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Unprecedented Opportunity (unprecedented + opportunity)
Selected AbstractsUsing the internet to research hidden populations of illicit drug users: a reviewADDICTION, Issue 9 2010Peter G. Miller ABSTRACT Aims To review the current research of hidden populations of illicit drugs users using web-based methods and discuss major advantages and disadvantages. Methods Systematic review of 16 databases, including PubMed, PsycINFO (EBSCOhost), CSA Sociological Abstracts, Expanded Academic ASAP and Google Scholar. Findings Substances researched were most commonly ,party/club drugs' (such as ecstasy) and cannabis. All of the studies reviewed concluded that the internet is a useful tool for reaching hidden populations, but is likely to impose some bias in samples. Advantages include: access to previously under-researched target groups; speed; international applications; increased ease of data entry; and improved confidentiality for respondents. The major disadvantage is a lack of representativeness of samples. Conclusions Internet research is successful at accessing hidden populations of illicit drugs users, when appropriately targeted and provides unprecedented opportunities for research across a wide range of topics within the addictions field. Findings are unlikely to be generalisable to the general public, but appropriate for describing target populations. [source] THE MACROEVOLUTIONARY DYNAMICS OF ANT DIVERSIFICATIONEVOLUTION, Issue 11 2009Marcio R. Pie The availability of increasingly comprehensive phylogenies has provided unprecedented opportunities to assess macroevolutionary patterns, yet studies on invertebrate diversification are few. In particular, despite the ecological and evolutionary importance of ants, little is known about their tempo and mode of diversification. Recent advances in ant phylogenetics can now provide a basis for rigorous analyses of the diversification of ant lineages. The goals of the present study are threefold. First, we demonstrate that a hypothesized disproportionate increase in ant diversification during the angiosperm radiation is largely artifactual. Rather, current evidence points to a fairly constant rate of lineage growth during its history. Moreover, an analysis of diversification patterns across the ant phylogeny indicates considerable rate heterogeneity among lineages. Indeed, and contrary to the expectation if lineages had experienced a single rate of lineage increase, we found no correspondence between genus age and diversity. Finally, we demonstrate a statistically significant phylogenetic signal in ant diversification: closely related genera have diversities that are more similar to one another than one would expect by chance. This suggests that the capacity for diversification may be itself a biological trait that evolved during the radiation of the family Formicidae. [source] Therapeutic angiogenesis and vasculogenesis for tissue regenerationEXPERIMENTAL PHYSIOLOGY, Issue 3 2005Paolo Madeddu Therapeutic angiogenesis/vasculogenesis holds promise for the cure of ischaemic disease. The approach postulates the manipulation of spontaneous healing response by supplementation of growth factors or transplantation of vascular progenitor cells. These supplements are intended to foster the formation of arterial collaterals and promote the regeneration of damaged tissues. Angiogenic factors are generally delivered in the form of recombinant proteins or by gene transfer using viral vectors. In addition, new non-viral methods are gaining importance for their safer profile. The association of growth factors with different biological activity might offer distinct advantages in terms of efficacy, yet combined approaches require further optimization. Alternatively, substances with pleiotropic activity might be considered, by virtue of their ability to target multiple mechanisms. For instance, some angiogenic factors not only stimulate the growth of arterioles and capillaries, but also inhibit vascular destabilization triggered by metabolic and oxidative stress. Transplantation of endothelial progenitor cells was recently proposed for the treatment of peripheral and myocardial ischaemia. Progenitor cells can be transplanted either without any preliminary conditioning or after ex vivo genetic manipulation. Delivery of genetically modified progenitor cells eliminates the drawback of immune response against viral vectors and makes feasible repeating the therapeutic procedure in case of injury recurrence. It is envisioned that these new approaches of regenerative medicine will open unprecedented opportunities for the care of life-threatening diseases. [source] Magnetic Resonance Microscopy Defines Ethanol-Induced Brain Abnormalities in Prenatal