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Selected AbstractsRelational Contracts and the Nature of Market InteractionsECONOMETRICA, Issue 3 2004Martin Brown We provide evidence that long-term relationships between trading parties emerge endogenously in the absence of third party enforcement of contracts and are associated with a fundamental change in the nature of market interactions. Without third party enforcement, the vast majority of trades are initiated with private offers and the parties share the gains from trade equally. Low effort or bad quality is penalized by the termination of the relationship, wielding a powerful effect on contract enforcement. Successful long-term relations exhibit generous rent sharing and high effort (quality) from the very beginning of the relationship. In the absence of third-party enforcement, markets resemble a collection of bilateral trading islands rather than a competitive market. If contracts are third party enforceable, rent sharing and long-term relations are absent and the vast majority of trades are initiated with public offers. Most trades take place in one-shot transactions and the contracting parties are indifferent with regard to the identity of their trading partner. [source] Biofilm Growth and Bed Fluidization in a Fluidized Bed Reactor Packed with Support Materials of Low Density,ENGINEERING IN LIFE SCIENCES (ELECTRONIC), Issue 2 2004R.A. Saucedo-Terán Abstract Support materials of low-density for fluidized bed reactors provide several operational advantages, including lower energy requirements and proper biofilm growth balance. The aim of this investigation was to study the extent of biofilm growth and bed fluidization in an experimental reactor, using polyester resin (,pr,=,1220,kg/m3) and vitrified expanded perlite (,vep,=,1710,kg/m3) as alternative support materials to conventional silica sand. A noteworthy amount of biofilm was observed to be attached to both support materials from the very beginning of the bioreactor operation. Nevertheless, there were significant variations in biofilm growth and activity over the course of the experimental trials. For both perlite and polyester beds, the highest biofilm mass and the highest total number of mesophilic bacteria were observed between the 7th and the 10th day, showing a steady state trend at the end of the experimental runs. The chemical oxygen demand (COD) removal levels were concomitant with biofilm mass and total mesophilic bacteria changes, although the polyester bed efficiency was slightly higher than that for the perlite bed. As expected, the polyester bed was fluidized at a lower re-circulation flow compared to the perlite bed. Reactor back-washing was not required for these support materials since biomass excess was adequately separated by means of a special internal device. The efficiencies of removal of organic matter achieved were acceptable (up to 78,%) despite the low volume of the support material (25,%) and the low hydraulic retention time (30,min). [source] Natural killer cells in viral hepatitis: facts and controversiesEUROPEAN JOURNAL OF CLINICAL INVESTIGATION, Issue 9 2010Mario U. Mondelli Eur J Clin Invest 2010; 40 (9): 851,863 Abstract Background, Hepatitis B virus (HBV) and hepatitis C virus (HCV) are major human hepatotropic pathogens responsible for a large number of chronic infections worldwide. Their persistence is thought to result from inefficiencies of innate and adaptive immune responses; however, very little information is available on the former. Natural killer (NK) cells are a major component of innate immunity and their activity is tightly regulated by several inhibitory and activating receptors. Design, In this review, we examine controversial findings regarding the role of NK cells in the pathogenesis of acute and chronic liver disease caused by HCV and HBV. Results, Recent studies built up on technical advances to identify NK receptors and their functional correlates in this setting. While NK cells seem to behave correctly during acute hepatitis, it would appear that the NK cytotoxic potential is generally conserved in chronic hepatitis, if not increased in the case of HCV. In contrast, their ability to secrete antiviral cytokines such as interferon ex vivo or after cytokine stimulation is severely impaired. Conclusions, Current evidence suggests the existence of an NK cell functional dichotomy, which may contribute to virus persistence, while maintaining low-level chronic liver inflammation. The study of liver-infiltrating NK cells is still at the very beginning, but it is likely that it will shed more light on the role of this simple and at the same time complex innate immune cell in liver disease. [source] Production of d -(,)-3-hydroxyalkanoic acid by recombinant Escherichia coliFEMS MICROBIOLOGY LETTERS, Issue 1 2003Kai Zhao Abstract Pathways for extracellular production of chiral d -(,)-3-hydroxybutyric acid (3HB) and d -(,)-3-hydroxyalkanoic acid (mcl-3HA) were constructed by co-expression of genes of ,-ketothiolase (phbA), acetoacetyl-CoA reductase (phbB) and 3-hydroxyacyl-ACP CoA transacylase (phaG), respectively, in Escherichia coli strain DH5,. The effect of acrylic acid and glucose on production of both 3HB and mcl-3HA was investigated. It was found that the addition