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Surprising Finding (surprising + finding)
Selected AbstractsPsychosis and offending in British Columbia: characteristics of a secure hospital populationCRIMINAL BEHAVIOUR AND MENTAL HEALTH, Issue 3 2001Nicola Hodelet Specialist Registrar Introduction There is an increased likelihood of violence in the mentally ill although the risk is small. Aims The study aimed to ascertain the features in a secure hospital population that linked offending and mental illness. Method A survey of patients in the high security hospital serving the province of British Columbia in Canada was carried out. Information on 175 mentally disordered offenders was extracted and included demographic data and specific characteristics of their offences, diagnoses and psychotic symptoms. Results The most prevalent offences were crimes of violence, but 39% of patients were not primarily violent offenders. Almost two-thirds (61%) had two or more diagnoses. A large majority of the patients were psychotic, schizophrenia being the most common diagnosis. There was a highly significant association between psychosis and violence, but the strength of the association was not increased by the presence of imperative hallucinations or delusions. The sample comprised various ethnic groups, one of which, Native Americans, was over-represented. However, no association was found between violent offending and ethnicity, or age or years of illness. Discussion The study replicates previous findings of the link between violent offending and psychosis, but not a specific link between violent offending and psychotic drive. A surprising finding was a lack of association between violent offences and substance misuse. Copyright © 2001 Whurr Publishers Ltd. [source] Unexpected roles for DEAD-box protein 3 in viral RNA sensing pathwaysEUROPEAN JOURNAL OF IMMUNOLOGY, Issue 4 2010Orla Mulhern Abstract Detection of viral nucleic acid within infected cells is essential to an effective anti-viral response. The retinoic acid-inducible gene-I-like receptors (RLR) form part of the virus detection repertoire and are critically important in sensing viral RNA in the cytoplasm. Efforts continue to define the signalling components downstream of RLR that are required to induce type I IFN (IFN-, and promoter stimulator-1) after viral infection. One surprising finding was that the Asp-Glu-Ala-Asp box helicase DEAD/H Box 3 (DDX3), known for some time to have a number of roles in cellular RNA regulation in the nucleus, has a role in the RLR cytoplasmic signalling pathway involved in promoter stimulator-1 induction. In this issue of the European Journal of Immunology, an article reports an additional distinct positive role for DDX3 in the RLR RNA sensing pathway. This further emphasises the importance of DDX3 in anti-viral immunity, and is consistent with the idea that viruses target DDX3 for immune evasion. [source] Early life modulators and predictors of adult synaptic plasticityEUROPEAN JOURNAL OF NEUROSCIENCE, Issue 2 2006Katherine G. Akers Abstract Early life experience can induce long-lasting changes in brain and behaviour that are opposite in direction, such as enhancement or impairment in regulation of stress response, structural and functional integrity of the hippocampus, and learning and memory. To explore how multiple early life events jointly determine developmental outcome, we investigated the combined effects of neonatal trauma (anoxia on postnatal day 1, P1) and neonatal novelty exposure (P2,21) on adult social recognition memory (3 months of age) and synaptic plasticity in the CA1 of the rat hippocampus (4.5,8 months of age). While neonatal anoxia selectively reduced post-tetanic potentiation (PTP), neonatal novel exposure selectively increased long-term potentiation (LTP). No interaction between anoxia and novelty exposure was found on either PTP or LTP. These findings suggest that the two contrasting neonatal events have selective and distinct effects on two different forms of synaptic plasticity. At the level of behaviour, the effect of novelty exposure on LTP was associated with increased social memory, and the effect of anoxia on PTP was not accompanied by changes in social memory. Such a finding suggests a bias toward the involvement of LTP over PTP in social memory. Finally, we report a surprising finding that an early behavioural measure of emotional response to a novel environment obtained at 25 days of age can predict adult LTP measured several months later. Therefore, individual differences in emotional responses present during the juvenile stage may contribute to adult individual differences in cellular mechanisms that underlie learning and memory. [source] Novel Crosslinking of High-order and Multiple Copper Twins in Advanced Microelectronics Packaging,ADVANCED ENGINEERING MATERIALS, Issue 4 2004W. Zhang Novel crosslinking of high-order and multiple copper twins has been formed in the metallization/solder interconnect subjected to the thermal aging. This surprising finding may illustrate a universal metallization failure mode. Meanwhile, many copper nanocrystals in situ originated from those twins