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Belonging
Kinds of Belonging Selected AbstractsConditional Belonging: Farm Workers and the Cultural Politics of Recognition in ZimbabweDEVELOPMENT AND CHANGE, Issue 1 2008Blair Rutherford ABSTRACT This article examines Zimbabwean land politics and the study of rural interventions, including agrarian reform, more broadly, using the analytical framework of territorialized ,modes of belonging' and their ,cultural politics of recognition'. Modes of belonging are the routinized discourses, social practices and institutional arrangements through which people make claims for resources and rights, the ways through which they become ,incorporated' in particular places. In these spatialized forms of power and authority, particular cultural politics of recognition operate; these are the cultural styles of interaction that become privileged as proper forms of decorum and morality informing dependencies and interdependencies. The author traces a hegemonic mode of belonging identified as ,domestic government', put in place on European farms in Zimbabwe's colonial period, and shows how it was shaped by particular political and economic conjunctures in the first twenty years of Independence after 1980. Domestic government provided a conditional belonging for farm workers in terms of claims to limited resources on commercial farms while positioning them in a way that made them marginal citizens in the nation at large. This is the context for the behaviour of land-giving authorities which have actively discriminated against farm workers during the politicized and violent land redistribution processes that began in 2000. Most former farm workers are now seeking other forms of dependencies, typically more precarious and generating fewer resources and services than they had accessed on commercial farms, with their own particular cultural politics of recognition, often tied to demonstrating support to the ruling political party. [source] Marking Difference and Negotiating Belonging: Refugee Women, Volunteering and EmploymentGENDER, WORK & ORGANISATION, Issue 3 2010Frances Tomlinson Refugee women occupy a position at a neglected point of intersection of many categories of difference. This article draws on a study of pathways from voluntary work into paid employment for refugee women in the UK and reveals how they drew on these markers of difference to express and explain their experiences of exclusion or belonging. Their accounts are considered alongside those of organizational representatives, who drew on vocabularies of equality and diversity to construct refugee women as organizational outsiders or insiders. The article explores the interplay between the active agency of refugee women in negotiating the possibilities of belonging and the effect of discursive practices and structural processes that tend to perpetuate their outsider status. It concludes by briefly considering the relevance of these findings to current controversies concerning the impact of policies of managing diversity and multiculturalism on combating inequality and discrimination. [source] The Politics of Belonging: Complexities of Identity in the Catalan BorderlandsGEOGRAFISKA ANNALER SERIES B: HUMAN GEOGRAPHY, Issue 3 2001Jouni Häkli The rise of the European nation,state system profoundly influenced the map of linguistic and cultural minorities. Catalonia in northeastern Spain is no exception. The consolidation of the Spanish and French kingdoms during the sixteenth and seventeenth centuries left Catalan speakers without political and cultural sovereignty. Furthermore, in the Treaty of the Pyrenees of 1659, the Catalan homeland els Països Catalans was divided by the Franco,Spanish border. Today, Catalan culture and politics enjoy increasing latitude in both Spain and France. This has encouraged various forms of cross,border co,operation in the Catalan borderlands. It has also led many Catalan nationalists to expect still greater political autonomy. Some activists have voiced claims for independence and even the reincorporation of the Spanish (el Principat) and French Catalonias (Catalunya Nord). However, political tensions regarding the borderland's development exist between the local actors and the Spanish and French national governments, as well as between Catalan nationalists and the population at large. This article examines these tensions, first by looking at cross,border co,operation efforts in Catalonia, and second by assessing the visible markers of identity that Catalan nationalists have placed in the border landscapes. These are contrasted with the results of a survey charting the opinions and attitudes of ,ordinary' Catalans. The article argues that there are significant cleavages among Catalans, and that the era of the nation,states has left a legacy of complex loyalties at international frontiers. [source] Searching for Belonging , An Analytical FrameworkGEOGRAPHY COMPASS (ELECTRONIC), Issue 6 2010Marco Antonsich Belonging is a notion both vaguely defined and ill-theorized. Scholars