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Together
Kinds of Together Selected AbstractsHeart Failure in Hispanic Patients: Coming Together?CONGESTIVE HEART FAILURE, Issue 4 2010Hector O. Ventura MD No abstract is available for this article. [source] February 15, or What Binds Europeans Together: A Plea for a Common Foreign Policy, Beginning in the Core of EuropeCONSTELLATIONS: AN INTERNATIONAL JOURNAL OF CRITICAL AND DEMOCRATIC THEORY, Issue 3 2003Jürgen Habermas First page of article [source] Opposite effects of overexpressed myosin Va or heavy meromyosin Va on vesicle distribution, cytoskeleton organization, and cell motility in nonmuscle cellsCYTOSKELETON, Issue 3 2008Robbin D. Eppinga Abstract Myosin Va, an actin-based motor protein that transports intracellular cargos, can bundle actin in vitro. Whether myosin Va regulates cellular actin dynamics or cell migration remains unclear. To address this, we compared Chinese Hamster Ovary (CHO) cells that stably express GFP fused to either full length mouse myosin Va (GFP-M5) or heavy meromyosin Va (GFP-M5,). GFP-M5 and GFP-M5, co-immunoprecipitate with CHO myosin Va and serve as overexpression of wild-type and dominant negative mutants of myosin Va. Compared to non-expressing control cells, GFP-M5-overexpressing cells have peripheral endocytic vesicles, spread slowly after plating, as well as produce robust interior actin stress fibers, myosin II bundles, and focal adhesions. However, these cells display normal cell migration and lamellipodial dynamics. In contrast, GFP-M5,-expressing cells have perinuclear endocytic vesicles, produce thin interior actin and myosin bundles and contain no interior focal adhesions. In addition, these cells spread rapidly, migrate slowly and display reduced lamellipodial dynamics. Similarly, neurite outgrowth is compromised in neurons cultured from transgenic Drosophila that express M5,-dsRed and in neurons cultured from Drosophila that produce a tailless version of endogenous myosin V. Together, these data suggest that myosin Va overexpression induces actin bundles in vivo whereas the tailless version fails to bundle actin and disrupts cell motility. Cell Motil. Cytoskeleton 2008. © 2007 Wiley-Liss, Inc. [source] Bowling Alone but Working and Worshiping TogetherDIALOG, Issue 4 2008Carol Schersten LaHurd Abstract:, The following article reviews both the strengths and weaknesses of the ELCA on the anniversary of 20 years of existence. The article emphasizes the increased diversity in the denomination, particularly the increased participation of women both in scholarship and leadership in the church. It also lifts up the importance of the strong ecumenical work that continues to take place, both nationally and internationally, which is evidenced in the ELCA's full communion agreements. Commitments to social justice, global connectedness and economic stewardship are also discussed. [source] Growing Together, Growing ApartDIALOG, Issue 2 2005By Mark S. Hanson Abstract:, How does diversity define the limits of the Body of Christ in the context of its fundamental unity? For Lutherans the visible unity of the church is grounded in those signs and constitutive elements which convey salvation. Unified on the basis of a common baptism, a common communion, and a common mission, the church of the gospel must be defined more by being than by doing. The church doing God's redemptive work in creation will always experience tension, but we must be mindful that wholeness is not equivalent to sameness. [source] Elevated dominance of extrafloral nectary-bearing plants is associated with increased abundances of an invasive ant and reduced native ant richnessDIVERSITY AND DISTRIBUTIONS, Issue 5 2009Amy M. Savage Abstract Aim, Invasive ants can have substantial and detrimental effects on co-occurring community members, especially other ants. However, the ecological factors that promote both their population growth and their negative influences remain elusive. Opportunistic associations between invasive ants and extrafloral nectary (EFN)-bearing plants are common and may fuel population expansion and subsequent impacts of invasive ants on native communities. We examined three predictions of this hypothesis, compared ant assemblages between invaded and uninvaded sites and assessed the extent of this species in Samoa. Location, The Samoan Archipelago (six islands and 35 sites). Methods, We surveyed abundances of the invasive ant Anoplolepis gracilipes, other ant species and EFN-bearing plants. Results,Anoplolepis gracilipes was significantly more widely distributed in 2006 than in 1962, suggesting that the invasion of A. gracilipes in Samoa has progressed. Furthermore, (non- A. gracilipes) ant assemblages differed significantly between invaded