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Systematic Data (systematic + data)
Selected AbstractsFindings from a multidisciplinary clinical case series of females with Rett syndromeDEVELOPMENTAL MEDICINE & CHILD NEUROLOGY, Issue 5 2003Hilary Cass BSc FRCPCH Systematic data from a multidisciplinary clinical assessment of a large series of females with Rett syndrome (RS; n=87) is presented. Participants' ages ranged from 2 years 1 month to 44 years 10 months. Areas assessed included oromotor skills, feeding problems, growth, breathing abnormalities, mobility, postural abnormalities and joint deformities, epilepsy, hand use and stereotypies, self-care, and cognitive and communication skills. Many previously reported trends in the presentation of RS over time were confirmed, notably the increasingly poor growth and near pervasiveness of fixed joint deformities and scoliosis in adulthood. In contrast, there was a slight trend towards improved autonomic function in adulthood, whereas feeding difficulties increased into middle childhood and then reached a plateau. Improvements in mobility into adolescence were followed by a decline in those skills in adulthood. Levels of dependency were high, confirming findings from previous studies. Despite the presence of repetitive hand movements, a range of hand-use skills was seen in individuals of all ages. Cognitive and communication skills were limited, but there was little evidence of deterioration of these abilities with age. These findings confirm that RS is not a degenerative condition and indicate that intervention and support to maintain and increase motor skills, daily living skills, and cognitive and communicative functioning are appropriate targets for individuals with RS. [source] Risk Modeling of Dependence among Project Task DurationsCOMPUTER-AIDED CIVIL AND INFRASTRUCTURE ENGINEERING, Issue 6 2007I-Tung Yang The assessments, however, can be strongly influenced by the dependence between task durations. In light of the need to address the dependence, the present study proposes a computer simulation model to incorporate and augment NORTA, a method for multivariate random number generation. The proposed model allows arbitrarily specified marginal distributions for task durations (need not be members of the same distribution family) and any desired correlation structure. This level of flexibility is of great practical value when systematic data is not available and planners have to rely on experts' subjective estimation. The application of the proposed model is demonstrated through scheduling a road pavement project. The proposed model is validated by showing that the sample correlation coefficients between task durations closely match the originally specified ones. Empirical comparisons between the proposed model and two conventional approaches, PERT and conventional simulation (without correlations), are used to illustrate the usefulness of the proposed model. [source] Wood distribution in neotropical forested headwater streams of La Selva, Costa RicaEARTH SURFACE PROCESSES AND LANDFORMS, Issue 9 2009Daniel Cadol Abstract Surveys of wood along 30 forested headwater stream reaches in La Selva Biological Station in north-eastern Costa Rica represent the first systematic data reported on wood loads in neotropical streams. For streams with drainage areas of 0·1,8·5 km2 and gradients of 0·2,8%, wood load ranged from 3 to 34·7 m3 wood/100 m channel and 41,612 m3 wood/ha channel. These values are within the range reported for temperate streams. The variables wood diameter/flow depth, stream power, the presence of backflooding, and channel width/depth are consistently selected as significant predictors by statistical models for wood load. These variables explain half to two-thirds of the variability in wood load. These results, along with the spatial distribution of wood with respect to the thalweg, suggest that transport processes exert a greater influence on wood loads than recruitment processes. Wood appears to be more geomorphically effective in altering bed elevations in gravel-bed reaches than in reaches with coarser or finer substrate. Copyright © 2009 John Wiley & Sons, Ltd. [source] Stopping smoking can cause constipationADDICTION, Issue 11 2003Peter Hajek ABSTRACT Setting Constipation is mentioned occasionally as a possible tobacco withdrawal symptom, but no systematic data have been published on this issue. Design Smokers' clinic patients provided ratings of their level of constipation on three occasions prior to their quit date, and then weekly after they stopped smoking. The total of 1067 participants maintained at least 1 week of continuous abstinence and provided usable data. Findings The three precessation ratings of constipation were stable. After cessation of smoking, the ratings increased significantly (P < 0.01). In 514 patients who maintained continuous abstinence for 4 weeks and provided complete data, constipation peaked at 2 weeks but remained elevated over the whole period. The net proportion of patients affected was 17%, including 9% who were symptom-free at baseline and became very or extremely constipated. In patients on nicotine replacement the increase in constipation, although significant, was less than in patients on bupropion. Conclusions Clinicians treating smokers need to be aware of a possibility that one in six quitters develop constipation, and that for about one in 11 the problem can be severe. Descriptions of tobacco withdrawal syndrome should include constipation. [source] Rhythmic hippocampal slow oscillation characterizes REM sleep in humansHIPPOCAMPUS, Issue 6 2001Róbert Bódizs Abstract Hippocampal rhythmic slow activity (RSA) is a well-known electrophysiological feature of exploratory behavior, spatial cognition, and rapid eye movement (REM) sleep in several mammalian species. Recently, RSA in humans during spatial navigation was reported, but systematic data regarding human REM sleep are lacking. Using mesio-temporal corticography with foramen ovale electrodes in epileptic patients, we report the presence of a 1.5,3-Hz synchronous rhythmic hippocampal oscillation seemingly specific to REM sleep. This oscillation is continuous during whole REM periods, is clearly observable by visual inspection, and appears in tonic and phasic