS JOURNAL, Issue 22 2006Jörg Howe Synthetic rhamnolipids, derived from a natural diacylated glycolipid, RL-2,214, produced by Burkholderia (Pseudomonas) plantarii, were analyzed biophysically. Changes in the chemical structures comprised variations in the length, the stereochemistry and numbers of the lipid chains, numbers of rhamnoses, and the occurrence of charged or neutral groups. As relevant biophysical parameters, the gel (,) to liquid crystalline (,) phase behavior of the acyl chains of the rhamnoses, their three-dimensional supramolecular aggregate structure, and the ability of the compounds to intercalate into phospholipid liposomes in the absence and presence of lipopolysaccharide-binding protein were monitored. Their biological activities were examined as the ability to induce cytokines in human mononuclear cells and to induce chemiluminescence in monocytes. Depending on the particular chemical structures, the physicochemical parameters as well as the biological test systems show large variations. This relates to the acyl chain fluidity, aggregate structure, and intercalation ability, as well as the bioactivity. Most importantly, the data extend our conformational concept of endotoxicity, based on the intercalation of naturally originating amphiphilic virulence factors into membranes from immune cells. This ,endotoxin conformation', produced by amphiphilic molecules with a hydrophilic charged backbone and apolar hydrophobic moiety, and adopting inverted cubic aggregate structures, causes high mechanical stress in target immune cells on integral proteins, eventually leading to cell activation. Furthermore, biologically inactive rhamnolipids with lamellar aggregate structures antagonize the endotoxin-induced activity in a way similar to lipid A-derived antagonists. [source] BALB/c mice resistant to Toxoplasma gondii infection proved to be highly susceptible when previously infected with Myocoptes musculinus fur mitesINTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, Issue 5 2007Áurea Welter Summary The immune response induced by Toxoplasma gondii is characterized by Th1 immune mechanisms. We previously demonstrated that C57BL/6 mice infested with Myocoptes musculinus and infected with T. gondii by intraperitoneal route undergo accelerated mortality according to Th2 immune mechanisms induced by the acarian. To evaluate whether infection with M. musculinus influences T. gondii -induced Th1 response in a resistant mouse lineage, BALB/c, which develops latent chronic toxoplasmosis in a way similar to that observed in immunocompetent humans, this study was done. The animals were infected with T. gondii ME-49 strain 1 month after M. musculinus infestation, being the survival and the immune response monitored. The double-infected displayed higher mortality rate if compared with the mono-infected mice. In addition, infection with M. musculinus changed the T. gondii -specific immune response, converting BALB/c host to a susceptible phenotype. Spleen cells had increased the levels of IL-4 in double-infected mice. This alteration was associated with severe pneumonia, encephalitis and wasting condition. In addition, a higher tissue parasitism was observed in double-infected animals. It can be concluded that infection with these two contrasting parasites, M. musculinus and T. gondii, may convert an immunocompetent host into a susceptible one, and such a host will develop severe toxoplasmosis. [source] Compatibility and viscoelastic properties of brominated isobutylene- co - p -methylstyrene rubber/tackifier blendsJOURNAL OF APPLIED POLYMER SCIENCE, Issue 3 2008K. Dinesh Kumar Abstract Brominated isobutylene- co-p -methylstyrene (BIMS) rubber has been blended with hydrocarbon resin tackifier and alkyl phenol formaldehyde resin tackifier, and the compatibility between the blend components has been systematically evaluated. Dynamic mechanical analysis (DMA) and differential scanning calorimetry (DSC) studies show that BIMS rubber and hydrocarbon resin tackifier blends are compatible at all blend proportions studied. However, BIMS rubber and phenol formaldehyde resin blends exhibit very limited compatibility with each other and phase separation even at very low phenolic tackifier concentration. Morphological studies of the rubber,resin blends by scanning electron microscopy (SEM) corroborate well with the DMA and DSC results. From the DMA frequency sweep and temperature sweep studies, it is shown that the hydrocarbon resin tackifier acts as a diluent and causes a decrease in the storage modulus values (by reducing the entanglement and network density) in the rubbery plateau region. On the other hand, phenol formaldehyde resin behaves in the way similar to that of the reinforcing filler by increasing the storage modulus values (by increasing the entanglement and network density) in the rubbery plateau zone. The relaxation time estimated from the different zones of frequency sweep master curves provides information about the influence of the two tackifiers on the viscoelastic properties of the BIMS rubber in the respective zones. © 2008 Wiley Periodicals, Inc. J Appl Polym Sci, 2008 [source] Modified Rachford-Rice equations including interfacial contributions and their application to the nucleation processAICHE JOURNAL, Issue 7 2010Bernardo Carreón-Calderón Abstract The Rachford-Rice expressions [Rachford HH, Rice JD, Petroleum Trans AIME 1952;195:327-328] have been modified to include interfacial contributions in the calculation of the equilibrium coexistence between two macroscopic