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Very Nature (very + nature)
Selected AbstractsA case study of shell at Sakhalin: having a whale of a time?CORPORATE SOCIAL RESPONSIBILITY AND ENVIRONMENTAL MANAGEMENT, Issue 3 2008Subhasis Ray Abstract This is a case study on the world's largest oil and gas project, at the Sakhalin Islands, Russia. Shell is the key promoter of this project. The case highlights the sustainability challenges that Shell faced when working on the mega-project. By their very nature, all such projects involve disruptions in the environmental and social fabric of the project site. NGOs often take up these issues and create international headlines, bringing pressure on the management team. The Russian government also changed its stand over a period of time. While many of these issues are valid in their own way, they often create managerial dilemmas. Traditional management approaches to community development and environmental conservation fell short of stakeholder expectations at Sakhalin. The issue of saving around 100 endangered whales put a cloud of doubt over this $20 billion project. The case highlights strategic issues involved in crafting sustainability strategies at mega-projects, possible pitfalls and the challenge of balancing project execution and stakeholder commitments against an unstable political backdrop. As Shell plans to start many exploration projects in bio-diversity rich parts of the world, the Sakhalin project acts as a pilot to and reminder of social responsibility challenges to big multi-nationals. Copyright © 2007 John Wiley & Sons, Ltd and ERP Environment. [source] Assessment of gestational age and neuromaturationDEVELOPMENTAL DISABILITIES RESEARCH REVIEW, Issue 1 2005Marilee C. Allen Abstract Neuromaturation is the functional development of the central nervous system (CNS). It is by its very nature a dynamic process, a continuous interaction between the genome and first the intrauterine environment, then the extrauterine environment. Understanding neuromaturation and being able to measure it is fundamental to infant neurodevelopmental assessment. Fetal and preterm neuromaturation has become easier to observe with the advent of prenatal ultrasonography and neonatal intensive care units. A number of measures of degree of fetal maturation have been developed and used to estimate gestational age (GA) at birth. The most reliable measures of GA are prenatal measures, especially from the first trimester. Postnatal GA measurements tend to be least accurate at the extremes of gestation, that is, in extremely preterm and post-term infants. Observations of measures of neuromaturation in infants born to mothers with pregnancy complications, including intrauterine growth restriction, multiple gestation, and chronic hypertension, have led to the discovery that stressed pregnancies may accelerate fetal pulmonary and CNS maturation. This acceleration of neuromaturation does not occur before 30 weeks' gestation and has a cost with respect to cognitive limitations manifested in childhood. The ability to measure fetal and preterm neuromaturation provides an assessment of neurodevelopmental progress that can be used to reassure parents or identify at risk infants who would benefit from limited comprehensive follow-up and early intervention services. In addition, measures of neuromaturation have the potential to provide insight into mechanisms of CNS injury and recovery, much-needed early feedback in intervention or treatment trials and a measure of early CNS function for research into the relationships between CNS structure and function. © 2005 Wiley-Liss, Inc. MRDD Research Reviews 2005;11:21,33. [source] Solution Processing of Chalcogenide Semiconductors via Dimensional ReductionADVANCED MATERIALS, Issue 31 2009David B. Mitzi Abstract The quest to develop thin-film solution processing approaches that offer low-cost and preferably low-temperature deposition, while simultaneously providing quality semiconductor characteristics, has become an important thrust within the materials community. While inorganic compounds offer the potential for outstanding electronic properties relative to organic systems, the very nature of these materials rendering them good electronic materials,namely strong covalent bonding,also leads to poor solubility. This review presents a "dimensional reduction" approach to improving the solubility of metal chalcogenide semiconductors, which generally involves breaking the extended framework up into discrete metal chalcogenide anions separated by small and volatile cationic species. The resulting soluble precursor may be solution-processed into thin-film form and thermally decomposed to yield the desired semiconductor. Several applications of this principle to the solution deposition of high-performance active layers for transistors (channel mobility >10,cm2 V,1 s,1), solar cells (power conversion efficiency of as high as 12%), and fundamental materials