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Treatment Type (treatment + type)
Selected AbstractsSites for depression on the web: a comparison of consumer, professional and commercial sitesAUSTRALIAN AND NEW ZEALAND JOURNAL OF PUBLIC HEALTH, Issue 4 2000HELEN CHRISTENSEN Objective: To provide information on the range of treatments for depression provided by commercial, professional and consumer web sites. Methods: An audit of the 21 most popular depression sites on the world wide web undertaken from March 1999 to July 1999, in Canberra, ACT. Treatment types and categories of treatment were compared among commercial, professional and consumer web sites. Results: A total of 53 treatments or treatment types were mentioned. The number of treatments mentioned per site ranged from 2 to 38. Antidepressant medication and psychotherapy were noted by almost all sites. Consumer sites mentioned psychological therapies less frequently but did not mention dietary supplements or complementary treatments more frequently. Conclusions and Implications: Consumer web sites provide a point of comparison to those from commercial or professional sources. They provide a voice to inform psychiatrists and GPs about preferred treatments and side effects and to alert researchers to areas that need formal investigation. [source] Nocturnal hypoglycaemia in Type 1 diabetic patients, assessed with continuous glucose monitoring: frequency, duration and associationsDIABETIC MEDICINE, Issue 5 2007I. M. E. Wentholt Abstract Aims, We quantified the occurrence and duration of nocturnal hypoglycaemia in individuals with Type 1 diabetes treated with continuous subcutaneous insulin infusion (CSII) or multiple-injection therapy (MIT) using a continuous subcutaneous glucose sensor. Methods, A microdialysis sensor was worn at home by 24 patients on CSII (mean HbA1c 7.8 ± 0.9%) and 33 patients on MIT (HbA1c 8.7 ± 1.3%) for 48 h. Occurrence and duration of nocturnal hypoglycaemia were assessed and using multivariate regression analysis, the association between HbA1c, diabetes duration, treatment type (CSII vs. MIT), fasting and bedtime blood glucose values, total daily insulin dose and mean nocturnal glucose concentrations, and hypoglycaemia occurrence and duration was investigated. Results, Nocturnal hypoglycaemia , 3.9 mmol/l occurred in 33.3% of both the CSII- (8/24) and MIT-treated patients (11/33). Mean (± sd; median, interquartile range) duration of hypoglycaemia , 3.9 mmol/l was 78 (± 76; 57, 23,120) min per night for the CSII- and 98 (± 80; 81, 32,158) min per night for the MIT-treated group. Multivariate regression analysis showed that bedtime glucose value had the strongest association with the occurrence (P = 0.026) and duration (P = 0.032) of nocturnal hypoglycaemia. Conclusions, Microdialysis continuous glucose monitoring has enabled more precise quantification of nocturnal hypoglycaemia occurrence and duration in Type 1 diabetic patients. Occurrence and duration of nocturnal hypoglycaemia were mainly associated with bedtime glucose value. [source] Resource consumption and costs in Dutch patients with Type 2 diabetes mellitus.DIABETIC MEDICINE, Issue 3 2002Results from 29 general practices Abstract Aims The aims of this study were to estimate the costs incurred by Dutch patients with Type 2 diabetes, examine which patient and/or treatment characteristics are associated with costs, and estimate the medical and non-medical costs of patients with Type 2 diabetes in The Netherlands. Methods Twenty-nine Dutch general practitioners provided information on all Type 2 diabetes patients in their practice (n = 1371), information on demography, clinical characteristics, treatment type, the presence of complications and the type and amount of medical consumption during the previous 6 months. Medical costs were analysed using multivariate linear regression. Estimates of costs seen in The Netherlands were based on these results plus information from other sources regarding costs of end-stage renal disease, appliances, travel and productivity loss. Results Although only 9% of patients were hospitalized within the previous 6 months, hospitalization costs represented one-third of the medical costs, drug costs 40% and ambulatory costs 26%. Patients using insulin, patients with macrovascular complications only or in combination with microvascular complications incurred higher medical costs than other patients. Age and hyperlipidaemia were also positively related to medical costs. When these results were combined with other data sources, we estimated that patients with Type 2 diabetes are responsible for £365 500 000 (1 271 000 000 guilders) or 3.4% of the relevant parts of health care costs in 1998. The non-medical costs (travel costs, productivity costs) are limited: 52 500 000 (183 000 000 guilders). Conclusions Independent determinants of the medical costs of Type 2 diabetes in The Netherlands include age, complications, insulin use and hyperlipidaemia. Diabet. Med. 