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Triterpenoid Saponins (triterpenoid + saponin)

Distribution by Scientific Domains
Chemistry72%

Kinds of Triterpenoid Saponins

  • new triterpenoid saponin
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    Selected Abstracts

    Accumulation and Dynamic Trends of Triterpenoid Saponin in Vegetative Organs of Achyranthus bidentata

    JOURNAL OF INTEGRATIVE PLANT BIOLOGY, Issue 2 2009
    Jinting Li
    Abstract The relationship between structural features of various vegetative organs and triterpenoid saponin accumulation in Achyranthus bidentata Blume was investigated using anatomy, histochemistry and phytochemistry. The results showed that the primary and secondary structures of roots, and the structures of stems and leaves of A. bidentata, were similar to those of ordinary dicotyledonous plants. The enlargement of its roots, however, was primarily associated with growth and differentiation of tertiary structures. There were collateral medullary vascular bundles in addition to the normal vascular bundles in the stem. The tertiary structure was not only main parts in the roots of A. bidentata, but also important storage region of triterpenoid saponin in its growth and development. The stem may be the essential transport organ of triterpenoid saponin, while palisade parenchyma may be the primary synthesis location. In November, the total quantity of triterpenoid saponin and overall biomass in the roots reach a maximum level. This was the best time, therefore, to harvest the roots and corresponded to the traditional harvest period. Despite the withered appearance of leaves, stems also contained substantial amounts of triterpenoid saponin, and it was recommended that the stems of A. bidentata should be used. [source]

    A New Triterpenoid Saponin and a New Glycoside from Epigynum aurilum

    CHINESE JOURNAL OF CHEMISTRY, Issue 12 2003
    Jian-Xin Cao
    Abstract A new triterpenoid saponin with novel sugar moiety (1), a new trisaccharide derivative (2), as well as a known monosaccharide derivative (3), were isolated from the dried stem of Epigynum aurilum. The structures of compounds 1 and 2 were determined by MS and NMR spectram analyses. [source]

    Triterpenoid Saponins from Pulsatilla cernua (Thunb.) Bercht. et Opiz.

    JOURNAL OF INTEGRATIVE PLANT BIOLOGY, Issue 2 2007
    Tun-Hai Xu
    Abstract To investigate saponins from the roots of Pulsatilla cernua (Thunb.) Bercht. et Opiz., two new compounds together with five known triterpenoid saponins were isolated. The structures of the two new triterpenoid saponins, named cernuasides A and B, were elucidated as 3-O-[p-,- D -xylopyranosyl(1,2)]-[,- L -rhamnopyranosyl(1,4)]-,- L -arabinopyranosyl hederagenin 28-O-,- D -glucopyranosyl ester (compound 1) and 3-O-[,- L -arabinopyranosyl(1,3)]-[,- L -rhamnopyranosyl (1,2)]-,- L -arabinopyranosyl hederagenin 28-O-,- D -glucopyranosyl ester (compound 2) by 1D, 2D-NMR techniques, ESIMS analysis, as well as chemical methods. [source]

    Protective effect of arjunolic acid against arsenic-induced oxidative stress in mouse brain,

    JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, Issue 1 2008
    Mahua Sinha
    Abstract Arsenic, a notoriously poisonous metalloid, is ubiquitous in the environment, and it affects nearly all organ systems of animals including humans. The present study was designed to investigate the preventive role of a triterpenoid saponin, arjunolic acid against arsenic-induced oxidative damage in murine brain. Sodium arsenite was selected as a source of arsenic for this study. The free-radical-scavenging activity and the in vivo antioxidant power of arjunolic acid were determined from its 2,2-diphenyl-1-picryl hydrazyl radical scavenging ability and ferric reducing/antioxidant power assay, respectively. Oral administration of sodium arsenite at a dose of 10 mg/kg body weight for 2 days significantly decreased the activities of antioxidant enzymes, superoxide dismutase, catalase, glutathione- S -transferase, glutathione reductase and glutathione peroxidase, the level of cellular metabolites, reduced glutathione, total thiols and increased the level of oxidized glutathione. In addition, it enhanced the levels of lipid peroxidation end products and protein carbonyl content. Treatment with arjunolic acid at a dose of 20 mg/kg body weight for 4 days prior to arsenic administration almost normalized above indices. Histological findings due to arsenic intoxication and arjunolic acid treatment supported the other biochemical changes in murine brains. Results of 2,2-diphenyl-1-picryl hydrazyl radical scavenging and ferric reducing/antioxidant power assays clearly showed the in vitro radical scavenging as well as the in vivo antioxidant power of arjunolic acid, respectively. The effect of a well-established antioxidant, vitamin C, has been included in the study as a positive control. Combining all, results suggest that arjunolic acid possessed the ability to ameliorate arsenic-induced oxidative insult in murine brain and is probably due to its antioxidant activity. © 2008 Wiley Periodicals, Inc. J Biochem Mol Toxicol 22:15,26, 2008; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/jbt.20209 [source]

