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Way
Kinds of Way Terms modified by Way Selected AbstractsIN AND OUT OF HARM'S WAY: VIOLENT VICTIMIZATION AND THE SOCIAL CAPITAL OF FICTIVE STREET FAMILIES,CRIMINOLOGY, Issue 4 2002BILL McCARTHY Homeless youth establish a variety of relationships with people they meet on the street. These associations generate different levels of the intangible resources of trust, commitment, and reciprocity that contribute to a person's social capital. We argue that the relationships homeless youth describe as "street families" resemble the fictive kin common among people who have limited resources, and that these relationships are a greater source of social capital than are other associations. Social capital may improve access to many valued outcomes, including protections. Regression analyses of violent victimization support our argument, demonstrating that fictive street families keep youth out of harm's way more than do other street associations. [source] DELIBERATING CRIME AND PUNISHMENT: A WAY OUT OF GET TOUGH JUSTICE?CRIMINOLOGY AND PUBLIC POLICY, Issue 1 2006VANESSA BARKER First page of article [source] FOSTERING SUSTAINABLE COMPLEXITY IN THE MICROFINANCE INDUSTRY: WHICH WAY FORWARD?ECONOMIC AFFAIRS, Issue 2 2005Emily Chamlee-Wright The microfinance movement has gained tremendous popularity over the past 30 years, but it is still far from meeting its full potential. The industry stands at a crossroads between increased commercialisation and increased philanthropic aid. Standard economic discourse does little to resolve the debate. F. A. Hayek's concept of the,extended order' sheds new light on how we might understand the future development of microfinance. [source] THE INDONESIAN CRISIS OF 1997/99 AND THE WAY OUT: WHAT ARE THE LESSONS OF HISTORY?,ECONOMIC PAPERS: A JOURNAL OF APPLIED ECONOMICS AND POLICY, Issue 2 2000ANNE BOOTH First page of article [source] REVISITING PAUL GOODMAN: ANARCHO-SYNDICALISM AS THE AMERICAN WAY OF LIFEEDUCATIONAL THEORY, Issue 2 2000Burton Weltman First page of article [source] Fenfluramine Blocks Low-Mg2+ -Induced Epileptiform Activity in Rat Entorhinal CortexEPILEPSIA, Issue 8 2000K. Gentsch Summary: Purpose: The entorhinal cortex (EC) represents the main input structure to the hippocampus and seems to be critically involved in temporal lobe epilepsy. Considering that the EC receives a strong serotonergic projection from the raphe nuclei and expresses a high density of serotonin (5-HT) receptors, the effect of the 5-HT,releasing drug fenfluramine (FFA) on epileptiform activity generated in the EC was investigated in an in vitro model of epilepsy. Methods: The experiments were performed on 43 horizontal slices containing the EC, the subiculum, and the hippocampal formation obtained from 230,250 g adult Wistar rats. Using extracellular recording techniques, we investigated the effect of bath-applied FFA (200 ,mol/L to 1 mmol/L) on epileptiform activity induced by omitting MgSO4 from the artificial cerebrospinal fluid. Results: We demonstrate that FFA reversibly blocks epileptiform activity in the EC. Surprisingly, in the presence of the 5-HT uptake blocker paroxetine, the FFA-induced effect was diminished. Coapplication of the 5-HTIA receptor antagonist WAY 100635 prevented the FFA-induced anticonvulsive effect, suggesting that (a) the FFA-induced suppression of epileptiform activity is mediated by the release of 5-HT from synaptic terminals within the EC rather than by an unspecific effect of FFA and (b) released 5-HT most likely blocks the activity by activation of 5-HTIA receptors. Conclusion: FFA, which is primarily used because of its anorectic activity, might get an additional therapeutic value in the treatment of temporal lobe epilepsy with parahippocampal involvement. [source] Somatodendritic autoreceptor regulation of serotonergic neurons: dependence on l -tryptophan and tryptophan hydroxylase-activating kinasesEUROPEAN JOURNAL OF NEUROSCIENCE, Issue 4 2005Rong-Jian Liu Abstract The somatodendritic 5-HT1A autoreceptor has been considered a major determinant of the output of the serotonin (5-HT) neuronal system. However, recent studies in brain