crosslinking shed a novel light on the synthesis approach to fascinating nanocrystalline metals. [source] Going in When it Counts: Military Intervention and the Outcome of Civil Conflicts,INTERNATIONAL STUDIES QUARTERLY, Issue 4 2008Stephen E. Gent Conventional wisdom suggests that biased military interventions in civil conflicts should increase the probability that the supported side will win. However, while this is the case for rebel groups, the same is not true for governments. The explanation for this surprising finding becomes clear once one considers the decision of a third-party intervener. Since interveners want to impact the outcomes of civil conflict, government- and rebel-biased interventions will be more likely when the government is facing a stronger rebel group. Given that government-biased third parties intervene in the ,,toughest'' cases, empirically they appear to be less effective than rebel-biased interveners. [source] B3LYP calculations on bishomoaromaticity in substituted semibullvalenes*JOURNAL OF COMPUTATIONAL CHEMISTRY, Issue 13 2001David A. Hrovat Abstract B3LYP/6-31G* calculations on the degenerate rearrangements of substituted semibullvalenes spuriously predict the relative enthalpies of the bishomoaromatic TSs to be lower than the experimental values. However, the calculations do make the useful and experimentally testable prediction that the two cyano and two phenyl substituents in 2,6-dicyano-4,8-diphenylsemibullvalene (9d) are more likely than four cyano substituents in 2,4,6,8-tetracyanosemibullvalene (9f) or the four phenyl substituents in 2,4,6,8-tetraphenylsemibullvalene (9g) to produce a semibullvalene that has a bishomoaromatic equilibrium geometry in the gas phase. The major reason for the surprising finding that 9d is more likely to be bishomoaromatic than 9g is shown to be steric interactions between the phenyl groups at C-2 and C-8 and at C-4 and C-6 in bishomoaromatic structure 10g. These interactions inhibit the conjugative stabilization of 10g; but they are absent in bishomoaromatic structure 10d, where cyano groups replace the phenyl groups at C-2 and C-6 in 10g. © 2001 John Wiley & Sons, Inc. J Comput Chem 22: 1565,1573, 2001 [source] Contrasting effects of long distance seed dispersal on genetic diversity during range expansionJOURNAL OF EVOLUTIONARY BIOLOGY, Issue 1 2006R. BIALOZYT Abstract Currently many attempts are made to reconstruct the colonization history of plant species after the last ice age. A surprising finding is that during the colonization phase genetic diversity did not decrease as much as expected. In this paper we examine whether long distance seed dispersal events could play a role in the unexpected maintenance of genetic diversity during range expansion. This study is based on simulations carried out with a maternally inherited haploid locus using a cellular automaton. The simulations reveal a close relationship between the frequency of long distance seed dispersal events and the amount of genetic diversity preserved during colonization. In particular, when the colonized region is narrow, a complete loss of genetic diversity results from the occurrence of very rare long distance dispersal (LDD) events. We call this phenomenon the ,embolism effect'. However, slightly higher rates of LDD events reverse this effect, up to the point that diversity is better preserved than in a pure diffusion model. This phenomenon is linked to the reorganization of the genetic structure during colonization and is called the ,reshuffling effect'. [source] Influences of alkyl group chain length and polar head group on chemical skin permeation enhancementJOURNAL OF PHARMACEUTICAL SCIENCES, Issue 8 2001Kevin S. Warner Abstract Previous investigations in our laboratory on the influence of the n -alkanols and the 1-alkyl-2-pyrrolidones as skin permeation enhancers for steroid molecules as permeants demonstrated that the enhancer potencies (based on aqueous concentration values) of these two homologous series were the same when compared at the same alkyl chain length; that is, the contribution of the hydroxyl group and that of the pyrrolidone group to enhancer potency were the same. The purpose of the present study was to further investigate what was believed to be a somewhat surprising finding, and two additional homologous series, the 1,2-alkanediols and N,N -dimethylalkanamides, were selected for study as enhancers. Corticosterone (CS) flux enhancement along the lipoidal pathway of hairless mouse skin stratum corneum was determined with 1,2-hexane-, 1,2-octane-, and 1,2-decanediol and with N,N -dimethylhexanamide, N,N - dimethylheptanamide, N,N -dimethyloctanamide, and N,N -dimethylnonanamide as enhancers. The enhancement factor (E) for the lipoidal pathway was calculated from the CS permeability coefficient and the CS solubility data over a 4 to 100 range of E values. Comparisons of the enhancer potencies of all four homologous series revealed that the enhancer potencies of all were very nearly the same when compared at equal alkyl group chain length. Moreover, the contribution of each of the polar head groups toward the enhancer potency was essentially