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Kinds of Toe Terms modified by Toe Selected AbstractsOcclusion of the right subclavian artery after insertion of a transoesophageal echocardiography probe in a neonatePEDIATRIC ANESTHESIA, Issue 7 2003Herbert Koinig MD Summary We present a case of occlusion of the right arm's blood supply in a neonate with a lusorian artery, a rare anomaly of the right subclavian artery, after insertion of a transoesophageal echocardiography (TOE) probe and discuss the impact of a lusorian artery on intraoperative TOE monitoring. [source] Mitochondrial Cytochrome b mRNA Editing in Dinoflagellates: Possible Ecological and Evolutionary Associations?THE JOURNAL OF EUKARYOTIC MICROBIOLOGY, Issue 6 2005HUAN ZHANG Abstract. To verify the hypothesis that mt mRNA editing is widespread in dinoflagellates, we analyzed cytochrome b (cob) mRNA editing for six species representing distinct ecotypes and taxonomic classes of Dinophyceae. Editing is detected in all, which is similar to the three other species studied previously in that edited sites appear to aggregate in four clusters and occur predominantly at first and second positions of codons (93%), overwhelmingly involving A,G, U,C, or C,U substitutions with a smaller number of G,C, G,A changes. Comparative analyses on editing characteristics reveal interesting trends related to phylogenetic relatedness and ecological features. Editing density (percentage of nucleotide that is affected by editing) increases from early to derived lineages. Higher editing densities also map to red tide-forming lineages. Furthermore, similarity of location of edited codons (LOE) and the type of nucleotide changes (TOE) in different lineages mirror the taxonomic affinity of the lineages. Phylogenetic trees constructed from LOE and TOE resemble those inferred from cob sequences. The results bolster our earlier hypothesis that cob editing is widespread in dinoflagellates and suggest that density, location, and type of editing may bear yet-to-be-defined evolutionary and ecological significance. [source] Percutaneous closure of patent foramen ovale with a bioabsorbable occluder device,CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS, Issue 4 2009Single-Centre Experience Abstract Background: Percutaneous closure of patent foramen ovale (PFO) is routinely performed with nonbiological devices, characterized by a persistent low-grade inflammatory response. We report our experience about PFO closure with a bioabsorbable device, BioSTAR® (NMT Inc, USA). Methods: From September 2007 to September 2008, 14 patients with migraine (eight with aura) and cerebral magnetic resonance positive for silent ischemia and nine patients with prior cardiovascular accident (CVA) underwent closure of PFO using BioSTAR®. One patient had heterozygosis for sickle-cell-anaemia. Nickel allergy was present in eight patients. Echocardiogram was performed at 24 hr, one and 6 months. At 6 and 12 months a contrast-transcranial-doppler (c-TCD) and a trans-oesophageal echocardiogram (TOE) were scheduled, respectively. Results: BioSTAR® was successfully implanted in 22 patients (96%). The mean procedural time and the mean fluoroscopy time were 22 ± 6 and 4 ± 2 minutes, respectively. The mean in-hospital stay was 3 ± 0.5 days. After a mean follow-up of 7.8 ± 3.5 months there was an hemorrhagic stroke related to double antiaggregation. No other CVA or allergic reactions were registered. There were two cases of atrial arrhythmia. Fifteen patients had not residual shunts at c-TCD, while in four patients we observed a trivial microbubbles passage. The TOE, achieved in nine patients without contrast, showed the device well positioned, with a low profile and without thrombus. Conclusions: In our experience PFO closure with BioSTAR® is safe and efficacious in preventing recurrent CVA. Its use could be advantageous in patients with nickel allergy and haematological disorders. The potential benefits of this device need to be certified in a larger cohort of patients with a longer follow-up. © 2009 Wiley-Liss, Inc. [source] Percutaneous closure of left atrial appendage to prevent embolic events in high-risk patients with chronic atrial fibrillation,CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS, Issue 2 2009FSCAI, Gian Paolo Ussia MD Abstract Background: Percutaneous closure of the left atrial appendage (LAA) is a novel alternative for the treatment of patients with atrial fibrillation (AF) and with a high risk of stroke who are not eligible for long-term anticoagulation therapy. The aim of this study was to asses the safety, feasibility, and long-term efficacy of this procedure. Methods: From July 2004 to June 2007, 20 patients (13 male, mean age 69 ± 8 years) with non,valvular AF (NV-AF) underwent LAA percutaneous closure using the PLAATOÔ system, implanted through a transeptal access. All patients had contraindications to anticoagulant therapy and were at high risk for cardioembolic stroke (mean CHADS2 score 3 ± 1.2). A trans-thoracic echocardiogram was performed at 1, 3, and every 6 months after the procedure, whereas a trans-oesophageal echocardiogram (TOE) was scheduled at 6 months. After 24 months, a phone interview was obtained. Results: All procedures were successfully performed in 18 patients. In two patients, LAA closure was not feasible for the presence of a multilobed LAA. Two patients