slices from the dorsal raphe nucleus have questioned the relevance of 5-HT autoinhibition under physiological conditions. In the present study, we found that the difficulty in demonstrating 5-HT tonic autoinhibition in slice results from in vitro conditions that are unfavorable for sustaining 5-HT synthesis. Robust, tonic 5-HT1A autoinhibition can be restored by reinstating in vivo 5-HT synthesizing conditions with the initial 5-HT precursor l -tryptophan and the tryptophan hydroxylase co-factor tetrahydrobiopterin (BH4). The presence of tonic autoinhibition under these conditions was revealed by the disinhibitory effect of a low concentration of the 5-HT1A antagonist WAY 100635. Neurons showing an autoinhibitory response to l -tryptophan were confirmed immunohistochemically to be serotonergic. Once conditions for tonic autoinhibition had been established in raphe slice, we were able to show that 5-HT autoinhibition is critically regulated by the tryptophan hydroxylase-activating kinases calcium/calmodulin protein kinase II (CaMKII) and protein kinase A (PKA). In addition, at physiological concentrations of l -tryptophan, there was an augmentation of 5-HT1A receptor-mediated autoinhibition when the firing of 5-HT cells activated with increasing concentrations of the ,1 adrenoceptor agonist phenylephrine. Increased calcium influx at higher firing rates, by activating tryptophan hydroxylase via CaMKII and PKA, can work together with tryptophan to enhance negative feedback control of the output of the serotonergic system. [source] ARE WE STALLED PART WAY THROUGH A MAJOR EVOLUTIONARY TRANSITION FROM INDIVIDUAL TO GROUP?EVOLUTION, Issue 10 2007Stephen C. Stearns First page of article [source] FEELING IS BELIEVING, OR LANDSCAPE AS A WAY OF BEING IN THE WORLDGEOGRAFISKA ANNALER SERIES B: HUMAN GEOGRAPHY, Issue 3 2007Edmunds Valdem, rs Bunk ABSTRACT. This article is work-in-progress, an orientation of thought towards possibilities for individual human beings to diminish the distance between outer and inner landscapes imposed by cultural norms and happenstances such as exile. The dominance of visual landscapes and visual perceptions is seen as a pivotal problem, to be solved by the engagement of all the senses in landscape discourse and formation. All the senses are engaged in earliest childhood, as they have been in ,primitive' societies. While returning to either a state of childhood or primitivism is an impossible dream, it is possible to edge closer to human nature by engaging and honing all the senses, especially the ,earth-bound senses' of feel, smell and taste. Cultivating those senses and developing discourse about them, and incorporating them into landscape formation and enjoyment, is much more difficult than having a discourse about sight and hearing, for which there is a rich and well-developed symbolic language and which can be shared through various types of media. The way towards a deeper discourse about the earth-bound senses, and the way out of the tyranny of the visual, is to be found in stories, as several thinkers suggest. The story told is autobiographical and literary , a mode of geographic writing that I developed in a 2004 book (Bunk,e 2004a), in which the complex dilemmas of home and road were explored. This article shows how in the early 1970s I defined the individual's landscape as ,a unity in one's surroundings perceived through all the senses', with imagination as the key human faculty. And I tell the story of how through complex circumstances, a visually and emotionally repugnant landscape became emotionally and intellectually attractive, with a scent, not a picture or image causing the initial attraction. The external and internal landscapes are thus unified, resulting in a sense of timelessness and placelessness of deep existential significance for the person. [source] N -[3-[4-(2-methoxyphenyl) piperaziny-1-yl]propyl]cyclam: synthesized as a potential 5-HT1A receptor ligand and labelled with 99mTc-nitrido coreJOURNAL OF LABELLED COMPOUNDS AND RADIOPHARMACEUTICALS, Issue 10 2008Fenglong Wang Abstract This paper reports the synthesis of new potential 5-HT1A receptor ligand N -[3-[4-(2-methoxyphenyl)piperaziny-1-yl]propyl]cyclam (MPPC) and radiolabelling of it with 99mTc-nitrido core. The novel neutral complex 99mTcN-MPPC combines 1,4,8,11-tetraazacyclotetradecane (cyclam) ligand as chelate moiety for 99mTc-nitrido with a 1-(2-methoxyphenyl)piperazine moiety derived from WAY 100635 via a 3-carbon alkyl chain. This provided a reliable and reproducible method for attaching the technetium to the pharmacophore moiety of WAY 100635. 