19, 246,253 (2002) [source] Extraction Using Moderate Electric FieldsJOURNAL OF FOOD SCIENCE, Issue 1 2004I. SENSOY ABSTRACT: During moderate electric field (MEF) processing, a voltage applied across a food material may affect the permeability of cell membranes. It is known that high electric fields can cause either reversible or irreversible rupture of cell membranes. In this research, the effect of MEF processing on permeability was studied. Effects of frequency and electric field strength were investigated. Cellular structure was investigated by transmission electron microscopy (TEM). Fermented black tea leaves and fresh or dry mint leaves were placed in tea bags or cut in 1 cm2 squares, depending on the experiment, and immersed in an aqueous fluid medium. Control samples were heated on a hot plate. MEF treatments were conducted by applying a voltage across electrodes immersed in opposite sides of the beaker. Control and MEF-treated fresh mint leaf samples heated to 50°C were analyzed by TEM. MEF processing significantly increased the extraction yield for fresh mint leaves because of additional electric field effects during heating. Dried mint leaves and fermented black tea leaves were not affected by the treatment type. Low frequency resulted in higher extraction rates for fresh mint leaves. The electric field strength study showed that electrical breakdown is achieved even at low electric field strengths. MEF treatment shows potential to be used as an alternative to conventional heating for extraction from cellular materials. [source] Simulated rainfall evaluation of revegetation/mulch erosion control in the Lake Tahoe Basin,1: method assessmentLAND DEGRADATION AND DEVELOPMENT, Issue 6 2004M. E. Grismer Abstract Revegetation of road cuts and fills is intended to stabilize those drastically disturbed areas so that sediment is not transported to adjacent waterways. Sediment has resulted in water quality degradation, an extremely critical issue in the Lake Tahoe Basin. Many revegetation efforts in this semiarid, subalpine environment have resulted in low levels of plant cover, thus failing to meet project goals. Further, no adequate physical method of assessing project effectiveness has been developed, relative to runoff or sediment movement. This paper describes the use of a portable rainfall simulator (RS) to conduct a preliminary assessment of the effectiveness of a variety of erosion-control treatments and treatment effects on hydrologic parameters and erosion. The particular goal of this paper is to determine whether the RS method can measure revegetation treatment effects on infiltration and erosion. The RS-plot studies were used to determine slope, cover (mulch and vegetation) and surface roughness effects on infiltration, runoff and erosion rates at several roadcuts across the basin. A rainfall rate of ,60,mm,h,1, approximating the 100-yr, 15-min design storm, was applied over replicated 0·64,m2 plots in each treatment type and over bare-soil plots for comparison. Simulated rainfall had a mean drop size of ,2·1,mm and approximately 70% of ,natural' kinetic energy. Measured parameters included time to runoff, infiltration, runoff/infiltration rate, sediment discharge rate and average sediment concentration as well as analysis of total Kjeldahl nitrogen (TKN) and dissolved phosphorus (TDP) from filtered (0·45,,m) runoff samples. Runoff rates, sediment concentrations and yields were greater from volcanic soils as compared to that from granitic soils for nearly all cover conditions. For example, bare soil sediment yields from volcanic soils ranged from 2,12 as compared to 0·3,3,g,m,2,mm,1 for granitic soils. Pine-needle mulch cover treatments substantially reduced sediment yields from all plots. Plot microtopography or roughness and cross-slope had no effect on sediment concentrations in runoff or sediment yield. RS measurements showed discernible differences in runoff, infiltration, and sediment yields between treatments. Runoff nutrient concentrations were not distinguishable from that in the rainwater used. Copyright © 2004 John Wiley & Sons, Ltd. [source] (631) Chronic Pain Treatment Meta-Analyses: A Mathematical and Qualitative ReviewPAIN MEDICINE, Issue 2 2000Article first published online: 25 DEC 200 Authors: Fishbain DA, University of Miami Comprehensive Pain Center; Rosomoff H, University of Miami Comprehensive Pain Center; Cutler RB, University of Miami Comprehensive Pain Center; Steele-Rosomoff R, University of Miami Comprehensive Pain Center Aim of Investigation: To critically review chronic pain treatment meta-analyses according to defined criteria. Methods: An extensive literature search yielded 22 meta-analyses dealing with pain. The following inclusion criteria were applied to these studies: (1) nonsurgical pain treatment outcome only, including nerve blocks; (2) chronic pain treatment outcome only; (3) nonmalignant pain only and; (4) study data presenting an effect size which enabled the calculation