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Transplanted Graft (transplanted + graft)

Distribution by Scientific Domains
Medical Sciences100%

Selected Abstracts

Transplantation and microsurgical anastomosis of free omental grafts: Experimental animal model of a new operative technique in dogs

MICROSURGERY, Issue 5 2003
Jozsef Pap-Szekeres M.D.
Our objective was the elaboration of a new animal model for the free transplantation of an omental flap and the examination of its viability in dogs. The cooled omental flap from the abdomen was freely transplanted to the lateral cervical region, and its blood supply was established with microsurgical anastomoses. The technique was developed in 5 dogs, and short-term survival examinations were later carried out in 3 cases by means of this method. Postoperative viability was assessed by angiography, methylene blue testing, and histology. Of the 3 transplanted grafts, 2 still survived 1 week after the operation. For technical reasons, 1 flap thrombotized. For determination of the viability of the transplanted graft, histology proved best. Vital reactions, including granulation tissue and angiogenesis, were present on the histological slides. The short-term survival of an omental flap can be ensured with microsurgical transplantation in dogs. A cseplesz lebeny szabad átültetésére, valamint az átültetett lebenyek életképességének vizsgálata céljából új állatkísérletes modellt dolgoztunk ki. Módszerünket 5 állaton dolgoztuk ki, majd további 3, m,tött állatnál rövidtavu túlélési vizsgálatokat végeztünk. Hasüregb,l nyert, megfelel,en el,készített és h,tött cseplesz lebenyt szabadon ültettünk át a laterális nyaki régióra. Az átültetett lebeny érellátását mik-rosebészeti módszerrel létrehozott anasztomózisokkal biztosítottuk. Az átültetett lebenyek életképességét angiográfia, metilénkék-festés és szövettani módszerekkel vizsgáltuk. A 3 átültetett lebeny közül 2 életképesnek bizonyult 1 héttel a m,tét után, technikai ok miatt 1 lebeny trombotizált. Az életképesség igazolására a szövettani vizsgálat bizonyult a legjobbnak, melynek segítségével granulációs szövet és angiogenezis is ábrázolható volt. Cseplesz lebeny rövidtávú túlélése biztosítható mikrosebészeti módszerrel történ, átültetéssel kutyán. © 2003 Wiley-Liss, Inc. MICROSURGERY 23:414,418 2003 [source]

HN09P ASSESSMENT OF FREE FIBULAR BONE IN THE RECONSTRUCTED MANDIBLE USING THREE-DIMENSIONAL COMPUTER GENERATED IMAGES

ANZ JOURNAL OF SURGERY, Issue 2007
H. Nabi
We report the preliminary results of the Royal Adelaide Hospital experience with multidimensional simulated views of the fibula-flap reconstructed mandible. The free fibular flap is a well recognised option for mandibular reconstruction. What is not well understood however is how the fibula behaves in comparison to the dentate mandible. To date, skeletal remodelling and bone atrophy has only been assessed using standard orthopantogram films. For many years three-dimensional (3D) computer generated models using data from CT scans have been utilised for craniofacial reconstruction. We proposed that these images will enable us to more accurately visualise the integration of the transplanted graft within the mandible. We recalled and CT scanned patients from 2004 to 2006 that underwent free fibular flaps for reconstruction of mandibular malignancy and performed 3D reconstruction of these images. This is the first reported series of multidimensional computer generated images to assess bone in the reconstructed mandible. [source]

Experimental study of a type 3 phosphodiesterase inhibitor on liver graft function

