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Vitamin C Supplementation (vitamin + c_supplementation)
Selected AbstractsThe role of diet in the management of gout: a comparison of knowledge and attitudes to current evidenceJOURNAL OF HUMAN NUTRITION & DIETETICS, Issue 1 2009P. Shulten Abstract Background:, Evidence supports dietary modifications in the management of gout. Despite this, the degree of implementation of this evidence by nutrition professionals and rheumatologists and those affected by gout is unknown. The present study aimed to compare usual dietary practices of patients with gout to evidence for dietary management of gout and to investigate whether the knowledge and attitudes of nutrition professionals and rheumatologists reflects current evidence. Methods:, A food frequency questionnaire was used to determine usual dietary intake of patients with gout, a separate questionnaire examined gout-related dietary modifications (n = 29). Online questionnaires to examine attitudes towards dietary management of gout were completed by nutrition professionals and rheumatologists. Results:, Proportions of participants whose reported intakes were inconsistent with current evidence for the dietary management of gout were: alcohol, n = 14 (48%); beer, n = 18 (62%); seafood, n = 29 (100%); meat, n = 7 (24%); beef/pork/lamb, n = 24 (83%); dairy products, n = 12 (41%); vitamin C supplementation, n = 29 (100%). Of the 61 rheumatologists and 231 nutrition professionals who completed the online survey, the majority considered that weight loss and decreased alcohol intake were important or very important outcomes. Proportions were lower for decreased purine intake. Thirty-four (56%) rheumatologists do not refer patients with gout to dietetic services and, of those who do, the majority refer less than half. Conclusions:, Overall, patients with gout in the present study were not implementing evidence for dietary management of their condition and complex dietary issues were evident. [source] Acute and chronic effects of vitamin C on endothelial fibrinolytic function in overweight and obese adult humansTHE JOURNAL OF PHYSIOLOGY, Issue 14 2008Gary P. Van Guilder We determined the effects of acute intra-arterial vitamin C administration and chronic oral vitamin C supplementation on the capacity of the endothelium to release t-PA in overweight and obese adults. Net endothelial t-PA release was determined in vivo in response to intrabrachial infusions of bradykinin and sodium nitroprusside in 33 sedentary adults: 10 normal-weight (BMI: 23.4 ± 0.5 kg m,2; 7M/3F); and 23 overweight/obese (BMI: 31.2 ± 0.8 kg m,2; 15M/8F). In 10 normal weight and eight overweight/obese adults the dose,response curves to bradykinin and sodium nitroprusside were repeated with a coinfusion of the antioxidant vitamin C (24 mg min,1). Seventeen of the 23 overweight/obese adults completed a 3 month chronic oral vitamin C (500 mg day,1) supplementation intervention. Intra-arterial administration of vitamin C significantly potentiated t-PA release in overweight/obese adults. Net release of t-PA was ,95% higher (P < 0.01) after (from ,0.9 ± 1.1 to 94.6 ± 16.2 ng (100 ml tissue),1 min,1) compared with before (from ,0.8 ± 0.8 to 49.9 ± 7.7 ng (100 ml tissue),1 min,1) vitamin C administration. Daily vitamin C supplementation significantly increased t-PA release in overweight/obese adults (from 0.2 ± 0.9 to 48.2 ± 6.5 ng (100 ml tissue),1 min,1) before supplementation versus (0.3 ± 0.5 to 66.3 ± 8.7 ng (100 ml tissue),1 min,1) after supplementation. These results indicate that the antioxidant vitamin C favourably affects the capacity of the endothelium to release t-PA in overweight/obese adults. Daily vitamin C supplementation represents an effective lifestyle intervention strategy for improving endothelial fibrinolytic regulation in this at-risk population. [source] Dietary vitamin C and E supplementation and reproduction of milkfish Chanos chanos ForsskalAQUACULTURE RESEARCH, Issue 7 2000A C Emata Milkfish Chanos chanos Forsskal broodstock (11 years old, average body weight 5.23,5.73 kg) reared in 10-m-diameter by 3-m-deep floating net cages (31,36 fish per cage) at SEAFDEC AQD's Igang Marine Substation in Guimaras Island, central Philippines, were fed daily at 3% of total body weight formulated diets (36% protein, 7,8% lipid) supplemented with 0.1% vitamin C, 0.05% vitamin E, both vitamin C and E or no vitamin supplementation (control) for 3 years. Reproductive performance was assessed in an attempt to determine the optimum nutrition for successful spawning of milkfish. The total egg production, mean number of eggs per spawning, number of spawns and mean egg diameter were not affected by dietary vitamin C and E supplementation. However, broodstock given dietary supplementation of vitamin C alone or in combination with vitamin E had a higher percentage of spawns with higher (> 90%) percentage egg viability, hatching and cumulative survival rate than those of the control. Broodstock given dietary vitamin E supplementation alone had few spawns, which made the results difficult to analyse. The results confirm the essentiality of vitamin C supplementation in producing more spawns with good egg and larval quality. The production of an adequate volume of good quality eggs and larvae to support hatchery operation is necessary to offset the huge investment in broodstock development, as it takes at least 5 years for milkfish to attain sexual maturation and spawning. [source] Effects of Three-month Oral Supplementation of ,-Carotene and Vitamin C on Serum Concentrations of Carotenoids and Vitamins in Middle-aged Subjects: A Pilot Study for a Randomized Controlled Trial to Prevent Gastric Cancer in High-risk Japanese PopulationCANCER SCIENCE, Issue 5 2000Satoshi Sasaki Prior to a randomized controlled trial to prevent gastric cancer by oral supplementation of ,-carotene and vitamin C in a high-risk Japanese population, we examined the serum response to threemonth oral supplementation of ,-carotene (0, 3, 30 mg/day) and vitamin C (0, 50, 1000 mg/day) by a three-by-three factorial design using 54 subjects (age range=40,69 years). Serum concentrations of carotenoids, ,-tocopherol, and ascorbic acid were examined at baseline, and one, two, and threemonth points. Both serum ,-carotene and ascorbic acid were significantly higher in high-dose groups than in each placebo group during the supplementation. The serum ,-carotene increased gradually (597,830% increase) during the study, whereas the serum ascorbic acid reached nearly a steady-state at the one-month point and remained stable thereafter (88,95% increase). No statistically significant interaction between ,-carotene and vitamin C supplementations was observed either for serum ,-carotene or for serum ascorbic acid. Among carotenoids and ,-tocopherol examined, serum lycopene in the high-dose ,-carotene group was significantly higher than in the placebo group at all points. No unfavorable change in carotenoids and ,-tocopherol was observed in any group. [source] | ||||||||||