of a confidence interval (CI). These inclusion criteria selected 16 studies from the original group. These remaining meta-analyses were then divided into 3 categories: (1) General pain facility treatment (n = 4); (2) Headache treatment (n = 5) and; (3) Specific treatment types, eg, manipulation, psychoeducational, antidepressant, etc. (n = 7). Within each meta-analysis the data was subdivided according to type of pain, treatment type and outcome variable. The CI was then calculated for each of these subdivisions within each meta-analysis. The quality of the 16 meta-analyses was also investigated according to 20 meta-analysis criteria previously presented in the literature. Results: (1) Overall, the pain facility treatment meta-analyses were remarkably consistent in demonstrating that pain facility treatment is effective for most treatment outcome variables. (2) Within pain facility treatments, biofeedback, cognitive therapy, operant conditioning, and package treatment were demonstrated to be efficacious. (3) Within the headache treatment meta-analyses, both relaxation/biofeedback and various medications were demonstrated to be efficacious. (4) Within the specific isolated treatments group, psychoeducation, antidepressants, capsaicin and spinal manipulation were found to have efficacy, for a number of treatment outcome variables. (5) The quality of the meta-analyses was variable but acceptable, according to the meta-analysis criteria utilized. Conclusions: Overall the results of the reviewed meta-analyses indicate that most treatments are effective for most pain patients but that some treatments appear to be more effective than others. [source] The breast cancer experience of rural women: a literature reviewPSYCHO-ONCOLOGY, Issue 10 2007B. Ann Bettencourt Abstract This report is a review of studies that focus on rural breast cancer survivorship. It includes a total of 14 studies using large databases and 27 other studies using qualitative and quantitative methods. In our review of this literature, we identified four broad themes, including access to treatment and treatment type, medical providers and health information, psychosocial adjustment and coping, and social support and psychological support services. We review the findings of the rural breast cancer survivorship studies within each of these broad themes. A few of the findings of the review include that rural and urban women receive different primary treatments for breast cancer, that rural women may have greater difficulty negotiating their traditional gender roles during and after treatment, that rural women desire greater health-related information about their breast cancer, and that rural women have less access to mental health therapy. The review discusses the implications of these findings as well as the weakness in the literature. Copyright © 2007 John Wiley & Sons, Ltd. [source] URBAN,RURAL DIFFERENCES IN THE MANAGEMENT OF SCREEN-DETECTED INVASIVE BREAST CANCER AND DUCTAL CARCINOMA IN SITU IN VICTORIAANZ JOURNAL OF SURGERY, Issue 11 2006David L. Kok Background: At least one-third of primary breast cancers in Australia are discovered by population-based mammographic screening. The aim of this study was to determine whether there were any differences in the surgical treatment of women diagnosed with breast cancer by BreastScreen Victoria between urban and rural populations and to investigate temporal changes in their pattern of care. Methods: An analysis of women diagnosed with breast cancer (invasive and non-invasive) by BreastScreen Victoria from 1993 to 2000 was conducted. Descriptive analyses of the proportion of women undergoing each surgical treatment type over time were carried out. Logistic regression was used to assess the effect of urban,rural residence on each treatment outcome while accounting for possible confounding factors. Results: Rural women with invasive breast cancer were less likely to undergo breast-conserving surgery (BCS) compared with urban women (odds ratio, 0.42; 95% confidence interval, 0.35,0.50). The same was also true for rural women with ductal carcinoma in situ (odds ratio, 0.53; 95% confidence interval, 0.29,0.96). This difference was independent of patient and tumour characteristics, including tumour size, surgeon caseload, patient's age and socioeconomic status. It also persisted over time despite a steady overall increase in use of BCS for both invasive and non-invasive cancers over the study period. Conclusions: Among Victorian women with screen-detected breast cancer, urban women consistently had higher rates of BCS compared with rural women despite increased overall adoption of BCS. Reasons for this disparity are still unclear and warrant further investigation. [source] Clinical and socio-demographic profile of an Australian multi-institutional prostate cancer cohortASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY, Issue 4 2009Kerri BECKMANN Abstract Aims: To describe the clinical and socio-demographic data