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Technological Advancements (technological + advancement)
Selected AbstractsTechnology-Mediated Learning 10 Years Later: Emphasizing Pedagogical or Utilitarian Applications?FOREIGN LANGUAGE ANNALS, Issue 1 2007Article first published online: 31 DEC 200, Nike Arnold Abstract: In recent years, educational technology has come a long way. Technological advancements and significant investments in computer equipment and training have opened new opportunities for foreign language teachers. In addition, instructional technology (IT) is now an accepted component of teacher training and foreign language teaching. This study addresses the question how IT actually is being used for foreign language learning in higher education. It reports the findings of an online survey, which was completed by 173 college foreign language teachers. Results suggest that the vast majority of participants do use computer technology for their teaching, but at a very basic level. Teachers' IT use seems to be motivated largely by utilitarian reasons, followed by a variety of pedagogical benefits. [source] Prospects for inferring pairwise relationships with single nucleotide polymorphismsMOLECULAR ECOLOGY, Issue 4 2003Jeffrey C. Glaubitz Abstract An extraordinarily large number of single nucleotide polymorphisms (SNPs) are now available in humans as well as in other model organisms. Technological advancements may soon make it feasible to assay hundreds of SNPs in virtually any organism of interest. One potential application of SNPs is the determination of pairwise genetic relationships in populations without known pedigrees. Although microsatellites are currently the marker of choice for this purpose, the number of independently segregating microsatellite markers that can be feasibly assayed is limited. Thus, it can be difficult to distinguish reliably some classes of relationship (e.g. full-sibs from half-sibs) with microsatellite data alone. We assess, via Monte Carlo computer simulation, the potential for using a large panel of independently segregating SNPs to infer genetic relationships, following the analytical approach of Blouin et al. (1996). We have explored a ,best case scenario' in which 100 independently segregating SNPs are available. For discrimination among single-generation relationships or for the identification of parent,offspring pairs, it appears that such a panel of moderately polymorphic SNPs (minor allele frequency of 0.20) will provide discrimination power equivalent to only 16,20 independently segregating microsatellites. Although newly available analytical methods that can account for tight genetic linkage between markers will, in theory, allow improved estimation of relationships using thousands of SNPs in highly dense genomic scans, in practice such studies will only be feasible in a handful of model organisms. Given the comparable amount of effort required for the development of both types of markers, it seems that microsatellites will remain the marker of choice for relationship estimation in nonmodel organisms, at least for the foreseeable future. [source] Political ergonomics, macroergonomic battlesHUMAN FACTORS AND ERGONOMICS IN MANUFACTURING & SERVICE INDUSTRIES, Issue 5 2008Leszek Pacholski Humanocentric-oriented social and technological systems have to be perceived as the main source of technological advancement. This source it so attractive that from the point of view of acquisition possibilities it captures the attention of not only business people but also political incumbents who (according to Buchanan's theory) want to satisfy their particular interests. A characteristic feature of social and technological systems is their competitive market position. Taking over these systems by political lobbies with the legitimate usage of intended violence is an example of a contemporary macroergonomic battle. Both of Clausewitz's objectives of war are present: a political objective that is forcing the community that makes up the system to fulfill the politically determined will of the party taking over, and a military objective consisting of an attempt of the moral, social, or even physical destruction of the system leader and its direct coworkers. This article presents a specific example: a case study of a macroergonomic battle fought with a big industrial enterprise. This study serves as a starting point for general methodological premises pertaining to an effective strategy of fighting a macroergonomic battle. The essence of this strategy is learning three so-called exogenic levers of occasional acquisition. © 2008 Wiley Periodicals, Inc. [source] Environmentally-friendly Aspects and Innovative Lightweight Traction System Technologies of the Shinkansen High-speed EMUsIEEJ TRANSACTIONS ON ELECTRICAL AND ELECTRONIC ENGINEERING, Issue 2 2008Yoshiyasu Hagiwara Member Abstract In 1964, the Tokaido Shinkansen marked the start of the world's first commercial service high-speed railway that operates at over 200 km/h. Since then, the Tokaido Shinkansen has demonstrated successful business and technological advancement. With the speeding-up of