underwent percutaneous closure of patent foramen ovale in the same session. In one patient, the procedure was complicated by cardiac perforation with pericardial effusion, treated with pericardiocentesis. At a mean follow up of 40 ± 10 months, no embolic events occurred. One patient died, after 36 months, for gastric cancer. TOE examination showed the complete exclusion of the LAA in all patients. Conclusions: Percutaneous closure of LAA is safe and efficacious to prevent stroke in patients with NV-AF at high risk for cardioembolic events, with contraindications to anticoagulant therapy. © 2009 Wiley-Liss, Inc. [source] Inherited Accessory Nail of the Fifth Toe Cured by Surgical MatricectomyDERMATOLOGIC SURGERY, Issue 8 2004Ching-Chi Chi MD Background. The inherited accessory nail of the fifth toe is a common condition in the Chinese population. Objective. The objective was to demonstrate three lesions in two cases of inherited accessory nail of the fifth toe successfully treated with surgical matricectomy. Methods. Under local anesthesia and use of tourniquet, the proximal nail fold was incised and the matrix of the accessory nail was exposed and then excised by scalpel surgery. The skin defect left after removal of the lesion was repaired with a rotation flap. Results. Histopathologic examination of the surgical specimens revealed that the matrices of the accessory nails were completely extirpated. No recurrence was found 2 years after operation. Conclusion. The inherited accessory nail of the fifth toe was cured by surgical matricectomy. [source] Clinical Pearls: Locked Great ToeACADEMIC EMERGENCY MEDICINE, Issue 8 2003Rahul Banerjee MD No abstract is available for this article. [source] HS07 TOE TRANSFER , TECHNIQUES & RESULTSANZ JOURNAL OF SURGERY, Issue 2007L. C. Teoh Toe to thumb-finger transfer requires the understanding of microsurgery and reconstructive technique. The success is measured by the viability of the toe and eventually recreating the function of the original loss. In harvesting of the toe, the big and second toe follows almost the same technique. Identifying the toe artery over the first web space and then dissecting proximally into the intermetatarsal artery is the best approach. To dissect the artery from proximal to distal is often fraught with many dangers. In my cases about 50% the plantar artery is dominant. Anticipation and planning of the artery length is crucial. In toe to thumb transfer the choice can be 2nd toe, total big toe, trimmed big toe or wrap around transfer. In our local populations, 2nd toe is always a good choice. First reconstruction with flap resurfacing may be necessary if the thumb amputation is very proximal. Toe to fingers transfer is usually indicated in 4 finger loss of the hand. In toe to finger transfer I prefer the two 2nd toes transfer into the middle and ring finger position. As the transferred toes can regain less that 50% of motion, the positioning of the toes should be opposable to the thumb. The concept of total reconstruction should be closely followed. Stable skeletal fixation, tendon weave technique, good nerve repair, adequate skin coverage and primary healing are important to ensure good outcome result. [source] The heel and toe of the cell's foot: A multifaceted approach for understanding the structure and dynamics of focal adhesionsCYTOSKELETON, Issue 11 2009Haguy Wolfenson Abstract Focal adhesions (FAs) are large clusters of transmembrane receptors of the integrin family and a multitude of associated cytoplasmic "plaque" proteins, which connect the extracellular matrix-bound receptors with the actin cytoskeleton. The formation of nearly stationary FAs defines a boundary between the dense and highly dynamic actin network in lamellipodium and the sparser and more diverse cytoskeletal organization in the lamella proper, creating a template for the organization of the entire actin network. The major "mechanical" and "sensory" functions of FAs; namely, the nucleation and regulation of the contractile, myosin-II-containing stress fibers and the mechanosensing of external surfaces depend, to a major extent, on the dynamics of molecular components within FAs. A central element in FA regulation concerns the positive feedback loop, based on the most intriguing feature of FAs; that is, their dependence on mechanical tension developing by the growing stress fibers. FAs grow in response to such tension, and rapidly disassemble upon its relaxation. In this article, we address the mechanistic relationships between the process of FA development, maturation and dissociation and the dynamic molecular events, which take place in different regions of the FA, primarily in the distal end of this structure (the "toe") and the proximal "heel," and discuss the central role of local mechanical forces in orchestrating the complex interplay between FAs and the actin system. Cell Motil. Cytoskeleton 66: 1017,1029, 2009. © 2009 Wiley-Liss, Inc. [source] Inherited Accessory Nail of the Fifth Toe Cured by Surgical MatricectomyDERMATOLOGIC SURGERY, Issue 8 2004Ching-Chi Chi MD Background. The inherited accessory nail of the fifth toe is a common condition in the Chinese population. Objective. The objective was to demonstrate three lesions in two cases of inherited accessory nail of the fifth toe successfully treated with surgical matricectomy. Methods. Under local anesthesia and use