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Third Position (third + position)
Selected AbstractsAssociation of polymorphisms in the interleukin-18 gene in patients with Crohn's disease depending on the CARD15/NOD2 genotypeINFLAMMATORY BOWEL DISEASES, Issue 12 2005Jürgen Glas MD Abstract Background: An increased expression of interleukin-18 (IL-18), a proinflammatory cytokine inducing interferon-,, has been found in Crohn's disease (CD). In the IL-18 gene, several partly functional relevant polymorphisms are known. This study sought to investigate associations of IL-18 polymorphisms in inflammatory bowel disease and CD according to CARD15/NOD2 mutation status and clinical phenotypes. Methods: The IL-18 polymorphisms ,607, ,137, and the third position of codon 35 (c35/3) were genotyped in 210 patients with CD, 140 patients with ulcerative colitis, and 265 healthy controls using polymerase chain reaction and restriction fragment length polymorphism analysis. Results: Frequencies of alleles and genotypes of the 3 polymorphisms and of the respective haplotypes and diplotypes displayed no significant differences between the whole groups of patients with CD and ulcerative colitis, respectively, compared with the controls. After stratification of patients with CD for CARD15/NOD2 status, significant associations of genotypes ,137 CC (P = 0.018) and c35/3 CC (P = 0.010) and of the diplotype 2-2 (P = 0.018) were found in cases carrying CARD15/NOD2 mutations. Associations of genotypes ,137 GG (P = 0.015) and c35/3 AA (P = 0.030) with colonic disease only in cases positive for CARD15/NOD2 mutations and of the genotype ,607 AA (P = 0.007) with fistulas in cases negative for CARD15/NOD2 mutations were observed. Conclusions: In this study, significant differences of several genotypes and diplotypes within the IL-18 gene in CD depending on CARD15/NOD2 status have been found. In context with an increased expression of IL-18 in CD, it remains to be shown whether the expression of IL-18 is influenced by CARD15/NOD2 mutation status. [source] Studies on codon usage in Thermoplasma acidophilum and its possible implications on the occurrences of lateral gene transferJOURNAL OF BASIC MICROBIOLOGY, Issue 5 2005S. K. Gupta Codon usage studies have been carried out on the coding sequences of Thermoplasma acidophilum, which is an archaeon and grows at very low pH and high temperature. Overall codon usage data analysis indicates that all the four bases are almost equifrequent at the third position of codons, which is expected (since genomic GC % of this genome is about 46%). However, multivariate statistical analysis indicates that there are two major trends in the codon usage variation among the genes in this organism. In the first major trend it is observed that genes having G and C ending codons are clustered at one end while, A and T ending ones are clustered at the other end. We have also found a significant positive correlation between the expressivities of genes and GC contents at the synonymous third codon positions. In the second major trend, it is seen that the genes are clustered into three distinct parts. A comparative analyses of codon usage data of T. acidophilum and Sulfolobus solfataricus reveals that one of the three clusters of genes of T. acidophilum is very similar to a considerable number of S. solfataricus genes, suggesting possible occurrences of lateral gene transfer between these two microorganisms as reported by earlier workers. (© 2005 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim) [source] How practitioners can systematically use empirical evidence in treatment selectionJOURNAL OF CLINICAL PSYCHOLOGY, Issue 10 2002Larry E. Beutler Contemporary concerns with "empirically supported treatments" emphasize the differences in outcomes that are associated with reliably delivered treatments, representing different models and theories. This approach often fails to address the fact that there is no consensus among scientists about whether there are enough differences between and among treatments to make this effort productive. There is a considerable body of data that suggests that all treatments produce very similar effects. This article reviews these viewpoints and presents a third position, suggesting that identifying common and differential principles of change may be more productive than focusing on the relative value of different theoretical models. © 2002 Wiley Periodicals, Inc. J Clin Psychol 58: 1199,1212, 2002. [source] Craniomandibular joint in South American burrowing rodents (Ctenomyidae): adaptations and constraints related to a specialized mandibular position in diggingJOURNAL OF ZOOLOGY, Issue 3 2006D. H. Verzi Abstract A quali-quantitative morphofunctional analysis of the craniomandibular joint in subterranean rodents