Mice: Effects of Acute Insult on Gestational Day 8ALCOHOLISM, Issue 6 2009Scott E. Parnell Background:, Magnetic resonance microscopy (MRM), magnetic resonance imaging (MRI) at microscopic levels, provides unprecedented opportunities to aid in defining the full spectrum of ethanol's insult to the developing brain. This is the first in a series of reports that, collectively, will provide an MRM-based atlas of developmental stage-dependent structural brain abnormalities in a Fetal Alcohol Spectrum Disorders (FASD) mouse model. The ethanol exposure time and developmental stage examined for this report is gestational day (GD) 8 in mice, when the embryos are at early neurulation stages; stages present in humans early in the fourth week postfertilization. Methods:, For this study, pregnant C57Bl/6J mice were administered an ethanol dosage of 2.8 g/kg intraperitoneally at 8 days, 0 hour and again at 8 days, 4 hours postfertilization. On GD 17, fetuses that were selected for MRM analyses were immersion fixed in a Bouin's/Prohance® solution. Control fetuses from vehicle-treated dams were stage-matched to those that were ethanol-exposed. The fetal mice were scanned ex vivo at 7.0 T and 512 × 512 × 1024 image arrays were acquired using 3-D spin warp encoding. The resulting 29 ,m (isotropic) resolution images were processed using ITK-SNAP, a 3-D segmentation/visualization tool. Linear and volume measurements were determined for selected brain, head, and body regions of each specimen. Comparisons were made between control and treated fetuses, with an emphasis on determining (dis)proportionate changes in specific brain regions. Results:, As compared with controls, the crown-rump lengths of stage-matched ethanol-exposed GD 17 fetuses were significantly reduced, as were brain and whole body volumes. Volume reductions were notable in every brain region examined, with the exception of the pituitary and septal region, and were accompanied by increased ventricular volumes. Disproportionate regional brain volume reductions were most marked on the right side and were significant for the olfactory bulb, hippocampus, and cerebellum; the latter being the most severely affected. Additionally, the septal region and the pituitary were disproportionately large. Linear measures were consistent with those of volume. Other dysmorphologic features noted in the MR scans were choanal stenosis and optic nerve coloboma. Conclusions:, This study demonstrates that exposure to ethanol occurring in mice at stages corresponding to the human fourth week postfertilization results in structural brain abnormalities that are readily identifiable at fetal stages of development. In addition to illustrating the utility of MR microscopy for analysis of an FASD mouse model, this work provides new information that confirms and extends human clinical observations. It also provides a framework for comparison of structural brain abnormalities resulting from ethanol exposure at other developmental stages and dosages. [source] Live imaging of fluorescent proteins in chordate embryos: From ascidians to miceMICROSCOPY RESEARCH AND TECHNIQUE, Issue 3 2006Yale J. Passamaneck Abstract Although we have advanced in our understanding of the molecular mechanisms intrinsic to the morphogenesis of chordate embryos, the question of how individual developmental events are integrated to generate the final morphological form is still unresolved. Microscopic observation is a pivotal tool in developmental biology, both for determining the normal course of events and for contrasting this with the results of experimental and pathological perturbations. Since embryonic development takes place in three dimensions over time, to fully understand the events required to build an embryo we must investigate embryo morphogenesis in multiple dimensions in situ. Recent advances in the isolation of naturally fluorescent proteins, and the refinement of techniques for in vivo microscopy offer unprecedented opportunities to study the cellular and molecular events within living, intact embryos using optical imaging. These technologies allow direct visual access to complex events as they happen in their native environment, and thus provide greater insights into cell behaviors operating during embryonic development. Since most fluorescent protein probes and modes of data acquisition are common across species, we have chosen the mouse and the ascidian, two model organisms at opposite ends of the chordate clade, to review the use of some of the current genetically-encoded fluorescent proteins and their visualization in vivo in living embryos for the generation of high-resolution imaging data. Microsc. Res. Tech. 69:160,167, 2006. © 2006 Wiley-Liss, Inc. [source] Transitioning from brick layer to cathedral