and uninvaded sites. Anoplolepis gracilipes workers were found more frequently at nectaries than other plant parts, suggesting that nectar resources were important to this species. There was a strong, positive relationship between the dominance of EFN-bearing plants in the community and A. gracilipes abundance on plants, a relationship that co-occurring ants did not display. High abundances of A. gracilipes at sites dominated by EFN-bearing plants were associated with low species richness of native plant-visiting ant species. Anoplolepis gracilipes did not display any significant relationships with the diversity of other non-native ants. Main conclusions, Together, these data suggest that EFN-bearing plants may promote negative impacts of A. gracilipes on co-occurring ants across broad spatial scales. This study underscores the potential importance of positive interactions in the dynamics of species invasions. Furthermore, they suggest that conservation managers may benefit from explicit considerations of potential positive interactions in predicting the identities of problematic invaders or the outcomes of species invasions. [source] Mate Choice for Genetic Benefits: Time to Put the Pieces TogetherETHOLOGY, Issue 1 2010Attila Hettyey It is thought that mate choice allows individuals to obtain genetic benefits for their offspring, and although many studies have found some support for this hypothesis, several critical questions remain unresolved. One main problem is that empirical studies on mate choice and genetic benefits have been rather piecemeal. Some studies (1) aimed to test how mate choice affects offspring fitness, but have not examined whether the benefits are because of genetic effects. Other studies tested whether mate choice provides (2) additive or (3) non-additive genetic benefits and only a few studies (4) considered these genetic effects together. Finally, some studies (5) examined whether the potential benefits that might be gained from mate choice are due to additive genetic effects vs. non-additive effects, and although they found evidence for both, they did not examine whether mate choice is relevant. Furthermore, previous studies have usually not controlled for non-genetic sources of variation in offspring fitness. Thus, there remain gaping holes in our understanding, and it is the connections among the research approaches that now need more attention. We suggest that studies are needed that measure non-genetic effects, the potential benefits from both additive and non-additive genetic effects, and also determine whether mate choice exploits these potential benefits. Such integrative studies are necessary to put the pieces together and clarify the role of genetic benefits in the evolution of mate choice. [source] All Bound up Together: The Woman Question in African American Public Culture, 1830,1900 by Martha S. JonesGENDER & HISTORY, Issue 1 2009JOHN A. KIRK No abstract is available for this article. [source] Plant and microbial N acquisition under elevated atmospheric CO2 in two mesocosm experiments with annual grassesGLOBAL CHANGE BIOLOGY, Issue 2 2005Shuijin Hu Abstract The impact of elevated CO2 on terrestrial ecosystem C balance, both in sign or magnitude, is not clear because the resulting alterations in C input, plant nutrient demand and water use efficiency often have contrasting impacts on microbial decomposition processes. One major source of uncertainty stems from the impact of elevated CO2 on N availability to plants and microbes. We examined the effects of atmospheric CO2 enrichment (ambient+370 ,mol mol,1) on plant and microbial N acquisition in two different mesocosm experiments, using model plant species of annual grasses of Avena barbata and A. fatua, respectively. The A. barbata experiment was conducted in a N-poor sandy loam and the A. fatua experiment was on a N-rich clayey loam. Plant,microbial N partitioning was examined through determining the distribution of a 15N tracer. In the A. barbata experiment, 15N tracer was introduced to a field labeling experiment in the previous year so that 15N predominantly existed in nonextractable soil pools. In the A. fatua experiment, 15N was introduced in a mineral solution [(15NH4)2SO4 solution] during the growing season of A. fatua. Results of both N budget and 15N tracer analyses indicated that elevated CO2 increased plant N acquisition from the soil. In the A. barbata experiment, elevated CO2 increased plant biomass N by ca. 10% but there was no corresponding decrease in soil extractable N, suggesting that plants might have obtained N from the nonextractable organic N pool because of enhanced microbial activity. In the A. fatua experiment, however, the CO2 -led increase in plant biomass N was statistically equal to the reduction