99mTcN-MPPC was prepared by a two-step procedure and the radiochemical purity was found to be greater than 95%. It was hydrophilic and stable for at least 4,h at room temperature. In vivo stability study in normal rats showed that no degradation of 99mTcN-MPPC was found in deproteinated blood samples at 2,h post-injection. This effective 99mTc-labelling strategy for obtaining neutral 99mTc nitrido complexes would be a useful tool to prepare new SPECT agents to image 5-HT1A receptor with cyclam conjugated ligands. Copyright © 2008 John Wiley & Sons, Ltd. [source] Effects of chronic paroxetine treatment on dialysate serotonin in 5-HT1B receptor knockout miceJOURNAL OF NEUROCHEMISTRY, Issue 1 2003A. M. Gardier Abstract The role of serotonin (5-HT)1B receptors in the mechanism of action of selective serotonin re-uptake inhibitors (SSRI) was studied by using intracerebral in vivo microdialysis in conscious, freely moving wild-type and 5-HT1B receptor knockout (KO 5-HT1B) mice in order to compare the effects of chronic administration of paroxetine via osmotic minipumps (1 mg per kg per day for 14 days) on extracellular 5-HT levels ([5-HT]ext) in the medial prefrontal cortex and ventral hippocampus. Basal [5-HT]ext values in the medial prefrontal cortex and ventral hippocampus, ,,20 h after removing the minipump, were not altered by chronic paroxetine treatment in both genotypes. On day 15, in the ventral hippocampus, an acute paroxetine challenge (1 mg/kg i.p.) induced a larger increase in [5-HT]ext in saline-pretreated mutant than in wild-type mice. This difference between the two genotypes in the effect of the paroxetine challenge persisted following chronic paroxetine treatment. Conversely, in the medial prefrontal cortex, the paroxetine challenge increased [5-HT]ext similarly in saline-pretreated mice of both genotypes. Such a challenge produced a further increase in cortical [5-HT]ext compared with that in saline-pretreated groups of both genotypes, but no differences were found between genotypes following chronic treatment. To avoid the interaction with raphe 5-HT1A autoreceptors, 1 µm paroxetine was perfused locally through the dialysis probe implanted in the ventral hippocampus; similar increases in hippocampal [5-HT]ext were found in acutely or chronically treated wild-type mice. Systemic administration of the mixed 5-HT1B/1D receptor antagonist GR 127935 (4 mg/kg) in chronically treated wild-type mice potentiated the effect of a paroxetine challenge dose on [5-HT]ext in the ventral hippocampus, whereas systemic administration of the selective 5-HT1A receptor antagonist WAY 100635 did not. By using the zero net flux method of quantitative microdialysis in the medial prefrontal cortex and ventral hippocampus of wild-type and KO 5-HT1B mice, we found that basal [5-HT]ext and the extraction fraction of 5-HT were similar in the medial prefrontal cortex and ventral hippocampus of both genotypes, suggesting that no compensatory response to the constitutive deletion of the 5-HT1B receptor involving changes in 5-HT uptake capacity occurred in vivo. As steady-state brain concentrations of paroxetine at day 14 were similar in both genotypes, it is unlikely that differences in the effects of a paroxetine challenge on hippocampal [5-HT]ext are due to alterations of the drug's pharmacokinetic properties in mutants. These data suggest that there are differences between the ventral hippocampus and medial prefrontal cortex in activation of terminal 5-HT1B autoreceptors and their role in regulating dialysate 5-HT levels. These presynaptic receptors retain their capacity to limit 5-HT release mainly in the ventral hippocampus following chronic paroxetine treatment in mice. [source] 5-HT1B Receptor-Mediated Regulation of