    Accumulation and Dynamic Trends of Triterpenoid Saponin in Vegetative Organs of Achyranthus bidentata

    JOURNAL OF INTEGRATIVE PLANT BIOLOGY, Issue 2 2009
    Jinting Li
    Abstract The relationship between structural features of various vegetative organs and triterpenoid saponin accumulation in Achyranthus bidentata Blume was investigated using anatomy, histochemistry and phytochemistry. The results showed that the primary and secondary structures of roots, and the structures of stems and leaves of A. bidentata, were similar to those of ordinary dicotyledonous plants. The enlargement of its roots, however, was primarily associated with growth and differentiation of tertiary structures. There were collateral medullary vascular bundles in addition to the normal vascular bundles in the stem. The tertiary structure was not only main parts in the roots of A. bidentata, but also important storage region of triterpenoid saponin in its growth and development. The stem may be the essential transport organ of triterpenoid saponin, while palisade parenchyma may be the primary synthesis location. In November, the total quantity of triterpenoid saponin and overall biomass in the roots reach a maximum level. This was the best time, therefore, to harvest the roots and corresponded to the traditional harvest period. Despite the withered appearance of leaves, stems also contained substantial amounts of triterpenoid saponin, and it was recommended that the stems of A. bidentata should be used. [source]

    Complete assignments of 1H and 13C NMR spectra of leucanthoside A, a new triterpenoid saponin from Cephalaria leucantha L.

    MAGNETIC RESONANCE IN CHEMISTRY, Issue 7 2006
    D. Go, evac
    Abstract Leucanthoside A, a new allose-containing triterpenoid saponin (1), was isolated from the aerial parts of Cephalaria leucantha L. Its structure was determined by electrospray ionization mass spectrometry and NMR spectroscopy. Complete assignments of the 1H and 13C NMR chemical shifts were achieved by two-dimensional NMR experiments: DQF-COSY, NOESY, TOCSY, HSQC, DINE-HSQC, HMBC, 13C- 1H 2D- J -resolved spectroscopy, and 1,1-ADEQUATE. Copyright © 2006 John Wiley & Sons, Ltd. [source]

    A New Triterpenoid Saponin and a New Glycoside from Epigynum aurilum

    CHINESE JOURNAL OF CHEMISTRY, Issue 12 2003
    Jian-Xin Cao
    Abstract A new triterpenoid saponin with novel sugar moiety (1), a new trisaccharide derivative (2), as well as a known monosaccharide derivative (3), were isolated from the dried stem of Epigynum aurilum. The structures of compounds 1 and 2 were determined by MS and NMR spectram analyses. [source]

    Oleanane Saponins from Rhizome of Anemone raddeana

    HELVETICA CHIMICA ACTA, Issue 1 2010
    Li Fan
    Abstract Two new oleanolic acid-type triterpenoid saponins, raddeanosides R22 and R23 (1 and 2, resp.), together with four known saponins were isolated from the rhizome of Anemone raddeanaRegel. The structures of the new compounds were elucidated as oleanolic acid 3- O - , - D -glucopyranosyl(1,2)[, - D -glucopyranosyl(1,4)]- , - L -arabinopyranoside (1) and oleanolic acid 3- O - , - L -arabinopyranosyl(1,3)- , - L -rhamnopyranosyl(1,2)[, - D -glucopyranosyl(1,4)]- , - L -arabinopyranoside (2). The four known compounds were identified as oleanolic acid 3- O - , - L -arabinopyranoside (3), oleanolic acid 3- O - , - D -glucopyranosyl(1,4)- , - L -arabinopyranoside (4), hederasaponin B (5), and hederacholchiside E (6) on the basis of chemical and spectral evidences. Compound 4 is reported for the first time from the Anemone genus, while the other three known compounds have been already found in this plant. [source]

    Triterpenoid Saponins from Pulsatilla cernua (Thunb.) Bercht. et Opiz.