of acrylic acid significantly increased production of 3HB and mcl-3HA consisting of 3-hydroxyoctanoic acid and 3-hydroxydecanoic acid in a ratio of 1:3 from 199 mg l,1 to 661 mg l,1 and from 27 mg l,1 to 135 mg l,1, respectively, in shake flask studies when glucose was present in the medium at the very beginning of fermentation. The timing of glucose addition had no effect on 3HB production. In contrast, mcl-3HA production was affected by glucose addition, an mcl-3HA concentration of 193 mg l,1 was obtained when glucose was added to the culture at 12 h. A more than seven-fold increase was obtained when compared with that in medium containing glucose at the beginning of fermentation. However, a decrease in production of 3HB and mcl-3HA was found when glucose was added at 12 h to the culture containing acrylic acid. The repressive effect of acrylic acid on acetic acid production was also evaluated and discussed. [source] Mass-independent fractionation of sulfur isotopes in sulfides from the pre-3770 Ma Isua Supracrustal Belt, West GreenlandGEOBIOLOGY, Issue 4 2006D. PAPINEAU ABSTRACT Redox chemistry of the coupled atmosphere,hydrosphere system has coevolved with the biosphere, from global anoxia in the Archean to an oxygenated Proterozoic surface environment. However, to trace these changes to the very beginning of the rock record presents special challenges. All known Eoarchean (c. 3850,3600 Ma) volcanosedimentary successions (i.e. supracrustal rocks) are restricted to high-grade gneissic terranes that seldom preserve original sedimentary structures and lack primary organic biomarkers. Although complicated by metamorphic overprinting, sulfur isotopes from Archean supracrustal rocks have the potential to preserve signatures of both atmospheric chemistry and metabolic fractionation from the original sediments. We present a synthesis of multiple sulfur isotope measurements (32S, 33S and 34S) performed on sulfides from amphibolite facies banded iron-formations (BIFs) and ferruginous garnet-biotite (metapelitic) schists from the pre-3770 Ma Isua Supracrustal Belt (ISB) in West Greenland. Because these data come from some of the oldest rocks of interpretable marine sedimentary origin, they provide the opportunity to (i) explore for possible biosignatures of sulfur metabolisms in early life; (ii) assess changes in atmospheric redox chemistry from ,3.8 Ga; and (iii) lay the groundwork to elucidate sulfur biogeochemical cycles on the early Earth. We find that sulfur isotope results from Isua do not unambiguously indicate microbially induced sulfur isotopic fractionation at that time. A significantly expanded data set of ,33S analyses for Isua dictates that the atmosphere was devoid of free oxygen at time of deposition and also shows that the effects of post-depositional metamorphic remobilization and/or dilution can be traced in mass-independently fractionated sulfur isotopes. [source] Ribonucleotide activation by enzyme ribonucleotide reductase: Understanding the role of the enzymeJOURNAL OF COMPUTATIONAL CHEMISTRY, Issue 16 2004Nuno M. F. S. A. Cerqueira Abstract This article focuses on the first step of the catalytic mechanism for the reduction of ribonucleotides catalyzed by the enzyme Ribonucleotide Reductase (RNR). This corresponds to the activation of the substrate. In this work a large model of the active site region involving 130 atoms was used instead of the minimal gas phase models used in previous works. The ONIOM method was employed to deal with such a large system. The results gave additional information, which previous small models could not provide, allowing a much clearer evaluation of the role of the enzyme in this step. Enzyme,substrate interaction energies, specific transition state stabilization, and substrate steric strain energies were obtained. It was concluded that the transition state is stabilized in 4.0 kcal/mol by specific enzyme,substrate interactions. However, this stabilization is cancelled by the cost in conformational energy for the enzyme to adopt the transition state geometry; the overall result is that the enzyme machinery does not lead to a rate enhancement in this step. It was also found that the substrate binds to the active site with almost no steric strain, emphasizing the complementarity and specificity of the RNR active site for nucleotide binding. The main role of the enzyme at the very beginning of the catalytic cycle was concluded to be to impose stereospecifity upon substrate activation and to protect the enzyme radical from the solvent, rather than to be an reaction rate enhancement. © 2004 Wiley Periodicals, Inc. J Comput Chem 25: 2031,2037, 2004 [source] Ultrasonic processing of suspensions of hematite nanopowder stabilized with sodium polyacrylate,AICHE JOURNAL, Issue 11 2009P. Ding Abstract The effect of power input, solid content, surfactant concentration, and pH on the kinetics of wet deagglomeration of hematite nanopowder in ultrasonic comminution device and on the rheology of resulting suspensions has been investigated and compared with the kinetics of deagglomeration and rheology of the suspensions of goethite nanopowder. It has been found that the main mechanisms are fragmentation and erosion, which leads to bimodal transient size distributions of aggregates. Fragmentation of large