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Traditional System (traditional + system)
Selected AbstractsHeating and cooling energy recovery for an HVAC system: Economic analysis for the Italian climateINTERNATIONAL JOURNAL OF ENERGY RESEARCH, Issue 8 2001Adolfo Palombo Abstract In this paper the economic analysis of the energy recovery in all-outdoor-air HVAC systems for the Italian climate is performed. The energy recovery device considered here is the same for both heating and cooling periods. During the summer season, the energy saving is achieved by evaporative cooling. The performances of the hybrid innovative HVAC system and the traditional system are calculated hour by hour by following the test reference year (TRY) profile. Such analysis is carried out taking into account simultaneously, the trend of some climatic indexes computed in order to (i) better understand the influence of climate on the HVAC system behaviour, (ii) obtain a swift feasibility analysis of the energy recovery system and (iii) perform a rough operating cost estimate of the traditional HVAC system. Copyright © 2001 John Wiley & Sons, Ltd. [source] Antihyperlipidemic activity of 3-hydroxymethyl xylitol, a novel antidiabetic compound isolated from Casearia esculenta (Roxb.) root, in streptozotocin-diabetic ratsJOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, Issue 2 2010Govindasamy Chandramohan Abstract Casearia esculenta root (Roxb.) is widely used in traditional system of medicine to treat diabetes in India. An active compound, 3-hydroxymethyl xylitol (3-HMX), has been isolated, and its optimum dose has been determined in a short duration study and patented. In addition, the long-term effect of 3-HMX in type 2 diabetic rats on carbohydrate metabolism was investigated, and its antihyperglycemic effect was shown previously (Chandramohan et al., Eur J Pharmacol 2008;590:437,443). In this study we investigated the effect of 3-HMX on plasma and tissue lipid profiles in streptozotocin-induced diabetic rats. Diabetes was induced in adult male albino rats of the Wistar strain, weighing 180,200 g, by administration of streptozotocin (40 mg/kg of body weight) intraperitoneally. The normal and diabetic rats were treated with 3-HMX (40 mg/kg BW/day) for 45 days. The levels of total cholesterol, triglycerides, free fatty acids, and phospholipids were assayed in the plasma besides lipoprotein-cholesterol (high-density lipoprotein-cholesterol (HDL-C), low-density lipoprotein-cholesterol (LDL-C), and very low density lipoprotein-cholesterol (VLDL-C)) and tissues (liver, kidney, heart, and brain). Total cholesterol, triglyceride, free fatty acid, and phospholipid (LDL-C and VLDL-C in plasma only) levels increased in plasma and tissues significantly, whereas plasma HDL-C significantly decreased in diabetic rats. Treatment with 3-HMX or glibenclamide reversed the above-mentioned changes and improved toward normalcy. Histological study of liver also confirmed the biochemical findings. Thus administration of 3-HMX is able to reduce hyperglycemia and hyperlipidemia related to the risk of diabetes mellitus. © 2010 Wiley Periodicals, Inc. J Biochem Mol Toxicol 24:95,101, 2010; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/jbt.20317 [source] The economic potential of precision nitrogen application with wheat based on plant sensingAGRICULTURAL ECONOMICS, Issue 4 2009Jon T. Biermacher Nitrogen fertilizer; Precision agriculture; Stochastic plateau; Wheat Abstract Plant-based precision nitrogen fertilizer application technologies have been developed as a way to predict and precisely meet nitrogen needs. Equipment necessary for precision application of nitrogen, based on sensing of growing wheat plants in late winter, is available commercially, but adoption has been slow. This article determines the expected profit from using a plant-sensing system to determine winter wheat nitrogen requirements. We find that plant-sensing systems have the potential to be more profitable than traditional nonprecise systems, but the existing system simulated was roughly breakeven with a traditional system. [source] Mint oil (Mentha spicata Linn.) offers behavioral radioprotection: a radiation-induced conditioned taste aversion studyPHYTOTHERAPY RESEARCH, Issue 2 2009A. Haksar Abstract Mentha spicata Linn. (mint), a herb well known for its gastroprotective properties in the traditional system of medicine has been shown to protect against radiation-induced lethality, and recently its constituents have been found to possess calcium channel antagonizing properties. The present study examined the behavioral radioprotective efficacy of mint oil (obtained from Mentha spicata), particularly in mitigating radiation-induced conditioned taste aversion (CTA), which has been proposed as a behavioral endpoint that is mediated by the toxic effects of gamma radiation on peripheral systems, primarily the gastrointestinal system in the Sprague-Dawley rat model. Intraperitoneal administration of Mentha spicata oil 10% (v/v), 1 h before 2 Gy gamma radiation, was found to render significant radioprotection against CTA (p < 0.05), by blocking the saccharin avoidance response within 5 post-treatment observational days, with the highest saccharin intake being observed on day 5. This finding clearly demonstrates that gastroprotective and calcium channel antagonizing properties of Mentha spicata can be effectively utilized in preventing radiation-induced behavioral changes. Copyright © 2008 John Wiley & Sons, Ltd. [source] Identification and characterisation of traditional chestnut varieties of southern Spain using morphological and simple sequence