BRITISH JOURNAL OF SURGERY (NOW INCLUDES EUROPEAN JOURNAL OF SURGERY), Issue 1 2001
T. Ikegami
Background: The number of liver transplant recipients is increasing but donor organ shortages have become more severe. The effect of milrinone, a type 3 phosphodiesterase inhibitor (PDEI), on non-heart-beating donor grafts was evaluated using an orthotopic liver transplantation model in rats. Methods: Type 3 PDEI or normal saline (control group) was given intravenously to the donor animals for 60 min continuously (50 µg kg,1 min,1 ) before 60 min of warm ischaemia followed by cold preservation and subsequent transplantation. Survival, serum chemistry, bile output, histopathological findings and tissue cyclic 3,,5,-adenosine monophosphate (cAMP) concentrations were then compared. Results: Five of seven animals in the PDEI group were alive at 7 days, compared with only one of seven rats in the control group (P < 0·01). Serum levels of alanine aminotransferase 2 and 6 h after reperfusion, and hyaluronic acid levels 6 h after reperfusion, were significantly lower in the PDEI group than in the control group. Bile output from the transplanted graft was significantly greater in the PDEI group than in controls 2 h after reperfusion (P < 0·01). The mean necrotic area 6 h after reperfusion was also reduced in the PDEI-treated grafts (P < 0·01). cAMP levels in liver tissue at the end of both warm and cold ischaemia, and 2 and 6 h after reperfusion, were significantly higher in the PDEI group compared with those in the control group. Conclusion: Type 3 PDEI attenuated the graft injury caused by warm and cold ischaemia and subsequent reperfusion injury via an increase in intracellular cAMP levels. This treatment may be a novel pharmacological intervention for safe and efficient usage of liver grafts from non-heart-beating donors. © 2001 British Journal of Surgery Society Ltd [source]

Effect of voriconazole on a corneal abscess caused by fusarium

ACTA OPHTHALMOLOGICA, Issue 6 2004
Anna Polizzi
Abstract. Purpose:, To describe a case of corneal abscess caused by Fusarium solani that did not respond to common antifungal agents. Method:, Case report. Results:, Twenty days after accidental contact with vegetation, a 56-year-old man presented with a corneal abscess. Corneal ulceration developed and a perforating keratoplasty was performed. After a microbiological examination, the diagnosis of F. solani infection was made. Systemic and topical amphotericin B and fluconazole were prescribed, with no results. A new abscess formed on the transplanted graft and a wound leak developed. We administered topical and systemic voriconazole. No side-effects were observed. The choroidal detachment and the surgical transplant recovered completely in 20 days. A vascular leukoma developed at the site of the transplanted corneal abscess. Conclusion:, From a functional point of view, another corneal transplant will be necessary. Voriconazole was effective in treating a severe keratomycosis caused by F. solani that was resistant to other topical and systemic antifungal agents. [source]

Transplantation and microsurgical anastomosis of free omental grafts: Experimental animal model of a new operative technique in dogs

MICROSURGERY, Issue 5 2003
Jozsef Pap-Szekeres M.D.
Our objective was the elaboration of a new animal model for the free transplantation of an omental flap and the examination of its viability in dogs. The cooled omental flap from the abdomen was freely transplanted to the lateral cervical region, and its blood supply was established with microsurgical anastomoses. The technique was developed in 5 dogs, and short-term survival examinations were later carried out in 3 cases by means of this method. Postoperative viability was assessed by angiography, methylene blue testing, and histology. Of the 3 transplanted grafts, 2 still survived 1 week after the operation. For technical reasons, 1 flap thrombotized. For determination of the viability of the transplanted graft, histology proved best. Vital reactions, including granulation tissue and angiogenesis, were present on the histological slides. The short-term survival of an omental flap can be ensured with microsurgical transplantation in dogs. A cseplesz lebeny szabad átültetésére, valamint az átültetett lebenyek életképességének vizsgálata céljából új állatkísérletes modellt dolgoztunk ki. Módszerünket 5 állaton dolgoztuk ki, majd további 3, m,tött állatnál rövidtavu túlélési vizsgálatokat végeztünk. Hasüregb,l nyert, megfelel,en el,készített és h,tött cseplesz lebenyt szabadon ültettünk át a laterális nyaki régióra. Az átültetett lebeny érellátását mik-rosebészeti módszerrel létrehozott anasztomózisokkal biztosítottuk. Az átültetett lebenyek életképességét angiográfia, metilénkék-festés és szövettani módszerekkel vizsgáltuk. A 3 átültetett lebeny közül 2 életképesnek bizonyult 1 héttel a m,tét után, technikai ok miatt 1 lebeny trombotizált. Az életképesség igazolására a szövettani vizsgálat bizonyult a legjobbnak, melynek segítségével granulációs szövet és angiogenezis is ábrázolható volt. Cseplesz lebeny rövidtávú túlélése biztosítható mikrosebészeti módszerrel történ, átültetéssel kutyán. © 2003 Wiley-Liss, Inc. MICROSURGERY 23:414,418 2003 [source]