of tourniquet, the proximal nail fold was incised and the matrix of the accessory nail was exposed and then excised by scalpel surgery. The skin defect left after removal of the lesion was repaired with a rotation flap. Results. Histopathologic examination of the surgical specimens revealed that the matrices of the accessory nails were completely extirpated. No recurrence was found 2 years after operation. Conclusion. The inherited accessory nail of the fifth toe was cured by surgical matricectomy. [source] A Painless Subungual Osteoid OsteomaDERMATOLOGIC SURGERY, Issue 8 2001Pelin Ekmekci MD Background. Osteoid osteoma is a benign bone tumor. Its etiology is not fully understood and the role of trauma is still elusive. Objective. Osteoid osteoma mostly presents with a poorly localized pain that is worst at night and characteristically relieved by salicylates. It usually occurs on the weight-bearing bones of the lower extremities, but toe location is quite rare. Here, we present a case of painless osteoid osteoma located subungually on the dorsum of the great toe. Result. A 29-year-old woman presented with a painless subungual mass on the dorsum of her great toe. Subungual exotosis, osteochondroma, and osteoma were considered in the differential diagnosis and the lesion was totally excised. Histopathologic examination showed characteristic findings of osteoid osteoma. Conclusion. A painless osteoid osteoma is rarely seen and it can be easily misdiagnosed if it occurs in an atypical location such as the subungual area. [source] TBI or not TBI: that is the question.DIABETIC MEDICINE, Issue 7 2001Is it better to measure toe pressure than ankle pressure in diabetic patients? Abstract Aims Measurement of ankle blood pressure is a simple method of assessing lower limb arterial blood supply. However, its use in diabetes has been questioned due to the presence of medial artery calcification. Measurement of toe blood pressure has been advocated as an alternative but it is technically more difficult. The aim of this study was to obtain information to guide clinicians as to when pressure measurements should be taken at the toe. Methods Ankle brachial index (ABI) and toe brachial index (TBI) were measured by Doppler ultrasound, or photoplethysmography on 174 subjects with diabetes and 53 control subjects. The Bland and Altman method, and the Cohen's method of measuring agreement between two tests were used to compare ABI with TBI. Results The mean differences between ABI and TBI in control and diabetic subjects are 0.40 ± 0.13 and 0.37 ± 0.15, respectively. Nearly all diabetic patients with an ABI <,1.3 have an ABI,TBI gradient falling within the normal range established from the non-diabetic cohort. In contrast, the majority of diabetic subjects with an ABI ,,1.3 have ABI,TBI differences outside this range. When patients are categorized according to ABI and TBI, there is also good agreement between the tests when ABI is low or normal (84% and 78% agreement, respectively), but not when ABI is elevated. Conclusion In the majority of patients with diabetes, assessment of TBI conveys no advantage over ABI in determining perfusion pressure of the lower limbs. Only in those patients with overt calcification, which gives an ABI ,,1.3, are toe pressure measurements superior. This guideline should simplify assessment and treatment of diabetic patients with disease of the lower limbs. Diabet. Med. 18, 528,532 (2001) [source] The effects of slope and slope position on local and upstream fluid threshold friction velocitiesEARTH SURFACE PROCESSES AND LANDFORMS, Issue 12 2008Ning Huang Abstract In deserts, dunes are common aeolian landforms, and parallel ridges are common in cultivated land. A computational fluid dynamics (CFD) model is used to simulate a stable wind blowing over slope beds of varying height and coupled with the slope-compensating fluid threshold friction velocity formula. The model accurately reproduced patterns of flow deceleration at the slope toe and stoss flow acceleration. Based on the CFD-based model, quantitative analyses of slope gradient and particle position on the initiation of particle movement are performed. Results indicate that the slope has a great influence on particle saltation in the windward slope, and the initiation of particle movement is particularly sensitive to particle position with respect to the slope. Copyright © 2008 John Wiley & Sons, Ltd. [source] Experimental study of rill bank collapseEARTH SURFACE PROCESSES AND LANDFORMS, Issue 2 2007Jovan R. Stefanovic Abstract Rill bank collapse is an important component in the adjustment of channel morphology to changes in discharge and sediment flux. Sediment inputs from bank collapse cause abrupt changes in flow resistance, flow patterns and downstream sediment concentrations. Generally, bank retreat involves gradual lateral erosion, caused by flow shear stress, and sudden bank collapse, triggered by complex interactions between channel flow and bank and soil water conditions. Collapse occurs when bank height exceeds the critical height where gravitational forces overcome soil shear strength. An experimental study examined conditions for collapse in eroding rill channels. Experiments with and without a deep water table were carried out on a meandering rill channel in a loamy sand and sandy loam in a laboratory flume under simulated rainfall and