repeat (SSRs) markersANNALS OF APPLIED BIOLOGY, Issue 3 2009M.A. Martin Abstract The maintenance of plant genetic resources requires the identification of places and agroforestry systems that support high levels of genetic diversity. The aim of this work was to clarify the number and names of chestnut (Castanea sativa) cultivars in the south of Spain. Accordingly, 100 grafted chestnut trees corresponding to 34 traditional names were evaluated using 10 qualitative morphological traits and seven simple sequence repeat (SSRs) markers. We identified 38 varieties, 12 in the Huelva region and 26 in Malaga, and synonymies and homonymies were discussed. This work demonstrated that the joint use of morphological traits and SSR markers is an efficient method to evaluate the agrobiodiversity of chestnut in this region. It was also stated that chestnut production in the south of Spain is a traditional system using varieties developed ,in situ'. This constitutes a genuine system of on-farm conservation, which is now threatened. Consequently, adopting strategies for its safeguarding are urgently recommended. [source] A simplified method for limit conversion calculation in membrane reactorsASIA-PACIFIC JOURNAL OF CHEMICAL ENGINEERING, Issue 1 2010Fausto Gallucci Abstract Membrane reactors (MRs) are often used to carry out equilibrium limited reactions. This is because the thermodynamic equilibrium is a strong constrain for traditional systems. Even with very active catalysts, traditional reactors (TRs) cannot give conversions higher than those allowed by the thermodynamic equilibrium. On the contrary, MRs are able to shift the equilibrium of a traditional system owing to the removal of at least one reaction product that takes place simultaneously to the reaction. In this work, a simplified method for the calculation of limit conversion in MR is discussed and compared with literature methods. The typical method for calculating equilibrium conversions in TR is also discussed. It has been demonstrated that the simplified method applied to two reaction systems gives fast predictions of the limit conversion for MR. Copyright © 2009 Curtin University of Technology and John Wiley & Sons, Ltd. [source] Maintenance of pluripotency in mouse embryonic stem cells cultivated in stirred microcarrier culturesBIOTECHNOLOGY PROGRESS, Issue 2 2010Paulo A. N. Marinho Abstract The development of efficient and reproducible culture systems for embryonic stem (ES) cells is an essential pre-requisite for regenerative medicine. Culture scale-up ensuring maintenance of cell pluripotency is a central issue, because large amounts of pluripotent cells must be generated to warrant that differentiated cells deriving thereof are transplanted in great amounts and survive the procedure. This study aimed to develop a robust scalable cell expansion system, using a murine embryonic stem cell line that is feeder-dependent and adapted to serum-free medium, thus representing a more realistic model for human ES cells. We showed that high concentrations of murine ES cells can be obtained in stirred microcarrier-based spinner cultures, with a 10-fold concentration of cells per volume of medium and a 5-fold greater cell concentration per surface area, as compared to static cultures. No differences in terms of pluripotency and differentiation capability were observed between cells grown in traditional static systems and cells that were replated onto the traditional system after being expanded on microcarriers in the stirred system. This was verified by morphological analyses, quantification of cells expressing important pluripotency markers (Oct-4, SSEA-1, and SOX2), karyotype profile, and the ability to form embryoid bodies with similar sizes, and maintaining their intrinsic ability to differentiate into all three germ layers. © 2009 American Institute of Chemical Engineers Biotechnol. Prog., 2010 [source] Independent foundations, public money and public accountability: Whither ministerial responsibility as democratic governance?CANADIAN PUBLIC ADMINISTRATION/ADMINISTRATION PUBLIQUE DU CANADA, Issue 1 2003Peter Aucoin The democratic control that is meant to obtain under the Constitution is not present in the design of these foundations. This article examines the ways in which their organizational design is contrary to the principles of responsible government as well as to the government's own policy on so-called alternative service-delivery structures. The article also discusses how the designers of these foundations relied primarily on results-based reporting instead of the traditional system of ministerial responsibility. The author concludes that these organizational designs are beyond the pale of the Constitution's requirements for democratic control over public administration and suggests measures that may correct these deficiences. Sommaire: Au cours de la demière décennie, le gouvernement fédéeral a mis sur pied un certain nombre de fondations indépendantes visant à consacrer des fonds publics aux affaires publiques. Ces fondations ne comportent pas dans leur conception le contrôle démocratique prévu par la Constitution. Le présent article examine comment leur conception organisationnelle va à l'encontre des principes de gouvemement responsable ainsi que la politique même du gouvernement sur ce qu'on appelle les modes altematifs de prestation de services. L'article examine également la manière dont les concepteurs de ces fondations se sont fiés essentiellement à la reddition de comptes axés sur les résultats plutôt qu'au système traditionnel de respon-sabilité ministérielle. L'auteur conclut que ces conceptions organisationnelles