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Sugar Systems (sugar + system)

Distribution by Scientific Domains

Chemistry	100%

Selected Abstracts

Interaction Between Potassium Sorbate and Aspartame in Aqueous Model Sugar Systems

JOURNAL OF FOOD SCIENCE, Issue 3 2001
M.F. Gliemmo
ABSTRACT: The interaction between potassium sorbate and aspartame in aqueous model sugar systems of 0.97 water activity and pH 3.0 was studied. Aspartame addition showed a protective effect over sorbate destruction in an aqueous system of approximately aw 1, as well as in a system containing glucose; but, in the presence of sucrose, it enhanced degradation. In all systems studied, addition of K sorbate and depression of water activity to 0.97 increased aspartame destruction. The combined use of K sorbate and aspartame exhibited strong nonenzymatic browning potential. The study demonstrated that nonenzynmatic browning can limit shelf life; and it is not recommended to use potassium sorbate together with aspartame. [source]

Sorption Isotherm and Calorimetric Behavior of Amorphous/Crystalline Raffinose-Water Systems

JOURNAL OF FOOD SCIENCE, Issue 4 2000
H.A. Iglesias
ABSTRACT: The water adsorption and desorption isotherms at 27 °C of initially amorphous raffinose over a range of relative humidity of 11% to 97% have been determined. Upon adsorption, the isotherm exhibited a "quasi" plateau, and the moisture content at this plateau was found to be very close to the amount required to form the crystalline raffinose pentahydrate (R.5 H2O). Crystallization of raffinose (R.5 H2O) during water adsorption at 52% and 58% RH was indicated by differential scanning calorimetry (DSC); both thermograms showed an endothermal peak of melting corresponding to R.5H2O. The results of the crystallization kinetics at 52% and 58% RH indicated that the time to assess the stable physical state in a sugar system for a given external condition has to be properly defined and depends on the (T-Tg) value. [source]

Interaction Between Potassium Sorbate and Aspartame in Aqueous Model Sugar Systems

Microparticulate formulations for the controlled release of interleukin-2

JOURNAL OF PHARMACEUTICAL SCIENCES, Issue 5 2004
Tommy T. Thomas
Abstract Interleukin 2 (IL-2) is a pleotropic growth factor essential to immune system function. Current methods of administration are limited by the necessity of hospitalization as well as dose-limiting toxicities and side effects. There is also the issue of low therapeutic concentrations at the desired site of action; for instance, in the case of solid tumor treatment. Here we describe the design of controlled-release vehicles for the local administration of IL-2 based on single (SE) and double emulsion (DE) poly(lactic- co -glycolic acid) (PLGA) systems and a newly developed class of spray-dried lipid,protein,sugar systems composed of L -,-dipalmitoylphosphatidylcholine (DPPC) and 0.2% Eudragit E 100. All three systems demonstrated the release of therapeutic drug quantities. Totals of 2.0, 0.5, and 2.8 ,g of IL-2 (per mg of solid) were encapsulated in the SE, DE, and spray-dried formulations, respectively. The SE and DE released of 30 and 15% of the encapsulated protein, respectively, with delivery of biologically active IL-2 during the first 5 to 10 days. The lipid,protein,sugar-based system demonstrated extended sustained release of biologically active IL-2 for a period of 4 months. These systems provide a potential framework for long-term loco-regional immunotherapeutic treatment regimens. © 2004 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 93:1100,1109, 2004 [source]