controlled runon. Different discharges were used to initiate knickpoint and rill incision. Soil water dynamics were monitored using microstandpipes, tensiometers and time domain reflectometer probes (TDR probes). Bank collapse occurred with newly developed or rising pre-existing water tables near rill banks, associated with knickpoint migration. Knickpoint scour increased effective bank height, caused positive pore water pressure in the bank toe and reduced negative pore pressures in the unsaturated zone to near zero. Matric tension in unsaturated parts of the bank and a surface seal on the ,interrill' zone behind the bank enhanced stability, while increased effective bank height and positive pore water pressure at the bank toe caused instability. With soil water contents >35 per cent (sandy loam) and >23 per cent (loamy sand), critical bank heights were 0·11,0·12 m and 0·06,0·07 m, respectively. Bank toe undercutting at the outside of the rill bends also triggered instability. Bank displacement was quite different on the two soils. On the loamy sand, the failed block slid to the channel bed, revealing only the upper half of the failure plane, while on the sandy loam the failed block toppled forwards, exposing the failure plane for the complete bank height. This study has shown that it is possible to predict location, frequency and magnitude of the rill bank collapse, providing a basis for incorporation into predictive models for hillslope soil loss or rill network development. Copyright © 2006 John Wiley & Sons, Ltd. [source] Overbank deposition along the concave side of the Red River meanders, Manitoba, and its geomorphic significanceEARTH SURFACE PROCESSES AND LANDFORMS, Issue 13 2005Gregory R. Brooks Abstract Slow earth sliding is pervasive along the concave side of Red River meanders that impinge on Lake Agassiz glaciolacustrine deposits. These failures form elongated, low-angled (c. 6 to 10°) landslide zones along the valleysides. Silty overbank deposits that accumulated during the 1999 spring freshet extend continuously along the landslide zones over hundreds of metres and aggraded the lower slopes over a distance 50 to 80 m from the channel margin. The aggradation is not obviously related to meander curvature or location within a meander. Along seven slope profiles surveyed in 1999 near Letellier, Manitoba, the deposits locally are up to 21 cm thick and generally thin with increasing distance from, and height above, the river. Local deposit thickness relates to distance from the channel, duration of inundation of the landslide surface, mesotopography, and variations in vegetation cover. Immediately adjacent to the river, accumulated overbank deposits are up to 4 m thick. The 1999 overbank deposits also were present along the moderately sloped (c. 23 to 27°) concave banks eroding into the floodplain, but the deposits are thinner (locally up to c. 7 cm thick) and cover a narrower area (10 to 30 m wide) than the deposits within the landslide zones. Concave overbank deposition is part of a sediment reworking process that consists of overbank aggradation on the landslide zones, subsequent gradual downslope displacement from earth sliding, and eventually reworking by the river at the toe of the landslide. The presence of the deposits dampens the outward migration of the meanders and contributes to a low rate of contemporary lateral channel migration. Concave overbank sedimentation occurs along most Red River meanders between at least Emerson and St. Adolphe, Manitoba. © Her Majesty the Queen in right of Canada. [source] Vegetation impacts on near bank flowECOHYDROLOGY, Issue 4 2009Leslie Hopkinson Abstract Vegetation is an important component of stream restoration designs used to control streambank retreat, but vegetation effects on near bank flows need to be quantified. The goal of this research was to evaluate how three-dimensional velocity structure and turbulence characteristics vary with three vegetation treatments: tree, shrub and grass. A second order prototype stream (Tom's Creek in Blacksburg, Virginia, USA) with individual reaches dominated by each vegetation treatment was modelled in a research flume using a fixed-bed Froude-scale modelling technique. One model streambank of the prototype stream was constructed for each vegetation type and compared to a bare control (only grain roughness). Velocity profiles perpendicular to the flume model boundary were measured using a three-dimensional acoustic Doppler velocimeter. Three-dimensional velocity records, turbulent kinetic energy characteristics, and Reynolds stresses were analysed. The addition of vegetation on a sloping streambank increased the free stream streamwise velocity as compared to a bare streambank. Velocity in the downstream direction decreased in the area close to the streambank boundary for all vegetation treatments. Tree turbulence intensity and Reynolds stress distributions were similar to the bare condition due to the sparse tree placement characteristic of mature forests. The turbulence caused by the upright shrub treatment increased turbulent kinetic energy and Reynolds stresses near the streambank, particularly at the toe. The flexible grass vegetation folded and protected the streambank, reducing shear stress near the boundary. Copyright © 2009 John Wiley & Sons, Ltd. [source] Shoeing sound Warmblood horses with a rolled toe optimises