of the family Ctenomyidae showed that specializations of this joint are coupled with adaptations to digging. The presence of a postglenoid articular region in the skull of Eucelophorus and Ctenomys implies a new position of the mandible in digging, different from those involved in gnawing and chewing. In this third position of the mandible, the mandibular joint is stabilized when the deeply inserted incisors attack the soil or an obstacle, preventing dislocation. The proposed new mandibular function imposes a mechanical constraint on size and shape of the auditory bullae in tooth-digger ctenomyids, because inflated bullae preclude a satisfactory opening of the mandible when it articulates in the postglenoid region. The configuration of the craniomandibular joint and other specializations for digging of Eucelophorus are unique among all South American rodents. The presence of non-homologous, and even more specialized, postglenoid cavities in burrowing rodents of other continents suggests a common requirement for stabilizing the mandibular joint when strong forces with incisors are developed. The less specialized postglenoid region of Eucelophorus and Ctenomys, with respect to that of other rodent clades, may be related to the more recent differentiation of ctenomyids. [source] Synthesis of New 2,3-Dihydroquinazolin-4(1H)-one Derivatives for Analgesic and Anti-inflammatory EvaluationARCHIV DER PHARMAZIE, Issue 5 2010Osama I. El-Sabbagh Abstract Starting from isatoic anhydrides, several new 2,3-dihydroquinazolin-4(1H)-one derivatives bearing chalcone or pyrazole or thiazole moieties at the third position were synthesized. The analgesic and anti-inflammatory activities for most compounds were studied at a dose level of 50 mg/kg via the acetic-acid-induced writhing-response method and carrageenan-induced edema method, respectively. The study showed that the chalcones bearing a 4-chlorophenyl group 4c or 4-nitrophenyl group 4b were the most active ones as analgesics. Both chalcone 4c and N -phenyl pyrazole bearing 4-methoxy phenyl group 5b showed a higher anti-inflammatory activity than celecoxib but still lower than that of diclofenac sodium. Moreover, the chalcone 4c has nearly the same ulcerogenic index as the selective cyclooxygenase-2 inhibitor celecoxib. [source] Capitalist models and social democracy: the case of New LabourBRITISH JOURNAL OF POLITICS & INTERNATIONAL RELATIONS, Issue 3 2001David Coates Some of the more critical readings of the adequacy and effectiveness of New Labour in power have been developed by scholars willing to link arguments about the trajectory of Labour politics to wider arguments about the character of the contemporary global economy and the space within it for the construction and development of distinctive capitalist models. Mark Wickham-Jones and Colin Hay in particular have made that linkage in a series of important writings on the contemporary Labour party. Their arguments are here subjected to critical review, and set against a third position on New Labour and global capitalism: one informed by the writings of Ralph Miliband on British Labour and by the arguments of Leo Panitch and Greg Albo on the limits of the ,progressive competitiveness' strategies associated with ,Third Way' social democratic governments. [source] From kissing to belly stridulation: comparative analysis reveals surprising diversity, rapid evolution, and much homoplasy in the mating behaviour of 27 species of sepsid flies (Diptera: Sepsidae)JOURNAL OF EVOLUTIONARY BIOLOGY, Issue 11 2009N. PUNIAMOORTHY Abstract Our understanding of how fast mating behaviour evolves in insects is rather poor due to a lack of comparative studies among insect groups for which phylogenetic relationships are known. Here, we present a detailed study of the mating behaviour of 27 species of Sepsidae (Diptera) for which a well-resolved and supported phylogeny is available. We demonstrate that mating behaviour is extremely diverse in sepsids with each species having its own mating profile. We define 32 behavioural characters and document them with video clips. Based on sister species comparisons, we provide several examples where mating behaviour evolves faster than all sexually dimorphic morphological traits. Mapping the behaviours onto the molecular tree reveals much homoplasy, comparable to that observed for third positions of mitochondrial protein-encoding genes. A partitioned Bremer support (PBS) analysis reveals conflict between the molecular and behavioural data, but behavioural characters have higher PBS values per parsimony-informative character than DNA sequence characters. [source] Phylogenetics, biogeography and classification of, and character evolution in, gamebirds (Aves: Galliformes): effects of character exclusion, data partitioning and missing