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Unique Facet (unique + facet)
Selected AbstractsGlobalization from Below: Free Software and Alternatives to NeoliberalismDEVELOPMENT AND CHANGE, Issue 6 2007Sara Schoonmaker ABSTRACT This article explores one of the central struggles over the politics of globalization: forging alternatives to neoliberalism by developing new forms of globalization from below. It focuses on a unique facet of this struggle, rooted in the centrality of information technologies for global trade and production, as well as new forms of media and digital culture. The analysis has four main parts: examining the key role of software as a technological infrastructure for diverse forms of globalization; conceptualizing the contradictory implications of three software business models for realizing the utopian potential of digital technology to develop forms of globalization from below; exploring how three free and open source software business models were put into practice by Red Hat, IBM and the Free Software Foundation; and analysing Brazilian software policy as a form of globalization from below that challenges the historical dominance of the global North and seeks to develop new forms of digital inclusion and digital culture. [source] CD40L-expressing CD8 T cells prime CD8,+ DC for IL-12p70 productionEUROPEAN JOURNAL OF IMMUNOLOGY, Issue 8 2008Loon Wong Abstract CD8,+ DC are implicated as the principle DC subset for cross-presentation and cross-priming of cytotoxic CD8 T cell responses. In this study, we demonstrate another unique facet of the CD8,+ DC and CD8 T cell relationship, by showing that CD8 T cells reciprocally activate CD8,+ DC, but not CD8,, DC, for IL-12p70 production, the key Th1-promoting cytokine. This effect was observed during an antigen-specific interaction between DC and activated CD8 T cells, along with secondary TLR stimulation of DC by LPS. Activated CD8 T cells use a combination of IFN-, and CD40L, which is rapidly up-regulated post-stimulation, to prime DC for IL-12p70 production during an antigen-specific response. Our results suggest that the interaction between CD8,+ DC and antigen-primed CD8 T cells may form an important component of Th1-mediated immunity through the induction of IL-12p70. [source] Cries From the MorgueJOURNAL OF CHILD AND ADOLESCENT PSYCHIATRIC NURSING, Issue 4 2003DF-IAFN, Paul T. Clements PhD TOPIC Family member homicide. PURPOSE To explore the unique facets of bereavement for a family member of a homicide victim in order to assist clinicians during assessment, evaluation, and intervention with children. SOURCES The authors' experience in working with children at a child grief center and published literature. CONCLUSIONS Children experience grief uniquely and use differing methods of coping and adaptation. Knowledge of these differences can assist clinicians with promotion of adaptive coping and grieving in children who have been exposed to murder. [source] New aspects of IFN-,/, signalling in immunity, oncogenesis and bone metabolismCANCER SCIENCE, Issue 5 2003Akinori Takaoka Although interferons (IFNs) were originally identified as humoral factors that confer an antiviral state upon cells, they have been demonstrated to be multifunctional in a variety of biological systems. The IFN-,/, system modulates not only the cellular immune response to viral and bacterial infections, but also the oncogenic process and bone metabolism. Further studies have revealed additional unique facets of the IFN-,/, system. A weak signal by constitutively produced IFN-,/, is critical not only for the regulation of cellular amplification of IFN-,/, production upon viral infection or the enhancement of signalling by other cytokines, but also for the regulation of adaptive immune responses, such as the enhancement of CD8+ T cell activation. Furthermore, IFN-, signalling is critical for the regulation of the bone-resorbing osteo-clasts. In this review, we focus on the newly discovered roles of the IFN-,/, system in host defense and bone remodeling, particularly on the functions of the weak IFN-,/, signalling in the context of what we refer to as the "rewing-up" model. (Cancer Sci 2003; 94: 405,411) [source] | ||||||||||