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Vivo Antifungal Activity (vivo + antifungal_activity)

Distribution by Scientific Domains

Chemistry	80%

Selected Abstracts

Original article: Antifungal activities of cinnamon oil against Rhizopus nigricans, Aspergillus flavus and Penicillium expansum in vitro and in vivo fruit test

INTERNATIONAL JOURNAL OF FOOD SCIENCE & TECHNOLOGY, Issue 9 2010
Yage Xing
Summary The postharvest pathogens such as R. nigricans, A. flavas and P. expansum are the causal agents of jujube or orange fruit, therefore, in vitro and in vivo antifungal activities of cinnamon oil to inactivate these fungi were investigated. Cinnamaldehyde is the main constituent of cinnamon oil. The minimum inhibitory concentrations of cinnamon oil against Rhizopus nigricans, Aspergillus flavus and Penicillium expansum were 0.64% (v/v), 0.16% (v/v) and 0.16% (v/v), respectively. The antifungal activity of cinnamon oil against A. flavus and P. expansum was stronger than that against R. nigricans and the activity was improved with increasing its concentration. In an in vivo study, cinnamon oil with concentrations of 2.0% (v/v) and 3.0% (v/v) showed complete control the growth of fungi in wound-inoculated Lingwu Long Jujube and Sand Sugar Orange fruits. These results revealed that cinnamon oil has a good potential to be as a natural antifungal agent for fruit applications. [source]

Isolation and antifungal activity of lignans from Myristica fragrans against various plant pathogenic fungi

PEST MANAGEMENT SCIENCE (FORMERLY: PESTICIDE SCIENCE), Issue 9 2007
Jun Young Cho
Abstract BACKGROUND: In a search for plant extracts with potent in vivo antifungal activity against various plant diseases, we found that treatment with a methanol extract of Myristica fragrans Houttyn (nutmeg) seeds reduced the development of various plant diseases. The objectives of the present study were to isolate and determine antifungal substances from My. fragrans and to evaluate their antifungal activities. RESULTS: Three antifungal lignans were isolated from the methanol extract of My. fragrans seeds and identified as erythro -austrobailignan-6 (EA6), meso -dihydroguaiaretic acid (MDA) and nectandrin-B (NB). In vitro antimicrobial activity of the three lignans varied according to compound and target species. Alternaria alternata, Colletotrichum coccodes, C. gloeosporioides, Magnaporthe grisea, Agrobacterium tumefaciens, Acidovorax konjaci and Burkholderia glumae were relatively sensitive to the three lignans. In vivo, all three compounds effectively suppressed the development of rice blast and wheat leaf rust. In addition, EA6 and NB were highly active against the development of barley powdery mildew and tomato late blight, respectively. Both MDA and NB also moderately inhibited the development of rice sheath blight. CONCLUSION: This is the first study to demonstrate the in vitro and in vivo antifungal activities of the three lignans from My. fragrans against plant pathogenic fungi. Copyright © 2007 Society of Chemical Industry [source]

In vivo morphological and antifungal study of the activity of a bergamot essential oil by-product

FLAVOUR AND FRAGRANCE JOURNAL, Issue 4 2006
Francesco Carmelo Pizzimenti
Abstract The in vivo antifungal activity of a bergamot processing by-product, named ,Peratoner', was evaluated through applications to male Wistar rats' back skin, previously infected with Candida albicans. Following the treatment, samples were taken to evaluate the fungal load and punch biopsies were carried out for morphological studies. In infected rats without Peratoner treatment, skin detachment with infiltrating cells was observed. The presence of C. albicans cells was evident on the surface strata of the epidermis, which was detached from the basal cells. After 24 h, in the case of Peratoner treatment, the epidermic strata were still few in number, while the infiltrating elements in the dermis were fewer in quantity and a small cluster of C. albicans cells, above the stratum corneous, was also visible. After 48 h of treatment, the skin revealed proliferation of the strata, while in the dermis infiltrating cells were still evident. Following this period and up to a week after treatment, a full recovery of the cutaneous structure was observed. Copyright © 2006 John Wiley & Sons, Ltd. [source]

In vitro and in vivo antifungal activity of cetrimide (cetyltrimethyl ammonium bromide) against fungal keratitis caused by Fusarium solani

MYCOSES, Issue 1 2007
Yehia A.-G.
Summary Mycotic keratitis is a devastating eye infection acquired after eye injury. Cetrimide at 15 and 20 mg ml,1 produced no surviving Fusarium solani growth with minimal inhibitory concentration value of 0.10 mg ml,1. Topical administration of three drops (0.3 ml) of cetrimide aqueous solution of 10 mg ml,1 at pH 6.4 three times daily succeeded to cure human severe resistant F. solani keratitis in a time course of <3 weeks, and with complete healing after 6 weeks. Cetrimide-treated rabbit corneas section appeared with normal compact epithelium and endothelium with no vacuolation in Descemet's endothelial complex: an indication that cetrimide has no significant toxic effects. So, cetrimide at 10 mg ml,1 may be effective and safe topical therapy in patients with mycotic keratitis, especially F. solani ulcers. Currently, there is no antimycotic drug with a good corneal penetration, which is safe and has a fungicidal activity. [source]