from a South Australian prostate cancer cohort (PCCOD). Methods: Clinical data for 2329 prostate cancer patients treated at three South Australian teaching hospitals between 1998 and 2007 were analyzed by place of residence, time of diagnosis and socioeconomic status (SES). ,2 tests were used to investigate differences in stage, grade and prostate-specific antigen (PSA) at diagnosis, among subgroups and over time. Logistic regression was used to examine predictors of treatment modalities. Five-year survival was assessed using Kaplan,Meier methods. Results: The distributions of age, SES and place of residence of PCCOD patients closely reflected those of the state-based prostate cancer population, with rural patients slightly underrepresented. Lower SES or rural residence was not associated with higher stage, grade, PSA level or disease-specific survival. Treatment modalities varied with SES (for radical prostatectomy), rural residence (radical prostatectomy, radiotherapy and androgen ablation), age and clinical characteristics. There was a trend over time towards a younger age at diagnosis and more favorable clinical profiles, consistent with earlier diagnosis. However, the current risk profile for this cohort is similar to that reported approximately a decade earlier in a US series. Conclusion: PCCOD patients have a broadly similar socio-demographic profile to prostate cancer patients statewide. Socioeconomic status is not associated with clinical characteristics at diagnosis, but does predict treatment type. The clinical characteristics of the cohort are consistent with a much later stage presentation than reported in current US case series. [source] Effects of epidermal growth factor receptor inhibitor-induced dermatologic toxicities on quality of life,CANCER, Issue 16 2010Smita S. Joshi MD Abstract BACKGROUND: Epidermal growth factor receptor (EGFR) inhibitors frequently result in dermatologic toxicities, including rash, xerosis, pruritus, and paronychia. Although the frequency and severity of these events have been described, their effect on health-related quality of life (QoL) remains poorly understood. By using a dermatology-specific questionnaire, the authors examined the effect of these toxicities on QoL. METHODS: Patients completed the Skindex-16, a questionnaire that measures the effects on 3 domains of QoL: symptoms, emotions, and functioning. The severity of dermatologic toxicities was assessed using the National Cancer Institute Common Terminology Criteria for Adverse Events, version 3.0 (NCI-CTCAE). Correlations of dermatology QoL scores with NCI-CTCAE grade, skin phototype (SPT), sex, age, type of EGFR inhibitor, and cancer type were investigated. RESULTS: Concordant with greater severity of rash grade, there was an increase in median scores for symptoms (P = .0006), emotions (P < .0001), function (P = .001), and overall score (P < .0001). There was an inverse correlation between age and emotions (r = ,0.26; P = .03) and overall score (r = ,0.25; P = .04). There was a significant difference between patients aged ,50 years and patients aged >50 years with regard to symptoms (P = .02), emotions (P = .03), functioning (P = .04), and overall score (P = .02). There were no significant differences between QoL and SPT, sex, treatment type, or cancer type (P > .05). CONCLUSIONS: Toxicities, including rash, xerosis, paronychia, and pruritus, adversely affected QoL, and rash was associated with a QoL greater decrease. Younger patients reported lower overall QoL than older patients who had the same toxicities. The current results support using the NCI-CTCAE as a correlative tool for measuring the effects of rash on dermatology-specific QoL. Cancer 2010. © 2010 American Cancer Society. [source] Primary central nervous system post-transplantation lymphoproliferative disorder,CANCER, Issue 4 2010An International Primary Central Nervous System Lymphoma Collaborative Group Report Abstract BACKGROUND: Primary central nervous system (CNS) post-transplantation lymphoproliferative disorder (PCNS-PTLD) is a rare complication of solid organ transplantation. The objectives of this study were to define the clinical, radiologic, and pathologic features of this disease and to explore the impact of treatment on patient outcomes. METHODS: The authors reviewed the databases of participating institutions of the International Primary CNS Lymphoma Collaborative Group for cases of PCNS-PTLD. Thirty-four patients who had pathologically confirmed PCNS-PTLD without evidence of systemic PTLD were investigated retrospectively. RESULTS: The median time from transplantation to diagnosis of PCNS-PTLD was 4.4 years. Disease usually was multifocal and involved any location of the brain but was most common in the cerebral hemispheres, usually in the subcortical white matter or basal ganglia. Radiographically, all lesions enhanced either homogenously or in a ring-enhancing pattern. Cerebral biopsy was required to establish diagnosis in most patients. Most