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Systematic Research (systematic + research)
Kinds of Systematic Research Selected AbstractsPerformance and effectiveness trade-off for checkpointing in fault-tolerant distributed systemsCONCURRENCY AND COMPUTATION: PRACTICE & EXPERIENCE, Issue 1 2007Panagiotis Katsaros Abstract Checkpointing has a crucial impact on systems' performance and fault-tolerance effectiveness: excessive checkpointing results in performance degradation, while deficient checkpointing incurs expensive recovery. In distributed systems with independent checkpoint activities there is no easy way to determine checkpoint frequencies optimizing response-time and fault-tolerance costs at the same time. The purpose of this paper is to investigate the potentialities of a statistical decision-making procedure. We adopt a simulation-based approach for obtaining performance metrics that are afterwards used for determining a trade-off between checkpoint interval reductions and efficiency in performance. Statistical methodology including experimental design, regression analysis and optimization provides us with the framework for comparing configurations, which use possibly different fault-tolerance mechanisms (replication-based or message-logging-based). Systematic research also allows us to take into account additional design factors, such as load balancing. The method is described in terms of a standardized object replication model (OMG FT-CORBA), but it could also be applied in other (e.g. process-based) computational models. Copyright © 2006 John Wiley & Sons, Ltd. [source] Oestrogen withdrawal associated psychosesACTA PSYCHIATRICA SCANDINAVICA, Issue 5 2001V. Mahé Objective: Oestrogen withdrawal has been hypothesized as playing a causal role in puerperal psychoses. However, oestrogen withdrawal exists in conditions others than puerperium. We searched the published case reports where a decrease in oestrogen levels not occurring during puerperium was associated with a psychotic disorder, in order to evaluate the relevance of this hypothesis. These cases were defined as oestrogen withdrawal associated psychoses. Method: A systematic research of the literature was conducted for the period 1960,2000. Results: We identified 26 observations reporting an association between a psychotic disorder and a phase of oestrogen withdrawal. Psychotic episodes were short and reversible with recurrences reported when oestrogen withdrawal recurred. Puerperal psychosis was frequently reported in the history of patients. Conclusion: The oestrogen withdrawal hypothesis can be extended to certain psychotic episodes not occurring during in puerperium. This provides an additional argument for the clinical relevance of oestrogen withdrawal in puerperal and related psychoses. [source] All-cause mortality and fatal alcohol poisoning in Belarus, 1970,2005DRUG AND ALCOHOL REVIEW, Issue 5 2008YURY E. RAZVODOVSKY Abstract Introduction and Aims. Although alcohol appears to be an important contributor to the burden of disease in the countries of eastern Europe, little systematic research has been undertaken on its impact on mortality in the former Soviet republic of Belarus. There may be a number of factors underlying the particularly negative effect of alcohol on mortality in Belarus, including the pattern of drinking and use of surrogates. A solid body of research and empirical evidence suggests that hazardous patterns of alcohol consumption (binge drinking) lead to quicker and deeper intoxication, increasing the propensity for alcohol-related mortality. Design and Method. To estimate the aggregate level effect of binge drinking on the all-cause mortality rate, trends in the all-cause mortality and fatal alcohol poisoning rates (as a proxy for binge drinking) in Belarus from 1970 to 2005 were analysed employing AutoRegressive Integrated Moving Average (ARIMA) time,series analysis in order to assess a bivariate relationship between the two time,series. Results. The results of time,series analysis suggest a close relationship between all-cause mortality and fatal alcohol poisoning rates at the population level. Conclusions. This study supports the hypothesis that alcohol and all-cause mortality are connected closely in countries where the drinking culture is characterised by heavy drinking episodes and adds to the growing body of evidence that a substantial proportion of total mortality in Belarus is due to acute effects of binge drinking. [source] The European Court, National Judges, and Legal Integration: A Researcher's Guide to the Data Set on Preliminary References in EC Law, 1958--98EUROPEAN LAW JOURNAL, Issue 2 2000Alec Stone Sweet We hope to stimulate more systematic research on all areas of legal integration by making available for free and open use a comprehensive data base on preliminary references in EC law. The Data Set, which has been under construction since 1996, is now online at various websites. The data are not publicly accessible elsewhere. In this article, we provide a brief summary of the data base and its potential uses. We begin by introducing the main features of the Data Set. We then discuss some of the dynamics of legal integration in light of our analyses of the data. [source] Impacts of long-term changes in fishery management on the trophic level water quality in Czech fish pondsFISHERIES