in various social disciplines often take this notion for granted, as if its meaning is somewhat self-explanatory. Others tend to equate it with the notion of identity, citizenship, or both. By relying on a critical reading of an extensive literature across academic disciplines, this study aims to offer an analytical framework for the study of belonging. I argue that belonging should be analyzed both as a personal, intimate, feeling of being ,at home' in a place (place-belongingness) and as a discursive resource that constructs, claims, justifies, or resists forms of socio-spatial inclusion/exclusion (politics of belonging). The risk of focusing only on one of these two dimensions is to fall in the trap of either a socially de-contextualized individualism or an all-encompassing social(izing) discourse. The open question is whether the increasing cultural and ethnic diversification of contemporary societies can lead to the formation of communities of belonging beyond communities of identity. [source] Imperial Citizenship: Empire and the Question of Belonging By Daniel GormanHISTORY, Issue 311 2008SIMON J. POTTER No abstract is available for this article. [source] Heritage, Identity and Belonging: African Caribbean Students and Art EducationINTERNATIONAL JOURNAL OF ART & DESIGN EDUCATION, Issue 3 2006Paul Dash This article addresses the issue of Caribbean cultural under-representation in school art departments. It argues that diasporic subjects are not seen and their cultures not recognised precisely because their contributions to the way we live are indivisible from the mainstream. This in contradistinction to some groups whose cultures and heritages are relatively distinct and separate from Western mores. Our ways of understanding culture do not take this into account. Yet diasporic contributions to the way we live have buttressed Western lifestyles since the beginning of the slave trade. The article argues that this relationship, characterised by multiple entanglements, must be recognised if Caribbean cultural identities are to be seen and valued. In doing so it challenges the way we construct notions of cultural heritage and belonging, and promotes the adoption of more risk-taking pedagogies possibly based on contemporary practices. [source] Developing a Chinese quality of life in dementia instrument for patients with early-to-moderate dementia: an exploratory test of validityJOURNAL OF CLINICAL NURSING, Issue 15-16 2010Yi-Chen Chiu Aims., The purpose of this study was to examine the psychometric properties of the Chinese Dementia Quality of Life instrument, which included testing the different pathways through theoretical quality of life domains (self-esteem, feelings of belonging and sense of aesthetics) to reach outcomes of positive and negative affect. Background., Perceived quality of life in dementia has been conceptualised based on dementia stages. However, the relationships among quality of life domains are unclear in patients with dementia with a Mini-Mental State Examination >10. Design., Cross-sectional study. Methods., Older people (n = 110) were consecutively recruited from memory disorder clinics and community wellness centres (controls). Of these participants, 27 were controls, 39 were diagnosed with questionable dementia and 44 with mild-to-moderate Alzheimer's disease. The instrument was back translated and validated. Results., The instrument has good overall internal consistency (Cronbach's alpha = 0·84,0·94). Item-total correlation coefficients, indicating construct validity, were all significant, except for one item. anova showed that controls, patients with questionable dementia and those with mild-to-moderate Alzheimer's disease differed significantly in scores on Sense of Aesthetics subscale. Instrument total score and scores on three of five subscales (not Feelings of Belonging) differed significantly between control and dementia groups, but not between patients with questionable dementia and those with mild-to-moderate Alzheimer's disease. Factor analyses showed two inconsistencies with the instrument's prior conceptualisation, namely the Self-Esteem and Negative Affect subscales. The Positive Affect path model was supported but not the Negative Affect path model. Conclusions., This patient-reported Dementia Quality of Life instrument has acceptable psychometric properties in Taiwanese patients with dementia with a Mini-Mental State Examination score >10. Relevance to clinical practice., The Chinese Dementia Quality of Life instrument can be used to assess subjective quality of life in Taiwanese patients with dementia with a Mini-Mental State Examination score >10. [source] Little India: Diaspora, Time, and Ethnolinguistic Belonging in Hindu Mauritius , By Patrick EisenlohrJOURNAL OF LINGUISTIC ANTHROPOLOGY, Issue 2 2009SONIA NEELA DAS [source] Chronic Stress, Sense of Belonging, and Depression Among Survivors of Traumatic Brain InjuryJOURNAL OF NURSING SCHOLARSHIP, Issue 3 2002Esther Bay Purpose: To test whether chronic stress, interpersonal relatedness, and