study will be presented using hydrazine as the deposition solvent. [source] The threat of corporate groups and the insolvency connectionINTERNATIONAL INSOLVENCY REVIEW, Issue 3 2009Alexander Dähnert, Article first published online: 27 OCT 200 This paper attempts to shed some light on the issue referred to by the term ,group threat'. The factual appearance of corporate groups will be emphasized, as well as the question of what particular dangers arise from groups of legal entities. It will be argued that the source of group threats lies in the supremacy of group interest over the interests of affiliates, particularly in groups acting as a single unit. However, while efficiency gains inherent in group structures have attracted considerable attention in the debate about the insolvencies of corporate groups, the aspect of how the restriction of group threats can be reconciled with these efficiency-preservation concepts has been neglected. This appears of some concern given the fact that group threats and group synergy effects are part of the same coin. Both sides of the Janus-head ought to be considered in insolvency concepts and an attempt will be made to put the specific aspect of group threats into the wider context of group insolvencies. Existing approaches will be introduced, summarized and categorized, with a particular view taken of their common characteristics. It is argued that most insolvency concepts suffer from the same fundamental deficiencies: the focus on the structure of groups, which makes the very nature of integrated companies difficult to grasp. Consequently, this calls into question the application of these concepts and leads, furthermore, to significant collateral damage in the shape of principles central to company law. Resulting from these shortcomings and from the insight that the supremacy of the group interest constitutes the fundamental source of group characteristics, this paper suggests as an alternative that the focus be placed on wrongful conduct, the argument being that it is not the static structure, but the way the group is directed and ruled, which constitutes the decisive criterion for insolvency concepts. The understanding of group threats is therefore the key to a satisfactory approach to group specific challenges in insolvency. Copyright © 2009 John Wiley & Sons, Ltd. [source] Flexible constraints for regularization in learning from dataINTERNATIONAL JOURNAL OF INTELLIGENT SYSTEMS, Issue 6 2004Eyke Hüllermeier By its very nature, inductive inference performed by machine learning methods mainly is data driven. Still, the incorporation of background knowledge,if available,can help to make inductive inference more efficient and to improve the quality of induced models. Fuzzy set,based modeling techniques provide a convenient tool for making expert knowledge accessible to computational methods. In this article, we exploit such techniques within the context of the regularization (penalization) framework of inductive learning. The basic idea is to express knowledge about an underlying data-generating process in terms of flexible constraints and to penalize those models violating these constraints. An optimal model is one that achieves an optimal trade-off between fitting the data and satisfying the constraints. © 2004 Wiley Periodicals, Inc. [source] Co-operatives in southern Spain: their development in the rural tourism sector in AndalucíaINTERNATIONAL JOURNAL OF TOURISM RESEARCH, Issue 3 2001Michael Barke Abstract This paper examines the characteristics of a number of recently established rural tourism co-operatives in Andalucía, southern Spain against the background of the theory of co-operatives as economic organisations. The origins and composition of the co-operatives are examined, their local impact, their policies on employment and remuneration, and their internal management characteristics. Few of the businesses in the sample appear to possess the characteristics of the ,ideal type' of co-operative identified in the literature. Although small-scale, beneficial impacts may be identified within their localities, these appear to be no different to those associated with any small business organisation in the rural tourism sector. Furthermore, it is concluded that their prospects for developing genuine alternative forms of employment structures are not strong, partly owing to the circumstances of their foundation and partly because of the very nature of rural tourism itself, where extreme seasonality imposes a very specific labour regime. Copyright © 2001 John Wiley & Sons, Ltd. [source] Mission Theology of the ChurchINTERNATIONAL REVIEW OF MISSION, Issue 1 2010Kirsteen Kim This article on the mission theology of the church, a personal perspective by the vice-moderator of CWME, draws on documentation produced by the commission and also responds to the Faith and Order document, The Nature and Mission of the Church. It is based on the trinitarian paradigm of mission