builder: Performance consulting and the power of onePERFORMANCE IMPROVEMENT, Issue 3 2010Darlene Van Tiem CPT In this time of great change, there are unprecedented opportunities for performance consultants to influence organizations to tie projects to Mega outcomes. To accomplish this, we must expand our thinking and view ourselves as transitioning from a focus on models, techniques, and interventions to a focus on improving a company's financial condition, saving jobs, and having an impact on the local economy. This article describes how four certified performance technologist standards can be applied to make this transition. [source] Professional development of statisticians in the pharmaceutical sector: evolution over the past decade and into the futurePHARMACEUTICAL STATISTICS: THE JOURNAL OF APPLIED STATISTICS IN THE PHARMACEUTICAL INDUSTRY, Issue 3 2008Trevor Lewis CStat Abstract The adoption of The International Conference on Harmonization Tripartite Guideline: Statistical Principles for Clinical Trials (ICH-E9) has provided a foundation for the application of statistical principles in clinical research and raised awareness of the value of a statistical contribution to the wider pharmaceutical R&D process. In addition, over the past decade globalization of the pharmaceutical R&D process and the measures taken to address reduced productivity and spiralling costs have impacted on the roles and career opportunities for statisticians working in the pharmaceutical sector. This has enhanced the need for continuing professional development to equip statisticians with the skills to fully contribute to creating innovative solutions. In the future, key areas of focus are the establishment of professional standards for statistical work and increasing the collaboration between statisticians working in industry, regulatory agencies and academia. In addition, the diversity of roles and potential career paths for statisticians embarking on a career in the pharmaceutical sector emphasizes the importance of mentoring and coaching. For the more experienced statisticians, there are unprecedented opportunities to lead and innovate. Copyright © 2008 John Wiley & Sons, Ltd. [source] Signal Transfer in Haloarchaeal Sensory Rhodopsin, Transducer Complexes,PHOTOCHEMISTRY & PHOTOBIOLOGY, Issue 4 2008Jun Sasaki Membrane-inserted complexes consisting of two photochemically reactive sensory rhodopsin (SR) subunits flanking a homodimer of a transducing protein subunit (Htr) are used by halophilic archaea for sensing light gradients to modulate their swimming behavior (phototaxis). The SR,Htr complexes extend into the cytoplasm where the Htr subunits bind a his-kinase that controls a phosphorylation system that regulates the flagellar motors. This review focuses on current progress primarily on the mechanism of signal relay within the SRII,HtrII complexes from Natronomonas pharaonis and Halobacterium salinarum. The recent elucidation of a photoactive site steric trigger crucial for signal relay, advances in understanding the role of proton transfer from the chromophore to the protein in SRII activation, and the localization of signal relay to the membrane-embedded portion of the SRII,HtrII interface, are beginning to produce a clear picture of the signal transfer process. The SR,Htr complexes offer unprecedented opportunities to resolve first examples of the chemistry of signal relay between membrane proteins at the atomic level, which would provide a major contribution to the general understanding of dynamic interactions between integral membrane proteins. [source] Attitudes towards globalization and cosmopolitanism: cultural diversity, personal consumption and the national economyTHE BRITISH JOURNAL OF SOCIOLOGY, Issue 2 2008Ian Woodward Abstract One of the widely accepted consequences of globalization is the development of individual outlooks, behaviours and feelings that transcend local and national boundaries. This has encouraged a re-assessment of important assumptions about the nature of community, personal attachment and belonging in the face of unprecedented opportunities for culture, identities and politics to shape, and be shaped by, global events and processes. Recently, the upsurge of interest in the concept of cosmopolitanism has provided a promising new framework for understanding the nexus between cosmopolitan dispositions and global interconnectedness across cultural, political and economic realms. Using data from a representative social survey of Australians this paper investigates the negotiation of belonging under the conditions of globalization. The data tap into attitudes and behaviours associated with a broad gamut of cosmopolitan traits in the domains of culture, consumption, human rights, citizenship, and