in soil extractable N. Although atmospheric CO2 enrichment enhanced microbial biomass C under A. barbata or microbial activity (respiration) under A. fatua, it had no significant effect on microbial biomass N in either experiment. Elevated CO2 increased the colonization of A. fatua roots by arbuscular mycorrhizal fungi, which coincided with the enhancement of plant competitiveness for soluble soil N. Together, these results suggest that elevated CO2 may tighten N cycling through facilitating plant N acquisition. However, it is unknown to what degree results from these short-term microcosm experiments can be extrapolated to field conditions. Long-term studies in less-disturbed soils are needed to determine whether CO2 -enhancement of plant N acquisition can significantly relieve N limitation over plant growth in an elevated CO2 environment. [source] Working Together or Pulling Apart?HEALTH & SOCIAL CARE IN THE COMMUNITY, Issue 6 2002Child Protection Networks, The National Health Service No abstract is available for this article. [source] Preserving and Strengthening Together: Collective Strategies of U.S. Women's College PresidentsHISTORY OF EDUCATION QUARTERLY, Issue 4 2008Auden D. Thomas First page of article [source] Investigating the role of heparin sulfate proteoglycans in hereditary multiple exostoses (HME) tumourigenesisINTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, Issue 4 2004Z.M. Scholefield Introduction Heparin sulfate (HS) has long been implicated in the bone deformity hereditary multiple exostoses (HME), and it is now clear that HME is associated with mutations in the HS biosynthetic genes EXT1 and EXT2. Interestingly, HME is also associated with an increased risk of chondro- and osteo-sarcomas. Methods and results Preliminary analysis of GAG samples purified from fibroblasts of both HME and isolated non-HME exostoses patients reveal a dramatic shift in the ratio of CS : HS, with the HME and isolated cases having a much higher proportion of CS relative to normal controls. This is true in the case of both shed and cell surface material but is far more extreme in the latter, with the HS reducing from approximately 45% in the controls to less than 10% in HME patients. Initial analysis also reveals shortened chain length within these samples; indeed they often have two populations of chains present. Simple analysis of the total disaccharide composition of these samples demonstrates no significant differences against controls. However, detailed analysis of the subpopulations of chains (as determined by chain length) within these samples as well as cartilaginous samples from exostoses patients may provide further insight into the changes that occur within the biosynthetic pathway following disrupted EXT function. We are also carrying out immunocytochemistry with a variety of HS-specific antibodies with the aim to further investigate normal HS structure and localization. This is being carried out on human primary chondrocytes isolated from normal patients and also adult mesenchymal stem cells as they undergo differentiation into chondrocytes. HS has been identified in both these cell types, and it is hoped that the manipulation of these cells through RNAi of different enzymes of the HS biosynthetic pathway will provide a suitable model for studying what changes may occur in cellular HS structures over the initial differentiation process in the growth plate. Discussion Together, these investigations should provide a good model to allow us to determine the role of HS in chondrocyte differentiation and maturation in both normal and diseased states. [source] Theology, Rhetoric, Manduction, or Reading Scripture Together on the Path to God , By Peter M. Candler JrINTERNATIONAL JOURNAL OF SYSTEMATIC THEOLOGY, Issue 1 2008Mike Higton First page of article [source] Serving God's Mission Together in Christ's Way: Reflections on the Way to Edinburgh 2010INTERNATIONAL REVIEW OF MISSION, Issue 1 2010Jacques Matthey This paper argues that missio Dei theology must continue to provide the basis for an ecumenical missiology, provided certain problems are revisited, in line with themes of the 2010 Edinburgh study process. Among them is the need for emphasizing the vertical dimension of a transformative spirituality, somehow neglected in earlier ecumenical theologies. Only this will prevent an over-estimation of humanity's capacities. Within a missio Dei theology the specific role of the church is to be reaffirmed: there is no way back behind integration, which remains a cornerstone of an ecumenical approach, provided it keeps a critical distance to dogmatic ecclesiologies that tend to hinder progress towards visible unity. The debate on gospel and culture has to be urgently taken up again, through a positive