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Their Biological Activities (their + biological_activity)

Distribution by Scientific Domains
Chemistry100%

Selected Abstracts

Rubriflordilactones A (I) and B (II), Two Novel Bisnortriterpenoids from Schisandra rubriflora and Their Biological Activities.

CHEMINFORM, Issue 29 2006
Han-Dong Sun
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF. [source]

Total Synthesis of the Cyclodepsipeptide Apratoxin A and Its Analogues and Assessment of Their Biological Activities

CHEMISTRY - A EUROPEAN JOURNAL, Issue 29 2006
Dawei Ma Prof. Dr.
Abstract A novel total synthesis of apratoxin A is described, with key steps including the assembly of its ketide segment through a D -proline-catalyzed direct aldol reaction and Oppolzer's anti aldol reaction and the preparation of its thiazoline unit in a biomimetic synthesis. An oxazoline analogue of apratoxin A has also been elaborated by a similar approach. This compound has a potency against HeLa cell proliferation only slightly lower than that of apratoxin A, whilst a C(40)-demethylated oxazoline analogue of apratoxin A displays a much lower cytotoxicity and the C(37)-epimer and C(37) demethylation product of this new analogue are inactive. These results suggest that the two methyl groups at C(37) and C(40) and the stereochemistry at C(37) are essential for the potent cellular activity of the oxazoline analogue of apratoxin A. Further biological analysis revealed that both synthetic apratoxin A and its oxazoline analogue inhibited cell proliferation by causing cell cycle arrest in the G1 phase. [source]

ChemInform Abstract: An Efficient Preparation of N-Alkyl-2-benzazepine Derivatives and Investigation of Their Biological Activity.

CHEMINFORM, Issue 45 2009
Akio Kamimura
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source]

Inhibition of Trypsin and Urokinase by Cbz-Amino(4-guanidinophenyl)methanephosphonate Aromatic Ester Derivatives: The Influence of the Ester Group on Their Biological Activity.

CHEMINFORM, Issue 34 2006
Marcin Sienczyk
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF. [source]