hoof-unrollment and lowers peak loading during breakoverEQUINE VETERINARY JOURNAL, Issue 3 2006M. C. V. van Heel Summary Reasons for performing study: Overload injuries in sport horses commonly occur; shoeing techniques are believed to be important in prevention of these injuries, but there is a paucity of scientific information identifying the potential connection. Objectives: To test a horseshoe with a modified rolled toe designed to ease the process of breakover and decrease loading of lesion-prone structures of the distal limb. Methods: Twenty clinically sound Warmblood horses trotted over a track containing a pressure/force measuring system and 6 infrared cameras. The horses were measured with 2 types of shoes, standard flat shoes and shoes with a rolled toe. The shoeing procedure was randomised and horses had 2 days between measurements to adapt to the shoes. Results: Limb placement and timing characteristics, e.g. breakover duration, did not change significantly. There was an improvement in the ease of movement to roll over the toe in the shoes with a rolled toe, due mainly to a smoother hoof-unrollment pattern. The peak indicative moment decreased substantially at the onset of breakover in the shoe with the rolled toe. Conclusions: With a rolled toe the process of hoof-unrollment is smoother, which improves the coordination of this process, and lowers peak loading of the distal limb during breakover. Potential relevance: This study stresses the importance of proper shoeing in sound horses, showing that shoe modifications can optimise the loading characteristics of the distal limb and therefore might be a means to prevent sport horses from overload injuries. [source] Nociceptive spinothalamic tract and postsynaptic dorsal column neurons are modulated by paraventricular hypothalamic activationEUROPEAN JOURNAL OF NEUROSCIENCE, Issue 3 2008Gerardo Rojas-Piloni Abstract Previously, we demonstrated that stimulation of the paraventricular hypothalamic nucleus diminishes the nociceptive dorsal horn neuronal responses, and this decrease was mediated by oxytocin in the rat. In addition, we have proposed that oxytocin indirectly inhibits sensory transmission in dorsal horn neurons by exciting spinal inhibitory GABAergic interneurons. The main purpose of the present study was to identify which of the neurons projecting to supraspinal structures to transmit somatic information are modulated by the hypothalamic-spinal descending activation. In anaesthetized rats, single-unit extracellular and juxtacellular recordings were made from dorsal horn lumbar segments, which receive afferent input from the toe and hind-paw regions. The projecting spinothalamic tract and postsynaptic dorsal column system were identified antidromically. Additionally, in order to label the projecting dorsal horn neurons, we injected fluorescent retrograde neuronal tracers into the ipsilateral gracilis nucleus and contralateral ventroposterolateral thalamic nucleus. Hence, juxtacellular recordings were made to iontophoretically label the recorded neurons with a fluorescent dye and identify the recorded projecting cells. We found that only nociceptive evoked responses in spinothalamic tract and postsynaptic dorsal column neurons were significantly inhibited (48.1 ± 4.6 and 47.7 ± 8.2%, respectively) and non-nociceptive responses were not affected by paraventricular hypothalamic nucleus stimulation. We conclude that the hypothalamic-spinal system selectively affects the transmission of nociceptive information of projecting spinal cord cells. [source] Fatigue crack initiation life estimation in a steel welded joint by the use of a two-scale damage modelFATIGUE & FRACTURE OF ENGINEERING MATERIALS AND STRUCTURES, Issue 5 2009N. LAUTROU ABSTRACT This work deals with the fatigue behaviour of S355NL steel welded joints classically used in naval structures. The approach suggested here, in order to estimate the fatigue crack initiation life, can be split into two stages. First, stabilized stress,strain cycles are obtained in all points of the welded joint by a finite element analysis, taking constant or variable amplitude loadings into account. This calculation takes account of: base metal elastic,plastic behaviour, variable yield stress based on hardness measurements in various zones of the weld, local geometry at the weld toe and residual stresses if any. Second, if a fast elastic shakedown occurs, a two-scale damage model based on Lemaitre et al.'s work is used as a post-processor in order to estimate the fatigue crack initiation life. Material parameters for this model were identified from two Wöhler curves established for base metal. As a validation, four-point bending fatigue tests were carried out on welded specimens supplied by ,DCNS company'. Two load ratios were considered: 0.1 and 0.3. Residual stress measurements by X-ray diffraction completed this analysis. Comparisons between experimental and calculated fatigue lives are promising for the considered loadings. An exploitation of this method is planned for another welding process. [source] Fatigue life prediction of cracked padded platesFATIGUE & FRACTURE OF ENGINEERING MATERIALS AND STRUCTURES, Issue 3-4 2008K. GUO ABSTRACT The fatigue crack propagation analyses of padded plates are conducted to predict the crack growth behaviour under various loading conditions. The fatigue life of a padded plate with a