patients had monomorphic, Epstein-Barr virus (EBV)-positive disease of B-cell origin. Response rates were high regardless of treatment type, and the median survival was 47 months. Age was the only factor predictive of survival. CONCLUSIONS: The current study demonstrated that PCNS-PTLD is typically an EBV-induced B-cell lymphoma that is responsive to treatment with favorable survival in many patients. An aggressive approach to tissue confirmation of diagnosis and treatment with chemotherapy or radiotherapy should be strongly considered. Cancer 2010. © 2010 American Cancer Society [source] Comparison of a Long-Pulse Nd:YAG Laser and a Combined 585/1,064-nm Laser for the Treatment of Acne Scars: A Randomized Split-Face Clinical StudyDERMATOLOGIC SURGERY, Issue 11 2009SEONG UK MIN MD BACKGROUND Nonablative laser is gaining popularity because of the low risk of complications, especially in patients with darker skin. OBJECTIVE To compare the efficacy and safety of a long-pulse neodymium-doped yttrium aluminium garnet (Nd:YAG) laser and a combined 585/1,064-nm laser for the treatment of acne scars. MATERIALS AND METHODS Nineteen patients with mild to moderate atrophic acne scars received four long-pulse Nd:YAG laser or combined 585/1,064-nm laser treatment sessions at fortnightly intervals. Treatments were administered randomly in a split-face manner. RESULTS Acne scars showed mild to moderate improvement, with significant Echelle d'évaluation clinique des cicatrices d'acné (ECCA) score reductions, after both treatments. Although intermodality differences were not significant, combined 585/1,064-nm laser was more effective for deep boxcar scars. In patients with combined 585/1,064-nm laser-treated sides that improved more than long-pulse Nd:YAG laser-treated sides, ECCA scores were significantly lower for combined 585/1,064-nm laser treatment. Histologic evaluations revealed significantly greater collagen deposition, although there was no significant difference between the two modalities. Patient satisfaction scores concurred with physicians' evaluations. CONCLUSION Both lasers ameliorated acne scarring with minimal downtime. In light of this finding, optimal outcomes might be achieved when laser treatment types are chosen after considering individual scar type and response. [source] Evaluation of the Personal Dental Services (Wave 1) for Lambeth, Southwark and Lewisham Primary Care Trusts , Part 2: Retrospective analyses of treatment and other dental record dataJOURNAL OF EVALUATION IN CLINICAL PRACTICE, Issue 3 2005Helen Best BDS MDS PhD Abstract Aim/Objective, The purpose of the study was to undertake analyses of treatment data for the Personal Dental Services (PDS) of Lambeth, Southwark and Lewisham Primary Care Trusts and relate the analyses to the PDS goals of supporting practitioners deliver appropriate quality dental care and ensuring that appropriate quality safety net services are available for all residents. Method, Analyses of treatment data provided by the Dental Practice Board were undertaken for the post-PDS period (February 1999,March 2003, based on data availability). Analyses of the clinic notes for 1500 patients were also undertaken for the 1 year pre-PDS period (October 1997,September 1998) and post-introduction of the PDS (October 1998,June 2003). Two sets of analyses were undertaken to evaluate trends in treatment claims for the Dental Practice Board data, absolute numbers of each type of treatment claimed each month and change in numbers of types of treatments claimed over time. The clinic notes were used to undertake post-PDS, pre-PDS comparisons of the number of treatment items and grouped treatment item categories undertaken and the number of courses and percentages of private treatment items provided. The following sociodemographic characteristics of the patients were also analysed, age, gender, exemption ,status ,and ,attendance ,status. Results, Overall it was identified that the percentage reduction in the number of treatment items undertaken was 13% (95% CI ,19%, ,7%), post- as compared to the pre-PDS introduction period. On an annual basis it was identified that the percentage reduction in the number of treatment items undertaken per year per patient post-PDS was 4% (95% CI ,6%, ,2%). There were significant variations in the impact of the PDS on the number of treatment items undertaken for different types of patients. A limited number of treatment types changed significantly post- as compared to pre-PDS. The proportion of exempt patients treated did not increase ,post-PDS. Conclusions, It is possible that a less, invasive style of dental treatment was provided during the course of the PDS, however, there was only limited evidence to indicate that dentists practice style changed based on types of treatment categories provided. The PDS provided a limited safety net service for local residents. In setting program goals the nature of quality dental practice requires definition and evaluation should