appreciation of syncretism and the related search for criteria in intercultural hermeneutics. This will lead to articulating pneumatological approaches to mission with Christologies. Indeed, the New Testament texts with the most universal horizon refer to Christ as Word or Wisdom and not to the Holy Spirit. The paper moves on to ask whether then the relevance of the biblical wisdom tradition should not feature more in missiology. It could provide fertile approaches to witness in a religiously plural and ecologically damaged world. Ecumenical mission should in future be shaped by wisdom as much as it has been by prophecy, and keep both traditions in creative tension. [source] MEK/ERK Signaling Controls Osmoregulation of Nucleus Pulposus Cells of the Intervertebral Disc by Transactivation of TonEBP/OREBP,JOURNAL OF BONE AND MINERAL RESEARCH, Issue 7 2007Tsung-Ting Tsai Abstract Earlier studies have shown that intervertebral disc cells express TonEBP, a transcription factor that permits adaptation to osmotic stress and regulates aggrecan gene expression. However, the mechanism of hyperosmotic activation of TonEBP in disc cells is not known. Results of this study show that hypertonic activation of ERK signaling regulates transactivation activity of TonEBP, modulating its function. Introduction: In an earlier report, we showed that tonicity enhancer binding protein (TonEBP) positively regulates aggrecan gene expression in disc cells, thereby autoregulating its osmotic environment. Although these studies indicated that the cells of the nucleus pulposus were optimally adapted to a hyperosmotic state, the mechanism by which the cells transduce the osmotic stress was not delineated. The primary goal of this study was to test the hypothesis that, in a hyperosmotic medium, the extracellular signal-regulated kinase (ERK) signaling pathway regulated TonEBP activity. Materials and Methods: Nucleus pulposus cells were maintained in isotonic or hypertonic media, and MAPK activation and TonEBP expression were analyzed. To study the role of MAPK in regulation of TonEBP function, gel shift and luciferase reporter assays were performed. ERK expression in cells was modulated by using expression plasmids or siRNA, and transactivation domain (TAD)-TonEBP activity was studied. Results: We found that hypertonicity resulted in phosphorylation and activation of ERK1/2 proteins and concomitant activation of C terminus TAD activity of ELK-1, a downstream transcription factor. In hypertonic media, treatment with ERK and p38 inhibitors resulted in downregulation of TonE promoter activity of TauT and HSP-70 and decreased binding of TonEBP to TonE motif. Similarly, forced expression of DN-ERK and DN-p38 in nucleus pulposus cells suppressed TauT and HSP-70 reporter gene activity. Finally, we noted that ERK was needed for transactivation of TonEBP. Expression of DN-ERK significantly suppressed, whereas, WT-ERK and CA-MEK1 enhanced, TAD activity of TonEBP. Experiments performed with HeLa cells indicated that the ERK signaling pathway also served a major role in regulating the osmotic response in nondiscal cells. Conclusions: Together, these studies showed that adaptation of the nucleus pulposus cells to their hyperosmotic milieu is dependent on activation of the ERK and p38- MAPK pathways acting through TonEBP and its target genes. [source] drr-2 encodes an eIF4H that acts downstream of TOR in diet-restriction-induced longevity of C. elegansAGING CELL, Issue 4 2010Tsui-Ting Ching Summary Dietary restriction (DR) results in a robust increase in lifespan while maintaining the physiology of much younger animals in a wide range of species. Here, we examine the role of drr-2, a DR-responsive gene recently identified, in determining the longevity of Caenorhabditis elegans. Inhibition of drr-2 has been shown to increase longevity. However, the molecular mechanisms by which drr-2 influences longevity remain unknown. We report here that drr-2 encodes an ortholog of human eukaryotic translation initiation factor 4H (eIF4H), whose function is to mediate the initiation step of mRNA translation. The molecular function of DRR-2 is validated by the association of DRR-2 with polysomes and by the decreased rate of protein synthesis observed in drr-2 knockdown animals. Previous studies have also suggested that DR might trigger a regulated reduction in drr-2 expression to initiate its longevity response. By examining the effect of increasing drr-2 expression on DR animals, we find that drr-2 is essential for a large portion of the longevity response to DR. The nutrient-sensing target of rapamycin (TOR) pathway has been shown to mediate the longevity effects of DR in C. elegans. Results from our genetic analyses suggest that eIF4H/DRR-2 functions downstream of TOR, but