international governance. They show how cosmopolitan outlooks are shaped by social structural factors, and how forms of identification with humanity and the globe are fractured by boundaries of self and others, threats and opportunities, and the value of things global and local. [source] The Grid Resource Broker workflow engineCONCURRENCY AND COMPUTATION: PRACTICE & EXPERIENCE, Issue 15 2008M. Cafaro Abstract Increasingly, complex scientific applications are structured in terms of workflows. These applications are usually computationally and/or data intensive and thus are well suited for execution in grid environments. Distributed, geographically spread computing and storage resources are made available to scientists belonging to virtual organizations sharing resources across multiple administrative domains through established service-level agreements. Grids provide an unprecedented opportunity for distributed workflow execution; indeed, many applications are well beyond the capabilities of a single computer, and partitioning the overall computation on different components whose execution may benefit from runs on different architectures could provide better performances. In this paper we describe the design and implementation of the Grid Resource Broker (GRB) workflow engine. Copyright © 2008 John Wiley & Sons, Ltd. [source] A CRITICAL LOOK AT PAP ADEQUECY: ARE OUR CRITERIA SATISFACTORY?CYTOPATHOLOGY, Issue 2006D.R. Bolick Liquid based Pap (LBP) specimen adequacy is a highly documented, yet poorly understood cornerstone of our GYN cytology practice. Each day, as cytology professionals, we make adequacy assessments and seldom wonder how the criteria we use were established. Are the criteria appropriate? Are they safe? What is the scientific data that support them? Were they clinically and statistically tested or refined to achieve optimal patient care? In this presentation, we will take a fresh look at what we know about Pap specimen adequacy and challenge some of the core assumptions of our daily practice. LBP tests have a consistent, well-defined surface area for screening, facilitating the quantitative estimates of slide cellularity. This provides an unprecedented opportunity to establish reproducible adequacy standards that can be subjected to scientific scrutiny and rigorous statistical analysis. Capitalizing on this opportunity, the TBS2001 took the landmark step to define specimen adequacy quantitatively, and set the threshold for a satisfactory LBP at greater than 5,000 well visualized squamous epithelial cells. To date, few published studies have attempted to evaluate the validity or receiver operator characteristics for this threshold, define an optimal threshold for clinical utility or assess risks of detection failure in ,satisfactory' but relatively hypocellular Pap specimens. Five years of cumulative adequacy and cellularity data of prospectively collected Pap samples from the author's laboratory will be presented, which will serve as a foundation for a discussion on ,Pap failure'. A relationship between cellularity and detection of HSIL will be presented. Risk levels for Pap failure will be presented for Pap samples of different cellularities. The effect of different cellularity criterion on unsatisfactory Pap rates and Pap failure rates will be demonstrated. Results from this data set raise serious questions as to the safety of current TBS2001 adequacy guidelines and suggest that the risk of Pap failure in specimens with 5,000 to 20 000 squamous cells on the slide is significantly higher than those assumed by the current criteria. TBS2001 designated all LBP to have the same adequacy criterion. Up to this point, it has been assumed that ThinPrep, SurePath, or any other LBP would be sufficiently similar that they should have the same adequacy criteria. Data for squamous cellularity and other performance characteristics of ThinPrep and SurePath from the author's laboratory will be compared. Intriguing data involving the recently approved MonoPrep Pap Test will be reviewed. MonoPrep clinical trial data show the unexpected finding of a strong correlation between abundance of endocervical component and the detection of high-grade lesions, provoking an inquiry of a potential new role for a quantitative assessment of the transition zone component. The current science of LBP adequacy criteria is underdeveloped and does not appear to be founded on statistically valid methods. This condition calls us forward as a body of practitioners and scientists to rigorously explore, clarify and define the fundamental nature of cytology adequacy. As we forge this emerging science, we will improve diagnostic performance, guide the development of future technologies, and better serve the patients who give us their trust. Reference:, Birdsong GG: Pap smear adequacy: Is our understanding satisfactory? Diagn Cytopathol. 