be undertaken on a prospective basis. [source] Dietary Na does not reduce dietary Cu uptake by juvenile rainbow troutJOURNAL OF FISH BIOLOGY, Issue 2 2005V. A. Kjoss Rainbow trout Oncorhynchus mykiss fry in moderately hard water were exposed to control or high levels of dietary Cu (c. 6 and 580 ug Cu g food,1) at one of three levels of Na (1·5, 3·0 or 4·5%) in the diet, i.e. six experimental groups. Fish were fed a 4% body mass ration daily for 28 days and 10 individuals from each group were sampled every 7 days. Concentrations of Cu and Na were measured in the gills, liver, gut and remaining carcass of sampled fish. Growth was not affected and no consistent differences were found in mass, total lengths (LT) or indices of body condition among any of the groups on any sampling day. Copper concentration was significantly higher in tissues of Cu-exposed groups, although within treatment types (control Cu v. high Cu diet), it did not differ consistently among groups that received different levels of dietary Na. Tissue Na concentration did not differ among any of the groups and did not show any marked changes over time. In Cu-exposed groups, the proportion of total body Cu burden contained in the liver approximately doubled over time, from c. 30% on day 7 to c. 60% on day 28. In unexposed fish, the liver maintained c. 25% of the total Cu burden throughout the experiment. In contrast, the proportion of the total body Cu burden contained in the gut decreased somewhat over time in Cu-exposed fish, from c. 40% on day 7 to c. 30% on day 28, and remained fairly stable at c. 25,30% in control groups, i.e. approximately equal to liver values. In all groups, the carcass contained by far the largest portion of the total Na content (>80%). Measurements made 36 h post-feeding indicated that all six groups had much higher Na efflux relative to influx, suggesting that the fish were eliminating excess Na taken up from the diet, and differences in Na influx rates were small. Na efflux rate was significantly higher in the high Cu and high Na group than in the high Cu and low Na group. The results indicate that at the concentrations used in this experiment, dietary Na has little effect on dietary Cu uptake by juvenile rainbow trout, and dietary Cu has little effect on Na homeostasis. [source] Report of the Council for the session 2006,2007JOURNAL OF THE ROYAL STATISTICAL SOCIETY: SERIES A (STATISTICS IN SOCIETY), Issue 4 2007Council Report President's foreword., This year's annual report shows another very successful year for the Society. The range of the Society's new initiatives bears testament to our vigour and to the energy and enthusiasm of Fellows and staff. It is difficult to summarize all of these but I offer a brief overview of some of the highlights. This year we have awarded the first annual prize for ,Statistical excellence in journalism'. It is too easy to bemoan the general quality of coverage of statistical issues in the press and other media. But simply moaning does not improve the situation. As a positive step, on the instigation of Sheila Bird and Andrew Garratt, the Society decided to initiate an award for the best journalistic coverage of a statistical issue. This year first prize was awarded to Ben Goldacre of The Guardian. I hope that these annual awards will offer a positive focus on good coverage and help us to promote best practice. This year, also, we have set up the Professional Development Centre to act as a focus for statistical training both for statisticians and for others who use statistical methods as part of their work. It thus reflects our support for continuing professional development for our Fellows and at the same time provides outreach to members of the statistical user community who want to improve their statistical skills. We welcome Nicola Bright as the Director of the Centre and wish her every success. I am pleased to say that it is not just the Society centrally that has taken new activities this year. The Manchester Local Group have initiated a prize for final year undergraduates from any higher education institute in the north-west. At a time when there are concerns about the number of well-qualified graduates coming into the statistics profession this seems an excellent way to attract the attention of final year undergraduates. I wish this initiative every success. Another development to which the Society has contributed is the Higher Education Funding Council for England project ,more maths grads' which is designed to promote participation in undergraduate degrees in the mathematical sciences. A good supply of mathematically trained graduates is essential to the UK economy in general and to the health of the statistics discipline in particular. It is good that the Society is involved in practical developments that are aimed at increasing participation. The final new initiative that I shall draw attention to is the ,first-in-man' report which is concerned with the statistical design of drug trials