cognitive burden could explain depression after traumatic brain injury (TBI). Design: A nonprobability sample of 75 mild-to-moderately injured TBI survivors and their significant others, were recruited from five TBI day-rehabilitation programs. All participants were within 2 years of the date of injury and were living in the community. Methods: During face-to-face interviews, demographic information, and estimates of brain injury severity were obtained and participants completed a cognitive battery of tests of directed attention and short-term memory, responses to the Perceived Stress Scale, Interpersonal Relatedness Inventory, Sense of Belonging Instrument, Neurobehavioral Functioning Inventory, and Center for Epidemiological Studies Depression Scale;. Findings: Chronic stress was significantly and positively related to post-TBI depression. Depression and postinjury sense of belonging were negatively related. Social support and results from the cognitive battery did not explain depression. Conclusions: Postinjury chronic stress and sense of belonging were strong predictors of post-injury depression and are variables amenable to interventions by nurses in community health, neurological centers, or rehabilitation clinics. Future studies are needed to examine how these variables change over time during the recovery process. [source] The Language of Belonging, Edited by Ulrike Hanna Meinhof and Dariusz Galasi,skiJOURNAL OF SOCIOLINGUISTICS, Issue 5 2006Anna De Fina [source] Opening Up Ownership: Community Belonging, Belongings, and the Productive Life of PropertyLAW & SOCIAL INQUIRY, Issue 3 2007Davina Cooper Drawing on empirical data and property theory, this article explores the property structure of a "free school" and the work property performs there. At Summerhill, we can see a tension between two property registers. On the one hand, the founder and present members stress the importance of individual ownership; at the same time the school's property regime involves property-limitation rules, a dispersal of rights, collective forms of property, and cross-cutting, pluralized sites of institutional recognition. In exploring how this tension is manifested through property's work, the article focuses on property's contribution to a variegated social life at the school, analyzed in terms of personal, civic, and boundary relations. With belonging treated as the central component of property rather than exclusion or control, ways of understanding what constitutes property and how it works shift. [source] The Language of Belonging: a Rhetorical Analysis of Kinship Language in First Corinthians , Mary Katherine BirgeRELIGIOUS STUDIES REVIEW, Issue 2 2006David Charles Aune No abstract is available for this article. [source] Language Learning and the Politics of Belonging: Sudanese Women Refugees Becoming and Being"American"ANTHROPOLOGY & EDUCATION QUARTERLY, Issue 4 2007Doris S. Warriner In this article, I explore the complicated relationship between ideologies of language and language learning, discourses of immigration and belonging, and the actual lived experiences of individual language learners. The analysis demonstrates how questions of educational access, economic stability, and social membership are all influenced by a range of social, political, and historical factors, particularly for recently arrived immigrants and refugees from war-torn African contexts. [source] Schools as Socialisation Contexts: Understanding the Impact of School Climate Factors on Students' Sense of School BelongingAPPLIED PSYCHOLOGY, Issue 2 2010Zeynep Cemalcilar Education is a top priority of the European Union (EU). The EU Education Council has declared that to be the world leader in terms of the quality of education and training systems by 2010, fundamental transformations in education should be carried out in each country according to its national context and traditions. As a candidate country, Turkey shares this common objective. Yet, the mean school attainment and net education enrollment rates in Turkey are still behind the EU averages. The education literature indicates students' sense of school belonging as an important predictor of school attainment. This study aims to identify the policy manipulable social aspects of schools that can be instrumental in increasing students' sense of school belonging in a sample of 799 middle school students attending public schools in Istanbul, Turkey. The conceptual model posits that students' satisfaction with both the social relationships in the school and the school environment has consequences for their sense of school belonging. The results of the structural equation model analysis revealed a plausible model. Satisfaction with social relationships emerged as a stronger predictor of sense of school belonging than satisfaction with the school environment. Further comparisons of the same conceptual model for schools with low and high socioeconomic conditions yielded different associations among the study variables. The findings are discussed in terms of their