Serotonin Clearance in Rat Hippocampus In VivoJOURNAL OF NEUROCHEMISTRY, Issue 5 2000Lynette C. Daws Abstract: The 5-hydroxytryptamine (5-HT; serotonin) transporter (5-HTT) is important in terminating serotonergic neurotransmission and is a primary target for many psychotherapeutic drugs. Study of the regulation of 5-HTT activity is therefore important in understanding the control of serotonergic neurotransmission. Using high-speed chronoamperometry, we have demonstrated that local application of 5-HT1B antagonists into the CA3 region of the hippocampus prolongs the clearance of 5-HT from extracellular fluid (ECF). In the present study, we demonstrate that the 5-HT1B antagonist cyanopindolol does not produce this effect by increasing release of endogenous 5-HT or by directly binding to the 5-HTT. Dose-response studies showed that the potency of cyanopindolol to inhibit clearance of 5-HT was equivalent to that of the selective 5-HT reuptake inhibitor fluvoxamine. Local application of the 5-HT1A antagonist WAY 100635 did not alter 5-HT clearance, suggesting that the effect of cyanopindolol to prolong clearance is not via a mechanism involving 5-HT1A receptors. Finally, the effect of low doses of cyanopindolol and fluvoxamine to inhibit clearance of 5-HT from ECF was additive. These data are consistent with the hypothesis that activation of terminal 5-HT1B autoreceptors increases 5-HTT activity. [source] A NOVEL WAY TO DIAGNOSE CYSTIC FIBROSIS IN THE NEONATE WITH A BOWEL OBSTRUCTION AND POSSIBLE MECONIUM ILEUSJOURNAL OF PAEDIATRICS AND CHILD HEALTH, Issue 9 2003V Sung No abstract is available for this article. [source] A NEW WAY OF REVITALIZING DISTRESSED URBAN COMMUNITIES?JOURNAL OF URBAN AFFAIRS, Issue 5 2006ASSESSING THE IMPACT OF THE FEDERAL EMPOWERMENT ZONE PROGRAM ABSTRACT:,The Empowerment Zone and Enterprise Community Initiative of 1993 offered targeted funding and tax incentives to distressed urban and rural communities. This initiative required a community-involvement component, setting it apart from more traditional economic development initiatives of the Reagan and Bush administrations. Using reports required by the U.S. Department of Housing and Urban Development (HUD) and census data, this study examines the programmatic emphases of four of the original six urban zones and evaluates the overall impact of zone programs on socioeconomic trends. These trends are evaluated by matching zone-designated census tracts to nonzone tracts through a propensity-score matching model using 1990 census data. Trends in poverty and other socioeconomic outcomes are measured by 1990,2000 change at the census tract level for individual zones, as well as across all zones using a series of fixed-effect models. Findings indicate that community building and involvement initiatives received the least amount of funding. Traditional economic development programs received the most emphasis but this did not translate into positive socioeconomic outcomes. With the exception of a few isolated incidences where individual zones fared better than comparison areas, zone initiatives had little impact. [source] MORE THAN ONE WAY TO STUDY A BUILDING: APPROACHES TO PREHISTORIC HOUSEHOLD AND SETTLEMENT SPACEOXFORD JOURNAL OF ARCHAEOLOGY, Issue 3 2006MARION CUTTING Summary. This article reviews a number of research methodologies used to record household and settlement architecture and assesses their value in the investigation of the human use of prehistoric built space. It exemplifies, through case studies, five broad approaches to, and research techniques associated with, the investigation of such architecture. These approaches are: architectural form; the spatial distribution of activities; continuity and standardization; the relationship between built and non-built space; and human patterns of movement. Then, drawing mainly on Near Eastern, and particularly Anatolian, material, it shows how a sixth approach, the use of ethnographic observation and analogy, provides insights into functional and seasonal variations in spatial use, patterns of movement and social organization. It identifies seven categories of data collection and nine observations drawn