single edge crack originating from the weld toe is calculated using the weight function approach. The fatigue strength of padded plates with different pad thickness under remote loading conditions was investigated and compared to the T-plate joint. The improvement of the fatigue strength of the pad design is verified. The thickness effect of the padded plate was investigated using the fracture mechanics approach. The geometrically similar model pairs with different initial crack sizes were investigated under remote loading conditions. It was shown that the thickness effect depends on both stress concentration and initial crack size. [source] Cruciform fillet welded joint fatigue strength improvements by weld metal phase transformationsFATIGUE & FRACTURE OF ENGINEERING MATERIALS AND STRUCTURES, Issue 2 2008PH. P. DARCIS ABSTRACT Arc welding typically generates residual tensile stresses in welded joints, leading to deteriorated fatigue performance of these joints. Volume expansion of the weld metal at high temperatures followed by contraction during cooling induces a local tensile residual stress state. A new type of welding wire capable of inducing a local compressive residual stress state by means of controlled martensitic transformation at relatively low temperatures has been studied, and the effects of the transformation temperature and residual stresses on fatigue strength are discussed. In this study, several LTTW (Low Transformation-Temperature Welding) wires have been developed and investigated to better characterize the effect of phase transformation on residual stress management in welded joints. Non-load-carrying cruciform fillet welded joints were prepared for measurement of residual stresses and fatigue testing. The measurement of the residual stresses of the three designed wires reveals a compressive residual stress near the weld toe. The fatigue properties of the new wires are enhanced compared to a commercially available wire. [source] A local strain method for the evaluation of welded joints fatigue resistance: the case of thin main-plates thicknessFATIGUE & FRACTURE OF ENGINEERING MATERIALS AND STRUCTURES, Issue 9 2005C. CASAVOLA ABSTRACT Current procedures for evaluating fatigue strength of welded structures may not be consistent with the real fatigue behaviour of welded joints. A local strain method for the prediction of the WELded joints FAtigue REsistance (WELFARE), by local strain measurements at the weld toe, was recently proposed on the basis of fatigue tests on more than 10 series of welded joints (T, cruciform, angular and butt joints) in structural steel, with 10,25 mm main-plate thickness. This paper reports fatigue test results obtained from 30 cruciform and butt welded joints (3,5 mm thick) under two load ratios (0.1 and ,1) in order to extend the applicability of the method to thin welded joints. [source] How would I manage a case of essential thrombocythaemia presenting with an ischaemic toeHEMATOLOGICAL ONCOLOGY, Issue 1 2008DP McLornan Abstract Essential thrombocythaemia (ET) is an acquired myeloproliferative disorder. The phenotypic and biological heterogeneity of ET can make management of individual cases problematic, especially in the era of changing ideas on the molecular pathogenesis of this disease process. This case discussion will explore the evidence base and rationale that guides treatment of a 46-year-old individual with ET presenting with an ischaemic episode. Copyright © 2007 John Wiley & Sons, Ltd. [source] Difference in somatosensory evoked fields elicited by mechanical and electrical stimulations: Elucidation of the human homunculus by a noninvasive methodHUMAN BRAIN MAPPING, Issue 4 2005Ken Inoue Abstract We recently recorded somatosensory evoked fields (SEFs) elicited by compressing the glabrous skin of the finger and decompressing it by using a photosensor trigger. In that study, the equivalent current dipoles (ECDs) for these evoked fields appeared to be physiologically similar to the ECDs of P30m in median nerve stimulation. We sought to determine the relations of evoked fields elicited by mechanically stimulating the glabrous skin of the great toe and those of electrically produced P40m. We studied SEFs elicited by mechanical and electrical stimulations from the median and tibial nerves. The orientations of dipoles from the mechanical stimulations were from anterior-to-posterior, similar to the orientations of dipoles for P30m. The direction of the dipole around the peak of N20m from median nerve electrical stimulation was opposite to these directions. The orientations of dipoles around the peak of P40m by tibial nerve stimulation were transverse, whereas those by the compression and decompression stimulation of the toe were directed from anterior-to-posterior. The concordance of the orientations in ECDs for evoked fields elicited by mechanical and electrical stimulations suggests that the ECDs of P40m are physiologically similar to those of P30m but not to those of N20m. The discrepancy in orientations in ECDs for evoked field elicited by these stimulations in the lower extremity suggests that electrical and compression stimulations elicit evoked fields responding to fast surface rubbing stimuli and/or stimuli to the muscle and joint. Hum. Brain Mapping 24:274,283, 2005. © 2005 Wiley-Liss, Inc. [source] Applying discontinuous deformation analysis to assess the