    JOURNAL OF INTEGRATIVE PLANT BIOLOGY, Issue 2 2007
    Tun-Hai Xu
    Abstract To investigate saponins from the roots of Pulsatilla cernua (Thunb.) Bercht. et Opiz., two new compounds together with five known triterpenoid saponins were isolated. The structures of the two new triterpenoid saponins, named cernuasides A and B, were elucidated as 3-O-[p-,- D -xylopyranosyl(1,2)]-[,- L -rhamnopyranosyl(1,4)]-,- L -arabinopyranosyl hederagenin 28-O-,- D -glucopyranosyl ester (compound 1) and 3-O-[,- L -arabinopyranosyl(1,3)]-[,- L -rhamnopyranosyl (1,2)]-,- L -arabinopyranosyl hederagenin 28-O-,- D -glucopyranosyl ester (compound 2) by 1D, 2D-NMR techniques, ESIMS analysis, as well as chemical methods. [source]

    Structure elucidation and complete NMR spectral assignments of two new oleanane-type pentacyclic triterpenoid saponins from the husks of Xanthoceras sorbifolia Bunge

    MAGNETIC RESONANCE IN CHEMISTRY, Issue 11 2009
    Ying Guo
    Abstract Two new saponins were isolated from husks of Xanthoceras sorbifolia Bunge and their structures were elucidated as 3-O-[,-D-galactopyranosyl(1,2)]-,-L-arabinofuranosyl(1,3)-,-D-methyl glucuronic acid-21-O-(3,4-diangeloyl)-,-L-rhamnose-3,, 16,, 21,, 22,, 28,-pentahydroxyl-22-acetoxy-olean-12-ene(1) and 3-O-[,-D-galactopyranosyl(1,2)]-,-L-arabinofuranosyl(1,3)-,-D-methyl glucuronic acid-21,22-O-diangeloyl-3,,15,,16,,21,,22,,28,-hexahydroxyl-olean-12-ene(2) on the basis of 1D and 2D NMR (including 1H, 13C-NMR, 1H1H COSY, HSQC, HMBC and DEPT), ESI-MS spectrometry and chemical methods. Copyright © 2009 John Wiley & Sons, Ltd. [source]

    Complete assignments of 1H and 13C NMR spectral data for three new triterpenoid saponins from Ilex hainanensis Merr.

    MAGNETIC RESONANCE IN CHEMISTRY, Issue 2 2009
    Xiao-Qing Chen
    Abstract Three new oleanane-type triterpenoid saponins, ilexhainanoside C, D and E, all with 24, 28-dioic acid groups, were isolated from the leaves of Ilex hainanensis. They were 3,-hydroxyolean-12-ene-24, 28-dioic acid-28- O -,- D -glucopyranoside(1), 3,, 19,-dihydroxyolean-12-ene-24, 28-dioic acid-28- O -,- D -glucopyranoside(2) and 3,, 29-dihydroxyolean-12-ene-24, 28-dioic acid-28- O -,- D -glucopyranoside(3). The structures of these three new compounds were elucidated and complete assignments of the 1H and 13C NMR spectroscopic data were achieved by 1D and 2D NMR experiments [heteronuclear single quantum coherence (HSQC), HMBC and rotational nuclear Overhauser effect spectroscopy (ROESY)]. Copyright © 2008 John Wiley & Sons, Ltd. [source]

    Five new bidesmoside triterpenoid saponins from Stauntonia chinensis

    MAGNETIC RESONANCE IN CHEMISTRY, Issue 7 2008
    Gao Hao
    Abstract Eleven triterpenoid saponins (1,11) were isolated from Stauntonia chinensis DC. (Lardizabalaceae), including five new compounds, yemuoside YM21,25 (1,3, 6, 7) structures of which were elucidated by chemical methods and a combination of MS, 1D- and 2D- NMR experiments including DEPT, 1H1H COSY, HSQC, HMBC, TOCSY, and NOESY as 3- O -,- L -arabinopyranosyl-(1 , 3)-[,- L -rhamnopyranosyl-(1 , 2)-],- L -arabinopyranosyl-akebonicacid-28- O -,- L -rhamnopyranosyl-(1 , 4)-,- D -glucopyranosyl-(1 , 6)-,- D -glucopyranosyl ester (1), 3- O -,- D -xylopyranosyl-(1 , 3)-,- L -rhamnopyranosyl-(1 , 2)-,- L -arabinopyranosyl-akebonic acid-28- O -,- L -rhamnopyranosyl-(1 , 4)-,- D -glucopyranosyl-(1 , 6)-,- D -glucopyranosyl ester (2), 3- O -,- D -glucopyranosyl-(1 , 3)-,- L -arabinopyranosyl-akebonic acid-28- O -,- L -rhamnopyranosyl-(1 , 4)-,- D -glucopyranosyl-(1 , 6)-,- D -glucopyranosyl ester (3), 3- O -,- L -arabinopyranosyl-(1 , 3)-[,- L -rhamnopyranosyl-(1 , 2)-],- L -arabinopyranosyl-akebonic cid-28- O -,- D -glucopyranosyl-(1 , 6)-,- D -glucopyranosyl ester (6), 3- O -,- L -arabinopyranosyl-(1 , 3)-[,- L -arabinopyranosyl-(1 , 2)-],- L -arabinopyranosyl-akebonic acid-28- O -,- D -glucopyranosyl-(1 , 6)-,- D -glucopyranosyl ester (7). Copyright © 2008 John Wiley & Sons, Ltd. [source]

