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Vitro Antitumor Activity (vitro + antitumor_activity)
Selected AbstractsChemInform Abstract: Synthesis and in vitro Antitumor Activities of Novel 4-Anilinoquinazoline Derivatives.CHEMINFORM, Issue 43 2009Venkateshappa Chandregowda Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source] ChemInform Abstract: Synthesis and in vitro Antitumor Activity of New Quinoxaline Derivatives.CHEMINFORM, Issue 31 2009Paola Corona Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source] Synthesis and in vitro Antitumor Activity of a New Series of 4-Chloro-2-mercapto-5-methylbenzenesulfonamide Derivatives.CHEMINFORM, Issue 52 2007J. Slawinski Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF. [source] Synthesis and in vitro Antitumor Activity of Substituted Anthracene-1,4-diones.CHEMINFORM, Issue 8 2005Duy H. Hua Abstract For Abstract see ChemInform Abstract in Full Text. [source] Synthesis, Crystal Structure and in vitro Antitumor Activity of Di- n -butyltin p -[N, N -Bis(2-chloroethyl)amino]benzoatesCHINESE JOURNAL OF CHEMISTRY, Issue 12 2005Zhong-Wei Zhang Abstract Di- n -butyltin oxide reacted with p- [N,N -bis(2-chloroethyl)amino]benzoic acid to yield the compounds {{4-[(ClCH2CH2)2N]C6H4COOSnBu2}2O}2 (1) and {4-[(ClCH2CH2)2N]C6H4COO}2SnBu2 (2), which have been characterized by IR and 1H NMR spectra. The X-ray diffractional studies of 1 reveal the structure of the molecule to be a dimer, in which the two Bu2Sn groups were linked via two bridging oxygen atoms to form a central Bu4Sn2O2 unit. And the tin atom adopts two carbons from two n -butyl groups and three oxygen atoms from the acid and the bridging oxygen. In vitro test showed compound 1 to exhibit high cytotoxicity against P388 and HL-60 cell lines. [source] Synthesis, characterization and in vitro antitumor activity of some arylantimony ferrocenecarboxylates and crystal structures of C5H5FeC5H4CO2SbPh4 and (C5H5FeC5H4CO2)2Sb(4-CH3C6H4)3APPLIED ORGANOMETALLIC CHEMISTRY, Issue 9 2003Run-Chang Liu Abstract A series of arylantimony ferrocenecarboxylates with the formula (C5H5FeC5H4CO2)nSbAr(5,n) (n = 1, 2; Ar = C6H5, 4-CH3C6H4, 3-CH3C6H4, 2-CH3C6H4, 4-ClC6H4, 4-FC6H4) were synthesized and characterized by elemental analysis, IR, 1H NMR and mass spectra. The crystal structures of (C5H5FeC5H4CO2)2Sb(4-CH3C6H4)3 and C5H5FeC5H4CO2SbPh4 were determined by X-ray diffraction. Four human neoplastic cell lines (HL-60, Bel-7402, KB and Hela) were used to screen these compounds. The results indicate that these compounds at 10 µM show certain in vitro antitumor activities. Copyright © 2003 John Wiley & Sons, Ltd. [source] Diorganotin(IV) Derivatives of Substituted Benzohydroxamic Acids with High Antitumor ActivityCHEMISTRY - A EUROPEAN JOURNAL, Issue 6 2004Qingshan Li Abstract A series of diorganotin(IV) and dichlorotin(IV) derivatives of 4-X-benzohydroxamic acids, [HL1 (X = Cl) or HL2 (X = OCH3)] formulated as [R2SnL2] (R = Me, Et, nBu, Ph or Cl; L = L1 or L2), along with their corresponding mixed-ligand complexes [R2Sn(L1)(L2)] have been prepared and characterized by FT-IR, 1H, 13C, and 119Sn NMR spectroscopy, mass spectrometry, elemental analysis, and melting points. In addition, single-crystal X-ray diffraction analyses were carried out for [Me2SnL2] (L = L1 or L2), which show coordination structures intermediate between distorted octahedra and bicapped tetrahedra. The hydroxamate ligands are asymmetrically coordinated by the oxygen atoms, the carbonyl oxygen atom is further away from the