phases. It is shown that two-phase equilibrium states for first-order phase transitions from nucleation to the presence of evolved macroscopic phases can be characterized by using these generalized expressions. Thus, this new treatment allows the determination of the critical inclusion of nucleation of the so-called dispersed phase in a way similar to the determination of incipient new-phase formation points of a saturated phase on the binodal curve. © 2009 American Institute of Chemical Engineers AIChE J, 2010 [source] TEXTURE PROFILE ANALYSIS APPLIED TO POUNDED YAMJOURNAL OF TEXTURE STUDIES, Issue 3 2007BOLANLE OTEGBAYO ABSTRACT Textural quality of pounded yam made from tubers of Dioscorea rotundata Poir. and Dioscorea alata L. that were freshly harvested or stored for 4 months were evaluated using texture profile analysis. Significant correlations were obtained between the values for texture attributes evaluated using sensory texture profile analysis and those from instrumental texture profile analysis (ITPA). This implies that ITPA had the ability to measure the textural quality of pounded yam in a way similar to a trained sensory panel and could be used as an objective method to evaluate the textural quality of pounded yam. PRACTICAL APPLICATIONS Because texture profile analysis (TPA) has been successfully used to study the textural quality of pounded yam, a glutinous dough, it can be used in the food industry to study the texture attributes of pounded yam or similar doughlike products. It can also be used to screen yam varieties for textural quality for subsequent utilization. [source] Order Patterns in Time SeriesJOURNAL OF TIME SERIES ANALYSIS, Issue 5 2007Chstoph Bandt We determine probabilities of order patterns in Gaussian and autoregressive moving-average (ARMA) processes. Two order functions are introduced which characterize a time series in a way similar to autocorrelation. For stationary ergodic processes, all finite-dimensional distributions are obtained from the one-dimensional distribution plus the order structure of a typical time series. [source] Review article: prebiotics in the gastrointestinal tractALIMENTARY PHARMACOLOGY & THERAPEUTICS, Issue 5 2006S. MACFARLANE Summary Background Prebiotics are short-chain carbohydrates that alter the composition, or metabolism, of the gut microbiota in a beneficial manner. It is therefore expected that prebiotics will improve health in a way similar to probiotics, whilst at the same time being cheaper, and carrying less risk and being easier to incorporate into the diet than probiotics. Aim To review published evidence for prebiotic effects on gut function and human health. Methods We searched the Science Citation Index with the terms prebiotic, microbiota, gut bacteria, large intestine, mucosa, bowel habit, constipation, diarrhoea, inflammatory bowel disease, Crohn's disease, ulcerative colitis, pouchitis, calcium and cancer, focussing principally on studies in humans and reports in the English language. Search of the Cochrane Library did not identify any clinical study or meta-analysis on this topic. Results Three prebiotics, oligofructose, galacto-oligosaccharides and lactulose, clearly alter the balance of the large bowel microbiota by increasing bifidobacteria and Lactobacillus numbers. These carbohydrates are fermented and give rise to short-chain fatty acid and intestinal gas; however, effects on bowel habit are relatively small. Randomized-controlled trials of their effect in a clinical context are few, although animal studies show anti-inflammatory effects in inflammatory bowel disease, while calcium absorption is increased. Conclusions It is still early days for prebiotics, but they offer the potential to modify the gut microbial balance in such a way as to bring direct health benefits cheaply and safely. [source] Lymphoid hyperplasia of the large intestine: A case report with immunohistochemical and gene analysisPATHOLOGY INTERNATIONAL, Issue 9 2000Sakae Nagaoka A case of lymphoid hyperplasia arising in the large intestine of a 54-year-old woman is described. Barium enema X-ray and colonoscopic examination revealed multiple small polyps in the right side of the colon. Pathological findings from forceps biopsy revealed similar features to a mucosa-associated lymphoid tissue (MALT) lymphoma. A right hemicolectomy with mesenteric lymph node dissection was carried out. Histological sectioning demonstrated hypertrophic lymphoid follicles with well-formed germinal centers. Occasionally, lymphocytes infiltrated the crypts, in a way similar to that found in lymphoepithelial lesions, which was suggestive of a MALT lymphoma diagnosis. Cryptitis was also observed in the lamina propria. Immunohistochemically, proliferating lymphocytes were positive for CD20 (L26) and negative for CD45RO (UCHL-1). Analyses of immunoglobulin gene (IgHJH) rearrangement could not detect any monoclonality in these cells. These findings suggested that the present case should be categorized as lymphoid hyperplasia rather than lymphoma. [source] A Finite Element Approach for the Simulation of Quasi-Brittle FracturePROCEEDINGS IN APPLIED MATHEMATICS & MECHANICS, Issue 1 2005Oliver Hilgert In the context of a strong discontinuity approach, we propose a finite element formulation with an embedded displacement discontinuity. The basic assumption of the proposed approach is the additive split of the total displacement field in a continuous and a discontinuous part. An arbitrary crack splits the linear triangular finite element into two parts, namely a triangular