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Thiosalicylic Acid (thiosalicylic + acid)
Selected AbstractsChemInform Abstract: A New Synthesis of Thioflavanones from Thiosalicylic Acid.CHEMINFORM, Issue 42 2008Jae In Lee Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source] Synthesis of phenyl furyl sulfides and phenyl furyl ethers by nucleophilic substitution of nitrofuransJOURNAL OF HETEROCYCLIC CHEMISTRY, Issue 5 2007Masayuki Ogawa Phenyl furyl sulfides (3a-j) and phenyl furyl ethers (3k-n), which are useful in synthesizing furocondensed 3-ring compounds, can be synthesized by nucleophilic substitution of nitrofurans having electron withdrawal groups. In our experiments using 5-nitrofurans having electron withdrawal groups (2a-i), nucleophilic substitution readily occurred with the benzenethiolate anion of thiosalicylic acid (1a), the benzenethiolate anion of thiosalicylate ester (1b), and the phenylate anions of salicylate esters (1c-d) to yield phenyl furyl sulfides (3a-j) and phenyl furyl ethers (3k-n). [source] Silver-bacterial cellulosic sponges as active SERS substratesJOURNAL OF RAMAN SPECTROSCOPY, Issue 4 2008Paula A. A. P. Marques Abstract Synthetic Ag-bacterial cellulose nanocomposites are reported here and their performance as surface enhanced Raman scattering (SERS) substrates was investigated using thiosalicylic acid and 2,2,-dithiodipyridine as analytes. These nanocomposite materials act as natural sponges when immersed in aqueous or ethanolic solutions allowing capture and SERS detection of certain dissolved molecules. The detection limits for the above organic analytes reached concentrations as low as 10,4 mol·dm,3 and are considerably lower than the conventional vegetable cellulose analogs. Furthermore, we anticipate that the use of these nanocomposites has a beneficial consequence for the development of handy and active cellulosic SERS substrates, in particular for bioanalysis, as we experimentally demonstrated by testing the amino acids L -phenylalanine, L -glutamin and L -histidine. Copyright © 2008 John Wiley & Sons, Ltd. [source] Thimerosal induces apoptosis and G2/M phase arrest in human leukemia cells,MOLECULAR CARCINOGENESIS, Issue 9 2006Kyung Jin Woo Abstract Thimerosal is an organomercury compound with sulfhydryl-reactive properties. The ability of thimerosal to act as a sulfhydryl group is related to the presence of mercury. Due to its antibacterial effect, thimerosal is widely used as preservatives and has been reported to cause chemically mediated side effects. In the present study, we showed that the molecular mechanism of thimerosal induced apoptosis in U937 cells. Thimerosal was shown to be responsible for the inhibition of U937 cells growth by inducing apoptosis. Treatment with 2.5,5 µM thimerosal but not thiosalicylic acid (structural analog of thimerosal devoid of mercury) for 12 h produced apoptosis, G2/M phase arrest, and DNA fragmentation in a dose-dependent manner. Treatment with caspase inhibitor significantly reduced thimerosal-induced caspase 3 activation. In addition, thimerosal-induced apoptosis was attenuated by antioxidant Mn (III) meso-tetrakis (4-benzoic acid) porphyrin (Mn-TBAP). These data indicate that the cytotoxic effect of thimerosal on U937 cells is attributable to the induced apoptosis and that thimerosal-induced apoptosis is mediated by reactive oxygen species generation and caspase-3 activation. © 2006 Wiley-Liss, Inc. [source] Novel anti-bacterial acid dyes derived from naphthalimide: synthesis, characterisation and evaluation of their technical properties on nylon 6COLORATION TECHNOLOGY, Issue 2 2010Zinat Mohammadkhodaei As an attempt to combine the dyeing and functional finishing steps into one process, two novel anti-bacterial monoazo acid dyes based on N -ester-1,8-naphthalimide were synthesised. To do this, 4-amino- N -ethyl glycinate-1,8-naphthalimide was prepared, diazotised and then coupled to thiosalicylic acid or salicylic acid to produce anti-bacterial dyes. The synthesised dyes were purified and then fully characterised using Fourier Transform,infrared spectrometry, proton nuclear magnetic resonance spectroscopy and melting point analysis. Dispersion of the dyes was prepared in water and applied to nylon 6 fabrics. The novel dyes offered good build-up properties on the substrate. The anti-bacterial efficacy of the synthesised dyes was assessed, with the dyes showing activity against both Gram-positive and Gram-negative bacteria. [source] | ||||||||||