2001 Feb; 24(2): 79,81. [source] Using Data from Hospital Information Systems to Improve Emergency Department CareACADEMIC EMERGENCY MEDICINE, Issue 11 2004Gregg Husk MD Abstract The ubiquity of computerized hospital information systems, and of inexpensive computing power, has led to an unprecedented opportunity to use electronic data for quality improvement projects and for research. Although hospitals and emergency departments vary widely in their degree of integration of information technology into clinical operations, most have computer systems that manage emergency department registration, admission,discharge,transfer information, billing, and laboratory and radiology data. These systems are designed for specific tasks, but contain a wealth of detail that can be used to educate staff and improve the quality of care emergency physicians offer their patients. In this article, the authors describe five such projects that they have performed and use these examples as a basis for discussion of some of the methods and logistical challenges of undertaking such projects. [source] THE AFRICANIZATION OF HONEYBEES (APIS MELLIFERA L.) OF THE YUCATAN: A STUDY OF A MASSIVE HYBRIDIZATION EVENT ACROSS TIMEEVOLUTION, Issue 7 2002Kylea E. Clarke Abstract Until recently, African and European subspecies of the honeybee (Apis mellifera L.) had been geographically separated for around 10,000 years. However, human-assisted introductions have caused the mixing of large populations of African and European subspecies in South and Central America, permitting an unprecedented opportunity to study a large-scale hybridization event using molecular analyses. We obtained reference populations from Europe, Africa, and South America and used these to provide baseline information for a microsatellite and mitochondrial analysis of the process of Africanization of the bees of the Yucatan Peninsula, Mexico. The genetic structure of the Yucatecan population has changed dramatically over time. The pre-Africanized Yucatecan population (1985) comprised bees that were most similar to samples from southeastern Europe and northern and western Europe. Three years after the arrival of Africanized bees (1989), substantial paternal gene flow had occurred from feral Africanized drones into the resident European population, but maternal gene flow from the invading Africanized population into the local population was negligible. However by 1998, there was a radical shift with both African nuclear alleles (65%) and African-derived mitochondria (61%) dominating the genomes of domestic colonies. We suggest that although European mitochondria may eventually be driven to extinction in the feral population, stable introgression of European nuclear alleles has occurred. [source] The Geysers geothermal field: results from shear-wave splitting analysis in a fractured reservoirGEOPHYSICAL JOURNAL INTERNATIONAL, Issue 3 2005Maya Elkibbi SUMMARY Clear shear-wave splitting (SWS) is observed in 1757 high signal-to-noise ratio microearthquake seismograms recorded by two high density seismic arrays in the NW and the SE Geysers geothermal fields in California. The Geysers reservoir rocks within the study area are largely composed of lithic, low-grade metamorphism, well-fractured metagraywackes which commonly lack schistosity, warranting the general assumption that shear-wave splitting here is induced solely by stress-aligned fracturing in an otherwise isotropic medium. The high quality of observed shear-wave splitting parameters (fast shear-wave polarization directions and time delays) and the generally good data spatial coverage provide an unprecedented opportunity to demonstrate the applicability and limitations of the shear-wave splitting approach to successfully detect fracture systems in the shallow crust based on SWS field observations from a geothermal reservoir. Results from borehole stations in the NW Geysers indicate that polarization orientations range between N and N60E; while in the SE Geysers, ground surface stations show polarization directions that are generally N5E, N35E-to-N60E, N75E-to-N85E, and N20W-to-N55W. Crack orientations obtained from observed polarization orientations are in good agreement with independent field evidence, such as cracks in geological core data, tracer tests, locally mapped fractures, and the regional tectonic setting. Time delays range typically between 8 and 40 ms km,1, indicating crack densities well within the norm of fractured reservoirs. The sizeable collection of high resolution shear-wave splitting parameters shows evidence of prevalent vertical to nearly vertical fracture patterns in The Geysers field. At some locations, however, strong