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Vast Potential (vast + potential)

Distribution by Scientific Domains

Chemistry	42%

Selected Abstracts

Neurophysiological tests and neuroimaging procedures in non-acute headache: guidelines and recommendations

EUROPEAN JOURNAL OF NEUROLOGY, Issue 4 2004
G. Sandrini
The use of instrumental examinations in headache patients varies widely. In order to evaluate their usefulness, the most common instrumental procedures were evaluated, on the basis of evidence from the literature, by an EFNS Task Force (TF) on neurophysiological tests and imaging procedures in non-acute headache patients. The conclusions of the TF regarding each technique are expressed in the following guidelines for clinical use. 1Interictal electroencephalography (EEG) is not routinely indicated in the diagnostic evaluation of headache patients. Interictal EEG is, however, indicated if the clinical history suggests a possible diagnosis of epilepsy (differential diagnosis). Ictal EEG could be useful in certain patients suffering from hemiplegic and basilar migraine. 2Recording of evoked potentials is not recommended for the diagnosis of headache disorders. 3There is no evidence to justify the recommendation of autonomic tests for the routine clinical examination of headache patients. 4Manual palpation of pericranial muscles, with standardized palpation pressure, can be recommended for subdividing patient groups but not for diagnosis. Pressure algometry and electromyography (EMG) cannot be recommended as clinical diagnostic tests. 5In adult and paediatric patients with migraine, with no recent change in attack pattern, no history of seizures, and no other focal neurological signs or symptoms, the routine use of neuroimaging is not warranted. In patients with atypical headache patterns, a history of seizures and/or focal neurological signs or symptoms, magnetic resonance imaging (MRI) may be indicated. 6If attacks can be fully accounted for by the standard headache classification [International Headache Society (IHS)], a positron emission tomography (PET) or single-photon emission computerized tomography (SPECT) and scan will generally be of no further diagnostic value. 7Nuclear medicine examinations of the cerebral circulation and metabolism can be carried out in subgroups of headache patients for diagnosis and evaluation of complications, when patients experience unusually severe attacks, or when the quality or severity of attacks has changed. 8Transcranial Doppler examination is not helpful in headache diagnosis. Although many of the examinations described are of little or no value in the clinical setting, most of the tools have a vast potential for further exploring the pathophysiology of headaches and the effects of pharmacological treatment. [source]

Concept of a spectrometer for resonant inelastic X-ray scattering with parallel detection in incoming and outgoing photon energies

JOURNAL OF SYNCHROTRON RADIATION, Issue 1 2010
V. N. Strocov
A spectrometer for resonant inelastic X-ray scattering (RIXS) is proposed where imaging and dispersion actions in two orthogonal planes are combined to deliver a full two-dimensional map of RIXS intensity in one shot with parallel detection at incoming hvin and outgoing hvout photon energies. Preliminary ray-tracing simulations with a typical undulator beamline demonstrate a resolving power well above 11000 with both hvin and hvout near 930,eV, with a vast potential for improvement. Combining this instrument , nicknamed hv2 spectrometer , with an X-ray free-electron laser source simplifies its technical implementation and enables efficient time-resolved RIXS experiments. [source]

Mass spectrometry-based metabolomics

MASS SPECTROMETRY REVIEWS, Issue 1 2007
Katja Dettmer
Abstract This review presents an overview of the dynamically developing field of mass spectrometry-based metabolomics. Metabolomics aims at the comprehensive and quantitative analysis of wide arrays of metabolites in biological samples. These numerous analytes have very diverse physico-chemical properties and occur at different abundance levels. Consequently, comprehensive metabolomics investigations are primarily a challenge for analytical chemistry and specifically mass spectrometry has vast potential as a tool for this type of investigation. Metabolomics require special approaches for sample preparation, separation, and mass spectrometric analysis. Current examples of those approaches are described in this review. It primarily focuses on metabolic fingerprinting, a technique that analyzes all detectable analytes in a given sample with subsequent classification of samples and identification of differentially expressed metabolites, which define the sample classes. To perform this complex task, data analysis tools, metabolite libraries, and databases are required. Therefore, recent advances in metabolomics bioinformatics are also discussed. © 2006 Wiley Periodicals, Inc., Mass Spec Rev 26:51,78, 2007 [source]