MANAGEMENT & ECOLOGY, Issue 1-2 2000L. Pechar The management of Czech fish ponds changed little from the Middle Ages until the end of the nineteenth century. The intensification of fish production was initiated during the first half of the twentieth century. During the 1930s, liming and manuring of the ponds became common. A greater density of stocking led to the use of artificial feeds in the form of pellets and grain. These changes in pond management have led to an increase in fish production from ,,50 to >,500 kg ha,1 year,1 over the last 5 decades. At the same time, the quality of the water and sediments has been deteriorating, and the functioning of the pond ecosystem has been disturbed. There are now massive blooms of phytoplankton, especially cyanobacteria, accompanied by great fluctuations in the oxygen concentration and pH. Data collected since 1925, when systematic research on the ponds started, allow the mechanisms responsible for the changes to be traced. [source] Evolution of Permanent Deformations (or Memory) in Nafion 117 Membranes with Changes in Temperature, Relative Humidity and Time, and Its Importance in the Development of Medium Temperature PEMFCs,FUEL CELLS, Issue 4 2009G. Alberti Abstract An important problem for medium temperature polymer electrolyte fuel cells (MT PEMFCs) operating in the temperature range 90,140,°C is the short time-life of proton conducting membranes. To shed some light on the empirical annealing treatments used for increasing the membrane durability, a systematic research on the effects of thermal treatments of Nafion 117 membranes was undertaken with the hope that the information obtained could be useful for a better understanding of the real limits for MT PEMFCs. Kinetic experiments showed that, for each couple of T,RH values, the water taken up from the membrane reaches a constant value only after long times of equilibration (,200,h). Taking into account that the enlargements provoked by the water-uptake remain as permanent deformations when the samples are cooled, it was found that the evolution of the deformations provoked by changes in temperature and RH can be conveniently estimated at 20,°C by determining the water taken up after equilibration in liquid water. By relating the counter-elastic index of the matrix (nc(m)) to the extent of these deformations, a set of equations were obtained which allowed us to predict their evolution with changes of temperature and relative humidity. A good agreement with experimental values was found. The importance of this discovery for the development of MT PEMFCs is discussed. [source] The cost effectiveness of specialised facilities for service users with persistent challenging behavioursHEALTH & SOCIAL CARE IN THE COMMUNITY, Issue 6 2001Angela Hallam MSc Abstract Little systematic research relates specifically to the last people to leave a psychiatric hospital at the end of a closure programme. The long-running evaluation of the reprovision of services from Friern Hospital in North London allowed a special study to be made of such a group (67 people in all), whose range of problem behaviours made placement in community settings most difficult. The patients were relatively young, with a shorter length of stay than the remainder of the former long-stay hospital population. They were assessed three times: before leaving Friern, and one and 5 years after relocation. The social and clinical characteristics of each person were measured, and the full costs of their care calculated. The ,difficult-to-place' patients moved to four highly staffed rehabilitation facilities, where the total cost of their care was, on average, £1230 per week. There was no overall change in their psychiatric state over the 5 years after they left Friern Hospital although, in the longer-term, they gained skills in several areas of daily functioning. Most importantly, there was a fall of almost 50% in the number of challenging behaviours exhibited by the study group. At the five-year follow-up point, the cost of care had fallen, on average, by £170 per week, and 24 people had been able to move to more independent accommodation arrangements. Study participants had gained a new network of community service contacts, and used services provided by a greater variety of agencies. The indicators suggest that high expenditure on alternative care was justified retrospectively by overall long-term outcomes. An important policy lesson from the Friern Hospital reprovision study is that adequate funds should be reserved until the end of the closure programme to allow the investment of resources in provision for patients with the most severe problem behaviours. [source] Family-based treatment of eating disordersINTERNATIONAL JOURNAL OF EATING DISORDERS, Issue S1 2005James Lock MD Abstract The current article provides a brief description of the theory and empirical support for family treatment of eating disorders. The main literature related to family treatment for anorexia nervosa (AN) and bulimia nervosa (BN) is reviewed and the findings highlighted. Family treatment, particularly as devised by researchers at the Maudsley Hospital, appears to be an effective treatment for adolescents with short-term AN. It also may be an appropriate treatment for BN in the same age group, although evidence for this is in much shorter supply. Data support the use of