aggregates starts after certain delay time but erosion of nanoparticles starts from very beginning of processing. Deaggregation of hematite nanopowder is only possible in the presence of surfactant, but increase of concentration of surfactant above certain critical value does not affect kinetics of deagglomeration. The increase of solid concentration up to 20 w/w% reduces the amount of energy necessary for deagglomeration of unit mass of the powder. Effect of pH on the kinetics of deagglomeration and the morphology/rheology of the resulting suspensions is discussed. © 2009 American Institute of Chemical Engineers AIChE J, 2009 [source] The cell differentiation protein SpoIIE contains a regulatory site that controls its phosphatase activity in response to asymmetric septationMOLECULAR MICROBIOLOGY, Issue 4 2002Andrea Feucht Summary Starvation induces Bacillus subtilis to initiate a simple, two-cell developmental process that begins with an asymmetric cell division. Activation of the first compartment-specific transcription factor, ,F, is coupled to this morphological event. SpoIIE, a bifunctional protein, is essential for the compartment-specific activation of ,F and also has a morphogenic activity required for asymmetric cell division. SpoIIE consists of three domains: a hydrophobic N-terminal domain, which targets the protein to the membrane; a central domain, involved in oligomerization of SpoIIE and interaction with the cell division protein FtsZ; and a C-terminal domain comprising a PP2C protein phosphatase. Here, we report the isolation of mutations at the very beginning of the central domain of spoIIE, which are capable of activating ,F independently of septum formation. Purified mutant proteins showed the same phosphatase activity as the wild-type protein in vitro. The mutant proteins were fully functional in respect of their localization to sites of asymmetric septation and support of asymmetric division. The data provide strong evidence that the phosphatase domain of SpoIIE is tightly regulated in a way that makes it respond to the formation of the asymmetric septum. [source] Ventricular shunts and the prevalence of sensitization and clinically relevant allergy to latex in patients with spina bifidaPEDIATRIC ALLERGY AND IMMUNOLOGY, Issue 2 2000Dietke Buck Patients with spina bifida represent the highest-risk group for developing hypersensitivity to latex. Recognized risk factors for these patients are repeated surgery and an atopic disposition. Our aim was to study the influence of a ventricular shunt as an independent risk factor. One hundred and sixty-one patients with spina bifida (median age 10 years) were investigated for the presence of a shunting device and the number, type and date of previous surgical interventions. Additionally, skin-prick tests and provocation tests were performed in order to classify sensitized and symptomatic latex-allergic individuals. Eighty-eight patients (54.7%) were sensitized; 55 (34.2%) were provocation-positive. Patients with a shunt system had undergone a significantly higher number of surgical procedures (p < 0.0001) and showed significantly higher levels of immunoglobulin E (IgE)-antibodies to latex (p < 0.0001) than patients without a shunting device. The total number of operations correlated significantly with the level of IgE-antibodies to latex in serum (p < 0.0001), whereas the number of shunt operations in patients with a ventricular shunt did not significantly correlate with the degree of sensitization. In conclusion, patients with spina bifida who have a ventricular shunt are at particularly high risk because they undergo a significantly higher number of operations than patients without a ventricular shunt. However, the ventricular shunt does not seem to be an independent risk factor. Furthermore, this study emphasizes that individuals at high risk, such as patients with spina bifida, should be handled latex-free from the very beginning of life. [source] Ab-initio theory of semiconductor band structures: New developments and progressPHYSICA STATUS SOLIDI (B) BASIC SOLID STATE PHYSICS, Issue 8 2009F. Bechstedt Abstract We present most recent developments to calculate the electronic states of semiconductors and insulators without taking into account experimental parameters. They are based on the solution of the quasiparticle equation starting with a reasonable zeroth order approximation for the electronic states and the GW approximation for the exchange,correlation self-energy. Due to inclusion of screened exchange effects from the very beginning, self-consistency can be easily reached. The advantages with respect to a starting point based on single-particle eigenfunctions and eigenvalues of the ground-state density functional theory (DFT) are clearly shown for band gaps, positions of semicore d-bands, and densities of states. The progress is demonstrated for compounds containing first-row elements such as metal oxides and nitrides whose gaps are much too small or even negative within the conventional DFT. (© 2009 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim) [source] Spin dynamics of exciton polaritons in microcavitiesPHYSICA STATUS SOLIDI (B) BASIC SOLID STATE PHYSICS, Issue 11 2005I. A. Shelykh Abstract In this chapter we address a complex set of optical phenomena