referred to as missio Dei, which emphasizes the priority of God's sending activity in the world, by the Son and the Spirit, and the contingency of the church and its mission activities upon that. Therefore, it is concerned with the participation of the church in God's mission to and in the world, and from this perspective, has a particular interest with the actual, empirical church rather than the ideal church, recognizing that the church exists in many different forms in particular social, cultural, economic and political contexts. The article argues that the church is "missionary by its very nature". Both theologically and empirically, it is impossible to separate the church from mission. Indeed mission is the very life of the church and the church is missionary by its very nature the Spirit of Christ breathed into the disciples at the same time as he sent them into the world. The mission theology of the church as it has developed in ecumenical discussion over the 20th and early 21st centuries is discussed in terms of the relationship of the church to the three persons of the Trinity: as foretaste of the kingdom of God; as the body of Christ; and as a movement of the Spirit. The article shows that being in mission is to cross the usual boundaries and bring new perspectives from outside to bear, and this is a never-ending, enriching process. [source] The SARS Crisis: Was Anybody Responsible?JOURNAL OF CONTINGENCIES AND CRISIS MANAGEMENT, Issue 2 2006Stephanie Buus As scholars in fields such as media studies, crisis studies and public policy studies have argued, there exists a fundamental link between crises and the media. Once an event has been interpreted as a crisis, questions of accountability inevitably appear on the media agenda, and the struggle to attribute blame and responsibility to a specific entity or entities,the blame game,thus becomes an inexorable part of the crisis process. Focusing on three liberal Western newspapers with an international, primarily Western elite readership and a reputation for in-depth analysis of global events, The Economist, the Financial Times and the International Herald Tribune, this article employs Iyengar's and Valkenburg's notions of responsibility frames to examine whether initial coverage of the 2003 SARS crisis in these accounts held any particular entity accountable for the crisis, looks at three key themes used to communicate to the reader a particular way of thinking about responsibility for SARS and examines some of the consequences of the kind of responsibility frame constructed around the SARS crisis in these accounts. As our findings show, there is an entity that the early news accounts studied consistently held responsible for the 2003 SARS crisis, the Chinese system, and the corresponding responsibility frame at operation in these accounts is thematic rather than episodic in nature, since it consistently places the SARS crisis within a broader context (a product of "China" itself and/or of societal-governmental forces in China) rather than in relation to a specific episode or as the result of the particular actions of individuals. The SARS crisis narrative therefore presented in these accounts tells the story of an anachronistic Chinese system faced with a contemporary health threat that, by its very nature, it is incapable of assessing accurately or managing responsibly. By way of conclusion, we argue that, while the use of such a thematic frame to explain China's role in the 2003 SARS crisis may be accurate in certain respects, this frame falls short in other respects and proves particularly inadequate to the challenge of capturing the economic complexities of China's role during the crisis. [source] Corporate restructurings: ripple effects on corporate philanthropyJOURNAL OF PUBLIC AFFAIRS, Issue 1 2004Jennifer J. Griffin Abstract Corporate restructurings, by their very nature, are inherently disrupting. With managerial discretion potentially curtailed, the ripple effects of restructurings are likely to be widespread and long-lasting. This paper examines one ripple effect of corporate restructurings: the effects of donations from corporate philanthropic foundations after acquisitions. By extending the business strategy merger and acquisition (M&A) literature to include philanthropic activities and applying the corporate citizenship literature to an M&A context, the author creates a model and tests hypotheses. Simultaneous examination of the impacts of corporate citizenship and business strategy is warranted in today's research on corporate restructurings, since larger acquisitions are occurring more frequently, and acquisitions have the potential to adversely affect large numbers of individuals. As ever-larger firms consolidate, with record-breaking merger announcements, the potential for increased scrutiny by the media, shareholders, anti-trust officials and salient stake-holders is heightened. These findings, contrary to predictions, suggest