    1H and 13C NMR spectral data of new saponins from Cordia piauhiensis

    MAGNETIC RESONANCE IN CHEMISTRY, Issue 8 2007
    Renata P. Santos
    Abstract Two new bidesmoside triterpenoid saponins were isolated from stems of Cordia piauhiensis. Their structures, characterized as 3- O -,- L -rhamnopyranosyl-(1 , 2)-,- D -glucopyranosyl pomolic acid 28- O -,- D -glucopyranosyl ester (1) and 3- O -,- L -rhamnopyranosyl-(1 , 2)-,- D -glucopyranosyl oleanolic acid 28- O -,- D -glucopyranosyl-(1 , 6)-,- D -glucopyranosyl ester (2), were unequivocally established after extensive NMR (1H, 13C, DEPT 135 , COSY, HSQC, HMBC, TOCSY, and NOESY) studies. Copyright © 2007 John Wiley & Sons, Ltd. [source]

    Cucurbitane triterpenoids from Momordica charantia

    MAGNETIC RESONANCE IN CHEMISTRY, Issue 6 2007
    Qing-Yan Li
    Abstract Three new cucurbitane-type triterpenoid saponins, 23- O -,- D -allopyranosyl-5,,19-epoxycucurbita-6,24-diene-3,,22(S),23(S)-triol-3- O -,- D -glucopyranoside (1), 23- O -,- D -allopyranosyl-5,,19-epoxycucurbita-6,24-diene-3,,22(S),23(S)-triol-3- O -,- D -allopyranoside (2), and 23- O -,- D -allopyranosyl-5,,19-epoxycucurbita-6,24-diene-3,,19(R), 22(S),23(S)-tetraol-3- O -,- D -allopyranoside (3), named momordicoside M, N, and O, respectively, along with one known saponin momordicoside L (4), were isolated from the fresh fruits of Momordica charantia. The structures of these saponins were elucidated on the basis of chemical properties and spectral data. Copyright © 2007 John Wiley & Sons, Ltd. [source]

    Complete assignments of 1H and 13C NMR spectroscopic data for two new triterpenoid saponins from Ilex hainanensis

    MAGNETIC RESONANCE IN CHEMISTRY, Issue 2 2007
    Sixiang Zhou
    Abstract Two novel unsaturated E-ring pentacyclic triterpenoid saponins, ilexhainanoside A and ilexhainanoside B, were isolated from the leaves of Ilex hainanensis. Their chemical structures were determined by MS, NMR spectroscopy and chemical analysis. Complete assignments of the 1H and 13C NMR spectroscopic data were achieved by 1D and 2D NMR experiments (HSQC, HMBC, ROESY and 1H,1H COSY). Copyright © 2006 John Wiley & Sons, Ltd. [source]

    Biological activities of synthetic saponins and cardiac glycosides

    PHYTOTHERAPY RESEARCH, Issue 1 2003
    Masayuki Takechi
    Abstract Comparisons of the biological activities of diosgenyl (DIO) ,- D -xylopyranosyl- (1,,,2)-,- D -glucopyranoside (2DX,) and ,- D -glucopyranosyl- (1,,,3)-,- D -glucopyranoside (3GL,) or methyl glycyrrhetinate (GAM) 2DX, and 3GL, with those of the other DIO- or GAM- glycosides confirmed our assumption that both haemolytic and antifungal activities of DIO-glycosides (steroid saponins) generally parallel each other, while almost all haemolytic GAM-glycosides (triterpenoid saponins) have no antifungal activity. By comparisons of digitoxigenyl (DIG) 2DX,, ,- D -xylopyranosyl- (1,,,2)-,- D -glucopyranoside (2DX,) and 3GL, with the other DIG-glycosides, the previous supposition on DIG-diglycosides (cardiac diglycosides) has been developed into the assumption that those having a (1,,,4), (1,,,3) or (1,,,2), sugar linkage show stronger anti-ATPase and antiviral activities than those with a (1,,,6) or (1,,,2), linkage. Copyright © 2003 John Wiley & Sons, Ltd. [source]

    Glycosides from the Leaves of Ilex latifolia

    CHINESE JOURNAL OF CHEMISTRY, Issue 9 2001
    Ming-An Ouyang
    Abstract Nine new triterpenoid saponins; latifolosides IQ and three known compounds: Kudinoside A, cis -roseoside, and kaempferol-3-O-,- L -rhamnopyranosyl (1,6)-O-,-D-glucopyanoside were isolated from the leaves of Ilex latifolia. Their structures were elucidated by spectroscopic and chemical methods. [source]