aimed at testing novel treatment types. The working party was set up as a result of the adverse reactions suffered by healthy volunteers to a first-in-man trial of monoclonal antibodies and who were subsequently admitted to Northwick Park hospital. The report makes a series of recommendations about the design of such trials and will, I hope, contribute to the safety of future trials. I would like to thank Stephen Senn and the members of the working party for their considerable efforts. As well as these new initiatives there were, of course, many other continuing activities that are noteworthy. The annual conference in Belfast was a great success with many lively sessions and a good number of participants. In particular it was good to see a high number of young statisticians participating in the conference, reflecting the continuing impact of the Young Statisticians Forum on which I commented in the previous annual report. Another continuing activity for the Society is the statistical legislation going through Parliament as I write. The Society has long campaigned for legislation for official statistics. The issue now is to try to get good legislation which will have the required effect and will help the Government Statistical Service and other statistical producers to produce high quality, authoritative statistics in an environment that commands public confidence. As first published, the Society was disappointed with the Bill but we have worked to build support for amendments that, in our view, are essential. Time alone will tell how effective the final legislation will be in meeting our aims. I would like to draw attention to the success of the Membership Services team. We, although with other statistical Societies, have experienced a decline in membership in recent years but the team have turned this round. They are helping to recruit new Fellows and to retain the commitment of existing Fellows. This is a fine achievement and I would like to thank Nicola Emmerson, Ed Swires-Hennessy and the whole team. Finally we have, at last, reached a conclusion in our dealings with the Privy Council and will implement the second phase of constitutional changes. In future our business year, financial year and year for elected appointments will all coincide on a calendar year basis. There will be transitional arrangements but in due course all our administrative arrangements will coincide and will improve efficiency and co-ordination. This has been a long journey, steered effectively by our Director General, Ivor Goddard, and I congratulate him for a successful outcome on your behalf. As you read this report, I hope that you will share my impression of a Society that is lively and spawning many new programmes. We have a dual commitment: to the well-being of statistics as a discipline and to the promotion of statistical understanding and practice to the benefit of Society at large. In both respects I feel that the Society is in good health. This is due to the unstinting efforts of a large number of individual volunteers, including in particular our Honorary Officers and also, of course, the staff at Errol Street. On behalf of all Fellows, I wish to express my thanks to everyone involved. Tim Holt [source] (631) Chronic Pain Treatment Meta-Analyses: A Mathematical and Qualitative ReviewPAIN MEDICINE, Issue 2 2000Article first published online: 25 DEC 200 Authors: Fishbain DA, University of Miami Comprehensive Pain Center; Rosomoff H, University of Miami Comprehensive Pain Center; Cutler RB, University of Miami Comprehensive Pain Center; Steele-Rosomoff R, University of Miami Comprehensive Pain Center Aim of Investigation: To critically review chronic pain treatment meta-analyses according to defined criteria. Methods: An extensive literature search yielded 22 meta-analyses dealing with pain. The following inclusion criteria were applied to these studies: (1) nonsurgical pain treatment outcome only, including nerve blocks; (2) chronic pain treatment outcome only; (3) nonmalignant pain only and; (4) study data presenting an effect size which enabled the calculation of a confidence interval (CI). These inclusion criteria selected 16 studies from the original group. These remaining meta-analyses were then divided into 3 categories: (1) General pain facility treatment (n = 4); (2) Headache treatment (n = 5) and; (3) Specific treatment types, eg, manipulation, psychoeducational, antidepressant, etc. (n = 7). Within each meta-analysis the data was subdivided according to type of pain, treatment type and outcome variable. The CI was then calculated for each of these subdivisions within each meta-analysis. The quality of the 16 meta-analyses was also investigated according to 20 meta-analysis criteria previously presented in the literature. Results: (1) Overall, the pain facility treatment meta-analyses were remarkably consistent in demonstrating that pain facility treatment is effective for most treatment outcome variables. (2) Within pain