in parallel to the S6K/PHA-4 pathway to mediate the lifespan effects of DR. Together, our findings reveal an important role for eIF4H/drr-2 in the TOR-mediated longevity responses to DR. [source] The Couple That Prays Together: Race and Ethnicity, Religion, and Relationship Quality Among Working-Age AdultsJOURNAL OF MARRIAGE AND FAMILY, Issue 4 2010Christopher G. Ellison A substantial body of research has shown that relationship quality tends to be (a) lower among racial and ethnic minorities and (b) higher among more religious persons and among couples in which partners share common religious affiliations, practices, and beliefs. However, few studies have examined the interplay of race or ethnicity and religion in shaping relationship quality. Our study addresses this gap in the literature using data from the National Survey of Religion and Family Life (NSRFL), a 2006 telephone survey of 2,400 working-age adults (ages 18,59), which contains oversamples of African Americans and Latinos. Results underscore the complex nature of the effects of race and ethnicity, as well as religious variables. In particular, we found that couples' in-home family devotional activities and shared religious beliefs are positively linked with reports of relationship quality. [source] Distinct patterns of evolution between respiratory syncytial virus subgroups A and B From New Zealand isolates collected over thirty-seven years,JOURNAL OF MEDICAL VIROLOGY, Issue 10 2006James W. Matheson Abstract Respiratory syncytial virus (RSV) is the most important cause of viral lower respiratory tract infections in infants and children worldwide. In New Zealand, infants with RSV disease are hospitalized at a higher rate than other industrialized countries, without a proportionate increase in known risk factors. The molecular epidemiology of RSV in New Zealand has never been described. Therefore, we analyzed viral attachment glycoprotein (G) gene sequences from 106 RSV subgroup A isolates collected in New Zealand between 1967 and 2003, and 38 subgroup B viruses collected between 1984 and 2004. Subgroup A and B sequences were aligned separately, and compared to sequences of viruses isolated from other countries during a similar period. Genotyping and clustering analyses showed RSV in New Zealand is similar and temporally related to viruses found in other countries. By quantifying temporal clustering, we found subgroup B viruses clustered more strongly than subgroup A viruses. RSV B sequences displayed more variability in stop codon usage and predicted protein length, and had a higher degree of predicted O-glycosylation site changes than RSV A. The mutation rate calculated for the RSV B G gene was significantly higher than for RSV A. Together, these data reveal that RSV subgroups exhibit different patterns of evolution, with subgroup B viruses evolving faster than A. J. Med. Virol. 78:1354,1364, 2006. © 2006 Wiley-Liss, Inc. [source] Staffing in acute hospital wards: part 1.JOURNAL OF NURSING MANAGEMENT, Issue 5 2003The relationship between number of nurses, ward organizational environment This paper is one of two that explores relationships between nursing staff resources, ward organizational practice and nurses' perceptions of ward environments. Here we examine relationships between staff numbers, care organization and nursing practice. A subsequent paper examines the effects of grade mix and staff stability. The data were collected in the mid-1990s from a nationally representative sample of 100 acute hospital wards and 825 nurses. Our analyses provide important insights for managers seeking to achieve the strategic aims set out in Working Together, and subsequent National Health Service (NHS) policy placing emphasis on making the best use of nurses, focussing on mobilising their knowledge, skills and talents within the context of extended work roles. Findings show that number of nurses is associated not only with ward organizational systems but also with a range of care processes and staff outcomes which hitherto have been linked only to ward organizational systems. The latter have been identified as providing different opportunities for developing multidisciplinary working and nurses' autonomy but the central importance of having an adequate number of staff to achieve these aims has been largely overlooked in research. Having fewer nurses was associated with both hierarchical ward organizational structures and hierarchical attitudes to care provision, denoting lower standards of nursing practice. A larger nursing complement was significantly associated with devolved organizational structures but no link was established between more staff and higher standards of nursing practice. When there were more staff there was a positive association with