constrained area of the unstable Chiu-fen-erh-shan landslide slopeINTERNATIONAL JOURNAL FOR NUMERICAL AND ANALYTICAL METHODS IN GEOMECHANICS, Issue 5 2007Jian-Hong Wu Abstract Chiu-fen-erh-shan landslide is a remarkable slope failure occurred during the Chi-Chi earthquake in 1999. In November of 2002, abnormal geomorphologic features, including buckling and ground subsidence, were observed on the lower slope of the Chiu-fen-erh-shan landslide. This study attempts to assess the constrained area of a future collapsing on the slope using a dynamic discrete numerical analysis method, discontinuous deformation analysis (DDA). The simulation results show that the depression in front of the toe of the slope provides a space for arresting the whole sliding rocks when only the unstable lower slope fails. However, as the whole slope slides, the rock fragments move farther into the memorial park and can impact other facilities resulting in the enlarging of constrained area. The authority should prohibit people from entrancing the constrained area in the rainy season. Copyright © 2006 John Wiley & Sons, Ltd. [source] A black plaque on the toe of a white maleINTERNATIONAL JOURNAL OF DERMATOLOGY, Issue 9 2008Brenda Chrastil MD No abstract is available for this article. [source] Leg ulcers and hydroxyurea: report of three cases with essential thrombocythemiaINTERNATIONAL JOURNAL OF DERMATOLOGY, Issue 12 2002Zeynep Demirçay MD Case 1,A 65-year-old woman with essential thrombocythemia (ET) had been taking oral hydroxyurea (HU), 1000 mg daily, for 7 years. Six months ago, she developed an ulcer on the outer part of her left ankle, which healed spontaneously within 2 months. She presented with a new, tender, shallow ulcer, 2 cm × 2 cm in size, at the same site. Doppler examination revealed thrombosis of the left common femoral vein and a calcified atheroma plaque of the left common femoral artery. The dosage of HU was decreased to 500 mg daily when the platelet counts were found to be within normal levels. The ulcer completely healed within 2 months with occlusive wound dressings, and has not recurred within the follow-up period of 1 year. Case 2,A 56-year-old women presented with multiple, painful, leg ulcers of 1 year duration. She had been diagnosed as having ET and had been on HU therapy, 1500 mg/day, for the past 5 years. Interferon-,-2b was started 3 months ago, in addition to HU, which was tapered to 1000 mg daily. She had suffered from hypertension for 20 years treated with nifedipine and enalapril, and had recently been diagnosed with diabetes mellitus which was controlled by diet. Examination revealed three ulcers located on the lateral aspects of both ankles and right distal toe. Arterial and venous Doppler examinations were within normal limits. Histopathology of the ulcer revealed nonspecific changes with a mixed inflammatory cell infiltrate around dermal vessels. The ulcers completely healed within 10 weeks with topical hydrocolloid dressings. After healing, she was lost to follow-up. A year later, it was learned that she had developed a new ulcer at her right heel, 3 months after her last visit (by phone call). This ulcer persisted for 8 months until HU was withdrawn. Case 3,A 64-year-old woman with ET presented with a painful leg ulcer of 6 months' duration. She had been taking oral HU for 5 years. She had a 20-year history of hypertension treated with lisinopril. Examination revealed a punched-out ulcer of 2 cm × 2 cm over the right lateral malleolus (Fig. 1). Doppler examination of the veins revealed insufficiency of the right greater saphenous and femoral veins. Angiography showed multiple stenoses of the right popliteal and femoral arteries. As her platelet count remained high, HU was continued. During the follow-up period of 13 months, the ulcer showed only partial improvement with local wound care. Figure 1. Punched-out ulcer surrounded by an erythematous border over the right malleolus (Case 3) [source] The intertarsal joint of the ostrich (Struthio camelus): Anatomical examination and function of passive structures in locomotionJOURNAL OF ANATOMY, Issue 6 2009Nina U. Schaller Abstract The ostrich (Struthio camelus) is the largest extant biped. Being flightless, it exhibits advanced cursorial abilities primarily evident in its characteristic speed and endurance. In addition to the active musculoskeletal complex, its powerful pelvic limbs incorporate passive structures wherein ligaments interact with joint surfaces, cartilage and other connective tissue in their course of motion. This arrangement may enable energy conservation by providing joint stabilisation, optimised limb segment orientation and automated positioning of ground contact elements independently of direct muscle control. The intertarsal joint is of particular interest considering its position near the mid-point of the extended limb and its exposure to high load during stance with significant inertial forces during swing phase. Functional-anatomical analysis of the dissected isolated joint describes the interaction of ligaments with intertarsal joint contours through the full motion cycle. Manual manipulation identified a passive engage-disengage mechanism (EDM) that establishes joint extension, provides bi-directional resistance prior to a transition point located at 115° and contributes to rapid intertarsal flexion at toe off and full extension prior