linked to the spin dynamics of exciton polaritons in semiconductor microcavities. When optically created, polaritons inherit the spin and dipole moment from the exciting light. Their state can be fully characterized by a so-called "pseudospin" accounting for both spin and dipole moment orientation. However, from the very beginning of their life in a microcavity, polaritons start changing their pseudospin state under effect of effective magnetic fields of different nature and due to scattering with acoustic phonons, defects, and other polaritons. This makes pseudospin dynamics of exciton polaritons rich and complex. It manifests itself in non-trivial changes in polarization of light emitted by the cavity versus time, pumping energy, pumping intensity and polarization. During the first years of theoretical research on exciton-polariton relaxation the polarization has been simply neglected. Later it has been understood that the energy and momentum-relaxation of exciton polaritons are spin-dependent. It is typically the case in the regime of stimulated scattering when the spin polarizations of initial and final polariton state have a huge effect on the scattering rate between these states. It appeared that critical conditions for polariton Bose-condensation are also polarization-dependent. In particular, the stimulation threshold (i.e. the pumping power needed to have a population exceeding 1 at the ground state of the lower polariton branch) has been experimentally shown to be lower under linear than under circular pumping. These experimental observations have stimulated the theoretical research toward understanding of mutually dependent polarization- and energy-relaxation mechanisms in microcavities. The authors of this chapter have been working on theoretical description of different specific effects of polariton spin-dynamics in microcavities for years. Here we attempted to put together all fragments and to formulate a general approach to the problem that would allow then to consider a variety of particular cases. We start from reminding the main spin-relaxation mechanisms known for free carriers and excitons. We then overview the most essential experimental results in this field before to present our original formalism which allowed us to interpret the key experimental findings. We are going to discuss only the strong coupling regime leaving aside all polarization effects in VCSELs. (© 2005 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim) [source] Genetics of human iris colour and patternsPIGMENT CELL & MELANOMA RESEARCH, Issue 5 2009Richard A. Sturm Summary The presence of melanin pigment within the iris is responsible for the visual impression of human eye colouration with complex patterns also evident in this tissue, including Fuchs' crypts, nevi, Wolfflin nodules and contraction furrows. The genetic basis underlying the determination and inheritance of these traits has been the subject of debate and research from the very beginning of quantitative trait studies in humans. Although segregation of blue-brown eye colour has been described using a simple Mendelian dominant-recessive gene model this is too simplistic, and a new molecular genetic perspective is needed to fully understand the biological complexities of this process as a polygenic trait. Nevertheless, it has been estimated that 74% of the variance in human eye colour can be explained by one interval on chromosome 15 that contains the OCA2 gene. Fine mapping of this region has identified a single base change rs12913832 T/C within intron 86 of the upstream HERC2 locus that explains almost all of this association with blue-brown eye colour. A model is presented whereby this SNP, serving as a target site for the SWI/SNF family member HLTF, acts as part of a highly evolutionary conserved regulatory element required for OCA2 gene activation through chromatin remodelling. Major candidate genes possibly effecting iris patterns are also discussed, including MITF and PAX6. [source] Questioning Cognitivism and Constructivism in IR Theory: Reflections on the Material Structure of IdeasPOLITICS, Issue 2 2001Andreas Bieler In recent years, it has been highlighted in international relations theory that mainstream approaches neglect the role of ideas in relation to the formation of interests and international co-operation. This article critically discusses the renewed emphasis on ideas. ,Cognitive' and ,constructivist' approaches are outlined as the two main strands in the debate and a neo-Gramscian position within it is sketched. Importantly, a neo-Gramscian position is able to conceptualise the material structure of ideas, thereby overcoming the separation between ideas and material structure from the very beginning. [source] Inter- and Extra-Indian Admixture and Genetic Diversity in Reunion Island Revealed by Analysis of Mitochondrial DNAANNALS OF HUMAN GENETICS, Issue 3 2009Vincent Dubut Summary Reunion Island is a French territory located in the western Indian Ocean. The genetic pattern of the Reunionese population has been shaped by contributions from highly contrasting regions of the world. Over the last 350 years, several migration waves and cultural and socio-economic factors have led to the emergence of six main ethnic groups in Reunion. India is one of the