variations of SWS parameters with ray azimuth and incident angle within the shear-wave window of seismic stations indicate the presence of more complex fracture patterns in the subsurface. [source] Callahan fails to meet the burden of proof for Thought Field Therapy claimsJOURNAL OF CLINICAL PSYCHOLOGY, Issue 3 2005Monica PignottiArticle first published online: 4 NOV 200 Callahan's response evades the key issues raised by merely restating and elaborating upon what has already been said, providing citations that are out of context and irrelevant to the issues at hand, and misrepresenting what was actually said by his critics and me and the authors of articles he cites. He spends paragraphs refuting "straw men." He provides additional anecdotes, which offer no convincing evidence for his claims. His critics have expressed concern that Callahan and Thought Field Therapy (TFT) proponents will cite his response article, as published in the Journal of Clinical Psychology, to promote TFT, as TFT proponents have repeatedly done for the non-peer-reviewed earlier issue devoted to TFT. Callahan has been given an unprecedented opportunity to present his work in a reputable journal without prior peer review and has failed to meet the burden of proof for his claims, thus undermining his own claim, that his work has been rejected solely as a result of bias against innovation. © 2004 Wiley Periodicals, Inc. J Clin Psychol. [source] Proteomic identification of biomarkers related to Helicobacter pylori -associated gastroduodenal disease: Challenges and opportunitiesJOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, Issue 11 2008Ming-Shiang Wu Abstract Helicobacter pylori colonize the stomach of over half the world's population. While 80,90% H. pylori -infected individuals have clinically asymptomatic gastritis, 10,15% develop peptic ulcer, and 1,2% gastric malignancies. These variable clinical outcomes have led to an interest in prognostic indicators. The current disease paradigm suggests that host genetics and bacterial virulence both play important roles in modulating the final outcome of H. pylori infection. Elucidation of the interaction between host and bacterium is essential to clarify pathogenesis and to develop new strategies for prevention and treatment. Proteomic technology is a powerful tool for simultaneously monitoring proteins and protein variation on a large scale in biological samples. It has provided an unprecedented opportunity to survey a cell's translational landscape comprehensively, and the results may allow in-depth analyses of host and pathogen interactions. Using this high-throughput platform and taking advantage of complete sequences for both the H. pylori and the human genome in available databases, we have identified several crucial proteins that have pathogenic and prognostic potential. Among them, antibodies to AhpC and GroEs of H. pylori could be utilized for identification of patients who are at high risk of disease complications after H. pylori infection. Evolving proteomic technologies, together with appropriate clinical phenotyping and genotype information should enhance understanding of disease pathogenesis and lead to more precise prediction of variable disease outcomes. It will also facilitate development of biomarkers for diagnosis, treatment, and prevention of H. pylori infection. [source] Harnessing Catastrophe to Promote Resource Recovery and Eco-industrial DevelopmentJOURNAL OF INDUSTRIAL ECOLOGY, Issue 4 2009Kristen B. Ardani Summary Hurricane Katrina devastated New Orleans, Louisiana, USA, causing widespread damage to industry, housing, and infrastructure. The area of New Orleans East was particularly devastated, including a cluster of industries, such as a major food-processing plant, manufacturing facilities, and bulk material and gas processors. Although this area was well suited for resource recovery and eco-industrial linkages, little progress has been made in implementation. This article explores New Orleans as a case study in the application of industrial ecology to disaster management. Hurricane Katrina's damage to New Orleans resulted in a significant increase in the amount of waste flowing into New Orleans East, which precipitated a massive expenditure of federal funds toward debris management. Those circumstances created an unprecedented opportunity to capitalize a resource recovery program and to establish eco-industrial relationships, both of which would have resulted in new jobs and environmental improvement. Yet straightforward opportunities for resource recovery and eco-industrial linkage were overlooked or dismissed, in spite of antilandfill activism from the environmental community and formal recommendations for recycling from scientists and other