ne repondent pas aux exigences de la Constitution pour ce qui est du contrôle démocratique de l'administration publique et propose des mesures qui pourraient pallier à ces insuffisances. [source] Effect of the alcoholic extract of Ashwagandha leaves and its components on proliferation, migration, and differentiation of glioblastoma cells: Combinational approach for enhanced differentiationCANCER SCIENCE, Issue 9 2009Navjot Shah Ashwagandha (Withania somnifera) is widely used in the Indian traditional system of medicine, Ayurveda. Although it is claimed to have a large variety of health-promoting effects, including therapeutic effects on stress and disease, the mechanisms of action have not yet been determined. In the present study, we aimed to investigate the growth inhibition and differentiation potential of the alcoholic extract of Ashwagandha leaves (i-Extract), its different constituents (Withaferin A, Withanone, Withanolide A) and their combinations on glioma (C6 and YKG1) cell lines. Withaferin A, Withanone, Withanolide A and i-Extract markedly inhibited the proliferation of glioma cells in a dose-dependent manner and changed their morphology toward the astrocytic type. Molecular analysis revealed that the i-Extract and some of its components caused enhanced expression of glial fibrillary acidic protein, change in the immunostaining pattern of mortalin from perinuclear to pancytoplasmic, delay in cell migration, and increased expression of neuronal cell adhesion molecules. The data suggest that the i-Extract and its components have the potential to induce senescence-like growth arrest and differentiation in glioma cells. These assays led us to formulate a unique combination formula of i-Extract components that caused enhanced differentiation of glial cells. (Cancer Sci 2009; 100: 1740,1747) [source] Does MPA mean ,Major Problem for Assessments'?FISH AND FISHERIES, Issue 4 2006Considering the consequences of place-based management systems Abstract Marine protected areas (MPAs) have been increasingly proposed, evaluated and implemented as management tools for achieving both fisheries and conservation objectives in aquatic ecosystems. However, there is a challenge associated with the application of MPAs in marine resource management with respect to the consequences to traditional systems of monitoring and managing fisheries resources. The place-based paradigm of MPAs can complicate the population-based paradigm of most fisheries stock assessments. In this review, we identify the potential complications that could result from both existing and future MPAs to the science and management systems currently in place for meeting conventional fisheries management objectives. The intent is not to evaluate the effects of implementing MPAs on fisheries yields, or even to consider the extent to which MPAs may achieve conservation oriented objectives, but rather to evaluate the consequences of MPA implementation on the ability to monitor and assess fishery resources consistent with existing methods and legislative mandates. Although examples are drawn primarily from groundfish fisheries on the West Coast of the USA, the lessons are broadly applicable to management systems worldwide, particularly those in which there exists the institutional infrastructure for managing resources based on quantitative assessments of resource status and productivity. [source] Ageing and the changing role of the family and the community: An African perspectiveINTERNATIONAL SOCIAL SECURITY REVIEW, Issue 1 2002Nana Araba Apt Global ageing, the major social issue of the twenty-first century, will have greater social repercussions for developing countries. The fastest increase of older persons in terms of ratio in relation to younger people is happening in developing countries, and in Africa segregation of older people in rural areas will become manifest. While beneficial changes for women have accompanied modernization in many of the developing countries, the situation of older women appears to be particularly precarious. Social changes brought about by modernization are also profoundly affecting the traditional systems of care for older people. Even though most older people requiring care are still looked after within the informal structures of the family, this can no longer be taken for granted as we move into the new century. This paper critically reviews social protection systems and the resource constraints which characterize developing countries and warns against blind development of social security systems based on those of the industrialized countries. The paper argues for the design of intergenerational support back into mainstream social relations so that older persons are not marginalized and put at risk through social protection programmes which reinforce physical vulnerability stereotypes and stress welfare needs over and above older people's social and economic contributions to society [source] Characteristics of ERP software maintenance: a multiple case studyJOURNAL OF SOFTWARE MAINTENANCE AND EVOLUTION: RESEARCH AND PRACTICE, Issue 6 2001Fiona Fui-Hoon Nah Abstract A multiple case study approach was employed to identify maintenance activities pertaining to enterprise resource planning (ERP) implementation, classify them into maintenance categories, and assess their relative frequency at various stages of the ERP maintenance lifecycle. Five maintenance categories (corrective, adaptive, perfective, preventive, user support) were identified from a review of the literature on software maintenance. A new category pertaining to ,communication, coordination and knowledge exchange with external parties' and