Home About us Contact
|
Home About us Contact | ||
|
|
||
Technical Information (technical + information)
Selected AbstractsA Systematic Approach for Scale-Down Model Development and Characterization of Commercial Cell Culture ProcessesBIOTECHNOLOGY PROGRESS, Issue 3 2006Feng Li The objective of process characterization is to demonstrate robustness of manufacturing processes by understanding the relationship between key operating parameters and final performance. Technical information from the characterization study is important for subsequent process validation, and this has become a regulatory expectation in recent years. Since performing the study at the manufacturing scale is not practically feasible, development of scale-down models that represent the performance of the commercial process is essential to achieve reliable process characterization. In this study, we describe a systematic approach to develop a bioreactor scale-down model and to characterize a cell culture process for recombinant protein production in CHO cells. First, a scale-down model using 2-L bioreactors was developed on the basis of the 2000-L commercial scale process. Profiles of cell growth, productivity, product quality, culture environments (pH, DO, pCO2), and level of metabolites (glucose, glutamine, lactate, ammonia) were compared between the two scales to qualify the scale-down model. The key operating parameters were then characterized in single-parameter ranging studies and an interaction study using this scale-down model. Appropriate operation ranges and acceptance criteria for certain key parameters were determined to ensure the success of process validation and the process performance consistency. The process worst-case condition was also identified through the interaction study. [source] Evaluation of the knowledge of the treatment of avulsions in elementary school teachers in Rio de Janeiro, BrazilDENTAL TRAUMATOLOGY, Issue 2 2003Luciana Fernandes Pacheco Abstract ,,,Avulsions are very common in a school setting. Teachers are often requested to help in such emergency situations. A survey consisting of seven simple questions regarding dental avulsion was answered by 60 teachers from five different elementary schools in Rio de Janeiro, Brazil, in order to evaluate their knowledge on the subject and establish a guideline to be followed when an accident of this type happens. A lack of technical information was observed among the teachers; most of them answered intuitively rather than on an informative basis. This study showed the need of a more effective communication between dental professionals and school teachers in order to better handle dental emergencies. [source] A Model Food Entrepreneur Assistance and Education Program: The Northeast Center for Food EntrepreneurshipJOURNAL OF FOOD SCIENCE EDUCATION, Issue 4 2005Michele R. Cranwell ABSTRACT: The Northeast Center for Food Entrepreneurship (NECFE) is a collaborative effort between Cornell Univ. and the Univ. of Vermont. NECFE uses a multi-institutional and regional collaboration approach, with specific expertise and necessary facilities and resources, to provide technical assistance and education for businesses in the food industry. The overall goals of NECFE are to support and sustain rural businesses and promote sustainable economic development of rural communities. Through process evaluation techniques, the evaluators of NECFE identified 5 essential components of a model food entrepreneurship assistance and education center, based on NECFE's experience: (1) multi-institutional and regional collaboration, (2) expertise, (3) facilities and resources, (4) services, and (5) evaluation of the center. These components build on each other and enable NECFE to provide clients with access to current food processing technology, technical information, and education that are directly applicable to a real business. Through replication of this model, other organizations and academic institutions may establish a regional food entrepreneurship assistance and education center. [source] Evaluation of the performance of iron-based oxygen scavengers, with comments on their optimal applicationsPACKAGING TECHNOLOGY AND SCIENCE, Issue 1 2005Joseph Miltz Abstract Oxygen scavengers are commonly used in packaged foods in Japan and much less so in other developed countries, in spite of the advantages that they offer in maintaining quality and extending shelf-life. The reason stems from the additional cost involved, and even more so because of the lack of sufficient technical information on their performance and the lack of understanding of how to apply them effectively. In the present study the performance of iron-based oxygen-scavenging sachets was evaluated. It was found that the actual scavenging capacity is much higher than the ,nominal' capacity provided by the manufacturers. Also, a significant distribution in the oxygen absorption capacity exists, even in the same scavenger type. The rate of oxygen scavenging was found to depend on the scavenger type and capacity. It was also found that in an atmosphere containing CO2 (as in MAP applications) the iron-based oxygen scavengers also absorb CO2. Copyright © 2004 John Wiley & Sons, Ltd. [source] Superfund cleanup: Designing containment remedies for recreational reuseREMEDIATION, Issue 2 2000Joseph D. King In July, 1999, EPA announced its Superfund Redevelopment Initiative, the Agency's effort to help communities bring Superfund sites back into productive use in a manner that is protective of human health and the environment. As part of the Superfund Redevelopment Initiative, the Agency is developing reuse design guides that provide technical information related to the design of remedies that safely support reuse. The design guides focus on the reuse of containment sites, and address such topics as settlement, gas control, irrigation, drainage, and operation and maintenance. Case studies of redeveloped sites