professionals. We describe the specific resource recovery and eco-industrial opportunities that were available to New Orleans East, especially those that were magnified by Hurricane Katrina, and analyze the barriers that prevented their actualization. We also provide recommendations for overcoming barriers to resource recovery and eco-industrial progress with the goal that future postcatastrophe scenarios may benefit from more effective use of relief and recovery funding. [source] A multi-ontology framework to guide agriculture and food towards diet and healthJOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE, Issue 8 2007Matthew C Lange Abstract Global increases in metabolic diseases that can be influenced by diet have re-emphasized the importance of considering how different foods can improve human health. The entire agricultural enterprise has an unprecedented opportunity to increase its value by producing foods that improve the health of consumers. Research efforts in agriculture/food science/nutrition are endeavoring to do so, although little tangible success has been achieved. At the core of the problem is a failure to define the goal itself: health. Health, as a scientifically measurable concept, is poorly defined relative to disease, and yet consensus-based, curated vocabularies that describe the multiple variations in human health in useful terms are critical to unifying the scientific fields related to agriculture and nutrition. Each of the life-science disciplines relating to health has developed databases, thesauri, and/or ontologies to capture such knowledge. High-throughput and -omic technologies are expanding both the amount and heterogeneity of available information. Unfortunately, the language used to describe substantially similar (even logically equivalent) concepts is often different between information systems. Increasing the future value of agriculture, therefore, will depend on creating a process for generating common ontologies of the concept of health, and guiding the development of a common language. This paper illustrates a framework for integrating heterogeneous ontologies into interdisciplinary, foods-for-health knowledge systems. A common system of language that describes health and is shared by all the life-science disciplines will provide immediate benefits in terms of increased health-claim regulatory efficiencies and predictive functions for individualized diets. Ultimately, these vocabularies will guide agriculture to its next goal of producing health-enhancing foods. Copyright © 2007 Society of Chemical Industry [source] A Tale of Two Cases: Lessons for Education From the Study of Two Boys Living With Half Their BrainsMIND, BRAIN, AND EDUCATION, Issue 2 2007Mary Helen Immordino-Yang ABSTRACT, In recent years, educators have been looking increasingly to neuroscience to inform their understanding of how children's brain and cognitive development are shaped by their learning experiences. However, while this new interdisciplinary approach presents an unprecedented opportunity to explore and debate the educational implications of neuropsychological research, a good model for this dialogue is lacking. This is in part because relatively little is known about the relationships between cognitive, emotional, and neurological development, in part because of a dearth of research methods designed to rigorously connect issues of learning and development to neuropsychological strengths and weaknesses, and in part because neuropsychological studies are rarely presented in a format that is conducive to meaningful cross-disciplinary dialogue with educators. To begin to address these issues, in this article, I present the complementary cases of Nico and Brooke, two high-functioning adolescents, who have suffered the removal of an entire brain hemisphere (Nico his right and Brooke his left) to control severe epilepsy. Through presenting a neuropsychological study of these rare boys' emotion and affective prosody (vocal intonation) through the developmental lens of an educator, I reinterpret the neuropsychological findings for what they reveal about how the boys leveraged their emotional and cognitive strengths to learn important skills for which they were each missing half of the normally recruited neural hardware. While Nico's and Brooke's results seem on the surface to contradict expectations based on neuropsychological findings with adults, they combine to reveal a compensatory logic that begins to elucidate the active role of the learner as well as the organizing role of emotion in brain development, providing a jumping-off point for discussion between educators and neuroscientists and a model for connecting neuropsychological strengths and weaknesses to learning. [source] Childhood