relevance to the education system in Turkey and other less affluent societies with similar social, cultural, and economic conditions. L'éducation est une priorité majeure de l'Union Européenne (UE). Le Conseil de l'Education de l'UE a déclaré que pour devenir le leader mondial de la qualité de l'éducation et de la formation en 2010, il fallait opérer des réformes d'importance dans le système d'éducation de chacun des pays dans le respect de leurs traditions et de leur contexte national. En tant que candidate pour intégrer l'Union, la Turquie partage cet objectif commun. Pourtant, les performances scolaires moyennes et le taux de scolarisation sont en Turquie toujours en-dessous des moyennes européennes. La littérature concernée montre que la conviction de l'élève d'être intégréà l'école est un prédicteur important de ses résultats scolaires. Cette étude cherche à définir les possibilités d'action politique sur les variables sociales scolaires susceptibles d'améliorer le sentiment d'appartenance à l'école, cela sur un échantillon de 799 élèves de collège fréquentant des établissements publics d'Istanbul. Le modèle pose que la satisfaction des élèves relative aux relations sociales à l'école et à l'environnement scolaire est en relation avec leur sentiment d'intégration à l'établissement. Les résultats de l'analyse en modèle d'équation structurale fournissent une structure plausible. La satisfaction liée aux relations sociales ressort comme un prédicteur du sentiment d'appartenance plus puissant que la satisfaction relative à l'environnement scolaire. Des manipulations complémentaires de ce même modèle à partir de conditions socio-économiques élevées ou basses débouchèrent sur de nouvelles associations entre les différentes variables. Ces résultats sont évalués sur la base de leur pertinence pour le système scolaire turque et celui d'autres pays moins prospères présentant des conditions économiques, sociales et culturelles analogues. [source] Belonging to a community-based football team: An ethnographic studyAUSTRALIAN OCCUPATIONAL THERAPY JOURNAL, Issue 4 2009Lorrae Mynard Purpose:,This study considered the benefits derived from participation in a community-based Australian Rules Football league in Melbourne, Australia. The RecLink league deliberately tackles the social and occupational disadvantages associated with mental illness, addictions, unemployment and homelessness. Methods:,An ethnographic methodology was used to study one team from the RecLink football league throughout an entire season. Fieldnotes were written following participant observation at training, games and events, and five in-depth interviews were conducted and transcribed. A constant comparative approach to data analysis was adopted. Results:,Three major themes were identified: a spirit of inclusion, team-building and meaning of team involvement. The first describes how members were accepted, welcomed and given the opportunity for team involvement, with the expectation that they ,had a go', and ,tried their best'. The second illustrates how the team collectively fostered a culture of friendship, cooperation and support. The third examines the significance of being part of the team, incorporating personal contributions and gains, and meanings attributed to team involvement. Conclusions:,These findings demonstrated how football can be used as non-clinical, community-based occupational therapy: enabling participation in a personally meaningful and culturally valued occupation. Occupational therapists are challenged to explore further how such community-based sports programs may complement existing clinical and welfare-based approaches to social disadvantage. [source] LIFE-CENTERED ETHICS, AND THE HUMAN FUTURE IN SPACEBIOETHICS, Issue 8 2009MICHAEL N. MAUTNER ABSTRACT In the future, human destiny may depend on our ethics. In particular, biotechnology and expansion in space can transform life, raising profound questions. Guidance may be found in Life-centered ethics, as biotic ethics that value the basic patterns of organic gene/protein life, and as panbiotic ethics that always seek to expand life. These life-centered principles can be based on scientific insights into the unique place of life in nature, and the biological unity of all life. Belonging to life then implies a human purpose: to safeguard and propagate life. Expansion in space will advance this purpose but will also raise basic questions. Should we expand all life or only intelligent life? Should we aim to create populations of trillions? Should we seed other solar systems? How far can we change but still preserve the human species, and life itself? The future of all life may be in our hands, and it can depend on our guiding ethics whether life will fulfil its full potentials. Given such profound powers, life-centered ethics can best secure future generations. Our descendants may then understand nature more deeply, and seek to extend life indefinitely. In that future, our human existence can find a cosmic purpose. [source] Phase Transformation and the Type of Lattice Distortion of Some Platinum-Rich Phases Belonging to the Cu Family.CHEMINFORM, Issue 25 2003H. Meininger Abstract For Abstract see ChemInform Abstract in Full Text. [source] ChemInform Abstract: Investigation of Bimetallic Thiocyanates Belonging to ABTC Structure Type: ZnCd(SCN)4 and AHg(SCN)4 (A: Zn, Cd, Mn) as Nonlinear Optical Crystal Materials.CHEMINFORM, Issue 22 2001X.