and a quadrilateral part. The discontinuous part of the displacement field in the quadrilateral portion is approximated using linear shape functions. For these purposes, the quadrilateral portion is divided into two triangular parts which is in this way similar to the approach proposed in [5]. In contrast, the discretisation is different compared to formulations proposed in [1] and [3], where the discontinuous part of the displacement field is approximated using bilinear shape functions. The basic theory of the underlying finite element formulation and a cohesive interface model to simulate brittle fracture are presented. By means of representative numerical examples differences and similarities of the present formulation and the formulations proposed in [1] and [3] are highlighted. (© 2005 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim) [source] The Stereospecific Ligand Exchange at a Pseudo-Benzylic T -4 Iridium Centre in Planar-Chiral Cycloiridium (,6 -Arene)tricarbonylchromium ComplexesCHEMISTRY - A EUROPEAN JOURNAL, Issue 41 2009Jean-Pierre Djukic Dr. Abstract The stereospecificity of ligand exchange at the IrIII centre of a cycloiridium arenetricarbonylchromium complex has been established experimentally by various analytical methods as well as by X-ray diffraction structural analysis and computational investigations. Two new cases of phenyl and methyl iridium(III) complexes have been prepared by reaction of (,)-chlorido{2-[(tricarbonyl)(,6 -phenylene-,C1,)chromium(0)]pyridine-,N}(pentamethylcyclopentadienyl)iridium(III) with PhMgBr and MeMgBr. The determining influence of electrostatic repulsion has been established by means of density functional theory at the Becke,Perdew/TZP(ZORA) level by using, among other means, energy partitioning analysis. It is also shown that the Cr(CO)3 fragment is likely to ease the ionic cleavage of the IrCl bond in chlorido cycloiridium tricarbonylchromium complexes in a way similar to that already established for the solvolysis of benzyl halide complexes, that is, through a direct interaction of the Cr0 centre with the cationic IrIII centre. [source] Balancing Expectations for Employability and Family Responsibilities While on Social Assistance: Low-Income Mothers' Experiences in Three Canadian Provinces,FAMILY RELATIONS, Issue 5 2007Amber Gazso Abstract: Drawing upon a discourse analysis of public-use policy documents and qualitative interview data, this paper explores how mothers on social assistance in three Canadian provinces balance actual or expected policy expectations of their employability (e.g., participation in welfare-to-work programming) with their caregiving responsibilities. The results suggest that mothers' experiences of a time crunch, overload, and interference varied depending on their employability status and that they often experienced work-family conflict in ways similar to that experienced by working mothers not on assistance. The policy implications of these findings are discussed. [source] Bacterial synthesis of biodegradable polyhydroxyalkanoatesJOURNAL OF APPLIED MICROBIOLOGY, Issue 6 2007R.A.J. Verlinden Summary Various bacterial species accumulate intracellular polyhydroxyalkanoates (PHAs) granules as energy and carbon reserves inside their cells. PHAs are biodegradable, environmentally friendly and biocompatible thermoplastics. Varying in toughness and flexibility, depending on their formulation, they can be used in various ways similar to many nonbiodegradable petrochemical plastics currently in use. They can be used either in pure form or as additives to oil-derived plastics such as polyethylene. However, these bioplastics are currently far more expensive than petrochemically based plastics and are therefore used mostly in applications that conventional plastics cannot perform, such as medical applications. PHAs are immunologically inert and are only slowly degraded in human tissue, which means they can be used as devices inside the body. Recent research has focused on the use of alternative substrates, novel extraction methods, genetically enhanced species and mixed cultures with a view to make PHAs more commercially attractive. [source] Supply chain risk identification using a HAZOP-based approachAICHE JOURNAL, Issue 6 2009Arief Adhitya Abstract Risk management has become imperative for today's complex supply chains. Most approaches reported in the literature have been ad-hoc and specific to certain risks; a general and comprehensive approach is lacking. To address this, we present a structured methodology for risk identification. Supply chain networks are in many ways similar to chemical plants, therefore well-established methods and concepts from chemical process risk management can be adapted to supply chains. Drawing from this analogy, we propose to represent supply chain structure and operations using flow and work-flow diagrams, equivalent to process flow diagrams (PFDs) and operating procedures. Following the HAZard and OPerability (HAZOP) analysis method common in process safety, risk identification can be performed by systematically generating deviations in different supply chain parameters and identifying their possible causes, consequences, safeguards, and mitigating actions. The application and benefits of the proposed approach are demonstrated using a refinery supply chain case study. © 2009 American Institute of Chemical Engineers AIChE J, 2009 [source] The Bible, Knowledge of God and Dei VerbumTHE HEYTHROP JOURNAL, Issue 2 2001Anthony Baxter How may an inquiring person fittingly look upon the