the Shinkansen, environmental matters such as noise and vibration have become critical issues. Measures taken to counter noise and vibration,such as weight reduction and aerodynamics,also effect global environmental measures to reduce energy consumption and CO2 emission. With the introduction of the Series 300, there was a system change of applying an AC drive system, and the lightweight body realized performance improvement over the earlier Series 0. The high-speed EMUs have readily taken advantage of technological innovation such as those achieved in electronics technology. In particular, an innovative AC drive system comprising a power converter with a GTO thyristor and asynchronous motors realized a high-performance and lightweight traction system for high-speed EMUs in the 1990s. Furthermore, recent innovations in electronics technology, such as low switching loss power devices and high-power permanent magnets, have improved the AC drive systems of the high-speed EMUs of the 21st century. This article starts out by introducing environmentally friendliness of the Shinkansen trains in terms of low energy consumption by means of traction system change, and then proceeds to describe the recent technological innovations that have given birth to lightweight traction systems, such as the Permanent Magnet Synchronous traction Motor (PMSM) and power converters with train-draft-cooling systems. The article concludes by summing up the environmentally friendly aspects of the Tokaido Shinkansen. Copyright © 2008 Institute of Electrical Engineers of Japan. Published by John Wiley & Sons, Inc. [source] Agricultural policies and the emergence of cotton as the dominant crop in northern Côte d'Ivoire: Historical overview and current outlookNATURAL RESOURCES FORUM, Issue 2 2009Oluyede Clifford Ajayi Abstract In most of sub-Saharan Africa, where the agricultural sector experiences dismal performance and is characterized by a gloomy picture, the cotton sub-sector in Côte d'Ivoire is often mentioned as a "success story" given the spectacular rise in the quantity of cotton production and the profile of the crop within the farming system. What are the historical and political antecedents of the development of cotton and the factors responsible for the feat accomplished in the midst of general failures in the same continent? To what extent can cotton be regarded as a "success story" and, what lessons can be drawn for agricultural development strategies based on the Ivorian case study? This paper traces the historical and socio-political background of cotton development in Côte d'Ivoire and identifies key policy and institutional interventions that have influenced the rise of cotton production and its emergence as the dominant crop in the farming systems of the country. Four stages in Ivorian cotton development are identified: planning, take off, crisis and the renaissance phases. The study demonstrates how a combination of good planning, technological advancement and appropriate policy and institutional conditions have contributed significantly to the rise of cotton production and its influence on the agricultural economy of northern Côte d'Ivoire. The study also highlights how the sustainability of agricultural development has been impacted by domestic and international policies and political events over which smallholder farm families have little control, and can at best only respond to. Important questions about cotton development in Côte d'Ivoire are raised that need to be answered before the program can be categorized conclusively as a success story. The study shows that there are no quick fixes to agricultural development in the sub-region. Rather, good planning and putting the necessary building blocks in place are important prerequisites. It is recommended that agricultural development efforts in the continent take cognizance of the complexity of the sector and address the inter-relationships that exist among the technical, policy, market and institutional factors that combine individually and collectively to influence African agriculture. [source] On the development and application of a self,organizing feature map,based patent mapR & D MANAGEMENT, Issue 4 2002Byung, Un Yoon Recently, the range of R&D management has expanded to include management of technological assets such as technology information, product/process data, and patents. Among others, patent map (PM) has been paid increasing attention by both practitioners and researchers alike in R&D management. However, the limitation of conventional PM has been recognized, as the size of patent database becomes voluminous and the relationship among attributes becomes complex. Thus, more sophisticated data,mining tools are required to make full use of potential information from patent databases. In this paper, we propose an exploratory process of developing a self,organizing feature map (SOFM),based PM that visualizes the complex relationship among patents and the dynamic pattern of technological advancement. The utility of SOFM, vis,à,vis other tools, is highlighted as the size and complexity of the database increase since it can reduce the amount