Prediction of Carbonic Anhydrase Activation by Tri-/Tetrasubstituted-pyridinium-azole Compounds: A Computational Approach using Novel Topochemical Descriptor

MOLECULAR INFORMATICS, Issue 7 2004
Sanjay Bajaj
Abstract A novel highly discriminating adjacency-cum-distance based topochemical descriptor, termed as Superadjacency topochemical index, has been derived and its discriminating power investigated with regard to activation of Carbonic anhydrase (CA) isozyme-I by tri-/tetrasubstituted-pyridinium-azole compounds. The new index is not only sensitive to the presence of heteroatoms but also overcomes the problem of degeneracy of many topological descriptors. The discriminating power of Superadjacency topochemical index was found to be far superior when compared with that of distance based Wiener,s index and adjacency based Molecular connectivity index. The values of Wiener,s index, path-one Molecular connectivity index and Superadjacency topochemical index of each of the 42 substituted-pyridinium-azole compounds comprising the dataset were computed. Resultant data was analyzed and suitable models developed after identification of the active ranges. Subsequently, a biological activity was assigned to each of the compounds involved in the dataset using these models, which was then compared with the reported activation constants for Carbonic Anhydrase isozyme-I. Excellent correlations were observed between the activation constants of CA isozyme-I and all the topological/topochemical descriptors. The overall accuracy of prediction was about 91% for models based upon both Molecular connectivity index as well as Wiener,s index, and 96% for model based upon Superadjacency topochemical index. Surprisingly, the accuracy of prediction in the active range was found to be 100% in all the models. Thus the proposed index offers a vast potential for structure-activity/structure-property studies. [source]

Reductive Engineering Patterns: An Interview with Hanif Kara

ARCHITECTURAL DESIGN, Issue 6 2009
Mark Garcia
Abstract For the structural engineer, patterns provide vast potential, ranging from the meta- to the microscale. Here, guest-editor Mark Garcia captures the ebullient enthusiasm Hanif Kara of Adams Kara Taylor has for this infinite topic, which is open-ended in its application, providing endless representational possibilities while also embracing both natural models and artificial forms and forces. Copyright © 2009 John Wiley & Sons, Ltd. [source]

Identification and Repair of Positive Binding Antibodies Containing Randomly Generated Amber Codons from Synthetic Phage Display Libraries

BIOTECHNOLOGY PROGRESS, Issue 3 2006
Warren D. Marcus
Phage display technology allows for the rapid isolation and characterization of monoclonal antibodies that have vast potential for therapeutic and diagnostic applications. However, the panning process, which utilizes a host strain that suppresses termination by the amber codon, has an inherent bias toward clones containing randomly generated amber stop codons, complicating identification of positive binding antibodies when the antibody genes are finally expressed in a nonsupressor host. Here, we perform biopanning against a Histone 2A peptide using streptavidin- or anti-biotin-coated beads. After four rounds, a dominant clone is characterized but contains a spurious amber stop codon. A protocol is given that readily corrects the amber codon, allowing for soluble antibody production once the phagemid is transformed into a nonsuppressor bacterial strain. This work also highlights the ability to isolate antibodies against a protein antigen by using only a small peptide (15 amino acids) representing a portion of the antigen. [source]

Taming the shadow: corporate responsibility in a Jungian context

CORPORATE SOCIAL RESPONSIBILITY AND ENVIRONMENTAL MANAGEMENT, Issue 4 2008
Tarja Ketola
Abstract Rampant shadows undermine true corporate responsibility (CR) when companies try to keep up appearances by fair means or foul. This paper studies the thoughts, words and deeds of CR actors in their Jungian context. The aim is to help CR actors to understand different CR behaviour and to gain new insights into developing CR values, discourses and practices. This research builds on earlier psychological articles published in this journal, and digs deeper into the psychological resources of the human mind to show what vast potentials lie there to solve CR issues. Jungian theories open up the individual, organizational and societal personality and give opportunities to expand it horizontally and vertically. The Jungian prospective quality of the psyche is illustrated by three levels of unconscious , personal, cultural and collective, which can help the development of CR values, discourses and actions of individuals, organizations, societies and humankind. Copyright © 2007 John Wiley & Sons, Ltd and ERP Environment. [source]