principal regions that contributed to the setting up of the Reunionese population. Diversity, demographic and admixture analyses were performed on mtDNA variation of the Reunionese of Indian ancestry, including the Malbar and Zarab ethnic groups, in order to question their history. Using a phylogeographical approach, we generated and analysed quantitative data on the contribution of the Indian parental populations. Furthermore, we showed that the settlement of Reunion Island by Indians did not involve a founder effect, except in the very beginning of the Reunionese settlement (at the end of the 17th century). The accuracy of our results was optimised by a re-evaluation of the classification of the Southern Asian mtDNA haplogroups. Finally, by comparing our results to a previous study dealing with the Reunionese population, we highlighted how ethno-historical data are critical for reconstructing the complex history of multiethnic populations. [source] A new adaptive backstepping Coulomb friction compensator for servo control systems,ASIAN JOURNAL OF CONTROL, Issue 1 2009Jen-te Yu Abstract A new Coulomb friction compensator is proposed for servo control systems in this paper. The novelty of the new approach lies in its capability of assigning the eigenvalues of the resulting closed loop system while attacking the problem. First, based on the standard backstepping methodology, an implicit Lyapunov function, with part of the components being only symbolically constructed at the very beginning, is utilized. To increase the robustness of the system against disturbance and model inaccuracy, an integral term is employed in the design. Using part of the variable gradient method, we are able to turn the implicit Lyapunov function into an explicit one, which is positive definite, and whose time-derivative is negative definite. Second, it will be shown that the resulting closed loop error system is a switched linear system with two possible active modes that share the same set of eigenvalues, which is at our disposal. Unlike the common adaptive control design methods, such as the Control Lyapunov Function approach, in which the gains are typically positive but otherwise arbitrary, and are hence difficult to choose and have a lack of connection with the system's performance, our new scheme imposes two further constraints on the gains. It turns out that we can then match these gains with the coefficients of the desired characteristic equation of the closed loop system. In this respect, the gains are linked to the system's overall performance, which is a new and very appealing feature for such a scheme. Finally, a procedure of constructing a common Lyapunov function is provided to prove exponential stability of the aforementioned switched linear system. In addition, using the invariance principle, we will show the convergence of the estimated Coulomb friction coefficient to its real value. Numerical simulations are given to validate the effectiveness of the design and its robustness against friction time-variations. Compared to existing results, the proposed scheme is much simpler, hence, much more advantageous computationally. Copyright © 2009 John Wiley and Sons Asia Pte Ltd and Chinese Automatic Control Society [source] Carbonate seismic stratigraphy of the Gulf of Papua mixed depositional system: Neogene stratigraphic signature and eustatic controlBASIN RESEARCH, Issue 2 2008Evgueni N. Tcherepanov ABSTRACT The Eocene,Miocene carbonate deposition in the Gulf of Papua (GoP) corresponds to the carbonate evolution phase of this continental margin mixed depositional system. Global sea-level (eustatic) fluctuations appear to have been the most important factor influencing the mixed depositional system development during its carbonate phase. Development of the major carbonate system in the Gulf was initiated during the Eocene. Subsequent to an early Oligocene hiatus, the carbonate system expanded its surface area, vertically aggraded, then systematically backstepped, and finally partially drowned during the late Oligocene,early part of the early Miocene. During the late early Miocene,early middle Miocene, the carbonate system continued its vertical growth in most platform areas, where it was able to keep up with sea-level rise. At the early middle/late middle Miocene (Langhian/Serravallian) boundary, carbonate deposition shifted downward during a long-term sea-level regression, exposing most of the early middle Miocene platform tops. Following this downward shift, active carbonate production became restricted during the late middle Miocene to only the northeastern part of the study area, and carbonate accumulation was characterized by four systematically prograding units. At the very beginning of the late Miocene, the platform tops were re-flooded. The carbonate system was partially drowned, systematically backstepped, and locally aggraded during part of the late Miocene, the early Pliocene, and the Quaternary. The overall organization of the carbonate sequence geometries, observed in the GoP, display a clear pattern, often referred to as the Oligocene,Neogene stratigraphic signature. This pattern is identical to contemporaneous sedimentary patterns observed in pure carbonate systems such as in the Maldives and in the Bahamas, and also in some