metal center than the other oxygen atom. The complexes are stable monomeric species; most of them are soluble not only in chlorohydrocarbon solvents, but also in alcohols and hydroalcoholic solutions. In polar solvents, the mixed-ligand complexes gradually decompose into the corresponding single-ligand complex couples. The complexes exhibit in vitro antitumor activities (against a series of human tumor cell lines) which, in some cases, are identical to, or even higher than, that of cisplatin. For the dialkyltin complexes, the activity increases with the length of the carbon chain of the alkyl ligand and is higher in the case of the chloro-substituted benzohydroxamato ligand. The [nBu2Sn(L1)2] complex displays a high in vivo activity against H22 liver and BGC-823 gastric tumors, and has a relatively low toxicity. [source] Lipophilic methotrexate conjugates with glucose-lipoamino acid moieties: Synthesis and in vitro antitumor activityDRUG DEVELOPMENT RESEARCH, Issue 3 2001Rosario Pignatello Abstract To obtain methotrexate (MTX) derivatives with a balanced hydrolipophilic character, we synthesized a series of conjugates in which the drug was linked to lipoamino acid (LAA)-glucose residues (LAAG-MTX). These conjugates displayed increased solubility in polar media compared with the corresponding LAA-MTX conjugates previously described. In vitro biological testing of LAAG-MTX indicated that the introduction of the sugar moiety decreased the biological activity of these MTX conjugates. The tetradecyl derivative 6b, however, was effective in inhibiting the dihydrofolate reductase activity in vitro and showed an inhibitory effect on human lymphoblastoid cell growth. Drug Dev. Res. 52:454,461, 2001. © 2001 Wiley-Liss, Inc. [source] Synthesis, characterization and in vitro antitumor activity of some arylantimony ferrocenecarboxylates and crystal structures of C5H5FeC5H4CO2SbPh4 and (C5H5FeC5H4CO2)2Sb(4-CH3C6H4)3APPLIED ORGANOMETALLIC CHEMISTRY, Issue 9 2003Run-Chang Liu Abstract A series of arylantimony ferrocenecarboxylates with the formula (C5H5FeC5H4CO2)nSbAr(5,n) (n = 1, 2; Ar = C6H5, 4-CH3C6H4, 3-CH3C6H4, 2-CH3C6H4, 4-ClC6H4, 4-FC6H4) were synthesized and characterized by elemental analysis, IR, 1H NMR and mass spectra. The crystal structures of (C5H5FeC5H4CO2)2Sb(4-CH3C6H4)3 and C5H5FeC5H4CO2SbPh4 were determined by X-ray diffraction. Four human neoplastic cell lines (HL-60, Bel-7402, KB and Hela) were used to screen these compounds. The results indicate that these compounds at 10 µM show certain in vitro antitumor activities. Copyright © 2003 John Wiley & Sons, Ltd. [source] Elucidation of Oxygenation Steps during Oviedomycin Biosynthesis and Generation of Derivatives with Increased Antitumor ActivityCHEMBIOCHEM, Issue 2 2009Felipe Lombó Dr. Abstract Eight different angucyclinones have been produced in Streptomyces albus by combining three oxygenase genes together with the polyketide synthase and cyclases genes from the oviedomycin biosynthetic gene cluster from Streptomyces antibioticus ATCC 11891. Four of these compounds were fully characterized for the first time. Three of these angucyclinones,prejadomycin-2-carboxylate (2), 4a,12b-dehydro-UWM6 (5), and prejadomycin (3),show a significant increase in their in vitro antitumor activity relative to oviedomycin (1). A hypothesis for the sequence of tailoring events catalyzed by these three oxygenases during oviedomycin biosynthesis is proposed. In this hypothesis OvmOII acts as a bifunctional oxygenase/dehydratase. [source] | ||||||||||