facility treatments, biofeedback, cognitive therapy, operant conditioning, and package treatment were demonstrated to be efficacious. (3) Within the headache treatment meta-analyses, both relaxation/biofeedback and various medications were demonstrated to be efficacious. (4) Within the specific isolated treatments group, psychoeducation, antidepressants, capsaicin and spinal manipulation were found to have efficacy, for a number of treatment outcome variables. (5) The quality of the meta-analyses was variable but acceptable, according to the meta-analysis criteria utilized. Conclusions: Overall the results of the reviewed meta-analyses indicate that most treatments are effective for most pain patients but that some treatments appear to be more effective than others. [source] Patterns and costs of treatment for heroin dependence over 12 months: fndings from the Australian Treatment Outcome StudyAUSTRALIAN AND NEW ZEALAND JOURNAL OF PUBLIC HEALTH, Issue 4 2006Marian Shanahan Objective: To determine patterns and costs of treatment for heroin dependence over a 12-month period among a cohort of heroin users seeking treatment. Methods: The design was a longitudinal cohort study of heroin users seeking treatment who participated in the Australian Treatment Outcome Study (ATOS), which was conducted in Sydney, Melbourne and Adelaide, Australia. Treatment for heroin dependence, for those who were followed up at 12 months, was recorded and costed. Unit costs, obtained from secondary sources, were used to estimate the cost of treatment. This study does not include wide societal costs and only includes personal costs as they pertain to treatment. Results: A follow-up rate of 81% at 12 months was achieved, resulting in data for 596 participants. Participants spent an average of 188 days in treatment over 2.7 episodes. Sixty-nine per cent of the sample reported at least one episode of treatment following their index treatment. There was a noticeable trend for subjects who received maintenance or residential rehabilitation as their index treatment to return to the same form of treatment for subsequent episodes. In contrast, those who received detoxifcation as index treatment accessed a wider variety of treatment types over the follow-up period. The cost of treatment over the 12-month follow-up totalled 3,901,416, with a mean of 6,517 per person. Conclusions and Implications: This study demonstrates that individuals seeking treatment have multiple treatment episodes throughout a 12-month period, with a tendency to return to the same form of treatment. This study also demonstrates that it is feasible and affordable to provide ongoing treatment for a group of heroin users seeking treatment. [source] Sites for depression on the web: a comparison of consumer, professional and commercial sitesAUSTRALIAN AND NEW ZEALAND JOURNAL OF PUBLIC HEALTH, Issue 4 2000HELEN CHRISTENSEN Objective: To provide information on the range of treatments for depression provided by commercial, professional and consumer web sites. Methods: An audit of the 21 most popular depression sites on the world wide web undertaken from March 1999 to July 1999, in Canberra, ACT. Treatment types and categories of treatment were compared among commercial, professional and consumer web sites. Results: A total of 53 treatments or treatment types were mentioned. The number of treatments mentioned per site ranged from 2 to 38. Antidepressant medication and psychotherapy were noted by almost all sites. Consumer sites mentioned psychological therapies less frequently but did not mention dietary supplements or complementary treatments more frequently. Conclusions and Implications: Consumer web sites provide a point of comparison to those from commercial or professional sources. They provide a voice to inform psychiatrists and GPs about preferred treatments and side effects and to alert researchers to areas that need formal investigation. [source] A Comprehensive and Comparative Review of Adolescent Substance Abuse Treatment OutcomeCLINICAL PSYCHOLOGY: SCIENCE AND PRACTICE, Issue 2 2000Robert J. Williams There are relatively few studies on adolescent substance abuse treatment. The ones that exist tend to be methodologically weak. Methodologically stronger studies have usually found most adolescents receiving treatment to have significant reductions in substance use and problems in other life areas in the year following treatment. Average rate of sustained abstinence after treatment is 38% (range, 30,55) at 6 months and 32% at 12 months (range, 14,47). Variables most consistently related to successful outcome are treatment completion, low pretreatment substance use, and peer/ parent social support/nonuse of substances. There is evidence that treatment is superior to no treatment, but insufficient evidence to compare the effectiveness of treatment types. The exception to this is that outpatient family therapy appears superior to other forms of outpatient treatment. [source] | ||||||||||||||||