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V Lesions (v + lesion)

Distribution by Scientific Domains

Medical Sciences	100%

Selected Abstracts

Relationship between histopathological features and type V pit pattern determined by magnifying videocolonoscopy in early colorectal carcinoma

DIGESTIVE ENDOSCOPY, Issue 2 2005
Shiro Oka
Background: The aim of the present study was to clarify the relationship between the histopathological features and type V pit pattern of early colorectal carcinoma. Methods: We examined the relationship between the type V pit pattern subtypes, the depth of submucosal invasion and the degrees of desmoplastic reaction, residual pit density and destruction of the intervening membrane between pits on the tumor surface in 135 cases of early colorectal carcinoma. The examinations involved magnifying videoendoscopy with indigo carmine dye spraying and crystal violet staining. The pit patterns were classified as one of two grades (VI, VN), and VN was further divided into three subtypes (A, B and C). The data obtained were evaluated by ,2 test, with significance accepted at < 0.05% for each analysis. Results: There were 64 VI, 24 VN -A, 28 VN -B and 19 VN -C lesions. The incidence of massive submucosal invasion (sm2, sm3) was significantly higher in VN -B and VN -C lesions than in VI and VN -A lesions (P < 0.05). Among VN pit pattern lesions, depth of submucosal invasion of VN -B and VN -C lesions was significantly greater than that of VN -A lesions (P < 0.01). The incidence of severe desmoplastic reaction in VN -B and VN -C lesions was significantly greater than that in VI lesions (P < 0.01). The incidence of severe desmoplastic reaction in VN -C lesions was significantly greater than that in VN -A lesions (P < 0.05). The incidence of low residual pit density in VN -C lesions was significantly greater than that in all other type V lesions. The incidence of mild to moderate and severe destruction of the intervening membrane between pits in VN lesions was significantly higher than that in VI lesions. Conclusions: Type V pit pattern subclassification is useful for predicting the depth of submucosal invasion in early colorectal carcinomas. The type V pit pattern subtypes are related to the degrees of desmoplastic reaction, the residual pit density and destruction of the intervening membrane between pits on the tumor surface. [source]

Three-year clinical evaluation of a resin modified glass,ionomer cement and a composite resin in non-carious class V lesions

JOURNAL OF ORAL REHABILITATION, Issue 11 2002
G. Özgünaltay
SUMMARY, The purpose of this study was a 3-year clinical evaluation of a resin modified glass,ionomer and a composite resin restorative material in non-carious class V lesions. In 24 patients 98 non-carious class V lesions were restored with either a resin modified glass,ionomer (Vitremer), or a composite resin restoration (Z100). The restorations were clinically evaluated after 6, 12, 24 and 36 months with the US Public Health Service criteria. At 3 years, 88 teeth of 21 patients were evaluated. All restorations were rated clinically acceptable for colour match, marginal discoloration, marginal adaptation and anatomical form. Restoration retention of both groups was high without any statistically significant difference. However, Vitremer restorations showed a lower incidence of Alfa scores for colour match and marginal discoloration than Z100 restorations (P < 0·05). [source]

Defining the Canonical Form of T-Cell-Mediated Rejection in Human Kidney Transplants

AMERICAN JOURNAL OF TRANSPLANTATION, Issue 4 2010
K. S. Famulski
Banff defines T-cell-mediated rejection (TCMR) using nonspecific lesions and arbitrary cutoffs, with no external gold standard. We reexamined features of TCMR using exclusively molecular definition independent of histopathology. The definition was derived from mouse kidney transplants with fully developed TCMR, and is based on high expression of transcripts reflecting IFNG effects and alternative macrophage activation. In 234 human kidney transplant biopsies for cause phenotyped by microarrays, we identified 26 biopsies meeting these criteria. After excluding three biopsies with unrelated diseases, all 23 biopsies had typical Banff lesions of TCMR (inflammation, tubulitis), with v lesions in 10/23. Banff histopathology diagnosed 18 as TCMR, 1 as mixed and 4 as borderline. Despite marked changes in transcriptome indicating tissue injury and dedifferentiation, all kidneys with molecularly defined TCMR, even with v lesions or late rejection, demonstrated excellent recovery of function at 6 months with no graft loss (mean follow-up 2.5 years). Thus TCMR defined exclusively by molecules manifests TCMR,related lesions and function impairment, but good recovery and survival, even with late rejection or arteritis. This combination of pathologic, clinical and molecular features constitutes the typical or canonical T-cell-mediated rejection. [source]