developmental disorders: an academic and clinical convergence point for psychiatry, neurology, psychology and pediatricsTHE JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY AND ALLIED DISCIPLINES, Issue 1-2 2009Allan L. Reiss Background:, Significant advances in understanding brain development and behavior have not been accompanied by revisions of traditional academic structure. Disciplinary isolation and a lack of meaningful interdisciplinary opportunities are persistent barriers in academic medicine. To enhance clinical practice, research, and training for the next generation, academic centers will need to take bold steps that challenge traditional departmental boundaries. Such change is not only desirable but, in fact, necessary to bring about a truly innovative and more effective approach to treating disorders of the developing brain. Methods:, I focus on developmental disorders as a convergence point for transcending traditional academic boundaries. First, the current taxonomy of developmental disorders is described with emphasis on how current diagnostic systems inadvertently hinder research progress. Second, I describe the clinical features of autism, a phenomenologically defined condition, and Rett and fragile X syndromes, neurogenetic diseases that are risk factors for autism. Finally, I describe how the fields of psychiatry, psychology, neurology, and pediatrics now have an unprecedented opportunity to promote an interdisciplinary approach to training, research, and clinical practice and, thus, advance a deeper understanding of developmental disorders. Results:, Research focused on autism is increasingly demonstrating the heterogeneity of individuals diagnosed by DSM criteria. This heterogeneity hinders the ability of investigators to replicate research results as well as progress towards more effective, etiology-specific interventions. In contrast, fragile X and Rett syndromes are ,real' diseases for which advances in research are rapidly accelerating towards more disease-specific human treatment trials. Conclusions:, A major paradigm shift is required to improve our ability to diagnose and treat individuals with developmental disorders. This paradigm shift must take place at all levels , training, research and clinical activity. As clinicians and scientists who are currently constrained by disciplinary-specific history and training, we must move towards redefining ourselves as clinical neuroscientists with shared interests and expertise that permit a more cohesive and effective approach to improving the lives of patients. [source] National rates of birth defects among hospitalized newborns,,§BIRTH DEFECTS RESEARCH, Issue 11 2006T.M. Bird Abstract BACKGROUND: The Healthcare Cost and Utilization Project (HCUP) family of hospital discharge databases offer an unprecedented opportunity to generate national estimates of newborn infants with birth defects. This report estimates national hospital admissions for newborn infants diagnosed with birth defects computed from HCUP and compares them to pooled prevalence figures computed from state birth defect surveillance systems. METHODS: HCUP-derived rates of 36 birth defects from 1997 through 2001 were compared to rates derived from pooled data reported by 26 state-based surveillance systems stratified by inclusion of elective terminations in case definitions. Rate ratios (RRs) were calculated for each birth defect by dividing the rate derived from HCUP by the rate derived from the relevant surveillance systems. RESULTS: HCUP newborn hospitalization rates for birth defects closely approximate pooled birth defect rates for surveillance systems that do not include elective terminations. HCUP rates were not significantly different for 35 of 36 defects. Overall, 20 HCUP rates were within 10% of state rates, 11 more were within 20% of state rates, and only 1 differed by more than 50%. HCUP rates compared most closely to state rates for cardiovascular (VSD RR = 0.98, ASD = 0.96, pulmonary valve atresia and stenosis = 0.92), orofacial (cleft palate RR = 1.10, cleft lip = 1.06), and genitourinary defects (obstructive genitourinary RR = 1.01, bladder exstrophy = 0.97). HCUP rates compared less favorably to rates derived from surveillance systems that included elective terminations. CONCLUSIONS: HCUP data approximate state-based surveillance system data for defects that are easily recognized in the newborn period and infrequently a cause for elective termination. HCUP data can be used to examine the impact of public health efforts on the number of infants born with birth defects as well as the cost and consequences of variations in the hospital management of birth defects. Birth Defects Research (Part A), 2006. © 2006 Wiley,Liss, Inc. [source] | ||||||||||||||||||||||