family treatments for adolescents with eating disorders. Controlled trials and other systematic research are needed to determine whether family treatment is the best approach. © 2005 by Wiley Periodicals, Inc. [source] An intellectual capital perspective of competitive advantage in nonprofit organisationsINTERNATIONAL JOURNAL OF NONPROFIT & VOLUNTARY SECTOR MARKETING, Issue 2 2008Eric Kong Very little systematic research has focused on applying the concept of intellectual capital (IC) within the nonprofit context; particularly in the highly competitive nonprofit environment. Based on a review of the existing literature, this paper firstly contributes to filling this gap by building an argument that IC can be utilised as a competitive tool in nonprofit organisations (NPOs). Secondly, an IC conceptual framework is proposed that explicitly links the attainment of competitive advantage with positive outcomes for NPOs. Finally, the paper discusses how the IC conceptual framework can be effectively utilised to foster competitive advantage in the nonprofit sector. Copyright © 2007 John Wiley & Sons, Ltd. [source] We are all different: insights from osteoporosis research in AsiaINTERNATIONAL JOURNAL OF RHEUMATIC DISEASES, Issue 4 2008Swan Sim YEAP Abstract Osteoporosis only became a ,disease' entity in the 20th century. After the initial observations and definitions of osteoporosis based on Caucasian populations, systematic research in Asian populations started in the 1980s. Significant variations between different ethnic groups with respect to the rate of osteoporotic fractures, bone mineral density and disease risk factors emerged from the data; this article highlights some of the earlier important findings and the dissimilarities. Osteoporosis is therefore not a homogeneous disease across the world. [source] Globalization: An Ascendant Paradigm?INTERNATIONAL STUDIES PERSPECTIVES, Issue 1 2002James H. Mittelman International Studies is on the cusp of a debate between para-keepers, observers who are steadfast about maintaining the prevailing paradigms and deny that globalization offers a fresh way of thinking about the world, and para-makers, who bring into question what they regard as outmoded categories and claim to have shifted to an innovatory paradigm. This distinction is a heuristic that allows for various gradations and dynamic interactions between the keepers and the makers. It helps to identify anomalies in and discomfort with International Studies. Partly as a response to these problems, globalization studies has evolved and may be tentatively delimited by a distinct set of characteristics. But, in the near term, there is no looming Kuhnian crisis in the sense of an impending overthrow that would quickly sweep away reigning paradigms. Given that systematic research on globalization is only slightly more than a decade in the making, it is most likely that International Studies has entered an interregnum between the old and the new. At this time, as a paradigm, globalization is more of a potential than a worked-out framework. It may be best understood as a proto-paradigm. [source] The Intra-National Struggle to Define "US": External Involvement as a Two-Way StreetINTERNATIONAL STUDIES QUARTERLY, Issue 3 2001Andrea Grove Three perspectives on the causes of communal conflict are visible in extant work: a focus on ancient hatreds, on leaders, or on the context that leaders "find" themselves in. Leaders therefore have all the power to mobilize people to fight (or not to) or leaders are driven by circumstantial opportunities or the primordial desires of the masses to resist peace or coexistence with historical enemies. Analysts who focus on leaders or context recognize that external actors affect internal conflicts, but little systematic research has explored the processes relating the domestic politics of nationalist mobilization to factors in the international arena. How does the international arena affect the competition among leaders? How do skillful leaders draw in external actors to lend credibility to their own views? This article asserts that leaders compete to frame identity and mission, and explores the degree to which international factors affect whose "definitions of the situation" are successful in precipitating mobilization shifts among potential followers. A unique finding of this longitudinal study of Northern Ireland is that the role played by international institutions and actors is affected by how domestic actors perceive, cultivate, and bring attention to the linkages between the two spheres. [source] Justice and local community change: Towards a substantive theory of justiceJOURNAL OF COMMUNITY PSYCHOLOGY, Issue 6 2002Neil M. Drew Justice is a core principle in community psychology, yet has been the subject of relatively little systematic research. In the social psychological literature on the other hand there is a long tradition of research on justice in social life. In this article the potential benefits of integrating the social justice aspirations of community psychology and the conceptualizations of procedural and distributive justice from social psychology are discussed in the context of planned community change. The benefits of exploring justice in this way are illustrated with reference to a research project examining public perceptions of the fairness of roadside tree