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Updated Model (updated + model)

Distribution by Scientific Domains
Life Sciences50%

Selected Abstracts

Applicant Reactions to Selection Procedures: An Updated Model and Meta-Analysis

PERSONNEL PSYCHOLOGY, Issue 3 2004
John P. Hausknecht
An updated theoretical model of applicant reactions to selection procedures is proposed and tested using meta-analysis. Results from 86 independent samples (N= 48,750) indicated that applicants who hold positive perceptions about selection are more likely to view the organization favorably and report stronger intentions to accept job offers and recommend the employer to others. Applicant perceptions were positively correlated with actual and perceived performance on selection tools and with self-perceptions. The average correlation between applicant perceptions and gender, age, and ethnic background was near zero. Face validity and perceived predictive validity were strong predictors of many applicant perceptions including procedural justice, distributive justice, attitudes towards tests, and attitudes towards selection. Interviews and work samples were perceived more favorably than cognitive ability tests, which were perceived more favorably than personality inventories, honesty tests, biodata, and graphology. The discussion identifies remaining theoretical and methodological issues as well as directions for future research. [source]

A Reassessment of the holocene stratigraphy of the Wadi Hasa Terrace and Hasa formation, Jordan

GEOARCHAEOLOGY: AN INTERNATIONAL JOURNAL, Issue 6 2007
Joseph Schuldenrein
Vita-Finzi's 1960s model for Mediterranean terrace evolution was once the basis for regional valley histories across much of the Levant. A revisit to the Hasa terrace, formerly considered Early to Middle Holocene in age, resulted in a revised chronostratigraphy. Sedimentological and geochemical analyses bolstered by radiocarbon dating indicate that valley floor construction began shortly after the end of the Middle Holocene, at least 2000 years later than initially proposed. An updated model for floodplain evolution proposes three discrete phases of accretion and alluvial plain formation. A weak cambic soil overprints the alluvium and suggests slightly moister climates than at present for much of the Late Holocene. This model is in accord with settlement data. Intensified uplands agropastoralism accelerated the erosion of slope soils that were recycled and deposited as alluvium across the valley floor. The valley floor sequences of the Hasa are analogous to alluvial chronologies for neighboring wadis of the eastern Jordan Rift and can be tied to key Middle and Late Holocene geomorphic events in the Dead Sea and the southwestern Levant. The data strongly indicate that alluvial fill histories after 1800 cal B.C. were anthropogenically driven, whereas Middle Holocene landscape changes were climatically and structurally triggered. © 2007 Wiley Periodicals, Inc. [source]

Munc18-1 as a key regulator of neurosecretion

JOURNAL OF NEUROCHEMISTRY, Issue 1 2010
Gayoung A. Han
J. Neurochem. (2010) 115, 1,10. Abstract Munc18-1 plays essential roles in neurosecretion by interacting with syntaxin-1 and controlling the formation of the soluble N -ethylmaleimide-sensitive factor attachment protein receptors (SNARE) complex. At least three important functions of Munc18-1 have been proposed: (i) molecular chaperone of syntaxin-1 for appropriate localization and expression of syntaxin-1, (ii) priming/stimulation of the SNARE-mediated membrane fusion, and (iii) docking of large dense-core vesicles to the plasma membrane. Similarly, at least two different binding modes have been proposed for the interaction between Munc18-1 and syntaxin-1: (i) binary binding to a ,closed' conformation of syntaxin-1, and (ii) binding to the N-terminal peptide of syntaxin-1, which is thought to enable an interaction with the quaternary SNARE complex and/or further stabilize the binary interaction between Munc18-1 and closed syntaxin-1. Recent structural analyses have identified critical Munc18-1 residues implicated in these different modes of binding. These have recently been tested functionally in rescue experiments using Munc18-1 null neurons, chromaffin cells and Munc18-1/-2 knockdown PC12 cells, allowing remarkable progress to be made in the structural/functional understanding of Munc18-1. In this review, we summarize these recent advances and attempt to propose an updated model of the pleiotropic functions of Munc18-1 in neuroexocytosis. [source]

Emerging views on tmRNA-mediated protein tagging and ribosome rescue

MOLECULAR MICROBIOLOGY, Issue 4 2001
Reynald Gillet
Transfer- messenger RNA (tmRNA), also known as SsrA or 10Sa RNA, is a bacterial ribonucleic acid that recycles 70S ribosomes stalled on problematic messenger RNAs (mRNAs) and also contributes to the degradation of incompletely synthesized peptides. tmRNA acts initially as transfer RNA (tRNA), being aminoacylated at its 3,-end by alanyl-tRNA synthetase, to add alanine to the stalled polypeptide chain. Resumption of translation ensues not on the mRNA on which the ribosomes were stalled but at an internal position in tmRNA. Termination soon occurs, tmRNA recruiting the appropriate termination factors allowing the release of the tagged protein that is subsequently recognized and degraded by specific cytoplasmic and periplasmic proteases, and permits ribosome recycling. Recent data suggest that tmRNA tags bacterial proteins in three other instances; when ribosomes stall at internal sites; during ,readthrough' of canonical termination codons; and when ribosomes are at the termination codon of intact messages. The importance of bacterial tmRNAs for survival, growth under stress, and pathogenesis is also discussed. Recent in vivo and in vitro studies have identified novel ligands of tmRNA. Based on the available experimental evidences, an updated model of tmRNA mediated protein tagging and ribosome rescue in bacteria is presented. [source]