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Vascular Architecture (vascular + architecture)

Distribution by Scientific Domains

Medical Sciences	50%
Life Sciences	50%

Selected Abstracts

VESGEN 2D: Automated, User-Interactive Software for Quantification and Mapping of Angiogenic and Lymphangiogenic Trees and Networks

THE ANATOMICAL RECORD : ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY, Issue 3 2009
Mary B. Vickerman
Pseudocolor view of vascular branching generations in the chorioallantoic membrane (CAM) of quail. Vascular architecture was analyzed using the automated, user-interactive software, VESsel GENeration Analysis (VESGEN). See Vickerman, et al., on page 320, in this issue. [source]

Tumor imaging in small animals with a combined micro-CT/micro-DSA system using iodinated conventional and blood pool contrast agents

CONTRAST MEDIA & MOLECULAR IMAGING, Issue 4 2006
Cristian T. Badea
Abstract X-ray based micro-computed tomography (CT) and micro-digital subtraction angiography (DSA) are important non-invasive imaging modalities for following tumorogenesis in small animals. To exploit these imaging capabilities further, the two modalities were combined into a single system to provide both morphological and functional data from the same tumor in a single imaging session. The system is described and examples are given of imaging implanted fibrosarcoma tumors in rats using two types of contrast media: (a) a new generation of blood pool contrast agent containing iodine with a concentration of 130,mg/mL (FenestraÔ VC, Alerion Biomedical, San Diego, CA, USA) for micro-CT and (b) a conventional iodinated contrast agent (Isovue®-370,mg/mL iodine, trademark of Bracco Diagnostics, Princeton, NJ, USA) for micro-DSA. With the blood pool contrast agent, the 3D vascular architecture is revealed in exquisite detail at 100,µm resolution. Micro-DSA images, in perfect registration with the 3D micro-CT datasets, provide complementary functional information such as mean transit times and relative blood flow through the tumor. This imaging approach could be used to understand tumor angiogenesis better and be the basis for evaluating anti-angiogenic therapies. Copyright © 2006 John Wiley & Sons Ltd. [source]

Three-dimensional reconstruction of the mucosa from sequential sections of biopsy specimens of patients with ulcerative colitis: Relationship between crypt structure and vascular architecture

DIGESTIVE ENDOSCOPY, Issue 2 2004
Hiroo Furukawa
Background:, In a previous paper, the stereographic reconstruction of the crypt structure of ulcerative colitis using the RATOCK System was described. The relationship between the blood vessels and the crypt structure is the focus of the current paper, using two kinds of tissue staining color in which the color differs. Stereographic images make the relationship between the crypt structure and blood vessel distribution understandable at a glance. Methods:, The methods used here are identical to those described in a previous paper. In the present paper, five cases of ulcerative colitis (UC) are examined. Biopsy specimens were obtained from the diseased, normal, and transitional zones (the area between the normal and diseased zones) from each patient. Three-dimensional reconstruction was created using TRI for Windows (RATOC System Tokyo, Japan) software. In the present paper, two kinds of dyeing method between H&E and monoclonal antibody staining of the tissue was used. It was proven that the distribution of gland and blood vessel is very clear in the 3-D reconstruction shown. Results:, (i) The blood vessels in the normal zones run parallel to the crypt in a regular manner and are almost identical to one another in diameter. (ii) In the transitional and diseased zones, the blood vessels show no clear direction and produce many branches without any apparent order. The blood vessels are, moreover, irregular in diameter. (iii) In short, clear parallelism is lost in both the transitional and diseased zones. Conclusion:, Stereographic reconstruction of endoscopically obtained biopsy specimens of UC-affected tissues makes it possible to understand at a glance the distribution of blood vessels and their relationship to crypts. The relationship of these was clarified by the combined use of two kinds of dyeing method with three-dimensional reconstruction. [source]

Carbohydrate translocation determines the phenolic content of Populus foliage: a test of the sink,source model of plant defense

NEW PHYTOLOGIST, Issue 1 2004
Tom Arnold
Summary ,,Here, we examine the influence of source-to-sink carbohydrate (CHO) flow on the development of constitutive and inducible levels of phenylpropenoids in hybrid poplar (Populus nigra × P. deltoides) foliage to determine if secondary metabolic processes in plant modules can be inhibited in a predictable manner by events such as herbivory and the development of new leaves and reproductive structures, which alter the path of phloem-borne resources. ,,Phenylpropenoid concentrations were determined for developing foliage after CHO flow, measured as the translocation of 13C from labeled sources was manipulated. ,,Phenylpropenoid metabolism in both unwounded and induced sink leaves was directly and positively linked to rates of CHO import. Alterations in rates of translocation yielded different results, depending on how CHO import was affected: the removal of competing sinks rapidly and dramatically increased leaf phenolic contents, whereas phenolic levels (and their inducibility) tended to be reduced when import was interrupted. ,,High and inducible sink strength in developing poplar leaves provides resources for phenolic biosynthesis and, as a result, restrictions or re-directions of CHOs affect the foliar quality. Sink strength and the vascular architecture of plants, which confer upon them a modular nature, can determine the direction and magnitude of defense responses in trees. [source]