that corporate philanthropy increases during the first year after an acquisition within the same industry. Moreover, the increase is sustained. Philanthropic donations continue to increase three years after acquisitions within the same industry. Implications for public affairs executives is examined. Copyright © 2004 Henry Stewart Publications [source] THE CONFESSING ANIMAL IN FOUCAULT AND WITTGENSTEINJOURNAL OF RELIGIOUS ETHICS, Issue 4 2006Bob Plant ABSTRACT In The History of Sexuality, Foucault maintains that "Western man has become a confessing animal" (1990, 59), thus implying that "man" was not always such a creature. On a related point, Wittgenstein suggests that "man is a ceremonial animal" (1996, 67); here the suggestion is that human beings are, by their very nature, ritualistically inclined. In this paper I examine this crucial difference in emphasis, first by reconstructing Foucault's "genealogy" of confession, and subsequently by exploring relevant facets of Wittgenstein's later thinking. While there are significant correlations between Foucault and Wittgenstein, an important disparity emerges in relation to the question of the "natural." By critically analyzing this, I show how Wittgenstein's minimal naturalism provides an important corrective to Foucault's more extravagant claims. By implication, we see why any radical relativist, historicist, and/or constructivist position becomes untenable on Wittgensteinian grounds, even though Wittgenstein himself is often read as promoting such views. [source] Sports Medicine and School Nurses: A Growing Need for Further Education and Appropriate ResourcesJOURNAL OF SCHOOL HEALTH, Issue 1 2006Cynthia S. Knight The use of exercise as a prerequisite for conditioning and proper treatment of injuries was first documented in early Greek civilization with the establishment of the Olympics. Today, sports by their very nature invite injury. In 2000, 2.5 million students participated in varsity sports with 750,000 injuries recorded. These numbers do not account for sports activities outside school or leisure activities. Another area of potential injury is physical education class. These classes are large with limited supervision and encompass students of varying age and abilities. Nurses do not have an extensive knowledge of injury prevention or assessment in their basic nursing education. School nurses, as a subspecialty within nursing, are expected to keep up with the requirements of the adolescent and pediatric populations as well basic nursing skills. Due to work schedules and limited resources for continuing education, school nurses are not afforded much time or benefits to attend classes that would teach them skills needed to assess athletic-type injuries. School nurses need printed resources specific to their setting to help fill this void. Recognizing this need, Sports Medicine Techniques for the School-Based Nurse is a manual in process that will help fill this void. Being developed specifically for school nurses, the manual will provide information on prevention, evaluation, and management of athletic-type injuries commonly seen in the school nurse's office. (J Sch Health. 2006;76(1):8-11) [source] Too hot to handle?JOURNAL OF SYNCHROTRON RADIATION, Issue 6 2002Synchrotron X-ray damage of lipid membranes, mesophases The call for brighter synchrotron X-radiation sources for use in structural biology research is barely audible as we enter the new millennium. Our brightest sources are already creating havoc when used at design specifications because of radiation damage. The time is long overdue to take stock of where we are and where we wish to go with regards to using existing sources and to designing new ones. The problem of radiation damage is particularly acute in studies involving kinetics and mechanisms where cryo-techniques are not always viable. Accordingly, we need to understand the very nature of radiation damage and to devise means of minimizing it. This is the thrust of the current report as applied to lipid membranes and mesophases. The experiments were performed at the most brilliant beamlines at CHESS, the APS and the ESRF. Two very different types of radiation damage are reported here. One involves a dramatic phase transformation and the other a disordering of lamellar stacking. How beam energy and dose rate affect damage is also discussed. The work highlights the free-radical-mediated nature of the damage process and the need for additional studies if the most efficient use is to be made of an important resource, synchrotron radiation. [source] Writing Revolution: British Literature and the French Revolution Crisis, a Review of Recent Scholarship1LITERATURE COMPASS (ELECTRONIC), Issue 6 2006M. O. Grenby The French Revolution had a profound effect on almost all aspects of British culture. French events and ideas were avidly discussed and disputed in Britain. Long-standing British political and cultural debates were given new life; new