constant, independent of the alkyl group chain length. It was reasoned that this outcome was either the result of the random selection of four polar head groups making the same contribution to enhancer potency or the result of these particular polar head groups not contributing to enhancer potency. To test the hypothesis that the former was more likely than the latter and that a suitable semipolar organic phase may mimic the microenvironment of the polar head group at the site of enhancer action, n -octanol,phosphate buffered saline (PBS) and n -hexane,PBS partition coefficients were determined for all the enhancers. The n -octanol,PBS partition coefficients for the enhancers, but not the n -hexane,PBS partition coefficients, were very nearly the same when compared at equal alkyl group chain lengths; this result supports the hypothesis that each of the four polar head groups likely contributes the same toward the enhancer potency and locates in the semipolar region of the hairless mouse skin stratum corneum lipid bilayers, which is well-approximated by water-saturated n -octanol. © 2001 Wiley-Liss, Inc. and the American Pharmaceutical Association J Pharm Sci 90:1143,1153, 2001 [source] A measure of disclosure risk for microdataJOURNAL OF THE ROYAL STATISTICAL SOCIETY: SERIES B (STATISTICAL METHODOLOGY), Issue 4 2002C. J. Skinner Summary. Protection against disclosure is important for statistical agencies releasing microdata files from sample surveys. Simple measures of disclosure risk can provide useful evidence to support decisions about release. We propose a new measure of disclosure risk: the probability that a unique match between a microdata record and a population unit is correct. We argue that this measure has at least two advantages. First, we suggest that it may be a more realistic measure of risk than two measures that are currently used with census data. Second, we show that consistent inference (in a specified sense) may be made about this measure from sample data without strong modelling assumptions. This is a surprising finding, in its contrast with the properties of the two ,similar' established measures. As a result, this measure has potentially useful applications to sample surveys. In addition to obtaining a simple consistent predictor of the measure, we propose a simple variance estimator and show that it is consistent. We also consider the extension of inference to allow for certain complex sampling schemes. We present a numerical study based on 1991 census data for about 450 000 enumerated individuals in one area of Great Britain. We show that the theoretical results on the properties of the point predictor of the measure of risk and its variance estimator hold to a good approximation for these data. [source] Dimensions of quality of life and psychosocial variables most salient to colorectal cancer patientsPSYCHO-ONCOLOGY, Issue 1 2006Jeff Dunn Abstract Colorectal cancer is one of the most common invasive cancers, and is responsible for considerable physical and psychosocial morbidity. Understanding the quality of life experienced by colorectal cancer patients is essential for evaluating the full impact of the disease on individuals, their families and their communities. Patient perspective is essential in establishing a proper understanding of the quality of life of colorectal cancer patients. Despite this, few studies have employed a qualitative methodology to explore quality of life issues for colorectal cancer patients. A review of the literature identified only seven qualitative studies pertaining to quality of life issues for colorectal cancer patients, a surprising finding given the prevalence of this cancer. Accordingly, this study sought to build on the findings of previous qualitative research by providing descriptive data on the quality of life and psychosocial variables most salient to colorectal cancer patients. Six core themes emerged from interview and focus group data: Satisfaction with diagnosis and treatment; support (including information provision); quality of life; benefits of diagnosis; making sense of the cancer experience; and coping strategies. The information derived from this study will help inform the development of supportive care services to address the needs of the increasing number of people diagnosed with colorectal cancer. Copyright © 2005 John Wiley & Sons, Ltd. [source] The Role of Champions in the External Commercialization of Knowledge,THE JOURNAL OF PRODUCT INNOVATION MANAGEMENT, Issue 4 2009Ulrich Lichtenthaler Besides applying knowledge in their own products or services, firms may externally commercialize their knowledge assets (e.g., by means of outlicensing). The literature on champions, however, has focused on internal innovation. This gap in prior research is particularly remarkable as the potential for promoting external knowledge exploitation is high. Some pioneering firms realize great benefits, whereas most others experience major managerial difficulties. This paper tests five hypotheses regarding the emergence and impact of champions of external knowledge exploitation with data from 152 firms across industries. The results of the questionnaire-based