to touch down. This effect was subsequently quantified by measurement of intertarsal joint moments in prepared anatomical specimens in a neutral horizontal position and axially-loaded vertical position. Correlation with kinematic analyses of walking and running ostriches confirms the contribution of the EDM in vivo. We hypothesise that the passive EDM operates in tandem with a stringently coupled multi-jointed muscle-tendon system to conserve the metabolic cost of locomotion in the ostrich, suggesting that a complete understanding of terrestrial locomotion across extinct and extant taxa must include functional consideration of the ligamentous system. [source] Modulation of peritendinous adhesion formation by alginate solution in a rabbit flexor tendon modelJOURNAL OF BIOMEDICAL MATERIALS RESEARCH, Issue 1 2007Jiro Namba Abstract To examine the antiadhesive effect of an alginate solution following tendon surgery, unilateral subtotal laceration of the flexor digitorum communis tendon was created in one hind limb while the other side was left intact in 32 Japanese white rabbits. The lesion was coated with alginate solution in 16 animals and not coated in the other 16. Degree of adhesion formation was assessed histologically and biomechanically by measuring the flexion angle of the first toe when the flexor digitorum tendon was pulled with a specified force at 4 weeks postoperatively. When compared with the control group, the alginate-treated group demonstrated significantly greater toe flexion, with less scar tissue formation at the repair site. Histologically, complete tendon healing with longitudinal remodeling of collagen fibers was observed in the alginate-treated group, while a random pattern of fibers was observed in the control group. Reduction in adhesion formation using alginate solution represents a novel strategy for the management of tendon injury and repair in the clinical setting. © 2006 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2007 [source] Development of the shields for tendon injury repair using polyvinyl alcohol , hydrogel ( PVA-H)JOURNAL OF BIOMEDICAL MATERIALS RESEARCH, Issue 4 2001Masanori Kobayashi Abstract In recent years, marked advances have been made in repair techniques for tendon injury, but the treatment of finger flexor tendon injury is still one of the most difficult and important problems in the orthopedic field. The main problem in tendon repair is adhesion between the tendon and surrounding tissue. To prevent this adhesion and achieve tendon union, we developed adhesion preventive shields for tendon repair using polyvinyl alcohol hydrogel ( PVA-H) with 90% water content, and carried out an implant experiment using the deep flexor tendon of the third toe of domestic fowl. Injured tendons shielded with PVA-H showed union at about 3 weeks after the operation without adhesion to the surrounding tissue and good function such as gliding and range of motion. Neither breakage of the PVA-H shield itself nor infection, nor degeneration in the surrounding tissue were observed. These results confirmed that the tendon itself has repair ability, and the tendon is regenerated by synovial nutrition through PVA-H. High water content PVA-H may have clinically potential and be applicable to adhesion-preventive shields for tendon repair. However, re-rupture was observed, probably due to accidental tendon injury at an early period after the operation. In some cases, tendon immobilization methods to prevent re-rupture might be necessary. © 2001 John Wiley & Sons, Inc. J Biomed Mater Res (Appl Biomater) 58: 344,351, 2001 [source] Pulse oximeter perfusion index as an early indicator of sympathectomy after epidural anesthesiaACTA ANAESTHESIOLOGICA SCANDINAVICA, Issue 8 2009Y. GINOSAR Background: The pulse oximeter perfusion index (PI) has been used to indicate sympathectomy-induced vasodilatation. We hypothesized that pulse oximeter PI provides an earlier and clearer indication of sympathectomy following epidural anesthesia than skin temperature and arterial pressure. Methods: Forty patients received lumbar epidural catheters. Patients were randomized to receive either 10 ml 0.5% bupivacaine or 10 ml 0.25% bupivacaine. PI in the toe, mean arterial pressure (MAP) and toe temperature were all assessed at baseline and at 5, 10 and 20 min following epidural anesthesia. The effect of epidural anesthesia over time was assessed by repeated measures analysis of variance. Additionally, we defined clinically evident sympathectomy criteria (a 100% increase in the PI, a 15% decrease in MAP and a 1 °C increase in toe temperature). The numbers of patients demonstrating these changes for each test were compared using the McNemar test for each time point. Results: Twenty-nine subjects had photoplethysmography signals that met a priori signal quality criteria for analysis. By 20 min, PI increased by 326%, compared with a 10% decrease and a 3% increase in MAP and toe temperature, respectively. For PI 15/29, 26/29 and 29/29 of the subjects met the sympathectomy criteria at 5, 10 and 20 min, respectively, compared with 4/29, 6/29 and 18/29 for MAP changes and 3/29, 8/29 and 14/29 for toe temperature changes. Conclusions: PI was an earlier, clearer and more sensitive indicator of the development of epidural-induced sympathectomy than either skin temperature or MAP. 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