are also presented in the guides. EPA is currently developing design guides that address the reuse of Superfund sites for commercial purposes, wildlife areas, parking lots, recreational sports fields, and golf courses. This article provides information on the first guide in the series-the reuse of Superfund sites for recreational purposes. [source] Manganese Black Pigments in Prehistoric Paintings: the Case of the Black Frieze of Pech Merle (France)ARCHAEOMETRY, Issue 2 2001B. Guineau Different black pigments of natural origin (mineral or organic) have been examined by means of several analytical methods (colour measurements, elemental analysis and structural analysis). The results, after being compared with each other, then served as reference points in the study of the ,Black Frieze' of the cave of Pech Merle (Lot). After that, colour measurement was investigated in situ on the paintings as a means of displaying small differences (in hue or chroma) between the black colours. The aim of this study was to verify several hypotheses concerning the techniques used by the painters of Pech Merle, and specifically by the one(s) of the Black Frieze. A first objective was that of identifying the nature and, if possible, the origin of the black pigments used in these figures. A second objective was that of determining in which parts of the frieze one or the other (or one and the other) had been used; and the final objective was to provide new technical information that might help us better to understand how the Pech Merle frieze was produced, whether by a single painter and in one episode, for the most part, or, on the contrary, in several episodes and by a succession of different painters. [source] Australia's National Action Plan for Salinity and Water Quality: a retrospective assessment,AUSTRALIAN JOURNAL OF AGRICULTURAL & RESOURCE ECONOMICS, Issue 4 2010David J. Pannell Perceptions of a salinity ,crisis' in Australia around 2000 resulted in the establishment of a major national program that aimed to prevent, stabilize, and reverse trends in salinity. The National Action Plan for Salinity and Water Quality allocated A$1.4 billion of public funds to 1700 projects over 7 years. Here, we assess the performance of the program in relation to 12 features that we propose as being essential for programs that aim to address complex environmental problems. The features include use of technical information to guide investment prioritization, use of socio-economic information, effective integration of information for prioritization, selection of appropriate targets, choice of appropriate policy mechanisms, and provision of incentives and support to environmental managers to pursue environmental outcomes cost effectively. Our assessment reinforces findings from a number of public reviews that found serious weaknesses in the program. Overall, with a few exceptions, projects under the National Action Plan generated few worthwhile salinity mitigation benefits and will have little enduring benefit. This was readily foreseeable given attention to the scientific and economic knowledge of salinity available at the time the program was developed. [source] Effects of alternative styles of risk information on EMF risk perceptionBIOELECTROMAGNETICS, Issue 7 2010Jesper Bo Nielsen Abstract Risk scenarios characterized by exposures to new technologies with unknown health effects, together with limited appreciation of benefits pose a challenge to risk communication. The present report illustrates this situation through a study of the perceived risk from mobile phones and mobile masts in residential areas. Good information should objectively convey the current state of knowledge. The research question is then how to inform lay people so that they trust and understand the information. We used an Internet-based survey with 1687 Danish participants randomized to three types of information about radiation from mobile phones and masts. The objective was to study whether different types of information were rated as equally useful, informative, comprehensible, and trustworthy. Moreover, an important issue was whether information would influence risk perception and intended behavior. The conclusion is that lay people rate information about risks associated with a new and largely unknown technology more useful and trustworthy when provided with brief statements about how to handle the risk, rather than more lengthy technical information about why the technology may or may not entail health hazards. Further, the results demonstrate that information may increase concern among a large proportion of the population, and that discrepancies exist between expressed concern and intended behavior. Bioelectromagnetics 31:504,512, 2010. © 2010 Wiley-Liss, Inc. [source] Recent advances in pharmacokinetic modelingBIOPHARMACEUTICS AND DRUG DISPOSITION, Issue 3 2007Alaa M. Ahmad Abstract A major part of the science of pharmacokinetics is the modeling of the underlying processes that contribute to drug disposition. The purpose of pharmacokinetic models is to summarize the knowledge gained in preclinical and clinical studies at various stages in drug development and to rationally guide future studies with the use of adequately predictive models. This review highlights a variety of recent advances in mechanistic pharmacokinetic modeling. It is aimed at a broad audience, and hence, an attempt was made to maintain a balance between technical information and practical applications of pharmacokinetic modeling. It is hoped that drug researchers from all disciplines would be able to get a flavor of the function and capacity of pharmacokinetic modelers and their contribution to drug development. While this review is not intended to be a technical reference on modeling approaches, the roles of statistical applications and population methodologies are discussed where appropriate. Copyright © 2007 John Wiley & Sons, Ltd. [source] | ||||||||||||||||