			Home About us Contact

Systemic Challenges (systemic + challenge)

Distribution by Scientific Domains

Medical Sciences	40%

Selected Abstracts

The adhesion receptor CD155 determines the magnitude of humoral immune responses against orally ingested antigens

EUROPEAN JOURNAL OF IMMUNOLOGY, Issue 8 2007
Michael
Abstract CD155, originally known as the cellular receptor for poliovirus, is the founding member of a subfamily of immunoglobulin-like adhesion receptors. Apart from its function in establishing adherens junctions between contacting epithelial cells, the engagement of CD155 with two recently identified ligands, CD226 and CD96, mediates immunologically relevant processes such as NK cell-driven killing of tumor cells in humans. Here we report on the generation and immunological analysis of mice constitutively deficient of CD155. Moreover, the expression profile of CD155 on hematopoietic cells has been determined using newly established antibodies. CD155-deficient mice develop normally without displaying an overt phenotype. However, the animals are distinguished by distinct deficits in the development of a regular humoral immune response. Whereas systemic challenges revealed no differences, orally administered antigen evoked less efficient IgG and IgA antibody responses despite of normal IgM titers when compared to wild-type mice. Therefore, CD155 may assist in an efficient humoral immune response generated within the intestinal immune system. [source]

A CASE FOR REFORM OF THE CHILD WELFARE SYSTEM

FAMILY COURT REVIEW, Issue 4 2007
Miriam Aroni Krinsky
There are more than half a million children in our nation's foster care system. While foster care is intended to provide a temporary safe harbor for abused and neglected children, too many of these youth spend years in foster care limbo,experiencing a turbulent life in motion as they move from placement to placement, community to community, and school to school. Youth in foster care commonly fail to receive basic health and psychological care, and nearly 20,000 youth age out of foster care every year to an adult path of homelessness, unemployment, and despair. Our entire community must work together to more responsibly parent these youth. This article will address how lawyers and child advocates can advocate for new approaches and enhanced support on behalf of the voiceless and most vulnerable members of our community. It will address existing hurdles and systemic challenges that have helped to create the current disheartening status quo. The article will then discuss strategies that advocates can employ to turn the corner on behalf of these youth at risk. [source]

Identifying challenges in supervising school psychologists,

PSYCHOLOGY IN THE SCHOOLS, Issue 6 2010
Virginia Smith Harvey
Previous studies suggest that the majority of school psychologists do not believe they receive sufficient supervision, despite a growing body of research providing empirical support for supervision to maintain and improve skills. This study explores the dynamics underlying the challenges of providing adequate supervision to school psychologists. Findings suggest that supervision of school psychologists is characterized by challenges that extend beyond the traditional demarcations of clinical and administrative supervision typical in clinical settings. Supervisors of school psychologists encounter systemic challenges, unique to school settings, which must be addressed for their supervisees to be able to function successfully. The findings suggest that a clinical,administrative,systemic model of supervision is most appropriate in the supervision of school psychologists. © 2010 Wiley Periodicals, Inc. [source]

Simulated reflux decreases vocal fold epithelial barrier resistance,,

THE LARYNGOSCOPE, Issue 8 2010
CF-SLP, Elizabeth Erickson MS
Abstract Objectives/Hypothesis: The vocal fold epithelium provides a barrier to the entry of inhaled and systemic challenges. However, the location of the epithelium makes it vulnerable to damage. Past research suggests, but does not directly demonstrate, that exposure to gastric reflux adversely affects the function of the epithelial barrier. Understanding the nature of reflux-induced epithelial barrier dysfunction is necessary to better recognize the mechanisms for vocal fold susceptibility to this disease. Therefore, we examined the effects of physiologically relevant reflux challenges on vocal fold transepithelial resistance and gross epithelial and subepithelial appearance. Study Design: Ex vivo, mixed design with between-group and repeated-measures analyses. Methods: Healthy, native porcine vocal folds (N = 52) were exposed to physiologically relevant acidic pepsin, acid-only, or pepsin-only challenges and examined with electrophysiology and light microscopy. For all challenges, vocal folds exposed to a neutral pH served as control. Results: Acidic pepsin and acid-only challenges, but not pepsin-only or control challenges significantly reduced transepithelial resistance within 30 minutes. Reductions in transepithelial resistance were irreversible. Challenge exposure produced minimal gross changes in vocal fold epithelial or subepithelial appearance as evidenced by light microscopy. Conclusions: These findings demonstrate that acidic environments characteristic of gastric reflux compromise epithelial barrier function without gross structural changes. In healthy, native vocal folds, reductions in transepithelial resistance could reflect reflux-related epithelial disruption. These results might guide the development of pharmacologic and therapeutic recommendations for patients with reflux, such as continued acid-suppression therapy and patient antireflux behavioral education. Laryngoscope, 2010 [source]

Creating Conditions for Success Beyond the Professional Training Environment

CLINICAL PSYCHOLOGY: SCIENCE AND PRACTICE, Issue 1 2010
Matthew R. Sanders
[Clin Psychol Sci Prac 17: 31,35, 2010] The systems-contextual approach to training of service providers to deliver evidence-based practices provides a useful framework for considering the broader ecological context within providers' work, including organizational, training, program design, supervision, and funding variables. Our experience of disseminating on a large scale an evidence-based system of parenting interventions is used to highlight the major organizational, structural, and systemic challenges that need to be addressed to ensure that programs are effectively used within service delivery systems. Solutions to these challenges and implications for policy and practice are discussed. [source]