study demonstrate the relevance of champions of external knowledge exploitation. Championing constitutes an essential success factor and has strongly contributed to the recent increase in external knowledge commercialization. These findings help to explain the discrepancies between the few successful and the majority of unsuccessful firms. Beyond existing insights, the emergence of champions is affected by external determinants in addition to internal determinants. There is an inverted U-shaped relationship between championing and the internal determinants, that is, organizational climate and active strategy. Moreover, there is a negative relationship between championing and market imperfection and an inverted U-shaped relationship between championing and competitive intensity, which both constitute external determinants of championing. In contrast to the traditional understanding, champions tend to emerge in supportive environments, in which internal and external barriers are relatively low. This surprising finding calls for rethinking the role and motivation of champions. [source] Regulation of hematopoietic niches by sympathetic innervationBIOESSAYS, Issue 7 2006Hector Leonardo Aguila Once hematopoiesis is established in the bone marrow, a continuous egress of hematopoietic stem cells (HSCs) to the periphery occurs at a low frequency. It has been proposed that this phenomenon is part of a regenerative homeostatic mechanism that ensures the maintenance of hematopoiesis through the life of the individual. The administration of certain cytotoxic drugs or cytokines can enhance the mobilization of hematopoietic progenitors to the periphery. During the past 15 years, granulocyte-colony stimulating factor (G-CSF) has been used as a standard cytokine for mobilization protocols in experimental models and in humans. Despite extensive efforts by multiple groups, a definitive mechanism explaining its role in mobilization has not been provided. In a recent paper, Katayama et al.,1 through a series of clever associations supported by well-defined experimental systems, proposed that signals through the sympathetic nervous system modify the activity of the hematopoietic niche, acting as regulators of the mobilization of hematopoietic progenitors. This surprising finding adds a new level of complexity to the cellular milieu responsible for generation and maintenance of the hematopoietic niche. BioEssays 28: 687,691, 2006. © 2006 Wiley Periodicals, Inc. [source] Bacillus Calmette-Guérin therapy in stage Ta/T1 bladder cancer: prognostic factors for time to recurrence and progressionBJU INTERNATIONAL, Issue 7 2004P. Andius OBJECTIVE To report prognostic factors for time to recurrence and progression after bacillus Calmette-Guérin (BCG) prophylaxis in patients with stage Ta/T1 papillary bladder cancer. PATIENTS AND METHODS The clinical records were assessed retrospectively for 236 patients with papillary stage Ta/T1 bladder cancer treated with BCG between 1986 and 2000. Patients with known carcinoma in situ were excluded. The median (range) follow-up was 44 (4,155) months. The effect of 13 variables on the time to recurrence and progression was evaluated using multivariate Cox proportional hazard regression and Kaplan-Meier analyses. RESULTS The recurrence rate was markedly reduced for all grades and stages. Patients with a negative first cystoscopy and maintenance BCG had a significantly longer time to recurrence than those treated with an induction course alone (P < 0.001). Thirty-seven patients (16%) progressed in stage. The result of the first cystoscopy (P < 0.001), tumour grade (P = 0.003) and six or fewer initial instillations (P = 0.002) had prognostic importance for the time to progression. Twenty-eight patients (12%) had a history of an upper tract tumour, which was 3,10 times the expected rate. Age, number of tumours, number of positive cystoscopies, length of tumour history before BCG, BCG strain and treatment year had no influence on time to recurrence and progression. CONCLUSIONS Maintenance treatment does not seem to be necessary among patients with TaG1-G2 disease after a negative first cystoscopy, as the progression rate was very low. One new finding was that BCG seemed to be equally effective among patients with or with no history of an upper tract tumour. Another new and surprising finding was that patients treated with fewer than six induction instillations, because of very bothersome side-effects, had an increased risk of tumour progression and of local failure. [source] Acute Hypervolaemia Improves Arterial Oxygen Pressure in Athletes with Exercise-Induced HypoxaemiaEXPERIMENTAL PHYSIOLOGY, Issue 4 2003Gerald S. Zavorsky The aim of this study was to determine the effect of acute plasma volume expansion on arterial blood-gas status during 6.5 min strenuous cycling exercise comparing six athletes with and six athletes without exercise-induced arterial hypoxaemia (EIAH). We hypothesized that plasma volume expansion could improve arterial oxygen pressure in a homogeneous sample of athletes - those with EIAH. In this paper we have extended the analysis and results of our recently published