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Suspension Array (suspension + array)

Distribution by Scientific Domains
Polymers and Materials Science80%

Selected Abstracts

Quantum-Dot-Tagged Bioresponsive Hydrogel Suspension Array for Multiplex Label-Free DNA Detection

ADVANCED FUNCTIONAL MATERIALS, Issue 6 2010
Yuanjin Zhao
Abstract A novel hydrogel suspension array, which possesses the joint advantages of quantum-dot-encoded technology, bioresponsive hydrogels, and photonic crystal sensors with full multiplexing label-free DNA detection capability is developed. The microcarriers of the suspension array are quantum-dot-tagged DNA-responsive hydrogel photonic beads. In the case of label-free DNA detection, specific hybridization of target DNA and the crosslinked single-stranded DNA in the hydrogel grid will cause hydrogel shrinking, which can be detected as a corresponding blue shift in the Bragg diffraction peak position of the beads that can be used for quantitatively estimating the amount of target DNA. The results of the label-free DNA detection show that the suspension array has high selectivity and sensitivity with a detection limit of 10,9,M. This method has the potential to provide low cost, miniaturization, and simple and real-time monitoring of hybridization reaction platforms for detecting genetic variations and sequencing genes. [source]

Multiplex Label-Free Detection of Biomolecules with an Imprinted Suspension Array,

ANGEWANDTE CHEMIE, Issue 40 2009
Yuan-Jin Zhao
Eindrucksvoll: Polymerkügelchen mit der Struktur photonischer Kristalle wurden hergestellt, die eine molekulare Prägung für das zu analysierende markierungsfreie Biomolekül aufweisen. Eine Reihe von Kügelchen, die einer Reihe von Analyten entsprechen, konnte für den parallelen Nachweis von Biomolekülen mit erstaunlicher Empfindlichkeit und Spezifität genutzt werden (siehe Bild). [source]

Quantum-Dot-Tagged Bioresponsive Hydrogel Suspension Array for Multiplex Label-Free DNA Detection

ADVANCED FUNCTIONAL MATERIALS, Issue 6 2010
Yuanjin Zhao
Abstract A novel hydrogel suspension array, which possesses the joint advantages of quantum-dot-encoded technology, bioresponsive hydrogels, and photonic crystal sensors with full multiplexing label-free DNA detection capability is developed. The microcarriers of the suspension array are quantum-dot-tagged DNA-responsive hydrogel photonic beads. In the case of label-free DNA detection, specific hybridization of target DNA and the crosslinked single-stranded DNA in the hydrogel grid will cause hydrogel shrinking, which can be detected as a corresponding blue shift in the Bragg diffraction peak position of the beads that can be used for quantitatively estimating the amount of target DNA. The results of the label-free DNA detection show that the suspension array has high selectivity and sensitivity with a detection limit of 10,9,M. This method has the potential to provide low cost, miniaturization, and simple and real-time monitoring of hybridization reaction platforms for detecting genetic variations and sequencing genes. [source]

Encoded Porous Beads for Label-Free Multiplex Detection of Tumor Markers

ADVANCED MATERIALS, Issue 5 2009
Yuanjin Zhao
Inverse-opaline photonic beads are used as the elements of a suspension array for label-free multiplex immunoassays. As in the case of tumor-marker detection, specific binding of tumor markers on the pore surfaces of the beads results in a shift in the diffraction-peak position, which can be used for quantitatively estimating the amount of bound tumor marker. [source]