REM sleep episodes equally. Quantitative analysis proved that this 1.5,3-Hz frequency band significantly differentiates REM sleep from waking and slow-wake sleep (SWS). No other frequency band proved to be significant or showed this high rhythmicity. Even in temporo-lateral surface recordings, although visually much less striking, the relative power of the 1.5,3-Hz frequency band differentiates REM sleep from other states with statistical significance. This could mean that the 1.5,3-Hz hippocampal RSA spreads over other cortical areas in humans as in other mammals. We suggest that this oscillation is the counterpart of the hippocampal theta of mammalian REM sleep, and that the 1.5,3-Hz delta EEG activity is a basic neurophysiological feature of human REM sleep. Hippocampus 2001;11:747,753. © 2001 Wiley-Liss, Inc. [source] Human metapneumovirus in hospitalized children in Amman, JordanJOURNAL OF MEDICAL VIROLOGY, Issue 6 2010Syed Asad Ali Abstract Human metapneumovirus (HMPV) has recently been identified as an important cause of acute respiratory infections (ARI) in children worldwide. However, there is little systematic data on its frequency and importance as a cause of ARI in the Middle East. We conducted a viral surveillance study in children <5 years of age admitted with respiratory symptoms and/or fever at two major tertiary care hospitals in Amman, Jordan from 1/18-3/29/07. Nose and throat swabs were collected and tested for HMPV and other respiratory viruses by real-time RT-PCR. A total of 743 subjects were enrolled. Forty-four (6%) subjects were positive for HMPV, 467 (64%) were positive for RSV and 13 (1.3%) had co-infection with both HMPV and RSV. The frequency of HMPV in January, February, and March was 4.1%, 3.0%, and 11.9% respectively. Clinical features associated with HMPV infection were similar to those of other respiratory viruses, except children with HMPV were more likely to present with fever than children not infected with HMPV. Children with HMPV and RSV co-infection were administered supplemental oxygen and were admitted to the ICU more frequently than children infected with HMPV alone or RSV alone, though these differences did not reach statistical significance. We conclude that HMPV is an important cause of acute respiratory infections in children in Amman, Jordan. Longer surveillance studies are needed to better understand the seasonal epidemiology of HMPV and to assess if co-infection with HMPV and RSV leads to more severe illness. J. Med. Virol. 82:1012,1016, 2010. © 2010 Wiley-Liss, Inc. [source] Lawyers for Conservative Causes: Clients, Ideology, and Social DistanceLAW & SOCIETY REVIEW, Issue 1 2003John P. Heinz Scholars have devoted attention to "cause lawyers" on the political left, but lawyers who work on the conservative side of the American political spectrum have received relatively little academic consideration. This article presents systematic data on the characteristics of and relationships among lawyers affiliated with organizations active on a selected set of 17 conservative issues. We find that the lawyers serve several separate and distinct constituencies,business conservatives, Christian conservatives, libertarians, abortion opponents,and that the credentials of the lawyers serving these varying constituencies differ significantly. The greatest degree of social separation occurs between the business constituency and the abortion opponents, with another clear separation between libertarians and the interest groups devoted to traditional family values and order maintenance. The divisions among these constituencies appear to reflect the difference between "insider politics" and "populism," which is manifested in part in actual geographic separation between lawyers located in the District of Columbia and those in the South, West, and Midwest. In the center of the network, however, we find some potential "mediators",prominent lawyers who may facilitate communication and coordination among the several constituencies. These lawyers and the organizations they serve attempt to merge morality, market freedom, and individual liberty concerns, and they convene meetings of diverse sets of lawyers and organizational leaders to seek consensus on policy goals. Nonetheless, the findings indicate that most organizations are seldom active on issues that lie beyond the relatively narrow boundaries of their own interests. [source] Cross-Cultural Perspectives on Physician and Lay Models of the Common ColdMEDICAL ANTHROPOLOGY QUARTERLY, Issue 2 2008Roberta D. Baer We compare physicians and laypeople within and across cultures, focusing on simi-larities and differences across samples, to determine whether cultural differences or lay,professional differences have a greater effect on explanatory models of the common cold. Data on explanatory models for the common cold were collected from physicians and laypeople in South Texas and Guadalajara, Mexico. Structured interview materials were developed on the basis of open-ended interviews with samples of lay informants at each locale. A structured questionnaire was used to collect information from each sample on causes, symptoms, and treatments for the common cold. Consensus analysis was used to estimate the cultural beliefs for each sample. Instead of systematic differences between samples based on nationality or level of professional training, all four samples largely shared a single-explanatory model of the common cold, with some differences on subthemes, such as the role of hot and cold forces in the etiology of the common cold. An evaluation of our findings indicates that, although there has been conjecture about whether cultural or lay,professional differences are of greater importance in understanding variation in explanatory models of disease and illness, systematic data collected on community and professional beliefs indicate that such differences may be a function of the specific illness. Further generalizations about lay,professional differences need to be based on detailed data for a variety of illnesses, to discern patterns that may be present. Finally, a systematic approach indicates that agreement across individual explanatory models is sufficient to allow for a community-level explanatory model of the common cold. [source] | |||||||||||||