socio-political ideologies rapidly emerged. The sense of political, religious and cultural crisis that developed in the 1790s was only slowly to dissipate. Generations afterwards, many British thinkers and writers were still considering and renegotiating their responses. The effect of the Revolution Crisis on British literature was particularly marked, something that was widely recognised at the time and has been the focus of much scholarship since. It has become something of a cliché that British literary Romanticism was born out of the Revolution. The last few decades have produced new waves of powerful criticism which has re-examined the relationship between the Revolution Crisis and the works it shaped. Different strands of radical writing have now received detailed investigation, as have equally complex conservative responses. Writing by and for women is now receiving as much attention as writing by men, and previously neglected forms, such as the popular novel, pamphlets and children's literature, are now the subject of an increasing number of studies. The writing of the 1790s and early 1800s has in fact provided many scholars with their test-case for exploring the very nature of the relationship between text and context. It is this profusion of recent, sophisticated and rapidly evolving scholarship which this article surveys. [source] Death of a living liver donor from illicit drugsLIVER TRANSPLANTATION, Issue 8 2007Burckhardt Ringe In children with acute hepatic failure, it has been suggested to offer living donor transplantation to all parents when a deceased donor organ can not be provided. Ethically, living related donation is coercive by its very nature, especially in emergencies. We report a 36-year-old woman who died from a drug overdose 57 days after living donor liver resection. The recipient was her 3-year-old son, who experienced acute hepatic failure as a result of acetaminophen intoxication. A deceased donor organ had not become available within 2 days after listing. Was the death of this living donor preventable or unpreventable? Certainly if the mother had decided not to take drugs, she would not have died from an overdose. One could argue that this was her personal choice, and beyond our influence. On the other hand, if we had not performed the surgery, the recipient might have died without receiving a liver transplant in time. Liver Transpl 13:1193,1194, 2007. © 2007 AASLD. [source] Physiological Linguistics, and Some Implications Regarding Disciplinary Autonomy and UnificationMIND & LANGUAGE, Issue 1 2007SAMUEL D. EPSTEIN At least current irreducibility of biology, including biolinguistics, stems in at least some cases from the very nature of what I will claim is physiological, or inter-organ/inter-component, macro-levels of explanation which play a new and central explanatory role in Chomsky's inter-componential (interface-based) explanation of certain (anatomical) properties of the syntactic component of Universal Grammar. Under this new mode of explanation, certain physiological functions of cognitive mental organs are hypothesized, in an attempt to explain aspects of their internal anatomy. Thus, the internal anatomy of the syntactic component exhibits features that enable it to effectively interface with (i.e. function in a coordinated fashion with) other ,adjacent' organs, such as the Conceptual-Intensional (C-I) (,meaning') system and the Sensory- Motor (SM) (,sound') system. These two interface systems take as their inputs the assembled outputs of the syntactic component and, as a result of the very syntactic structure imposed by the syntax (as opposed to countless imaginable alternatives) are then able to assign their (linearized) sound and (compositional) meaning interpretations. If this is an accurate characterization, Chomsky's long-standing postulation of mental organs, and I will argue, the advancement of new hypotheses concerning physiological inter-organ functions, has attained in current biolinguistic Minimalist method a significant unification with foundational aspects of physiological explanation in other areas of biology. [source] Conditioning Factors for Fertility Decline in Bengal: History, Language Identity, and Openness to InnovationsPOPULATION AND DEVELOPMENT REVIEW, Issue 4 2000Alaka Malwade Basu This article argues that looking solely for the immediate causes of reproductive change may distort our understanding of policy options by failing to take into account the historical and cultural factors that affect not only the impact of policies and programs but their very nature and existence. The article examines the historical origins and spread of "modern" ideas in Bangladesh and the state of West Bengal in India. It concludes that a colonial history in which education and modernization processes took hold very early among the elites in the larger Bengal region was paradoxically accompanied by a strong allegiance to the Bengali language. This strong sense