siliciclastic systems. Because this pattern is observed in several globally distributed locations, the recognition of the Oligocene,Neogene stratigraphic signature in the GoP demonstrates that the depositional evolution during the late Oligocene,Miocene and the early Pliocene must have been dominantly controlled by eustatic fluctuations. [source] On Genes, Brains, and Behavior: Why Should Developmental Psychologists Care About Brain Development?CHILD DEVELOPMENT PERSPECTIVES, Issue 3 2009Joan Stiles Abstract, The past several decades have seen tremendous progress in understanding mammalian brain development. The models that have emerged suggest that this development is dynamic and, from the very beginning, involves the continuous interaction of genetic, organismic, and environmental factors. The central question posed in this article is whether these models of brain development should be of import to developmental psychologists. It is argued that the key debates in psychology are founded on assumptions that are integrally related to questions of biology and biological inheritance. The construct of innateness, in particular, is central to these debates, and the biological system most critically implicated in claims about innate behaviors is the brain. However, as this article attempts to show, the underlying assumptions of contemporary psychological models reflect largely outdated ideas about what it means for something to be innate. Contemporary models of brain development challenge the foundational constructs of the nature versus nurture formulation, emphasizing that the processes of brain development engage both inherited and environmental factors and rely upon their continuous interaction. These models also emphasize that the relationship between brain and behavioral development is one of interdependence and reciprocity: Behaviors influence brain development and the brain mediates all behavior. Thus, the key to understanding the origins and emergence of both the brain and behavior lies in understanding how genetic, organismic, and environmental factors are engaged in the dynamic and interactive processes that define development of the neurobehavioral system. [source] The History of Sclerosing FoamsDERMATOLOGIC SURGERY, Issue 5 2004Jan-Christoph G. R. Wollmann MD Background. The use of foamed sclerosants in phlebology is undergoing a renaissance. The use of foam sclerotherapy was relaunched only a few years ago. Despite this, the early developments, pioneer findings, and improvements, especially in foaming techniques, are not widely recognized. Objective. The objective of this study was to give an overview from the very beginnings of foam sclerotherapy until the most recent and progressive techniques, as described by Tessari or the double syringe system technique. Results. The publications found after a thorough research for literature about foam sclerotherapy allow us to examine what has been invented between Orbach's work in 1944 and now and,surprisingly,even before 1944. The contributions of greatly reputed and also of unknown colleagues, such as Orbach, Sigg, Mayer, or Flückiger, are presented, giving a historical overview from the very beginnings of foam sclerotherapy until the most recent techniques. Basically, the literature shows that remarkable work was carried out in the field of noncommercial foam sclerotherapy and that sclerosing foams have been used by numerous doctors continuously for the past six decades, especially for the treatment of varicose veins of the lower limbs. Conclusion. The use of foamed sclerosing agents in therapy of large or small varicose veins is not new. It started as early as 1939 and has continuously been improved in the past decades. [source] The logic of turmoil: Some epistemological and clinical considerations on emotional experience and the infiniteTHE INTERNATIONAL JOURNAL OF PSYCHOANALYSIS, Issue 4 2008Pietro Bria The idea of the infinite has its origins in the very beginnings of western philosophy and was developed significantly by modern philosophers such as Galileo and Leibniz. Freud discovered the Unconscious which does not respect the laws of classical logic, flouting its fundamental principle of non-contradiction. This opened the way to a new epistemology in which classical logic coexists with an aberrant logic of infinite affects. Matte Blanco reorganized this Freudian revolution in logic and introduced the concept of bi-logic, which is an intermingling of symmetric and Aristotelic logics. The authors explore some epistemological and clinical aspects of the functioning of the deep unconscious where the emergence of infinity threatens to overwhelm the containing function of thought, connecting this topic to some of Bion's propositions. They then suggest that bodily experiences can be considered a prime source of the logic of turmoil, and link a psychoanalytic consideration of the infinite to the mind,body relation. Emotional catastrophe is seen both as a defect,a breakdown of the unfolding function which translates unconscious material into conscious experience,and as the consequence of affective bodily pressures. These pressures function in turn as symmetrizing or infinitizing operators. Two clinical vignettes are presented to exemplify the hypotheses. [source] | ||||||||||||||||||||||