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Synthesis Methodology (synthesis + methodology)
Selected AbstractsImmobilization of flame retardant onto silica nanoparticle surface and properties of epoxy resin filled with the flame retardant-immobilized silicaJOURNAL OF POLYMER SCIENCE (IN TWO SECTIONS), Issue 22 2009Takeshi Yamauchi Abstract To prepare silica nanoparticle having flame retardant activity, the immobilization of flame retardant onto hyperbranched poly(amidoamine) (PAMAM)-grafted silica was investigated. Grafting of PAMAM onto a silica surface was achieved in a solvent-free dry-system using PAMAM dendrimer synthesis methodology. The immobilization of bromine flame retardant, poly(2,2,,6,6,-tetrabromobisphenol-A) diglycidyl ether (PTBBA), was successfully achieved by the reaction of terminal amino groups of PAMAM-grafted silica (Silica-PAMAM) with epoxy groups of PTBBA. The immobilization of PTBBA was confirmed by FTIR and thermal decomposition GC-MS. The amount of PTBBA immobilized onto Silica-PAMAM was determined to be 60 wt %. PTBBA-immobilized Silica-PAMAM (Silica-PAMAM-PTBBA) was dispersed uniformly in a epoxy resin, and the epoxy resin was cured in the presence of hexamethylenediamine. Flame retardant activity of the epoxy resin filled with Silica-PAMAM-PTBBA was estimated by limiting oxygen index (LOI). The LOI of epoxy resin filled with Silica-PAMAM-PTBBA was higher than that filled with untreated silica and free PTBBA. It was confirmed that the flame retardant activity of epoxy resin was improved by the addition of the Silica-PAMAM-PTBBA. The elimination of PTBBA from the epoxy resin filled with Silica-PAMAM-PTBBA into boiling water was hardly observed by immobilization of PTBBA onto silica surface. © 2009 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 47: 6145,6152, 2009 [source] Grafting of hyperbranched poly(amidoamine) onto carbon black surfaces using dendrimer synthesis methodologyPOLYMERS FOR ADVANCED TECHNOLOGIES, Issue 10 2001Norio Tsubokawa Abstract To modify carbon black surface, the surface grafting of hyperbranched poly(amidoamine) onto the surface by using dendrimer synthesis methodology was investigated. Carbon black having amino groups (initiator sites) was prepared by the reduction of surface nitro groups introduced by nitration of aromatic rings. It was found that hyperbranched poly(amidoamine) was propagated from carbon black surface by repeating two processes: (1) Michael addition of methyl acrylate (MA) to surface amino groups and (2) amidation of the resulting esters with ethylenediamine: the percentage of poly(amidoamine) grafting reached to 96.2% after 10th-generation. The grafting of hyperbranched poly(amidoamine) onto polystyrene-bead as a model compound of carbon black was also achieved by the above procedures. However, the theoretical propagation of poly(amidoamine) dendrimer was not achieved, because of steric hindrance of grafted polymer. Hyperbranched poly(amidoamine)-grafted carbon black gave a stable dispersion in a good solvent for poly(amidoamine). Copyright © 2001 John Wiley & Sons, Ltd. [source] The World of , - and , -Peptides Comprised of Homologated Proteinogenic Amino Acids and Other ComponentsCHEMISTRY & BIODIVERSITY, Issue 8 2004Dieter Seebach The origins of our nearly ten-year research program of chemical and biological investigations into peptides based on homologated proteinogenic amino acids are described. The road from the biopolymer poly[ethyl (R)-3-hydroxybutanoate] to the , -peptides was primarily a step from organic synthesis methodology (the preparation of enantiomerically pure compounds (EPCs)) to supramolecular chemistry (higher-order structures maintained through non-covalent interactions). The performing of biochemical and biological tests on the , - and , -peptides, which differ from natural peptides/proteins by a single or two additional CH2 groups per amino acid, then led into bioorganic chemistry and medicinal chemistry. The individual chapters of this review article begin with descriptions of work on , -amino acids, , -peptides, and polymers (Nylon-3) that dates back to the 1960s, even to the times of Emil Fischer, but did not yield insights into structures or biological properties. The numerous, often highly physiologically active, or even toxic, natural products containing ,- and ,-amino acid moieties are then presented. Chapters on the preparation of homologated amino acids with proteinogenic side chains, their coupling to provide the corresponding peptides, both in solution (including thioligation) and on the solid phase, their isolation by preparative HPLC, and their characterization by mass spectrometry (HR-MS and MS sequencing) follow. After that, their structures, predominantly determined by NMR spectroscopy in methanolic solution, are described: helices, pleated sheets, and turns, together with stack-, crankshaft-, paddlewheel-, and staircase-like patterns. The presence of the additional CC bonds in the backbones of the new peptides did not give rise to a chaotic increase in their secondary structures as many protein specialists might have expected: while there are indeed more structure types than are observed in the , -peptide realm , three different helices (10/12 -, 12 -, and 14 -helix) if we include oligomers of trans -2-aminocyclopentanecarboxylic acid, for example , the structures are already observable with chains made up of only four components, and, having now undergone a learning process, we are able to construct them by design. The structures of the shorter , -peptides can also be reliably determined by molecular-dynamics calculations (in solution; GROMOS program package). Unlike in the case of the natural helices, these compounds' folding into secondary structures is not cooperative. In , - and , -peptides, it is possible to introduce heteroatom substituents (such as halogen or OH) onto the backbones or to incorporate heteroatoms (NH, O) directly into the chain, and, thanks to this, it has been possible to study effects unobservable in the world of the , -peptides. Tests with proteolytic enzymes of all types (from mammals, microorganisms, yeasts) and in vivo examination (mice, rats, insects, plants) showed , - and , -peptides to be completely stable towards proteolysis and, as demonstrated for two , -peptides, extraordinarily stable towards metabolism, even when bearing functionalized side chains (such as those of Thr, Tyr, Trp, Lys, or Arg). The , -peptides so far examined also normally display no or only very weak cytotoxic, antiproliferative, antimicrobial, hemolytic, immunogenic, or inflammatory properties either in cell cultures or in vivo. Even biological degradation by microbial colonies of the types found in sewage-treatment plants or in soil is very slow. That there are indeed interactions of ,- and ,-peptides with biological systems, however, can be seen in the following findings: i) organ-specific distribution takes place after intravenous (i.v.) administration in rats, ii) transport through the intestines of rodents has been observed, iii) , -peptides with positively charged side chains (Arg and Lys) settle on cell surfaces, are able to enter into mammalian cells (fibroplasts, keratinocytes, HeLa cells), and migrate into their cell nuclei (and nucleoli), and iv) in one case, it has already been established that a , -peptide derivative can up- and down-regulate gene expression rates. Besides these less sharply definable interactions, it has also been possible to construct , - and , -peptide agonists of naturally occurring peptide hormones, MHC-binding , -peptides, or amphipathic , -peptide inhibitors of membrane-bound proteins in a controlled fashion. Examples include somatostatin mimics and the suppression of cholesterol transport through the intestinal brush-border membrane (by the SR-BI-protein). The results so far obtained from investigations into peptides made up of homologues of the proteinogenic amino acids also represent a contribution to deepening of our knowledge of the natural peptides/proteins, while potential for biomedicinal application of this new class of substances has also been suggested. [source] | ||||||||||