-Q. Wang Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source] ChemInform Abstract: Synthesis of Thiosulfonates Belonging to Quinoline Derivatives.CHEMINFORM, Issue 16 2001V. I. Lubenets Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source] Condition Assessment by Visual Inspection for a Bridge Management SystemCOMPUTER-AIDED CIVIL AND INFRASTRUCTURE ENGINEERING, Issue 2 2005Vincenzo Gattulli This article deals with a procedure for bridge condition assessment by visual inspection developed during the planning and preliminary design of the BMS for the public railway networks in Italy. The main modules adopted in the procedure are: bridge inventory, computer-aided visual inspection, automated defect catalog, and priority-ranking procedure. The probabilistic models used to calibrate the condition evaluation algorithm are discussed. Different levels of deficiency have been individuated for each class of bridge structure belonging to the managed stock. The procedure allows comparison and relative ranking of deficiency conditions across different types of bridge structures. The results of a visual inspection campaign conducted for a set of bridges with different structural characteristics are reported and evaluated within the framework of the developed BMS. [source] The Grid Resource Broker workflow engineCONCURRENCY AND COMPUTATION: PRACTICE & EXPERIENCE, Issue 15 2008M. Cafaro Abstract Increasingly, complex scientific applications are structured in terms of workflows. These applications are usually computationally and/or data intensive and thus are well suited for execution in grid environments. Distributed, geographically spread computing and storage resources are made available to scientists belonging to virtual organizations sharing resources across multiple administrative domains through established service-level agreements. Grids provide an unprecedented opportunity for distributed workflow execution; indeed, many applications are well beyond the capabilities of a single computer, and partitioning the overall computation on different components whose execution may benefit from runs on different architectures could provide better performances. In this paper we describe the design and implementation of the Grid Resource Broker (GRB) workflow engine. Copyright © 2008 John Wiley & Sons, Ltd. [source] Characterizing Core and Corridor Use by Nubian Ibex in the Negev Desert, IsraelCONSERVATION BIOLOGY, Issue 1 2000Yehoshua Shkedy To identify and characterize corridors used by Nubian ibex (Capra ibex nubiana), we analyzed sighting data recorded for the past 20 years in the Israel Nature Reserves Authority data banks. We categorized each recorded sighting as belonging to a corridor or a core zone based on the total number of sightings in its vicinity. We identified three main core populations, a natural corridor connecting two of them, and a corridor that was not evident connecting the third population. Ibex inside and outside core zones were sighted on steeper terrain than expected by chance; this was more pronounced inside the core zones than outside them. We hypothesize that because ibex outside core zones must move rapidly and directionally across unfamiliar habitats, they must use more moderate terrain. Although ibex sightings in core zones were mostly in the vicinity of water, we found no relationship between the location of the sightings and proximity to water sources in the corridor. Hence, water does not appear to be an important factor in movement through corridors. It was more common to observe ibex out of the core zones during the summer. Males, which can be twice the size of females, were found traveling alone in corridors more often than in core zones. There was no difference between males and females in the steepness of terrain in which they were sighted outside core zones. Our data show that protecting ibex habitat in core zones and corridors is important to ibex conservation in Israel's arid zones. In addition, protecting this habitat may benefit other rock-dwelling species in the area. Resumen: Los corredores son un factor clave en esfuerzos de conservación. Para identificar y caracterizar el uso de corredores por el íbice de Nubia (Capra ibex nubiana) analizamos datos de avistamiento de los últimos 20 años en las bases de datos de la Autoridad Israelí de Reservas Naturales. Categorizamos cada registro asignándolo a un corredor o a una zona núcleo basándonos en el total de registros cercanos. Identificamos tres poblaciones en zona núcleo, un corredor natural que conectaba a dos de ellas y un corredor, no muy evidente, conectando a la tercera población. Se registraron íbices en terrenos