of data by clustering and visualize the reduced data onto a lower,dimensional display simultaneously. Specifically, three types of PM, technology vacuum map, claim point map, technology portfolio map, are suggested. The proposed maps may be used in monitoring technological change, developing new products, and managing intellectual property. [source] Private Gain and Public Pain: Financing American Health CareTHE JOURNAL OF LAW, MEDICINE & ETHICS, Issue 4 2008Bruce Siegel Health care spending comprises about 16% of the total United States gross domestic product and continues to rise. This article examines patterns of health care spending and the factors underlying their proportional growth. We examine the "usual suspects" most frequently cited as drivers of health care costs and explain why these may not be as important as they seem. We suggest that the drive for technological advancement, coupled with the entrepreneurial nature of the health care industry, has produced inherently inequitable and unsustainable health care expenditure and growth patterns. Successful health reform will need to address these factors and their consequences. [source] The World Has Changed,Have Analytical Procedure Practices?CONTEMPORARY ACCOUNTING RESEARCH, Issue 2 2010GREG TROMPETER M1; M42 Analytical Procedures (APs) provide a means for auditors to evaluate the "reasonableness" of financial disclosures by comparing a client's reported performance to expectations gained through knowledge of the client based on past experience and developments within the company and its industry. Thus, APs are fundamentally different than other audit tests in taking a broader perspective of an entity's performance vis-à-vis its environment. As such, APs have been found to be a cost-effective means to detect misstatements, and many have argued that a number of prior financial frauds would have been detected had auditors employed effective APs. With several dramatic and far-reaching developments over the past decade, the current study examines whether and how APs have changed during this period. In particular, we focus on the impact of significant "enablers" and "drivers" of change such as technological advancements and the enactment of the Sarbanes-Oxley Act. We also compare our findings to an influential study of the practices of APs by Hirst and Koonce (1996) that was conducted over 10 years ago. We interview 36 auditors (11 seniors, 13 managers, and 12 partners) from all of the Big 4 firms using a structured questionnaire. The data reveal some similarities in findings when compared to prior research (e.g., auditors continue to use fairly simple analytical procedures). However, there are a number of significant differences reflecting changes in AP practices. For instance, as a result of technology auditors now rely more extensively on industry and analyst data than previously. Further, auditors report that they develop more precise quantitative expectations and use more non-financial information. They also appear to rely more on lower level audit staff to perform APs, conduct greater inquiry of non-accounting personnel, and are willing to reduce substantive testing to a greater extent as a result of APs conducted in the planning phase. Finally, the Sarbanes-Oxley Act has had an impact in greater consideration and knowledge of internal controls, which is seen as the most important factor driving the use and reliance on APs. [source] From age correction to genome-wide associationACTA PSYCHIATRICA SCANDINAVICA, Issue 5 2009S. Cohen-Woods Objective:, Eric Strömgren was one of the pioneers of psychiatric genetics and family studies. There has now been an explosion of interest in this field and research progress, including linkage and association studies, whole genome genotyping, copy number variants and epigenetics is reviewed here. Method:, An overview of this area of psychiatric research is presented and discussed based on the relevant literature aiming at giving a recent status of the progress. Results:, Broadly speaking linkage and association are complementary approaches used to locate genes contributing to the genetic aetiology of psychopathology. Linkage can be detected over comparatively large distances, however power is problematic when searching for quantitative trait loci with small effect sizes. In contrast, association studies can detect small effects but only over very small distances. Therefore, while several genome-wide linkage studies in psychiatric disorders have been performed, the majority of association studies have investigated specific functional candidate genes. Conclusion:, Due to very recent technological advancements, genome-wide association studies have now become possible and have identified some completely novel susceptibility loci. Other recent advances include the discovery of epigenetic phenomena and copy number variants. [source] Monoclonal antibodies: a morphing landscape for therapeuticsDRUG DEVELOPMENT RESEARCH, Issue 10 2006Nicholas C. Nicolaides Abstract The concept of using antibodies as therapeutics to cure human diseases was postulated nearly 100 years ago by Paul Ehrlich and subsequently