surprising findings that lengthening cardiopulmonary transit time did not improve arterial blood-gas status in a heterogeneous sample of endurance cyclists. One 500 ml bag of 10% Pentastarch (infusion condition) or 60 ml 0.9% saline (placebo) was infused prior to exercise in a randomized, double-blind fashion on two different days. Power output, cardiac output, oxygen consumption and arterial blood gases were measured during strenuous exercise. Cardiac output and oxygen consumption were not affected by acute hypervolaemia. There were group × condition interaction effects for arterial oxygen pressure and alveolar-arterial oxygen pressure difference, suggesting that those with hypoxaemia experienced improved arterial oxygen pressure (+4 mmHg) and lower alveolar-arterial oxygen pressure difference (-2 mmHg) with infusion. In conclusion, acute hypervolaemia improves blood-gas status in athletes with EIAH. The impairment of gas exchange occurs within the first minute of exercise, and is not impaired further throughout the remaining duration of exercise. This suggests that arterial oxygen pressure is only minimally mediated by cardiac output. [source] WHY DO COMMUNITIES MOBILIZE AGAINST GROWTH: GROWTH PRESSURES, COMMUNITY STATUS, METROPOLITAN HIERARCHY, OR STRATEGIC INTERACTION?JOURNAL OF URBAN AFFAIRS, Issue 1 2009MAI THI NGUYEN ABSTRACT:,Findings from this study challenge the conventional wisdom about the motivations for local growth control. Using data of California ballot box growth controls merged with city level demographic and housing data from the U.S. Census Bureau, logit models are estimated to test four hypotheses for why communities mobilize against growth. Of the four hypotheses, growth pressures, community status, metropolitan hierarchy, and strategic interaction, the only hypothesis that was strongly supported by the logistic regression analyses was strategic interaction. Support for the strategic interaction hypothesis reveals that jurisdictions located in regions where growth control policies are more abundant have a higher probability of mobilizing against growth. In other words, jurisdictions' growth control policies influence the growth decisions made by neighboring jurisdictions within the same region. One of the most surprising findings in the logistic regression analyses is that low-income suburbs are significantly more likely to mobilize against growth than high-income suburbs. These results refute the commonly held belief that growth control is strictly a concern of elite communities and suggest that residents of low-income suburbs may be turning to the ballot box to control growth because their communities are the locations of choice for noxious land uses. [source] Dendronized Polymers via Macromonomer Route in Supercritical Carbon DioxideMACROMOLECULAR RAPID COMMUNICATIONS, Issue 19 2008Liborio Ivano Costa Abstract Radical polymerizations from third to fifth generation macromonomers were conducted in supercritical carbon dioxide (scCO2). It was found that all monomers were not soluble in such a medium, and reactions occurred in the CO2 -swollen monomer matrices. Despite the expected severe diffusion limitations, very high conversions and molecular weights were obtained. It is believed that the plasticization effect induced by the CO2 plays a key role in these surprising findings. Scanning force microscopical analyses confirmed that mainly linear dendronized polymers were obtained and therefore chain transfer to polymer is virtually irrelevant. [source] Genetics of individual differences in bitter taste perception: lessons from the PTC geneCLINICAL GENETICS, Issue 4 2005UK Kim The ability or inability to taste the compound phenylthiocarbamide (PTC) is a classic inherited trait in humans and has been the subject of genetic and anthropological studies for over 70 years. This trait has also been shown to correlate with a number of dietary preferences and thus may have important implications for human health. The recent identification of the gene that underlies this phenotype has produced several surprising findings. This gene is a member of the T2R family of bitter taste receptor genes. It exists in seven different allelic forms, although only two of these, designated the major taster and major non-taster forms, exist at high frequency outside sub-Saharan Africa. The non-taster allele resides on a small chromosomal region identical by descent, indicating that non-tasters are descended from an ancient founder individual, and consistent with an origin of the non-taster allele preceding the emergence of modern humans out of Africa. The two major forms differ from each other at three amino acid positions, and both alleles have been maintained at high frequency by balancing natural selection, suggesting that the non-taster allele serves some function. We hypothesize that this function is to serve as a receptor for another, as yet unidentified toxic bitter substance. At least some of the remaining five haplotypes appear to confer intermediate sensitivity to PTC, suggesting future detailed studies of the relationships between receptor structure and taste function. [source] | ||||||||||||||||||||||