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Surrogate Mothers (surrogate + mother)

Distribution by Scientific Domains

Medical Sciences	50%

Selected Abstracts

Passively acquired anti-SSA/Ro antibodies are required for congenital heart block following ovodonation but maternal genes are not

ARTHRITIS & RHEUMATISM, Issue 10 2010
Antonio Brucato
Anti-SSA/Ro antibodies are necessary but not sufficient to provoke autoimmune-associated congenital heart block (CHB). Genetic factors are likely contributory. Accordingly, HLA-related candidates and single-nucleotide polymorphisms in the promoter region of tumor necrosis factor , and codon 10 in transforming growth factor ,1 (TGF,1) were evaluated in a unique family: the surrogate mother (anti-SSA/Ro positive), the biologic father, and the CHB-affected child (product of ovodonation). There was an HLA mismatch between the affected child and the surrogate mother. However, both the biologic and the surrogate mothers shared DQ2 and the profibrosing leucine polymorphism at codon 10 of TGF,. In conclusion, we observed that CHB can develop in a genetically unrelated child exposed in utero to anti-SSA/Ro antibodies. Testing for anti-SSA/Ro antibodies might be considered in women undergoing artificial fertilization. It is possible that there is no direct association of maternal genes beyond a contributory role in generating the autoantibody. [source]

Maternal environment affects endogenous virus induction in the offspring of type 1 diabetes model non-obese diabetic mice

CONGENITAL ANOMALIES, Issue 3 2005
Yukiko Kagohashi
ABSTRACT Type 1 diabetes results from the destruction of pancreatic b-cells (insulitis). It is a multifactorial disease involving genetic and environmental factors, including the maternal environment. Viruses have also been implicated in the pathogenesis of human type 1 diabetes as well as in its model non-obese diabetic (NOD) mice during the perinatal period, as endogenous viruses and/or as infectious agents vertically transmitted from mothers. However, the role of virus as genetic or environmental factor and its interaction with other maternal factors remain unclear. In a series of experiments, we transplanted preimplantation-stage NOD embryos into the uterus of recipient Institute of Cancer Research (ICR) mice, which are without diabetic genetic predisposition, and NOD mice, which did not exhibit overt diabetes during the experiment, and designated offspring as NOD/ICR and NOD/NOD, respectively. We previously observed that NOD/ICR offspring developed insulitis significantly earlier than NOD/NOD offspring. To assess the role of viruses in the development of insulitis, we examined the appearance of viral particles and expression of retroviruses between NOD/ICR and NOD/NOD. NOD/ICR showed earlier expression of env region of the xenotropic type C retrovirus by polymerase chain reaction analysis than NOD/NOD, while the retrovirus-like particles were observed in the islet b-cells similarly in both groups by electron microscopy. Serum corticosterone level, which is suggested to enhance retroviral induction, was significantly higher in the ICR than in the NOD surrogate mothers. These findings suggest that the observed virus is endogenous and that maternal environmental factors, including hormone levels, affect the induction of endogenous viruses and cause the earlier onset of insulitis. [source]

Elizabeth I as Stepmother

ENGLISH LITERARY RENAISSANCE, Issue 2 2009
Jacqueline Vanhoutte
As a number of scholars have shown, Tudor male subjects were able to arrogate to themselves unprecedented powers by playing gender against class hierarchies. This essay considers how tropes of surrogacy furthered this process of political enfranchisement. As Victor Turner suggests, recurrent tropes are dynamic phenomena, which change meaning over time in a way that reveals the "emotional and volitional dimensions" present in social contexts. The prevalence of surrogate mothers in Elizabethan political and literary discourses reflects such a volitional dimension: writers (e.g. Lyly and Shakespeare), courtiers (e.g., Sir Philip Sidney), and politicians (e.g. members of Parliament) used images of stepmothers in consciously manipulative ways. Because of the ambiguous nature of figurative language, these men posited innovative ideas indirectly long before it became possible to articulate them directly. The evil stepdames of Tudor lore form an important precedent for John Locke's enlightened "foster father," whose acquired authority undermines the divine rights of fathers and kings. Stepmother tropes provided an alternative to the dominant analogies between family and state,analogies that aimed at suppressing disobedience and rebellion and at naturalizing the status quo. While men like Sidney and John Stubbs probably intended only limited applications for their stepmother tropes, this essay shows that these tropes called their monarch's absolute rule into question and justified their own political activity. Elizabethan writers thus contributed to the process of unmooring the English monarchy from divine right ideology, a process that culminated, intellectually speaking, in Locke's insistence on the consensual nature of government. (J.V.) [source]

Navigating Rough Waters: An Overview of Psychological Aspects of Surrogacy

JOURNAL OF SOCIAL ISSUES, Issue 1 2005
Janice C. Ciccarelli
This article provides an overview of the social and psychological aspects surrounding the surrogacy process including attitudes about surrogacy, perceptions and problems of surrogate mothers and intended/social parents, and questions concerning children resulting from contractual parenting. Review of the literature on contractual parenting reveals a wealth of discussion about the ethical, moral, legal, and psychological implications, but limited empirical data on the psychological and social aspects. Future research can provide empirical evidence as a foundation for counseling at all phases of the surrogacy process. [source]

Influence of Ovulation Status, Seasonality and Embryo Transfer Method on Development of Cloned Porcine Embryos

REPRODUCTION IN DOMESTIC ANIMALS, Issue 5 2010
OJ Koo
Contents To improve pig cloning efficiency, the present study evaluated the effect of ovulation status, seasonality and embryo transfer (ET) method on in vivo development of cloned porcine embryos. Cloned embryos were transferred to surrogate mothers on the same day of somatic cell nuclear transfer. In pre-ovulation stage (PO), pregnancy rate (PR) and delivery rate (DR) were 36.3% and 9.4%, respectively. In post-ovulation stage, 22.7% PR and 2.1% DR were recorded (both PR and DR are significantly higher in PO). When ET was performed during winter (December,February), spring (March,May), summer (June,August) and autumn (September,November), the PRs were 13.4%, 37.3%, 24.6% and 51.0%, while DRs were 0%, 12.7%, 4.3% and 7.8%, respectively. The highest PRs were recorded in autumn groups. However, DRs were significantly lower in autumn (7.8%) group compared with spring (12.7%) group. The PR was the lowest and no piglets were born in winter group, which might be because of the effect of low temperature during ET. To overcome the low PR in winter group, 0.25 ml straws were used for ET to minimize exposure time of embryos to ambient temperature. The straw ET group showed significantly higher PR in the winter group (23. 9%) compared with the conventional catheter-loading group (7.7%). We suggest that using PO recipient and ET in spring is the best condition for pig cloning. In addition, alternative method to reduce cold shock during ET in winter is necessary. [source]