lopping. Although the issue may appear trivial, it was seen by the local residents as important. The results support the development, application, and utility of a social community psychology of justice to issues of community change. © 2002 Wiley Periodicals, Inc. [source] Multilevel governance and organizational performance: Investigating the political-bureaucratic labyrinthJOURNAL OF POLICY ANALYSIS AND MANAGEMENT, Issue 1 2004Kenneth J. Meier Research on governance has extensively explored the complex interactions of governmental, nongovernmental, and for-profit entities in the execution of public policy. It has consistently failed, however, to model empirically the joint effects of political and bureaucratic actors in governance systems. To address this issue, a theory of multilevel governance built upon the foundation of representative bureaucracy was developed and tested. Results from an analysis of Texas school districts suggest that Latinos at all levels of the governance system, political and managerial, influence representation at other levels. Findings also indicate that Latinos at each level of governance have positive effects, directly and indirectly, on outcomes for Latino students. The influence of both political and managerial actors at times extends beyond the immediately adjoining level; the effects of such actors cascade through the governance system. The results show that a priority for systematic research should be the identification of approaches and settings for examining the multilevel aspect of governance. © 2004 by the Association for Public Policy Analysis and Management. [source] The importance of news media in pharmaceutical risk communication: proceedings of a workshop,,§PHARMACOEPIDEMIOLOGY AND DRUG SAFETY, Issue 5 2005Felicia E. Mebane PhD Abstract In response to mass media's role in the national and global system of pharmaceutical risk communication, the Centers for Education and Research on Therapeutics (CERTs) convened a ,think tank' session on the ,Importance of Media in Pharmaceutical Risk Communication'. Prominent journalists and experts from the pharmaceutical industry, academia, medical practice and government were invited to consider the benefits and challenges of improving the way we communicate the benefits and risks of therapeutics via mass media, especially news media. Workshop discussions revealed a paucity of systematic research directed towards understanding how and why news media report on therapeutic risk, the impact of this coverage and how coverage can be improved. Consequently, participants produced a research agenda capturing the key aspects of the flow of information around this topic, including the meaning of risk, how news audiences process and use therapeutic risk information in the news, how and why news organizations report on therapeutic risk, and the role and impact of the pharmaceutical industry, government officials and academic researchers as sources of therapeutic risk information. The workshop ended with a discussion on action items addressing what news professionals, representatives of regulatory agencies and the medical products industry, and academic researchers can and should do to enable news media to effectively report therapeutic risk information. In sum, this proceedings report provides an outline for developing mass media risk communication research, influencing the practices of journalists and expert sources and ultimately, improving the quality of the public's life. Copyright © 2004 John Wiley & Sons, Ltd. [source] Is DSM widely accepted by Japanese clinicians?PSYCHIATRY AND CLINICAL NEUROSCIENCES, Issue 5 2001Toshiyuki Someya MD Abstract The Diagnostic and Statistical Manual of Mental Disorders, 3rd edition (DSM-III), a new standardized diagnostic system with multiaxial diagnosis, operational criteria and renewed definitions of mental disorders, was introduced in 1980 and prompted movements to reform conventions in Japanese psychiatry. This review overviews the initial response of Japanese clinicians to accept DSM-III, and its effects on the development of systematic research of psychiatric diagnosis. These new research activities include those on reliability of psychiatric diagnosis, application of various evaluation tools, discussion on the concept of mental disorders, relation of personality disorders with depressive disorders, and Taijin-kyofusho, or culturally distinctive phobia in Japan. A reference database search to survey the latest trend on psychiatric research indicated that the number of papers published by Japanese workers increased sharply after 1987, and DSM apparently greatly influenced their internationalization. Twenty years after the publication of DSM-III, a questionnaire on the use of DSM-IV was set out in 2000 to survey how widely DSM is utilized in clinical practice in Japan. Two hundred and twelve psychiatrists answered the questionnaire, and the results show that DSM has been accepted positively by the younger generation, while the older generation (over 40s) has still less interest in DSM, and DSM is used mainly for research purposes rather than in daily practice. [source] Speeding up tandem mass spectrometry based database searching by peptide and spectrum indexingRAPID COMMUNICATIONS IN MASS SPECTROMETRY, Issue 6 2010You Li Database searching is the technique of choice for shotgun