inclinados dentro y fuera de zonas núcleo más de lo esperado al azar; esto fue más marcado dentro de las zonas núcleo que afuera. Hipotetizamos que deben utilizar terrenos más moderados, debido a que los íbices fuera de las zonas núcleo deben moverse rápida y direccionalmente a través de hábitats no familiares. Aunque los registros de íbices en zonas núcleo estuvieron cercanos a agua, no encontramos relación entre la localización de los registros y la cercanía a fuentes de agua en el corredor. Por tanto, el agua no parece ser un factor importante en el movimiento en los corredores. Fue más común observar íbices afuera de las zonas núcleo en el verano. Los machos, que pueden ser dos veces más grandes que hembras, fueron registrados desplazándose solos en los corredores más a menudo que en las zonas núcleo. No hubo diferencia entre machos y hembras en la pendiente del terreno en que fueron registrados fuera de las zonas núcleo. Nuestros resultados indican que la protección del hábitat de íbices en zonas núcleo y corredores es importante para la conservación de íbices en las zonas áridas de Israel. Además, la protección de este hábitat puede beneficiar a otras especies en el área. [source] Imidazolium based ionic liquid crystals: structure, photophysical and thermal behaviour of [Cnmim]Br·xH2O (n = 12, 14; x=0, 1)CRYSTAL RESEARCH AND TECHNOLOGY, Issue 11 2008A. Getsis Abstract The long chain imidazolium halides [Cnmim]Br·xH2O (n = 10, 12; x = 0, 1) have been synthesized and their structural and thermal behaviour together with their photophysical properties characterized. X-ray structure analyses of the monohydrates ([C12mim]Br·H2O: triclinic, P1, no. 2, Z = 2, Pearson code aP112, a = 550.0(5) pm, b = 779.4(5) pm, c = 2296.1(5) pm, , = 81.89(5)°, , = 83.76(5)°, , = 78.102(5)°, 3523 unique reflections with Io > 2,(Io), R1 = 0.0263, wR2 = 0.0652, GooF = 1.037, T = 263(2) K; [C14mim]Br,H2O: triclinic, P1, no. 2, Z = 12, Pearson code aP11, a = 549.86(8) pm, 782.09(13) pm, c = 2511.3(4) pm, , = 94.86(2)°, , = 94.39(2)°, , = 101.83(2)°, 2063 unique reflections with Io > 2,(Io), R1 = 0.0429, wR2 = 0.0690, GooF = 0.770, T = 293(2) K) show for both compounds similar bilayered structures. Sheets composed of hydrophilic structure regions constituted by positively charged imidazolium head groups, bromide anions and hydrogen bonded water alternate with hydrophobic areas formed by interdigitated long alkyl chains belonging to imidazolium cations with different orientation. Combined differential scanning calorimetry and polarizing optical microscopy shows that the monohydrates as well as the anhydrous imidazolium salts are thermotropic liquid crystals which adopt smectic mesophases. The mesophase region is larger in case of the monohydrates when compared to the anhydrous compounds indicating that water obviously stabilizes the mesophase. All compounds show an intense whitish photoluminescence with short lived (1,,1,*) and long lived (1,,3,*) transitions. (© 2008 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim) [source] Growth of YCOB single crystals by flux technique and their characterizationCRYSTAL RESEARCH AND TECHNOLOGY, Issue 5 2008R. Arun Kumar Abstract Nonlinear optical single crystals of YCOB with good optical quality were grown by the flux technique for the first time. Polycrystalline YCOB samples were synthesized by solid state reaction method. The thermal analysis of the sample was performed with lithium carbonate flux in different weight proportions and the growth temperature was optimised. Single crystals of YCOB with dimensions 3 × 3 × 5 mm3 were obtained by the method of ,slow-cooling'. The grown crystals were characterized by XRD, UV-VIS-NIR, EDAX, FTIR and etching studies. The powder XRD pattern revealed the formation of YCOB compound. The lattice parameters were identified through single crystal XRD studies. The UV-VIS-NIR results showed that the crystal has a sharp cutoff at 220 nm and is nearly 55% transparent over a wide wavelength range enabling applications in the UV region. The EDAX measurement revealed the ,flux-free' crystal formation. The presence of the functional groups belonging to the YCOB crystals was identified by the FTIR results. ,Hillock-like' patterns are observed in the etching studies. The primary emphasis in this study is laid to describe ,flux technique' as an alternative method to grow YCOB crystals. The results are presented and discussed. (© 2008 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim) [source] Tumoral and tissue-specific expression of the major human ,-tubulin isotypes,CYTOSKELETON, Issue 4 2010Luis J. Leandro-García Abstract The ,-tubulins are microtubule components encoded by a multigene family, which produces slightly different proteins with complex expression patterns. Several widely used anticancer drugs base their activity on ,-tubulin binding, microtubule dynamics alteration, and cell division blockage. The expression of these drug targets in tumoral and normal cells could be of crucial importance for therapy outcome, unfortunately, the