from the ethnographic material which together provide an investigative and interpretative framework for the study of early farming communities in the Near East and elsewhere. [source] DOES PART-TIME EMPLOYMENT PROVIDE A WAY OF ACCOMMODATING A DISABILITY?,THE MANCHESTER SCHOOL, Issue 6 2007MELANIE K. JONES In this paper, I examine the reasons for high rates of part-time employment among disabled workers in the UK. Evidence from the Labour Force Survey suggests that part-time employment provides an important way of accommodating a work-limiting disability rather than reflecting marginalization of the disabled by employers. Differences in part-time employment within the disabled group are also examined. [source] TURTLES ALL THE WAY DOWN: REGRESS, PRIORITY AND FUNDAMENTALITYTHE PHILOSOPHICAL QUARTERLY, Issue 230 2008Ross P. Cameron I address an intuition commonly endorsed by metaphysicians, that there must be a fundamental layer of reality, i.e., that chains of ontological dependence must terminate: there cannot be turtles all the way down. I discuss applications of this intuition with reference to Bradley's regress, composition, realism about the mental and the cosmological argument. I discuss some arguments for the intuition, but argue that they are unconvincing. I conclude by making some suggestions for how the intuition should be argued for, and discussing the ramifications of giving the justification I think best. [source] REASONS-RESPONSIVENESS, ALTERNATIVE POSSIBILITIES, AND MANIPULATION ARGUMENTS AGAINST COMPATIBILISM: REFLECTIONS ON JOHN MARTIN FISCHER'S MY WAY.ANALYTIC PHILOSOPHY, Issue 3 2006Derk Pereboom First page of article [source] ALL THE WAY: SUBSTANTIVE SOURCE-HISTORICISM FOR SEMI-COMPATIBILISTSANALYTIC PHILOSOPHY, Issue 3 2006David Zimmerman First page of article [source] DANCING YEARS, OR WRITING AS A WAY OUTART HISTORY, Issue 4 2009ADRIAN RIFKIN This essay is concerned with the random and arbitrary nature of the relation between taste, love, desire and knowledge as the basis for disciplinary formation. As an expanded oxymoron it thinks of the constitutive irrationality of the history of art as the space in which it can be shaped politically and theoretically through contingent and singular moments. It understands the Warburgian notion of nachleben not so much as a returning figure of older affective forms as the form of the return of the incomplete in the historically inexhaustible life of images and figures, taking together merging the visible forms in Gerard David, Goya and the photograph of a 1960s tennis star. [source] HERRI MET DE BLES'S WAY TO CALVARY: A SILENIC LANDSCAPEART HISTORY, Issue 2 2009MICHEL WEEMANS Herri met de Bles's Way to Calvary is a ,visual exegesis' closely related to Erasmus' exegetical theory. Erasmus conceived exegesis as a dialectical tension between the two extremes senses of the Biblical text (literal and spiritual), mediated by the figure of allegory. Not only does allegory designate Christ, but also the veiled language of the Scriptures and Christ's constant use of enigmatic, paradoxical and obscure figures. Interpreted in the light of the Erasmian exegetical model, and related to the figure of the Silenus popularized by the Christian humanist, Bles's landscape reveals the presence of a specific pictorial phenomenon of crypto-anthropomorphosis. This landscape of a procession following a tiny mocked Christ-Silenus, is also a portrait of a gigantic rocky mocking Silenus. This pictorial device is an integral part of the exegetical logic of the picture and is instrumental in inviting the beholder to conversion. [source] PARENTAL VIRTUE: A NEW WAY OF THINKING ABOUT THE MORALITY OF REPRODUCTIVE ACTIONSBIOETHICS, Issue 4 2007ROSALIND MCDOUGALL ABSTRACT In this paper I explore the potential of virtue ethical ideas to generate a new way of thinking about the ethical questions surrounding the creation of children. Applying ideas from neo-Aristotelian virtue ethics to the parental sphere specifically, I develop a framework for the moral assessment of reproductive actions that centres on the concept of parental virtue. I suggest that the character traits of the good parent can be used as a