proteomics, and to date much research effort has been spent on improving its effectiveness. However, database searching faces a serious challenge of efficiency, considering the large numbers of mass spectra and the ever fast increase in peptide databases resulting from genome translations, enzymatic digestions, and post-translational modifications. In this study, we conducted systematic research on speeding up database search engines for protein identification and illustrate the key points with the specific design of the pFind 2.1 search engine as a running example. Firstly, by constructing peptide indexes, pFind achieves a speedup of two to three compared with that without peptide indexes. Secondly, by constructing indexes for observed precursor and fragment ions, pFind achieves another speedup of two. As a result, pFind compares very favorably with predominant search engines such as Mascot, SEQUEST and X!Tandem. Copyright © 2010 John Wiley & Sons, Ltd. [source] Physical and emotional development, appetite and body image in adolescents who failed to thrive as infantsTHE JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY AND ALLIED DISCIPLINES, Issue 5 2006R.F. Drewett Background:, Previous studies suggest that failure to thrive in infancy may be associated with adverse sequelae in childhood. Although cognitive abilities have been extensively investigated, little systematic research is available on other aspects of development. Methods:, Eighty-nine children who failed to thrive as infants and 91 controls were followed up when twelve years old and examined using anthropometric measurement, self-ratings of appetite and body image, the Dutch Eating Behaviour Questionnaire, the Self-perception Profile for Children, The Revised Children's Manifest Anxiety Scale, the parent and child form of the Mood and Feelings Questionnaire and the parent and teacher's form of the Child Behavior Checklist. Results:, The children who failed to thrive were significantly shorter and lighter at twelve and had significantly lower BMIs, but they did not go into puberty any later. They were more likely to rate their appetite as lower than their best friend's, were generally more satisfied with their body shape, and had significantly lower restraint score on the Dutch Eating Behaviour Questionnaire. They were not significantly different from controls on any of the measures reflecting anxiety, depression or low self-esteem. Conclusions:, Failure to thrive in infancy is not associated with adverse emotional development in childhood. [source] Cryotherapy as the treatment modality of postcoital bleeding: A randomised clinical trial of efficacy and safetyAUSTRALIAN AND NEW ZEALAND JOURNAL OF OBSTETRICS AND GYNAECOLOGY, Issue 5 2009Grace Wing Shan KONG Background:, Postcoital bleeding is a common gynaecological problem that impacts on a woman's quality of life and sexual function. There is little systematic research into its management. Aims:, To assess the efficacy and side-effects of cryotherapy as treatment for postcoital bleeding. Methods:, A prospective randomised controlled trial was conducted in a tertiary referral hospital in Hong Kong. A total of 85 women who presented with postcoital bleeding were recruited, and randomised to cryotherapy or no treatment. The treatment group received cryotherapy with compressed carbon dioxide through a cryoprobe placed on the cervix, and controls had cryoprobe on the cervix without compressed carbon dioxide flow. All recruited women were followed up two weeks, three months and six months to review their symptoms and response to the treatment. Results:, The treatment group had a significantly better long-term cure rate and improvement rate. At six months, the cryotherapy group reported a cure rate of 72.1% while that in the control group the cure rate was 50.0% (P = 0.04). The number needed to treat was 5. The mean improvement rate of the cryotherapy group was 82.88% ± 35.87 but was only 61.62% ± 55.30 in the control group (P = 0.04). The results were more significant in women with the defined pathological cervix. Apart from the vaginal discharge at second week follow up in the treatment group, there was no statistical significant difference in side-effects and complications among two groups. Conclusion:, Our study demonstrated that cryotherapy is a safe and an effective treatment for postcoital bleeding. [source] Biological collections and ecological/environmental research: a review, some observations and a look to the futureBIOLOGICAL REVIEWS, Issue 2 2010Graham H. Pyke Housed worldwide, mostly in museums and herbaria, is a vast collection of biological specimens developed over centuries. These biological collections, and associated taxonomic and systematic research, have received considerable long-term public support. The work remaining in systematics has been expanding as the estimated total number of species of organisms on Earth has risen over recent decades, as have estimated numbers of undescribed species. Despite this increasing task, support for taxonomic and systematic research, and biological collections upon which such research is based, has declined over the last 30-40 years, while other areas of biological research have grown considerably, especially those that focus on environmental issues. Reflecting increases in research that deals with ecological questions (e.g. what