enabled by the discovery of hybridoma technology by Kohler and Milstein in 1975. While the use of monoclonal antibodies (mAbs) as drugs that can specifically target a disease-associated antigen is compelling, it has taken a quarter century for these molecules to be adopted as bona fide therapeutic agents. Despite their slow pursuit in drug development during the pioneering years, it is now estimated that there are nearly 500 mAb-based therapies in development. Major factors that have influenced the acceptance of monoclonal antibodies as therapeutics include their drug safety profiles, technological advancements for facilitating mAb discovery and development, and market success. Early on, it was demonstrated that antibodies could elicit clinical benefit by antagonizing a specific antigen without the common side effects that are prevalent with small chemical entities due to their nonspecific effects on homeostatic biochemical pathways. In addition, the significant technological advances that the biotechnology industry has established for developing and producing monoclonal antibodies at commercial scale in a more efficient and cost-effective manner has broadly enabled their use as therapeutics. However, despite the beneficial pharmacologic advantages and technological advances, it has been the sheer market success that monoclonal antibody products have achieved over the past few years that has propelled their vast pursuit by the biopharmaceutical industry in light of their value-creating potential. Here we provide an overview of the monoclonal antibody industry and discuss evolving technologies and strategies that are being pursued to overcome challenges in the changing marketplace. Drug Dev. Res. 67:781,789, 2006. © 2007 Wiley-Liss, Inc. [source] Severe Deep Moist Convective Storms: Forecasting and MitigationGEOGRAPHY COMPASS (ELECTRONIC), Issue 1 2008David L. Arnold Small-scale (2,20 km) circulations, termed ,severe deep moist convective storms', account for a disproportionate share of the world's insured weather-related losses. Spatial frequency maximums of severe convective events occur in South Africa, India, Mexico, the Caucasus, and Great Plains/Prairies region of North America, where the maximum tornado frequency occurs east of the Rocky Mountains. Interest in forecasting severe deep moist convective systems, especially those that produce tornadoes, dates to 1884 when tornado alerts were first provided in the central United States. Modern thunderstorm and tornado forecasting relies on technology and theory, but in the post-World War II era interest in forecasting has also been driven by public pressure. The forecasting process begins with a diagnostic analysis, in which the forecaster considers the potential of the atmospheric environment to produce severe convective storms (which requires knowledge of the evolving kinematic and thermodynamic fields, and the character of the land surface over which the storms will pass), and the likely character of the storms that may develop. Improvements in forecasting will likely depend on technological advancements, such as the development of phased-array radar systems and finer resolution numerical weather prediction models. Once initiated, the evolution of deep convective storms is monitored by satellite and radar. Mitigation of the hazards posed by severe deep moist convective storms is a three-step process, involving preparedness, response, and recovery. Preparedness implies that risks have been identified and organizations and individuals are familiar with a response plan. Response necessitates that potential events are identified before they occur and the developing threat is communicated to the public. Recovery is a function of the awareness of local, regional, and even national governments to the character and magnitude of potential events in specific locations, and whether or not long-term operational plans are in place at the time of disasters. [source] Processing of Bulk Metallic GlassADVANCED MATERIALS, Issue 14 2010Jan Schroers Abstract Bulk metallic glass (BMG) formers are multicomponent alloys that vitrify with remarkable ease during solidification. Technological interest in these materials has been generated by their unique properties, which often surpass those of conventional structural materials. The metastable nature of BMGs, however, has imposed a barrier to broad commercial adoption, particularly where the processing requirements of these alloys conflict with conventional metal processing methods. Research on the crystallization of BMG formers has uncovered novel thermoplastic forming (TPF)-based processing opportunities. Unique among metal processing methods, TPF utilizes the dramatic softening exhibited by a BMG as it approaches its glass-transition temperature and decouples the rapid cooling required to form a glass from the forming step. This article reviews crystallization processes in BMG former and summarizes and compares TPF-based processing methods. Finally, an assessment of scientific and technological advancements required for broader commercial utilization of BMGs will be made. [source] Phospho-proteomic