herein labeled ,external parties' is introduced to highlight the supporting role of external parties in ERP maintenance. This category includes reporting problems to vendors and consultants, tracking their progress towards problem resolution, and coordinating work and relations with vendors, consultants, and external user-organizations. This study also highlights some differences between maintenance trends of ERP versus traditional systems. Copyright © 2001 John Wiley & Sons, Ltd. [source] Pharmacokinetic interaction of single dose of piperine with steady-state carbamazepine in epilepsy patientsPHYTOTHERAPY RESEARCH, Issue 9 2009Smita Pattanaik Abstract Piperine, the active principle of piper species, is commonly used as a spice and adjuvant in various traditional systems of medicine. It has been known as a bioavailability-enhancer. The present study aimed at evaluating the effect of piperine on the steady-state pharmacokinetics of a single dose of carbamazepine in poorly controlled epilepsy patients on carbamazepine monotherapy. Patients (n = 10 each) receiving either 300 mg or 500 mg dose of carbamazepine twice daily were selected. After administration of carbamazepine, venous blood samples were collected at 0, 0.5, 1, 2, 4, 6, 9, 12 h. Subsequently, piperine (20 mg p.o.) was administered along with carbamazepine and samples were collected similarly. The pharmacokinetic parameters were compared by Students t -test. Piperine significantly increased the mean plasma concentrations of carbamazepine at most of the time points in both dose groups. There was a significant increase in AUC0-12hr (p < 0.001), average Css (p < 0.001), t1\2el (p < 0.05) and a decrease in Kel (p < 0.05), in both the dose groups, whereas changes in Ka and t1\2a were not significant. Cmax (p < 0.01) and tmax (p < 0.01) were increased significantly following piperine administration in the 500 mg dose group; however, these parameters were not significant in the lower dose group. Piperine could significantly enhance the oral bioavailability of carbamazepine, possibly by decreasing the elimination and/or by increasing its absorption. Copyright © 2009 John Wiley & Sons, Ltd. [source] A simplified method for limit conversion calculation in membrane reactorsASIA-PACIFIC JOURNAL OF CHEMICAL ENGINEERING, Issue 1 2010Fausto Gallucci Abstract Membrane reactors (MRs) are often used to carry out equilibrium limited reactions. This is because the thermodynamic equilibrium is a strong constrain for traditional systems. Even with very active catalysts, traditional reactors (TRs) cannot give conversions higher than those allowed by the thermodynamic equilibrium. On the contrary, MRs are able to shift the equilibrium of a traditional system owing to the removal of at least one reaction product that takes place simultaneously to the reaction. In this work, a simplified method for the calculation of limit conversion in MR is discussed and compared with literature methods. The typical method for calculating equilibrium conversions in TR is also discussed. It has been demonstrated that the simplified method applied to two reaction systems gives fast predictions of the limit conversion for MR. Copyright © 2009 Curtin University of Technology and John Wiley & Sons, Ltd. [source] A predictive high-throughput scale-down model of monoclonal antibody production in CHO cellsBIOTECHNOLOGY & BIOENGINEERING, Issue 6 2009Rachel Legmann Abstract Multi-factorial experimentation is essential in understanding the link between mammalian cell culture conditions and the glycoprotein product of any biomanufacturing process. This understanding is increasingly demanded as bioprocess development is influenced by the Quality by Design paradigm. We have developed a system that allows hundreds of micro-bioreactors to be run in parallel under controlled conditions, enabling factorial experiments of much larger scope than is possible with traditional systems. A high-throughput analytics workflow was also developed using commercially available instruments to obtain product quality information for each cell culture condition. The micro-bioreactor system was tested by executing a factorial experiment varying four process parameters: pH, dissolved oxygen, feed supplement rate, and reduced glutathione level. A total of 180 micro-bioreactors were run for 2 weeks during this DOE experiment to assess this scaled down micro-bioreactor system as a high-throughput tool for process development. Online measurements of pH, dissolved oxygen, and optical density were complemented by offline measurements of glucose, viability, titer, and product quality. Model accuracy was assessed by regressing the micro-bioreactor results with those obtained in conventional 3,L bioreactors. Excellent agreement was observed between the micro-bioreactor and the bench-top bioreactor. The micro-bioreactor results were further analyzed to link parameter manipulations to process outcomes via leverage plots, and to examine the interactions between process parameters. The results show that feed supplement rate has a significant effect (P,<,0.05) on all performance metrics with higher feed rates resulting in greater cell mass and product titer. Culture pH impacted terminal integrated viable cell concentration, titer and intact immunoglobulin G titer, with better results obtained at the lower pH set point. The results demonstrate that a micro-scale system can be an excellent model of larger scale systems, while providing data sets broader and deeper than are available by traditional methods. Biotechnol. Bioeng. 2009; 104: 1107,1120. © 2009 Wiley Periodicals, Inc. [source] | |||||||||||||||||||