dataCLADISTICS, Issue 6 2006Timothy M. Crowe The phylogenetic relationships, biogeography and classification of, and morpho-behavioral (M/B) evolution in, gamebirds (Aves: Galliformes) are investigated. In-group taxa (rooted on representatives of the Anseriformes) include 158 species representing all suprageneric galliform taxa and 65 genera. The characters include 102 M/B attributes and 4452 nucleic acid base pairs from mitochondrial cytochrome b (CYT B), NADH dehydrogenase subunit 2 (ND2), 12S ribosomal DNA (12S) and control region (CR), and nuclear ovomucoid intron G (OVO-G). Analysis of the combined character data set yielded a single, completely resolved cladogram that had the highest levels of jackknife support, which suggests a need for a revised classification for the phasianine galliforms. Adding 102 M/B characters to the combined CYT B and ND2 partitions (2184 characters) decisively overturns the topology suggested by analysis of the two mtDNA partitions alone, refuting the view that M/B characters should be excluded from phylogenetic analyses because of their relatively small number and putative character state ambiguity. Exclusion of the OVO-G partition (with >,70% missing data) from the combined data set had no effect on cladistic structure, but slightly lowered jackknife support at several nodes. Exclusion of third positions of codons in an analysis of a CYT B + ND2 partition resulted in a massive loss of resolution and support, and even failed to recover the monophyly of the Galliformes with jackknife support. A combined analysis of putatively less informative, "non-coding" characters (CYT B/ND2 third position sites + CR +12S + OVO-G sequences) yielded a highly resolved consensus cladogram congruent with the combined-evidence cladogram. Traditionally recognized suprageneric galliform taxa emerging in the combined cladogram are: the families Megapodiidae (megapodes), Cracidae (cracids), Numididae (guineafowls), Odontophoridae (New World quails) and Phasianidae (pheasants, pavonines, partridges, quails, francolins, spurfowls and grouse) and the subfamilies Cracinae (curassows, chachalacas and the horned guan), Penelopinae (remaining guans), Pavoninae sensu lato (peafowls, peacock pheasants and argus pheasants), Tetraoninae (grouse) and Phasianinae (pheasants minus Gallus). The monophyly of some traditional groupings (e.g., the perdicinae: partridges/quails/francolins) is rejected decisively, contrasted by the emergence of other unexpected groupings. The most remarkable phylogenetic results are the placement of endemic African galliforms as sisters to geographically far-distant taxa in Asia and the Americas. Biogeographically, the combined-data cladogram supports the hypothesis that basal lineages of galliforms diverged prior to the Cretaceous/Tertiary (K-T) Event and that the subsequent cladogenesis was influenced by the break-up of Gondwana. The evolution of gamebirds in Africa, Asia and the Americas has a far more complicated historical biogeography than suggested to date. With regard to character evolution: spurs appear to have evolved at least twice within the Galliformes; a relatively large number of tail feathers (, 14) at least three times; polygyny at least twice; and sexual dimorphism many times. © The Willi Hennig Society 2006. [source] Taxon sampling and seed plant phylogenyCLADISTICS, Issue 5 2002Catarina Rydin We investigated the effects of taxon sampling on phylogenetic inference by exchanging terminals in two sizes of rbcL matrices for seed plants, applying parsimony and bayesian analyses to ten 38-taxon matrices and ten 80-taxon matrices. In comparing tree topologies we concentrated on the position of the Gnetales, an important group whose placement has long been disputed. With either method, trees obtained from different taxon samples could be mutually contradictory and even disagree on groups that seemed strongly supported. Adding terminals improved the consistency of results for unweighted parsimony, but not for parsimony with third positions excluded and not for bayesian analysis, particularly when the general time-reversible model was employed. This suggests that attempting to resolve deep relationships using only a few taxa can lead to spurious conclusions, groupings unlikely to be repeatable with different taxon samplings or larger data sets. The effect of taxon sampling has not generally been recognized, and phylogenetic studies of seed plants have often been based on few taxa. Such insufficient sampling may help explain the variety of phylogenetic hypotheses for seed plants proposed in recent years. We recommend that restricted data sets such as single-gene subsets of multigene studies should be reanalyzed with alternative selections of terminals to assess topological consistency. [source] | ||||||||||