complex ,-tubulin expression patterns have been poorly characterized in human. In this study, we developed a quantitative RT-PCR technique that accurately determines the mRNA expression of the eight human ,-tubulin isotypes, encoding class I, IIa, IIb, III, IVa, IVb, V, and VI and applied it to 21 nontumoral tissues and 79 tumor samples belonging to seven cancer types. In the nontumoral tissues, we found that, overall, TUBB (I), TUBB2C (IVb), and TUBB6 (V) were ubiquitous, TUBB1(VI) was hematopoietic cell-specific, and TUBB2A (IIa), TUBB2B (IIb), TUBB3 (III), and TUBB4 (IVa) had high expression in brain; however, the contribution of the different isotypes to the total ,-tubulin content varied for each tissue and had a complex pattern. In tumoral tissues, most isotypes exhibited an altered expression in specific tumor types or related to tumoral characteristics. In general, TUBB3 showed a great increase in expression while TUBB6 expression was largely decreased in most tumors. Thus, normal tissues showed a complex ,-tubulin isotype distribution, which could contribute to the toxicity profile of the microtubule-binding drugs. In addition, the specific isotypes significantly altered in tumors might represent markers for drug response. © 2010 Wiley-Liss, Inc. [source] Cell distribution of stress fibres in response to the geometry of the adhesive environmentCYTOSKELETON, Issue 6 2006Manuel Théry Abstract Cells display a large variety of shapes when plated in classical culture conditions despite their belonging to a common cell type. These shapes are transitory, since cells permanently disassemble and reassemble their cytoskeleton while moving. Adhesive micropatterns are commonly used to confine cell shape within a given geometry. In addition the micropattern can be designed so as to impose cells to spread upon adhesive and nonadhesive areas. Modulation of the pattern geometry allows the analysis of the mechanisms governing the determination of cell shape in response to external adhesive conditions. In this study, we show that the acquisition of cell shape follows two stages where initially the cell forms contact with the micropattern. Here, the most distal contacts made by the cell with the micropattern define the apices of the cell shape. Then secondly, the cell borders that link two apices move so as to minimise the distance between the two apices. In these cell borders, the absence of an underlying adhesive substrate is overcome by stress fibres forming between the apices, which in turn are marked by an accumulation of focal adhesions. By inhibiting myosin function, cell borders on nonadhesive zones become more concave, suggesting that the stress fibres work against the membrane tension in the cell border. Moreover, this suggested that traction forces are unevenly distributed in stationary, nonmigrating, cells. By comparing the stress fibres in cells with one, two, or three nonadherent cell borders it was reasoned that stress fibre strength is inversely proportional to number. We conclude that cells of a given area can generate the same total sum of tractional forces but that these tractional forces are differently spaced depending on the spatial distribution of its adherence contacts. Cell Motil. Cytoskeleton 2006. © 2006 Wiley-Liss, Inc. [source] Conditional Belonging: Farm Workers and the Cultural Politics of Recognition in ZimbabweDEVELOPMENT AND CHANGE, Issue 1 2008Blair Rutherford ABSTRACT This article examines Zimbabwean land politics and the study of rural interventions, including agrarian reform, more broadly, using the analytical framework of territorialized ,modes of belonging' and their ,cultural politics of recognition'. Modes of belonging are the routinized discourses, social practices and institutional arrangements through which people make claims for resources and rights, the ways through which they become ,incorporated' in particular places. In these spatialized forms of power and authority, particular cultural politics of recognition operate; these are the cultural styles of interaction that become privileged as proper forms of decorum and morality informing dependencies and interdependencies. The author traces a hegemonic mode of belonging identified as ,domestic government', put in place on European farms in Zimbabwe's colonial period, and shows how it was shaped by particular political and economic conjunctures in the first twenty years of Independence after 1980. Domestic government provided a conditional belonging for farm workers in terms of claims to limited resources on commercial farms while positioning them in a way that made them marginal citizens in the nation at large. This is the context for the behaviour of land-giving authorities which have actively discriminated against farm workers during the politicized and violent land redistribution processes that began in 2000. Most former farm workers are now seeking other forms of dependencies, typically more precarious and generating fewer resources and services than they had accessed on commercial farms, with