of language identity has facilitated and reinforced the diffusion of modern ideas both within and between the two Bengali-speaking regions. Thus, to understand the fertility decline in Bangladesh, for example, one needs to look also at cultural boundaries. In this case, the cultural commonality through language facilitates the spread of new ideas across the two Bengals. In turn, the strong sense of language identity has facilitated mass mobilization more easily and intensely within the two Bengals. Shaped by these processes, Bangladesh and West Bengal today are more amenable to social change than many other parts of South Asia and the Middle East. [source] Engineering psychophysiology: Issues and applications, edited by Richard W. Backs and Wolfram Bousein.PSYCHOPHYSIOLOGY, Issue 3 20022000., Hillsdale, NJ: Lawrence Erlbaum Associates Advancing technology changes the very nature of the world in which we interact. Often these changes introduce unintended stresses and strains on the individual attempting to interact with this new technology. The objective of this 17-chapter edited volume is to promote engineering psychophysiology as a discipline that uses a variety of psychophysiological measures to understand and potentially improve the nature of our interactions in the real world. The target audience for the book is the researcher who is new to the use of psychophysiological measures in engineering applications. [source] Whose middle is it anyway?PUBLIC POLICY RESEARCH, Issue 4 2009Why universal welfare matters Tim Horton and James Gregory consider why in this general election the battle for the middle will illuminate perhaps the most important left-right strategic battle for a century or more: the battle to define the very nature of our welfare state [source] Are potential natural vegetation maps a meaningful alternative to neutral landscape models?APPLIED VEGETATION SCIENCE, Issue 2 2002Carlo Ricotta Abstract. In this paper, we present a short overview of neutral landscape models traditionally adopted in the landscape ecological literature to differentiate landscape patterns that are the result of simple random processes from patterns that are generated from more complex ecological processes. Then, we present another family of models based on Tuxen' s definition of potential natural vegetation that play an important role, especially in Europe, for landscape planning and management. While neutral landscape models by their very nature do not take into account vegetation dynamics, nor abiotic constraints to vegetation distribution, the concept of potential natural vegetation includes the effects of vegetation dynamics in a spatially explicit manner. Therefore, we believe that distribution maps of potential natural vegetation may represent an ecological meaningful alternative to neutral landscape models for evaluating the effects of landscape structure on ecological processes. [source] An Evaluation Crucible: Evaluating Policy Advice in Australian Central AgenciesAUSTRALIAN JOURNAL OF PUBLIC ADMINISTRATION, Issue 1 2000Michael Di Francesco Policy advice is a core function of government that until quite recently remained outside the formal processes of performance evaluation. Evaluation, by its very nature, is designed to question both the effectiveness and relevance of government activities; applying it to policy advice opens up a traditionally confidential and politically sensitive arena. This paper reports on an evaluation experiment in Australian government , policy management reviews (PMRs) , that sought to evaluate the quality of central agency policy advice. It traces the development of the PMR model around interdepartmental committee processes, the bureaucratic politics that diluted the focus on policy outcomes, and examines how central agencies steered evaluation away from questions of public accountability towards arrangements for achieving more effective control of the processes underpinning production of advice. By targeting the process rather than outcomes of policy advising, PMRs sought unsuccessfully to adhere to the divide between management and policy and, in doing so, marked out the limits to performance evaluation. [source] Aerodynamically assisted jetting and threading for processing concentrated suspensions containing advanced structural, functional and biological materialsBIOTECHNOLOGY JOURNAL, Issue 1 2009Sumathy Arumuganathar Abstract In recent years material sciences have been interpreted right across the physical and the life sciences. Essentially this discipline broadly addresses the materials, processing, and/or fabrication right up to the structure. The materials and structures areas can range from the micro- to the nanometre scale and, in a materials sense, span from the structural, functional to the most complex, namely biological (living cells). It is generally recognised that the processing or fabrication is fundamental in bridging the materials with their structures. In a