nurses' perceptions of multidisciplinary collaboration, their ability to cope with workload and job satisfaction. Employing an adequate number of nurses to provide care is clearly beneficial for nurses themselves. Patients are also likely to benefit from a lower incidence of ,hierarchical practice' associated with having a low nurse/bed ratio within a ward. [source] Knowledge and Social Capital: Foundations and Applications by Eric L. Lesser and Getting Agencies to Work Together: The Practice and Theory of Managerial Craftsmanship by Eugene BardachJOURNAL OF POLICY ANALYSIS AND MANAGEMENT, Issue 3 2002Steve Kelmen [source] Common genetic variants associated with plasma fibrin D-dimer concentration in older European- and African-American adultsJOURNAL OF THROMBOSIS AND HAEMOSTASIS, Issue 4 2008L. A. LANGE Summary.,Background and Objectives:,D-dimer is a hemostasis marker that reflects ongoing fibrin formation and degradation. There is significant inter-individual and inter-population variability in D-dimer concentration, but whether genetic factors underlie these differences is largely unknown. We hypothesized that common coagulation gene variants contribute to differences in circulating D-dimer concentration. Methods:,The setting was European-American (EA; n = 1858) and African-American (AA; n = 327) unrelated older adults from the Cardiovascular Health Study (CHS), in which we genotyped SNPs in 42 genes related to blood coagulation and fibrinolysis. Results:,Several fibrinogen gene polymorphisms, including the Thr312Ala A, chain variant and the FGG-10034 C/T variant, were associated with ,20% higher plasma D-dimer levels in EA (false discovery rate < 5% for covariate-adjusted model). There was also some evidence that a Pro41Leu variant of the PLAU gene encoding urinary plasminogen activator and non-coding polymorphism of the plasminogen activator inhibitor type 1 gene (SERPINE1) were associated with higher plasma D-dimer in EA. There were no significant associations between the studied coagulation or fibrinolysis gene SNPs and plasma D-dimer levels in the smaller AA sample. However, each standard deviation increase in European ancestry assessed by ancestry-informative gene markers was associated with ,10% lower mean D-dimer levels in AA. Conclusions:,Together, common coagulation/fibrinolysis gene SNPs explained only ,2% of the variance in plasma D-dimer levels in EA. These findings suggest that the association of D-dimer with risk of vascular outcomes may be mediated largely by environmental factors, other genes, and/or genetic interactions. [source] Inhibition of Canonical Wnt Signaling Increases Microvascular Hemorrhaging and Venular Remodeling in Adult RatsMICROCIRCULATION, Issue 5 2010JASON T. GLAW Microcirculation (2010) 17, 348,357. doi: 10.1111/j.1549-8719.2010.00036.x Abstract Objective:, The canonical Wnt signaling pathway, heavily studied in development and cancer, has recently been implicated in microvascular growth with the use of developmental and in vitro models. To date, however, no study exists showing the effects of perturbing the canonical Wnt pathway in a complete microvascular network undergoing physiological remodeling in vivo. Our objective was to investigate the effects of canonical Wnt inhibition on the microvascular remodeling of adult rats. Methods:, Canonical Wnt inhibitor DKK-1, Wnt inhibitor sFRP-1, BSA or saline was superfused onto the exteriorized mesenteric windows of 300 g adult female Sprague-Dawley rats for 20 minutes. Three days following surgery, mesenteric windows were imaged intravitally and harvested for immunofluorescence staining with smooth muscle alpha-actin and BRDU. Results:, We observed prominent differences in the response of the mesenteric microvasculature amongst the various treatment groups. Significant increases in hemorrhage area, vascular density, and draining vessel diameter were observed in windows treated with Wnt inhibitors as compared to control-treated windows. Additionally, confocal imaging analysis showed significant increases in proliferating cells as well as evidence of proliferating smooth muscle cells along venules. Conclusions:, Together, our results suggest that canonical Wnt inhibition plays an important role in microvascular remodeling, specifically venular remodeling. [source] How Can the Educational Community Come Together on Language Issues?Notes From the Discussion GroupMODERN LANGUAGE JOURNAL, Issue 4 2008ROSEMARY G. FEAL No abstract is available for this article. [source] Bound Together: The Future of GlobalizationNEW PERSPECTIVES QUARTERLY, Issue 2 2008NAYAN CHANDA Globalization has indeed flattened the earth, paving the way for new beginnings and the resurgence of old cultures alike by levelling the playing field for all comers. While