their own particular cultural politics of recognition, often tied to demonstrating support to the ruling political party. [source] Twilight Institutions: Public Authority and Local Politics in AfricaDEVELOPMENT AND CHANGE, Issue 4 2006Christian Lund ABSTRACT Public authority does not always fall within the exclusive realm of government institutions; in some contexts, institutional competition is intense and a range of ostensibly a-political situations become actively politicized. Africa has no shortage of institutions which attempt to exercise public authority: not only are multiple layers and branches of government institutions present and active to various degrees, but so-called traditional institutions bolstered by government recognition also vie for public authority, and new emerging institutions and organizations also enter the field. The practices of these institutions make concepts such as public authority, legitimacy, belonging, citizenship and territory highly relevant. This article proposes an analytical strategy for the understanding of public authority in such contexts. It draws on research from anthropologists, geographers, political scientists and social scientists working on Africa, in an attempt to explore a set of questions related to a variety of political practices and their institutional ramifications. [source] Pomegranate flower: a unique traditional antidiabetic medicine with dual PPAR-,/-, activator propertiesDIABETES OBESITY & METABOLISM, Issue 1 2008Yuhao Li PPARs are transcription factors belonging to the superfamily of nuclear receptors. PPAR-, is involved in the regulation of fatty acid (FA) uptake and oxidation, inflammation and vascular function, while PPAR-, participates in FA uptake and storage, glucose homeostasis and inflammation. The PPARs are thus major regulators of lipid and glucose metabolism. Synthetic PPAR-, or PPAR-, agonists have been widely used in the treatment of dyslipidaemia, hyperglycaemia and their complications. However, they are associated with an incidence of adverse events. Given the favourable metabolic effects of both PPAR-, and PPAR-, activators, as well as their potential to modulate vascular disease, combined PPAR-,/-, activation has recently emerged as a promising concept, leading to the development of mixed PPAR-,/-, activators. However, some major side effects associated with the synthetic dual activators have been reported. It is unclear whether this is a specific effect of the particular synthetic compounds or a class effect. To date, a medication that may combine the beneficial metabolic effects of PPAR-, and PPAR-, activation with fewer undesirable side effects has not been successfully developed. Pomegranate plant parts are used traditionally for the treatment of various disorders. However, only pomegranate flower has been prescribed in Unani and Ayurvedic medicines for the treatment of diabetes. This review provides a new understanding of the dual PPAR-,/-, activator properties of pomegranate flower in the potential treatment of diabetes and its associated complications. [source] Rheological determinants of red blood cell aggregation in diabetic patients in relation to their metabolic controlDIABETIC MEDICINE, Issue 2 2002K. Elishkevitz Abstract Aims To determine whether increased red blood cell adhesiveness/aggregation in diabetic patients is related to the extent of their metabolic control. Methods We measured erythrocyte adhesiveness/aggregation in a group of 85 adult patients with diabetes mellitus by using citrated venous whole blood and a simple slide test. The erythrocyte adhesiveness/aggregation was determined by measuring the size of the spaces that are formed between the aggregated erythrocytes. We divided the patients into those with either low or high erythrocyte adhesiveness/aggregation values. Results The erythrocyte adhesiveness/aggregation values of the two groups differed significantly in terms of their fibrinogen concentration, erythrocyte sedimentation rate, high sensitive C-reactive protein (CRP), total cholesterol and triglyceride concentrations. There was no difference between the two groups regarding the concentrations of HbA1c. Logistic regression was applied to construct a model to predict the belonging of a patient in the low or high erythrocyte adhesiveness/aggregation group. A linear regression was applied to construct a model to predict the erythrocyte adhesiveness/aggregation values. Both models turned out to include gender, age, fibrinogen, triglyceride, retinopathy, coronary artery disease and age and gender interaction. Neither HbA1c nor CRP entered the models. Conclusions The degree of erythrocyte adhesiveness/aggregation and several variables of the acute-phase response in patients with diabetes mellitus are not directly related to the degree of metabolic control as evaluated by means of HbA1c concentration. Diabetic patients might benefit from rheological or anti-inflammatory interventions regardless of their metabolic control. [source] | ||||||||||||||||||||||||||||||||||||||||||||||