immune analysis by flow cytometry: from mechanism to translational medicine at the single-cell levelIMMUNOLOGICAL REVIEWS, Issue 1 2006Omar D. Perez Summary:, Understanding a molecular basis for cellular function is a common goal of biomedicine. The complex and dynamic cellular processes underlying physiological processes become subtly or grossly perturbed in human disease. A primary objective is to demystify this complexity by creating and establishing relevant model systems to study important aspects of human disease. Although significant technological advancements over the last decade in both genomic and proteomic arenas have enabled progress, accessing the complexity of cellular interactions that occur in vivo has been a difficult arena in which to make progress. Moreover, there are extensive challenges in translating research tools to clinical applications. Flow cytometry, over the course of the last 40 years, has revolutionized the field of immunology, in both the basic science and clinical settings, as well as having been instrumental to new and exciting areas of discovery such as stem cell biology. Multiparameter machinery and systems exist now to access the heterogeneity of cellular subsets and enable phenotypic characterization and functional assays to be performed on material from both animal models and humans. This review focuses primarily on the development and application of using activation-state readouts of intracellular activity for phospho-epitopes. We present recent work on how a flow cytometric platform is used to obtain mechanistic insight into cellular processes as well as highlight the clinical applications that our laboratory has explored. Furthermore, this review discusses the challenges faced with processing high-content multidimensional and multivariate data sets. Flow cytometry, as a platform that is well situated in both the research and clinical settings, can contribute to drug discovery as well as having utility for both biomarker and patient-stratification. [source] Impact of interviewing by proxy in travel survey conducted by telephoneJOURNAL OF ADVANCED TRANSPORTATION, Issue 1 2002Daniel A. Badoe Telephone-interview surveys are a very efficient way of conducting large-scale travel surveys. Recent advancements in computer technology have made it possible to improve upon the quality of data collected by telephone surveys through computerization of the entire sample-control process, and through the direct recording of the collected data into a computer. Notwithstanding these technological advancements, potential sources of bias still exist, including the reliance on an adult member of the household to report the travel information of other household members. Travel data collected in a recent telephone interview survey in the Toronto region is used to examine this issue. The statistical tool used in the research was the Analysis of Variance (ANOVA) technique as implemented within the general linear model framework in SAS. The study-results indicate that reliance on informants to provide travel information for non-informant members of their respective households led to the underreporting of some categories of trips. These underreported trip categories were primarily segments of home-based discretionary trips, and non home-based trips. Since these latter two categories of trips are made primarily outside the morning peak period, estimated factors to adjust for their underreporting were time-period sensitive. Further, the number of vehicles available to the household, gender, and driver license status respectively were also found to be strongly associated with the underreporting of trips and thus were important considerations in the determination of adjustment factors. Work and school trips were found not to be underreported, a not surprising result giving the almost daily repetitiveness of trips made for these purposes and hence the ability of the informant to provide relatively more precise information on them. [source] Mechanical Circulatory Support for AMI and Cardiogenic ShockJOURNAL OF CARDIAC SURGERY, Issue 4 2010Yasir Abu-Omar D.Phil. The dismal prognosis associated with post-MI cardiogenic shock, allied with surgical and technological advancements, has shifted the treatment paradigm toward wider use of mechanical circulatory support devices (MCSD). Current experience demonstrates that better outcomes may be achieved with early MCSD deployment (prior to the onset of end-organ dysfunction). However, perceived limitations with existing devices mean that they remain infrequently applied. There is an urgent need for increased awareness of MCSD options among clinicians treating post-MI shock patients. (J Card Surg 2010;25:434-441) [source] Mitochondrial DNA mutations as a fundamental mechanism in physiological declines associated with agingAGING CELL, Issue 1 2003Jeong W. Pak Summary The hypothesis that mitochondrial DNA damage accumulates and contributes to aging was proposed decades ago. Only recently have technological advancements, which facilitate microanalysis of single cells or portions of cells, revealed that mtDNA deletion mutations