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Uncertain Origin (uncertain + origin)

Distribution by Scientific Domains

Medical Sciences	75%

Selected Abstracts

The Schnitzler syndrome: Chronic urticaria and monoclonal gammopathy , an autoinflammatory syndrome?

JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT, Issue 8 2008
Elisabeth Eiling
Summary Schnitzler syndrome describes the simultaneous occurrence of monoclonal gammopathy and chronic urticaria with at least two additional minor symptoms (arthralgia, bone pain, fever of uncertain origin, hepato- or splenomegaly, lymphadenopathy, increased erythrocyte sedimentation rate, leukocytosis/thrombocytosis or increased bone density). Schnitzler syndrome is not wellknown and very likely under-recognized. Comprehensive diagnostic examinations are necessary to rule out other diseases, especially those of hematologic origin. Close interdisciplinary collaboration is mandatory. The etiology of Schnitzler syndrome is unclear, but the rapid response to the interleukin-1 receptor inhibitor anakinra underlines the pivotal role which the proinflammatory cytokine interleukin-1 may play in the pathophysiology of this potentially autoinflammatory disorder. [source]

Oral bleeding: Child abuse alert

JOURNAL OF PAEDIATRICS AND CHILD HEALTH, Issue 5 2002
T Stricker
Abstract: Physicians must be aware of histories, behaviours and physical findings of maltreated children. We report two cases of physical child abuse in which the initial symptom was oral bleeding. In both cases, the diagnosis was delayed and was made only after severe injuries were inflicted. Injuries to the oral cavity and oral bleeding of uncertain origin in infants should be considered seriously and should be carefully assessed in relation to adequacy of history to explain the mechanism of injury. When an infant has been injured and no adequate explanation is available to account for the mechanism, inflicted injury must be suspected and evaluated, so that in cases of child maltreatment, diagnosis and protection of the child from further injury can take place as early as possible. [source]

Modification of impact craters in the northern plains of Mars: Implications for Amazonian climate history

METEORITICS & PLANETARY SCIENCE, Issue 10 2006
M. A. Kreslavsky
Two of the 130 craters have unusually rough ejecta; they are deep, have steep walls, and are apparently the youngest in the population. Icy mantles filling the local subkilometer-scale topographic lows is the main contribution to ejecta smoothing, which occurs at a time scale on the order of tens of Myr. Wall degradation and crater shallowing generally occur at longer time scales, comparable to the duration of the Amazonian period. Many craters are shallow due to filling of the crater with specific ice-rich material of uncertain origin. We use our collected data to infer the nature of the past climate back through the Amazonian, a period prior to ,10,20 Myr ago, when orbital parameter solutions are chaotic and one must rely on geological data to infer climate conditions. We conclude that moderately high obliquity and wide obliquity variations were probable during the last 40,160 Myr. We tentatively conclude that high obliquity peaks (>40,45°) may have occurred episodically through the last 210,430 Myr. A sharp step in the frequency distribution of wall steepness at 20° may indicate a geologically long period prior to that time where obliquity never exceeded 40,45°. [source]

Astroblastoma: Report of a case with microsatellite analysis

NEUROPATHOLOGY, Issue 3 2000
Shanop Shuangshoti
A 5-year-old girl who developed progressive headache, vomiting, and left hemiparesis was found to have a cystic tumor with an enhanced mural nodule in the right frontoparietal region on a computed tomography examination. The lesion was histologically and ultrastructurally verified as an astroblastoma, an uncommon neuroepithelial tumor of uncertain origin. Molecular analysis using 17 microsatellite markers on chromosomes 9, 10, 11, 17, 19, and 22 showed loss of heterozygosity at the D19S412 locus on the long arm of chromsome 19. This observation suggests that there is a tumor suppressor gene in this chromosomal region, which plays a role in the pathogenesis of astroblastoma. [source]