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Valuable Test (valuable + test)
Selected AbstractsComparison of ADA and WHO criteria for the diagnosis of diabetes in elderly KoreansDIABETIC MEDICINE, Issue 10 2002K. M. Choi Abstract Aims This study was conducted to compare the prevalence and cardiovascular risk factors of different categories of glucose tolerance in the elderly Korean population using World Health Organization (WHO) and American Diabetes Association (ADA) criteria. Methods This study included 1456 non-diabetic subjects over the age of 60 years, selected from a cross-sectional study, which was conducted in 1999 in Seoul, Korea. Fasting and post-challenge 2-h plasma glucose, insulin levels, body mass index (BMI), waist,hip ratio (WHR), blood pressure, and lipid profiles were examined. Prevalence of glucose tolerance categories and the level of agreement (, statistics) were obtained using WHO 2-h criteria and ADA fasting criteria. Comparison of cardiovascular risk factors among several concordant and discordant glucose intolerance groups was done. Results The prevalence rates of newly diagnosed diabetes of elderly men defined by WHO 2-h criteria and ADA fasting criteria were 11.8% and 4.8%, respectively. That of elderly women was 8.1% by WHO 2-h criteria and 3.1% by ADA fasting criteria. The prevalence of impaired glucose tolerance (IGT) by WHO criteria was also higher than that of impaired fasting glucose (IFG) by ADA criteria (23.5% vs. 10.0% men, 23.7% vs. 7.5% women). The level of agreement between ADA fasting criteria and WHO 2-h criteria was low (weighted , = 0.228 men, weighted , = 0.301 women). The concordant diabetic women by both ADA fasting criteria and WHO 2-h criteria showed higher BMI, WHR, diastolic blood pressure, total cholesterol and triglyceride levels than concordant normal subjects. However, the isolated post-challenge hyperglycaemia (IPH) women group was not different significantly from the concordant normal women group except in BMI. Conclusions Our results clearly show that the 1997 ADA fasting criteria are less sensitive for diagnosing diabetes than oral glucose tolerance test (OGTT)-based WHO criteria in elderly Koreans. Also, there is a poor agreement of different categories of glucose tolerance between ADA and WHO criteria; therefore, the OGTT remains a valuable test in diagnosing diabetes and classifying various categories of glucose intolerance, especially in elderly Koreans. [source] Heat conduction in granular materialsAICHE JOURNAL, Issue 5 2001Watson L. Vargas Heat transfer in particulate systems is important to a vast array of industries, yet is poorly understood even in the simplest case,conduction through the solid phase. This is due in part to the stress and contact heterogeneities inherent to these systems. Heat conduction in a packet bed of cylinders is investigated both experimentally and computationally. A novel model is developed based on the Discrete Element Method, which not only sheds light on fundamental issues in heat conduction in particles, but also provides a valuable test bed for existing theories. By explicitly modeling individual particles within the bulk material, bed heterogeneities are directly included, and dynamic temperature distributions are obtained at the particle level. Comparison with experiments shows that this model yields a quantitatively accurate temperature field without the need for adjustable parameters or detailed microstructural information. This simple system may also provide insight into such phenomena as reactor hot spot formation and spontaneous combustion of bulk reactive materials. [source] Release liner removal method for transdermal drug delivery systems (TDDS)JOURNAL OF PHARMACEUTICAL SCIENCES, Issue 7 2010Anna M. Wokovich Abstract A release liner removal test is a valuable test for assessing the quality of a transdermal drug delivery system (i.e., TDDS, patch). This test measures the force required to remove the release liner from a patch. The objective of the present study was to establish sample preparation and instrument parameters for measuring release liner removal adhesion for TDDS. Ten TDDS were evaluated (six drugs for a total of 29 lots). Patches which had a rate-controlling membrane were run as-is, since they could not be cut to a precise width without sacrificing their structural integrity. Patches that were square or rectangular in shape were run as-is, and the width of these patches was determined using a digital caliper. Patches which were not square or rectangular in shape and did not have a rate-controlling membrane were cut to a precise width using a specimen cutter. Double-sided tape was used to adhere the liner side of the transdermal system to a clean stainless steel test panel. A release liner peel adhesion method for TDDS is proposed using a dwell time of approximately 3,min, a peel angle of 90°, and a peel speed of 300,mm/min. © 2010 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 99:3177,3187, 2010 [source] Normative reference values for lung transfer factor in Isfahan, IranRESPIROLOGY, Issue 4 2006Babak AMRA Objectives and background: Transfer factor or carbon monoxide diffusing capacity (DLCO) is a particularly valuable test of the appropriateness of gas exchange across the alveolocapillary membrane. The purpose of this study is to derive predictive equations for DLCO and its derivative volume-corrected DLCO (DLCO/VA) measured by single-breath method in a large non-smoking population sample in Isfahan. Methodology: We evaluated 1429 randomly selected subjects (732 men, aged 5,85 years). Gender-specific linear prediction equations were developed by multiple regression analysis; with measured DLCO, and DLCO/VA values (mmol/min/kPa), as dependent variables regressed against age (A), height (H) and body surface area (BSA). Results: For both genders, age had negative effects on DLCO, while height had a positive effect on DLCO and DLCO/VA (P < 0.01). The prediction equations for DLCO and DLCO/VA are: ,0.152 × height , 0.056 × age , 11.595' and ,,0.12 × age + 2.467', for men and: ,,0.035 × age , 0.133 × height , 10.707' and ,,0.012 × age , 0.02 × height + 2.755', for women, respectively. Conclusions: Our results therefore provide an original frame of reference for either DLCO or DLCO/VA in Iranian population, obtained from a standardized single-breath technique. [source] | |||||||||||||