and, perhaps, single nucleotide mutations accumulate to physiologically relevant levels in the tissues of various species with age. Although a link between single nucleotide mutations and physiological consequences in aging tissue has not been established, the accumulation of deletion mutations in skeletal muscle fibres has been associated with sarcopenia. Different, and apparently random, deletion mutations are specific to individual fibres. However, the mtDNA deletion mutation within a phenotypically abnormal region of a fibre is the same, suggesting a selection, amplification and clonal expansion of the initial deletion mutation. mtDNA deletion mutations within a muscle fibre are associated with specific electron transport system abnormalities, muscle fibre atrophy and fibre breakage. These data point to a causal relationship between mitochondrial DNA mutations and the age-related loss of muscle mass. [source] Molecular marker systems in insects: current trends and future avenuesMOLECULAR ECOLOGY, Issue 11 2006SUSANTA K. BEHURA Abstract Insects comprise the largest species composition in the entire animal kingdom and possess a vast undiscovered genetic diversity and gene pool that can be better explored using molecular marker techniques. Current trends of application of DNA marker techniques in diverse domains of insect ecological studies show that mitochondrial DNA (mtDNA), microsatellites, random amplified polymorphic DNA (RAPD), expressed sequence tags (EST) and amplified fragment length polymorphism (AFLP) markers have contributed significantly for progresses towards understanding genetic basis of insect diversity and for mapping medically and agriculturally important genes and quantitative trait loci in insect pests. Apart from these popular marker systems, other novel approaches including transposon display, sequence-specific amplification polymorphism (S-SAP), repeat-associated polymerase chain reaction (PCR) markers have been identified as alternate marker systems in insect studies. Besides, whole genome microarray and single nucleotide polymorphism (SNP) assays are becoming more popular to screen genome-wide polymorphisms in fast and cost effective manner. However, use of such methodologies has not gained widespread popularity in entomological studies. The current study highlights the recent trends of applications of molecular markers in insect studies and explores the technological advancements in molecular marker tools and modern high throughput genotyping methodologies that may be applied in entomological researches for better understanding of insect ecology at molecular level. [source] Product ion mass spectra of amphetamine-type substances, designer analogues, and ketamine using ultra-performance liquid chromatography/tandem mass spectrometry,RAPID COMMUNICATIONS IN MASS SPECTROMETRY, Issue 15 2006Luigino G. Apollonio This paper describes the application of ultra-performance liquid chromatography/tandem mass spectrometry (UPLC/MS/MS) technology to separate and identify amphetamine-type substances (amphetamine, methamphetamine), common and novel designer analogues (MDA, MDMA, PMA, 4-MTA, MBDB), and ketamine using Acquity UPLC/Micromass Quattro Micro API mass spectrometer instrumentation (Waters Corporation, USA). From injection of drug reference standards, it was demonstrated that these compounds can be identified by product ion mass spectra in less than 4,min total analysis time, indicating that the technological advancements associated with UPLC/MS/MS allow it to serve as a powerful analytical tool for high-throughput testing. In addition to demonstrating the separation and response of these drug compounds under the stated UPLC/MS/MS conditions, we believe the acquired product ion spectra will be a beneficial reference to laboratories interested in incorporating the use of this technology in the routine analysis of drugs of abuse. Copyright © 2006 John Wiley & Sons, Ltd. [source] Forty-five years in climatology,a personal odysseyTHE CANADIAN GEOGRAPHER/LE GEOGRAPHE CANADIEN, Issue 1 2008WAYNE R. ROUSE This article presents a personal perspective on an academic and research vocation spanning a period of over 45 years. It starts with my early involvement in geography and climatology and terminates with my recent experience in a large interdisciplinary research venture. The presentation highlights, with specific examples, the importance of mentors. Also emphasized is the indispensable input of colleagues and graduate students to successful research endeavours. Most of my career has been centred on McMaster University, and I naturally draw on my experiences there. There have been great changes in the research world over the past few decades. Although the number of faculty and graduate students at McMaster remained relatively constant, the research output per person more than doubled. This is attributed in large part to the accelerating technological advancements in our ability to measure and our ability to process and manipulate data. In the environmental sciences, this has revolutionized the spatial and temporal scope of the scientific questions that can be addressed. Such major