this new era of post-globalization certainly heralds de-Westernization by century's end, is it more likely to mean a revival of the old ways of the East or the new hybrid ways of the first global civilization? Some of Asia's most provocative voices, as well as the world's most renowned cellist and cross-pollinating musician, offer their views. [source] Sexuality and Alzheimer's Disease: Can the Two Go Together?NURSING FORUM, Issue 4 2006Nili Tabak RN The issue of sexual relations in nursing homes between patients with Alzheimer-related dementia is in ward practice largely characterized by confusion and ignorance. Staff are seriously conflicted on how to respond and almost totally untrained on the subject. Patients are being mistreated and humiliated. Central to this state of affairs is insufficient awareness of the ethical and human rights elements in nursing care. Two case studies illustrate the practical dilemmas nurses must solve. A decision-making process is set out to reach an ethical and practical conclusion. Recommendations for action by nurses, the nursing profession, nursing home owners, and policy-makers are given. [source] FGF signaling in mandibular skeletogenesisORTHODONTICS & CRANIOFACIAL RESEARCH, Issue 2 2007M Mina Structured Abstract Authors,,, Mina M, Havens B Objective,,, To examine the functions of FGF/FGFR signaling during mandibular skeletogenesis in ovo. Design,,, We examined the effects of inhibition of FGF signaling during mandibular skeletogenesis by overexpressing replication-competent RCAS virus encoding a truncated form of FGFR3 in the chicken mandibular process between stages 17 and 26. Results,,, Injection of RCAS-dnFGFR3 into the developing mandible resulted in abnormalities in a stage- and region-dependent manner. Injection at early stages of development resulted in the truncation of Meckel's cartilage, severely reduced outgrowth of the mandibular process and absence of five of the mandibular bones. Injection at later stages did not affect the outgrowth of the mandibular process and Meckel's cartilage but resulted in abnormalities in mandibular osteogenesis in a region-specific manner. The bones in the more caudal region were frequently truncated whereas bones in the more rostral regions such as dentary and splenial bones were frequently absent. Conclusion,,, Together these experiments have revealed essential roles for FGF/FGFR signaling in the elongation of Meckel's cartilage, development of osteogenic condensations and appositional growth of mandibular bones. [source] Considering the Risks of Benzodiazepines and Opioids TogetherPAIN MEDICINE, Issue 6 2010Lynn R. Webster MD No abstract is available for this article. [source] Palliative Care and Pain Medicine Come Together to Optimally Treat Cancer Pain: What We Can Learn from the British Pain SocietyPAIN MEDICINE, Issue 5 2010Allen W. Burton MD No abstract is available for this article. [source] Primary Care and Health Services Section: An Opportunity for Pain Medicine and Primary Care to Come TogetherPAIN MEDICINE, Issue 5 2008Matthew J. Bair MD No abstract is available for this article. [source] Sense of coherence as a protective factor for demoralisation in women with a recent diagnosis of gynaecological cancerPSYCHO-ONCOLOGY, Issue 3 2007Nadia Boscaglia Abstract Background: Demoralisation is a dysphoric mood state commonly seen in the medically ill. Its core features comprise hopelessness, helplessness, loss of purpose and meaning, despair, and existential distress. Sense of Coherence (SOC) is a quantifiable dispositional orientation that captures the character traits likely to protect against demoralisation. In this study, we hypothesised on theoretical grounds that a strong SOC would be associated with lower levels of demoralisation in the context of gynaecological cancer (GC). Method: One hundred and twenty women with a recent (<12 months) diagnosis of GC were recruited from outpatient clinics. Participants were interviewed and completed questionnaire measures of demoralisation and SOC. A multiple regression analysis was performed using the five subscales of the Demoralisation Scale as predictor variables and SOC as the dependent variable. Results: Together, the five subscales of the Demoralisation Scale accounted for 60% of the variance in SOC. Conclusions: The results supported the hypothesis, suggesting that SOC may be protective against demoralisation in the context of serious illness. Larger, multivariate studies that examine additional variables (such as coping) would be required to further clarify the relationship between SOC and demoralisation. In the meantime, clinicians may want to consider efforts to enhance SOC in patients. Copyright © 2006 John Wiley & Sons, Ltd. [source] | ||||||||||||||||||||||||||||||||||