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Very Effective Tool (very + effective_tool)
Selected AbstractsCapillary zone electrophoresis with a dynamic double coating for analysis of carbohydrate-deficient transferrin in human serum: Impact of resolution between disialo- and trisialotransferrin on reference limitsELECTROPHORESIS, Issue 24 2003Christian Lanz Abstract Capillary electrophoresis with a dynamic double coating formed by charged polymeric reagents represents a very effective tool for the separation of iron-saturated transferrin (Tf) isoforms and thus the determination of carbohydrate-deficient transferrin (CDT) in human serum. The resolution between di- and trisialo-Tf is dependent on the applied voltage and capillary temperature. With a 50 ,m inside diameter (ID) capillary of about 60 cm total length mounted into the P/ACE MDQ, 28 kV and 40°C, the resolution of the two Tf isoforms is shown to be between 1.0 and 1.4, whereas with reduced voltage and/or temperature, increased resolution at the expense of elongated run times is observed. Best data with complete resolution (Rs , 1.4) are obtained at 20 kV and 30°C. For the determination of CDT in serum, incomplete separation of di- and trisialo-Tf is demonstrated to have an impact on the reference limits. Analysis of the sera of 54 healthy individuals with no or moderate alcohol consumption and using valley-to-valley peak integration, the upper (lower) reference limits for CDT in relation to total Tf at the two power levels are 1.33 (0.52) and 1.57 (0.81)%, respectively, representing intervals that are significantly different (P < 0.001). Furthermore, the reference intervals are shown to be strongly dependent on the peak integration approach used. Valley-to-valley peak integration should only be employed for conditions with complete resolution between disialo- and trisialo-Tf. [source] Relaxation Time Spectrum of Hydrogels by CONTIN AnalysisJOURNAL OF FOOD SCIENCE, Issue 3 2000R. Mao ABSTRACT: CONTIN is a general-purpose program for inverting noisy linear algebraic and integral equations by means of inverse Laplace transform. This study explored the application of CONTIN analysis to determine the relaxation time distribution spectra for food gels, including gellan, carrageenan, whey protein, and gelatin gels, based on stress-relaxation data. CONTIN results represent the continuous relaxation time spectra when the number of the terms in the discrete Maxwell stress-relaxation model approached infinity. The CONTIN results for gellan gels were correlated to the texture properties of gels from compression tests with respect to the effects of calcium concentrations. CONTIN analysis may be a very effective tool in elucidating the microstructural properties of a hydrogel from mechanical testing. [source] Microenvironmental pH modulation in solid dosage formsJOURNAL OF PHARMACEUTICAL SCIENCES, Issue 5 2007Sherif I. Farag Badawy Abstract There are many reports in the literature referring to the effect of ,microenvironmental pH' on solid dosage form performance, particularly stability and dissolution profiles. Several techniques have been proposed for the measurement of the microenvironmental pH. Those techniques use certain assumptions and approximations and many of them employ a solution calibration curve of a probe to predict hydrogen ion activity in a substantially dry solid. Despite the limitation of the methodology, it is clear from the literature that microenvironmental pH has a significant impact on stability of compounds which demonstrate pH dependent stability in solution. Degradation kinetics of such compounds, and in some cases degradation profile as well, are dependent on the microenvironmental pH of the solid. Modulation of the microenvironmental pH through the use of pH modifiers can hence prove to be a very effective tool in maximizing solid dosage form stability. Judicial selection of the appropriate pH modifier, its concentration and the manufacturing process used to incorporate the pH modifier is necessary to enhance stability. Control of microenvironmental pH to maximize stability can be achieved without the use of pH modifier in some cases if an appropriate counter ion is used to provide an inherently optimal pH for the salt. Microenvironmental pH modulation was also shown to control the dissolution profile of both immediate and controlled release dosage forms of compounds with pH dependent solubility. The pH modifiers have been used in conjunction with high energy or salt forms in immediate release formulations to minimize the precipitation of the less soluble free form during initial dissolution. Additionally, pH modifiers were utilized in controlled release dosage forms of weakly basic drugs which exhibit diminished release in dissolution media with high pH. The incorporation of acidic pH modifiers in the controlled release formulation increases the solubility of the basic drug even as the high pH dissolution medium enters into the dosage form hence increasing drug release rate. © 2007 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 96: 948,959, 2007 [source] Digital photography for patient counseling in dermatology , a studyJOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY & VENEREOLOGY, Issue 11 2008F Kaliyadan Abstract Objectives To evaluate the use of digital photography in dermatology as an aid to patient counseling and follow-up. Materials and methods Two hundred patients attending the dermatology Out-Patient Department at our centre over a 1-year period were included. Half the group, randomly assigned (G1), had their clinical photographs taken and were counseled using basic imaging software, their images and other relevant images regarding their disease and possible treatment outcomes. The control group (G0) was counseled without using any kind of imaging. Patient satisfaction was scored in both groups after the initial counseling session and then after 2 months. Results The test group (G1) gave statistically significant higher scores at both readings compared with the control group (G0). Conclusion Digital imaging can be a very effective tool for the dermatologist for patient counseling. [source] A Critique of the Private Health Insurance RegulationsTHE AUSTRALIAN ECONOMIC REVIEW, Issue 3 2004Rhema Vaithianathan The private health insurance sector is one of the most regulated sectors in Australia. The Private Health Insurance Incentives Scheme, along with community rating, is intended to make private insurance equitable, profitable and popular. We argue that the subsidy to health insurance ought to be a very effective tool for increasing insurance,but it was ineffective because community rating was ineffective. Using data from the Household Expenditure Survey we find that despite community rating rules which prohibit age-adjusted premiums, young adults paid considerably less for their insurance than older adults. We conclude that insurers circumvented community rating through plan design, screening older consumers into more expensive plans. We also find that the penalty of 2 per cent per year for delaying insurance, introduced as part of the lifetime cover plan, is too low to be effective. We reflect on the New Zealand experience, where a completely deregulated insurance industry continues to be profitable and enjoys similar rates of coverage to those of Australia, and we ask whether Australia too could not benefit from complete deregulation. [source] | ||||||||||