changes have stimulated a marked trend towards interdisciplinary research that has evolved from mainly wishful talking to active pursuit in a search to understand complex environmental interactions. Important among these is gaining insights into the processes and feedbacks driving climate change, whether natural or anthropologically induced. Equally important is gaining an understanding of the potential impacts resulting from climate change. My perception of my successes, failures and near misses divides chronologically into three periods that cover research in the early years, research in the central subarctic and research in the Mackenzie River Basin. Quarante-cinq ans en climatologie , une odyssée personnelle Cet article propose un regard personnel sur une carrière universitaire et en recherche échelonnée sur plus de 45 ans, de mes premières contributions à la géographie et la climatologie à mes expériences actuelles au sein d'un projet de recherche interdisciplinaire. L'importance du rôle des mentors est illustrée par des exemples. Le concours indispensable apporté par les collègues et les étudiants des cycles supérieurs au succès des démarches de recherche est également souligné. La majeure partie de mes expériences professionnelles s'est déroulée à l'université McMaster et c'est pourquoi il est naturel pour moi d'y faire référence. De grands changements ont bouleversé le monde de la recherche depuis quelques décennies. Malgré le fait que le nombre de professeurs et d'étudiants des cycles supérieurs soit demeuré relativement stable, la publication de résultats de recherche par personne a plus que doublé. Ceci est attribuable en grande partie au développement rapide des technologies qui nous permettent d'évaluer, de traiter et de manipuler les données. Nous assistons donc à une révolution dans le domaine des sciences environnementales au niveau des dimensions spatiales et temporelles des questions scientifiques que nous pouvons aborder. Ces changements d'envergure alimentent une tendance nette en faveur de la recherche interdisciplinaire qui a évolué d'un v,u pieux à une entreprise active visant à comprendre les interactions environnementales d'un haut niveau de complexité. Il est essentiel de mieux prendre conscience des processus et rétroactions qui interviennent dans les changements climatiques naturels ou d'origine anthropiques. Il est aussi très important de mieux comprendre les effets induits par les changements climatiques. Ma manière de percevoir mes réussites, échecs et quasi-succès se divise chronologiquement en trois époques: les recherches durant les premières années, les recherches menées dans le subarctique, et les recherches sur le bassin du fleuve Mackenzie. [source] Oral antiplatelet therapy in PCI patients,CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS, Issue S1 2010Samin K. Sharma MD Abstract The use of percutaneous coronary intervention (PCI) in the treatment of obstructive coronary artery disease has expanded rapidly in the past decade. Despite the extensive technological advancements in the field, pharmacotherapy has remained a cornerstone in the overall treatment strategy. Oral antiplatelet therapy has become an essential component of therapy with acute coronary syndromes and in PCI by improving clinical outcomes. This article reviews the antiplatelet options for patients undergoing PCI, including aspirin, ADP receptor blockers, and glycoprotein IIb/IIIa inhibitors. © 2010 Wiley-Liss, Inc. [source] Digital image analysis of plus disease in retinopathy of prematurityACTA OPHTHALMOLOGICA, Issue 4 2009Tariq Aslam Abstract. An accurate assessment of retinopathy of prematurity (ROP) is essential in ensuring correct and timely treatment of this potentially blinding condition. Current modes of assessment are based upon clinical grading by expert examination of retinal changes. However, this may be subjective, unreliable and difficult and there has been significant interest in alternative means of measurement. These have been made possible through technological advancements in image capture and analysis as well as progress in clinical research, highlighting the specific importance of plus disease in ROP. Progress in these two fields has highlighted the potential for digital image analysis of plus disease to be used as an objective, reliable and valid measurement of ROP. The potential for clinical and scientific advancement through this method is argued and demonstrated in this article. Along with the potential benefits, there are significant challenges such as in image capture, segmentation, measurement of vessel width and tortuosity; these are also addressed. After discussing and explaining the challenges involved, the research articles addressing digital image analysis of ROP are critically reviewed. Benefits and limitations of the currently published techniques for digital ROP assessment are discussed with particular reference to the validity and reliability of outcome measures. Finally, the general limitations of current methods of analysis are discussed and more diverse potential areas of development are discussed. [source] | |||||||||||||||||||||||||