determines species distribution and abundance) or environmental issues (e.g. toxic pollution), the level of research attempting to use biological collections in museums or herbaria in an ecological/environmental context has risen dramatically during about the last 20 years. The perceived relevance of biological collections, and hence the support they receive, should be enhanced if this trend continues and they are used prominently regarding such environmental issues as anthropogenic loss of biodiversity and associated ecosystem function, global climate change, and decay of the epidemiological environment. It is unclear, however, how best to use biological collections in the context of such ecological/environmental issues or how best to manage collections to facilitate such use. We demonstrate considerable and increasingly realized potential for research based on biological collections to contribute to ecological/environmental understanding. However, because biological collections were not originally intended for use regarding such issues and have inherent biases and limitations, they are proving more useful in some contexts than in others. Biological collections have, for example, been particularly useful as sources of information regarding variation in attributes of individuals (e.g. morphology, chemical composition) in relation to environmental variables, and provided important information in relation to species' distributions, but less useful in the contexts of habitat associations and population sizes. Changes to policies, strategies and procedures associated with biological collections could mitigate these biases and limitations, and hence make such collections more useful in the context of ecological/environmental issues. Haphazard and opportunistic collecting could be replaced with strategies for adding to existing collections that prioritize projects that use biological collections and include, besides taxonomy and systematics, a focus on significant environmental/ecological issues. Other potential changes include increased recording of the nature and extent of collecting effort and information associated with each specimen such as nearby habitat and other individuals observed but not collected. Such changes have begun to occur within some institutions. Institutions that house biological collections should, we think, pursue a mission of ,understanding the life of the planet to inform its stewardship' (Krishtalka & Humphrey, 2000), as such a mission would facilitate increased use of biological collections in an ecological/environmental context and hence lead to increased appreciation, encouragement and support from the public for these collections, their associated research, and the institutions that house them. [source] Engineering and biotechnological aspects for the manufacturing of high quality fried potato productsBIOTECHNOLOGY JOURNAL, Issue 4 2006Ernst H. Reimerdes Abstract Fried potato products have become very popular foods over the last decades. High quality standards have been established for these products by the food industry including uniform brown color and crispness. During frying, Maillard reactions takes place which contribute to color and taste development in these products. However, safety aspects are also influenced by these reactions, e.g., acrylamide formation. Maintaining high safety standards as well as the expected quality requires systematic research based on an integrated approach including all relevant variables, e.g., raw material properties, processing conditions and equipment concepts. Selected results of these investigations are presented and discussed, regarding influence of composition, e.g., precursor levels for Maillard reactions, treatment of raw materials and addition of reactants to frying fat. It has been demonstrated that a combined treatment of the potato sticks by coating of product surfaces and partial pre-drying can be successfully applied to produce well-browned French fries with lower acrylamide contents. Reductions up to 75% could be reached compared to samples without treatment. Furthermore, addition of a water/oil emulsion containing glutamine in the aqueous phase has been shown to influence Maillard reactions at the product surface, resulting in lower acrylamide contents at the same state of browning. [source] Theory and practice of public meetingsCOMMUNICATION THEORY, Issue 1 2001Katherine A. McComas Public meetings are among the most commonly used, frequently criticized, yet least understood methods of public participation in community planning. Although systematic research on public meetings is sparse, a vast, if fragmented, amount of experiential knowledge exists, and that can form the basis for a working theory of why some public meetings work and others do not. Characteristics of successful public meetings can be generally grouped by whether they relate to the process or the outcomes of public participation. Although a relationship exists, extant research would suggest that successful processes do not always lead to successful outcomes; however, officials interviewed for this study tended to equate successful outcomes with successful processes. Officials' satisfaction with public meetings seemed to be more tied to outcomes, and most officials were only moderately satisfied with public meetings. [source] | ||||||||||||||||||||||||||||