basis for determining the moral permissibility of a particular reproductive action. I posit three parental virtues and argue that we can see the moral status of a reproductive action as determined by the relationship between such an action and (at least) these virtues. Using a case involving selection for deafness, I argue that thinking in terms of the question ,would a virtuous parent do this?' when morally assessing reproductive action is a viable and useful way of thinking about issues in reproductive ethics. [source] SCREENING FOR PROSTATE CANCER: THE WAY AHEADBJU INTERNATIONAL, Issue 3 2010Roger S. Kirby No abstract is available for this article. [source] 5-HT1B but not 5-HT6 or 5-HT7 receptors mediate depression of spinal nociceptive reflexes in vitroBRITISH JOURNAL OF PHARMACOLOGY, Issue 4 2002G Hedo The identity of the serotonin (5-HT) receptors modulating the transmission of segmental C-fibre mediated signals was studied using an in vitro preparation of the hemisected spinal cord from rat pups. Responses to trains of stimuli delivered to a lumbar dorsal root were recorded from the corresponding ventral root. The resulting cumulative depolarization (CD) mediated by unmyelinated fibres was quantified in terms of integrated area. The amplitude of the mono-synaptic reflex was also measured. Serotonergic agents were superfused at known concentrations and their effects on the reflexes evaluated. 5-HT had depressant effects on the CD (EC50 34 ,M). The rank order of potency of agonists for the depression of the CD was 5-carboxamidotryptamine (5-CT)>,-methylserotonin (,-met-5-HT) ,5-HT>42-methylserotonin (2-met-5-HT),8-OH-DPAT. All the agonists including 2-met-5-HT and 8-OH-DPAT had strong depressant effects on the mono-synaptic reflex with the following order of potency: 5-CT>48-OH-DPAT>4,-met-5-HT ,5-HT,2-met-5-HT. The inhibitory effects of 5-HT, ,-met-5-HT and 5-CT were attenuated by the non-specific 5-HT antagonist methiothepin (1 ,M) and by the 5-HT1A/1B antagonist SDZ 21009 (100 nM) but not by the selective 5-HT1A antagonist WAY 100135 (1 ,M). Other antagonists known to block 5-HT2, 5-HT6 and/or 5-HT7 receptors (ketanserin, RO 04-6790, ritanserin and clozapine) did not change the effect of the agonists. The data suggest an important contribution of 5-HT1B receptors to the inhibition of spinal C-fibre mediated nociceptive reflexes but no experimental support was found for the intervention of 5-HT2, 5-HT6 or 5-HT7 receptors in this in vitro model. British Journal of Pharmacology (2002) 135, 935,942; doi:10.1038/sj.bjp.0704526 [source] FORBIDDEN WAYS OF LIFETHE PHILOSOPHICAL QUARTERLY, Issue 233 2008Ben Colburn I examine an objection against autonomy-minded liberalism sometimes made by philosophers such as John Rawls and William Galston, that it rules out ways of life which do not themselves value freedom or autonomy. This objection is incorrect, because one need not value autonomy in order to live an autonomous life. Hence autonomy-minded liberalism need not rule out such ways of life. I suggest a modified objection which does work, namely that autonomy-minded liberalism must rule out ways of life that could not develop under an autonomy-promoting education. I conclude by suggesting some reasons why autonomy-minded liberals should bite the bullet and accept this. [source] AN AUDIT OF OPERATIVE NOTES: FACTS AND WAYS TO IMPROVE,ANZ JOURNAL OF SURGERY, Issue 9 2008Liviu P. Lefter Background: Accurate operation record keeping is an important element of risk management. Handwritten surgical notes are often produced as evidence in medico-legal malpractice cases and incomplete and illegible notes may be a source of weakness in a surgeon's defence. Therefore, we audited the surgical notes in a teaching hospital surgical department. Methods: During 1 week 190 operative notes were audited for patient identity details, preoperative diagnosis, operation title and details, CMB code, postoperative instruction and author of the note. The operative notes were assessed by a medico-legal lawyer and a medical expert to establish level of legibility and usefulness in a virtual court case. Results: Several operative notes were found incomplete (51.57%) missing important information as CMB code (13.68%), patient details (6.8%) preoperative diagnosis (6.31%), operation title (6.31%) and postoperative instruction (14.73%). Overall, only 92 notes were complete. Conclusion: This audit suggests that handwritten surgical notes generate several errors that could lead to confusion when notes are reviewed for further follow up or are produced as evidence in medico-legal disputes. [source] FAIRE DE SON HISTOIRE UNE BOUCLE (NOIRE): WAYS OF LOOKING AT TRISTAN TZARAART HISTORY, Issue 1 2009ELIZABETH LEGGE A close examination of pictorial and verbal portraits of Tzara, by both himself and others (Breton, Louis Aragon, Picabia, Germaine Everling, Man Ray, Hans Arp) , as filtered in the art and texts of the dadas and their critics through adaptations of cabbalism, Tao-inflected Africanism, spirit photography and Maurice Barrès's ponderously mystical nationalism , yields a peculiar portrait of Paris dada, and of Tristan Tzara's ethical role within it. Anti-Semitic slurs against Tzara, used as weapons in dada power politics, while construable as a knowingly disingenuous use of cliché and caricature, raise questions of idiom. Raoul Hausmann's Mechanical Head: the Spirit of Our Time (1919) is analysed as an exemplary approach to dada portraiture, in which constellations of contradictory readymade attributes and associations, including anti-Semitic stereotypes, configure a tragicomic array of received social constructions, revolutionary aspirations, prejudices and ambivalences that constitute individuals as social actors within and outside dada. [source] NEW WAYS OF CONCEPTUALISING OCCUPATION BY DRAWING ON THE OCCUPATIONAL CHOICES OF PEOPLE WITH ENDURING MENTAL ILLNESSAUSTRALIAN OCCUPATIONAL THERAPY JOURNAL, Issue 3 2003M. Clare Taylor No abstract is available for this article. [source] ENACTMENTS: MOVING FROM DEADLY WAYS OF RELATING TO THE BEGINNINGS OF MENTAL LIFEBRITISH JOURNAL OF PSYCHOTHERAPY, Issue 2 2008David Morgan abstract The author discusses the vicissitudes of working analytically with patients who present with monolithic forms of thinking. He describes an approach that emphasizes the importance of the analyst as a real object that has at first to be explored to discover whether or not what is projected corresponds to the analyst's mind. This exploration of the other often confronts the analyst with their own issues surrounding sanity and madness, life and death; it is through this exploration of these real anxieties in the mind of the object that can lead to the beginnings of thinking in severely ill patients. [source] TRANSLATIONAL RESEARCH GOES BOTH WAYS: LESSONS FROM CLINICAL STUDIESCLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, Issue 4 2008John W Funder SUMMARY 1It is currently assumed that translational research goes from benchtop to bedside; that aldosterone elevates blood pressure via its effects on salt and water homeostasis; that mineralocorticoid receptors (MR) and glucocorticoid receptors (GR) share a common immediate ancestor; and that aldosterone plays a deleterious role in essential hypertension and heart failure. 2Meta-analysis of clinical trials in essential hypertension, in which eplerenone was dose-titrated to attain diastolic blood pressure < 90 mmHg, showed no relationship between blood pressure response and electrolyte effects, as judged by change in plasma (K). 3Reexamination of sequence data, and insights from the S810L MR mutant gene causing juvenile hypertension exacerbated by pregnancy, suggest that MR were the first to branch off the primordial ancestor for MR, GR, androgen receptors (AR) and progesterone receptors (PR). 4In clinical trials of MR blockade in heart failure and essential hypertension baseline aldosterone levels are in the low to normal range and sodium status unremarkable. Under such circumstances cortisol appears to be responsible for MR activation, thus exculpating aldosterone in these conditions. 5On the basis of these clinical studies, there is need to revisit the basic biology of aldosterone and MR as translational research very clearly goes both ways. [source] | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||