Bible? In what manner can a person's attention to the Bible assist them to knowledge? For a Catholic Christian analysis, what ideas are suitable about the place of the Bible in relations between God and humans, and in appropriation by a person today of whatever divine disclosure or revelation is at hand? This article outlines reflections on these matters. Links are apparent with key points in Vatican II's Dei Verbum. The first of four sections concerns a fundamentalist outlook. Section II has to do with certain limited but significant ways in which a person may look on the Bible: ways similar to ways in which a person may look on other texts. Section III pauses on inquiries into ,deep, inner' matters of life where the person inquiring does not proceed from a perspective of Catholic Christian faith. Section IV surveys a broad range of thoughts that may aptly be endorsed from within a perspective of Catholic Christian faith. The thoughts concern the nature of the situation by which a Catholic Christian person today can advance in knowledge of God: in appropriation of divine disclosure. Ways in which a person may look on the Bible that go beyond those exhibited earlier are now made explicit. (The article fully allows that numerous views held by one or another follower of Jesus who does not adhere to Roman Catholicism may, in respects at stake, harmonize with a Catholic Christian faith-perspective.) [source] Practitioner Review: Psychopharmacology in children and adolescents with mental retardationTHE JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY AND ALLIED DISCIPLINES, Issue 9 2006Benjamin L. Handen Background:, The use of psychotropic medication to treat children and adults with mental retardation (MR) has a long and extensive history. There are no identified medications to address specific cognitive deficits among persons with MR. Instead, psychotropic medications are used to treat specific behavioral symptoms and/or psychiatric syndromes. The purpose of this review is to provide an overview of the recent literature regarding the use of psychotropic medications in this population, focusing primarily on children and adolescents. Methods:, The paper is divided into five general drug categories: psychostimulants, antipsychotics, antidepressants, mood stabilizers, and other drugs. Each section offers an overview of the research supporting the use of that class of medications in children and adolescents with MR as well as cautions regarding potential side effects. Finally, specific clinical recommendations are offered. Results:, The majority of studies in MR tend to be open trials, case reports, or controlled studies with small samples. The available data suggests that persons with MR respond to various psychotropic medications in ways similar to the typically developing population. However, rates of response tend to be poorer and the occurrence of side effects tends to be more frequent. Conclusions:, The use of psychotropic medications in children and adolescents with MR requires even greater monitoring and the use of lower doses and slower dosage increases than in the general population. [source] Bringing features of human dialogue to web surveysAPPLIED COGNITIVE PSYCHOLOGY, Issue 2 2007Frederick G. Conrad When web survey respondents self-administer a questionnaire, what they are doing is in many ways similar to what goes on in human,human interviews. The studies presented here demonstrate that enabling web survey respondents to engage in the equivalent of clarification dialogue can improve respondents' comprehension of questions and thus the accuracy of their answers, much as it can in human,human interviews. In two laboratory experiments, web survey respondents (1) answered more accurately when they could obtain clarification, that is, ground their understanding of survey questions, than when no clarification was available, and (2) answered particularly accurately with mixed-initiative clarification, where respondents could initiate clarification or the system could provide unsolicited clarification when respondents took too long to answer. Diagnosing the need for clarification based on respondent characteristics,in particular, age,proved more effective than relying on a generic model of all respondents' need for clarification. Although clarification dialogue increased response times, respondents preferred being able to request clarification than not. The current results suggest that bringing features of human dialogue to web surveys can exploit the advantages of both interviewer- and self-administration of questionnaires. Copyright © 2007 John Wiley & Sons, Ltd. [source] Repeat Teenage Pregnancy in Two Cultures,The Meanings Ascribed by TeenagersCHILDREN & SOCIETY, Issue 3 2010Jean Clarke This qualitative study charts the views, feelings and experiences of two diverse, yet in many ways similar, groups of respondents from two cultures , one group of 26 respondents from the Caribbean islands of Jamaica and Barbados and the other group of 26 respondents from London, who have experienced repeat teenage pregnancies. The study uses a comparative approach to provide a psychosocial, emotional and economic understanding of the factors, which lead to repeat pregnancies. This study cautions against an over reliance on a mechanistic understanding and management of both single and repeat teenage pregnancies, and emphasises the fact that economic, social, psychological and emotional processes are also crucial to our understanding of repeat teenage pregnancies. [source] | ||||||||||||||||||||||