Barbituric Acid Derivatives (barbituric + acid_derivative)

Distribution by Scientific Domains


Selected Abstracts


Benzothiazole Incorporated Barbituric Acid Derivatives: Synthesis and Anticonvulsant Screening

ARCHIV DER PHARMAZIE, Issue 8 2009
Nadeem Siddiqui
Abstract A series of 1-(6-substituted-1,3-benzothiazol-2-yl)-3-(substituted phenyl)hexahydro-2,4,6-pyrimidinetriones 4a,t were synthesized starting from substituted anilines. These compounds contained two active anticonvulsant pharmacophores, benzothiazole and barbituric acid. Structures of the compounds were confirmed on the basis of different spectroscopic techniques. All the compounds were evaluated for their anticonvulsant activity. Three compounds 4c, 4d, and 4s showed promising anticonvulsant activities in Maximal Electroshock Seizure test (MES) and subcutaneous pentylenetetrazole test (scPTZ). They also displayed a wide safety profile when tested for the minimal motor impairment test. [source]


ChemInform Abstract: Synthesis of a Series of Perfluoroalkyl Containing Sprio Cyclic Barbituric Acid Derivatives.

CHEMINFORM, Issue 46 2009
Shunli Zhang
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source]


ChemInform Abstract: Remarkable Solvent Effect on Pd(0)-Catalyzed Deprotection of Allyl Ethers Using Barbituric Acid Derivatives: Application to Selective and Successive Removal of Allyl, Methallyl, and Prenyl Ethers.

CHEMINFORM, Issue 18 2008
Hirokazu Tsukamoto
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source]


Parahydrogen induced polarization of barbituric acid derivatives: 1H hyperpolarization studies

MAGNETIC RESONANCE IN CHEMISTRY, Issue 8 2008
Meike Roth
Abstract Homogeneous hydrogenation of barbituric acid derivatives with parahydrogen yields a substantial increase of the 1H NMR signals of the reaction products. These physiologically relevant compounds were hydrogenated at both ambient and elevated temperatures and pressures using a standard cationic rhodium catalyst. The resulting nonthermal nuclear spin polarization (hyperpolarization) is limited by the spin,lattice relaxation time T1 of the corresponding nuclei in the products, being shorter than the time constant of the hydrogenation. The signal-to-noise ratio of the NMR spectra could be further increased upon signal averaging the antiphase PHIP signals of 25 successive scans following 30 pulse experiments and a delay of 10 s. Copyright 2008 John Wiley & Sons, Ltd. [source]