global perspective, processing has not only contributed to the materials sciences but its very nature has bridged the physical with the life sciences. In this review we discuss one such swiftly emerging fabrication approach having a plethora of applications spanning the physical and life sciences. [source] A ,business opportunity' model of corporate social responsibility for small- and medium-sized enterprisesBUSINESS ETHICS: A EUROPEAN REVIEW, Issue 1 2009Heledd Jenkins In their book ,Corporate Social Opportunity', Grayson and Hodges maintain that ,the driver for business success is entrepreneurialism, a competitive instinct and a willingness to look for innovation from non-traditional areas such as those increasingly found within the corporate social responsibility (CSR) agenda'. Such opportunities are described as ,commercially viable activities which also advance environmental and social sustainability'. There are three dimensions to corporate social opportunity (CSO) , innovation in products and services, serving unserved markets and building new business models. While small- and medium-sized enterprises (SMEs) have traditionally been presented as non-entrepreneurial in this area, this paper demonstrates how SMEs can take advantage of the opportunities presented by CSR. Using data from 24 detailed case studies of UK SMEs from a range of sectors, the paper explores the numerous CSR opportunities that present themselves to SMEs, such as developing innovative products and services and exploiting niche markets. There are inevitable challenges for SMEs undertaking CSR, but by their very nature they have many characteristics that can aid the adoption of CSR; the paper explores these characteristics and how the utilisation of positive qualities will help SMEs make the most of CSOs. Integrating CSR into the core of a company is crucial to its success. Using the case studies to illustrate key points, the paper suggests how CSR can be built into a company's systems and become ,just the way we do things'. There are a number of factors that characterise the CSO ,mentality' in an organisation, and Grayson and Hodges's book describes seven steps that will move a company in the direction of a ,want to do' CSO mentality. This paper adapts these steps for SMEs, and by transferring and building on knowledge from the 24 detailed case studies, it develops a ,business opportunity' model of CSR for SMEs. [source] The role of evidence-based medicine and clinical trials in rare genetic disordersCLINICAL GENETICS, Issue 3 2008MC Kruer The drive to empirically evaluate and analyze tools for the screening, diagnosis, management and monitoring of disease captured by the phrase ,evidence-based medicine (EBM)' has firmly entrenched itself as part of standard clinical care. However, rare genetic disorders, by their very nature, challenge the generation and application of EBM. This review presents many of the challenges encountered in applying EBM to rare genetic disorders, highlighting areas of recent emphasis in establishing multi-institutional collaborative research networks and in the systematic evaluation of developing therapies. Resources for identifying EBM tools for the practitioner are discussed, and the features and limitations of such resources are presented. Although the application of EBM to rare genetic disorders has definite limitations, a foundation has been established, and ongoing efforts seeking to systematically summarize and critically evaluate available evidence will continue to help identify the most effective tools for screening, diagnosis, management, and monitoring. [source] Are normal and complicated grief different constructs?CLINICAL PSYCHOLOGY AND PSYCHOTHERAPY (AN INTERNATIONAL JOURNAL OF THEORY & PRACTICE), Issue 6 2008A confirmatory factor analytic test Nowadays, much debate in the bereavement domain is directed towards the inclusion of Complicated Grief (CG) as a separate category in the Diagnostic and Statistical Manual of Mental Disorders. Important within this discussion is the conceptual relationship between CG reactions and normal grief (NG) reactions. This study aims at elucidating this relationship by using data from 456 bereaved young adults, aged 17 to 25 years. We examined the structural distinctiveness of CG and NG reactions, using two criteria sets. The first set ties in with previous research in bereaved adults on the distinctiveness of CG and NG and allows to test the replicability of earlier findings. The second set links up with the recently revised criteria for CG and permits to investigate whether earlier findings hold for the new criteria. For both sets, two models for NG and CG were compared using confirmatory factor analytic procedures. These analyses revealed that CG and NG reactions can be distinguished by their very nature, except for one CG reaction (viz. ,yearning'), that loaded on both factors.,Copyright © 2008 John Wiley & Sons, Ltd. [source] | |||||||||||||||||||||||||