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Successive Treatment (successive + treatment)

Distribution by Scientific Domains

Medical Sciences	60%
Chemistry	40%

Selected Abstracts

Pilonidal Sinus Disease Treated by Depilation Using an 800 nm Diode Laser and Review of the Literature

DERMATOLOGIC SURGERY, Issue 5 2005
Anthony V. Benedetto DO, FACP
background. Pilonidal sinus disease is a debilitating, disfiguring chronic ailment that is often resistant to therapy. Its etiology and treatment remain in question. objective. To assess the efficacy of an 800 nm diode laser in the treatment of recalcitrant pilonidal sinus disease. methods. Two patients with recalcitrant pilonidal sinus disease were treated in the lower back, buttocks, and perigluteal cleft area with an 800 nm diode laser with a spot size of 9 × 9 mm, fluences of 30 to 48 J/cm2, and pulse widths of 15 to 24 milliseconds. results. Long-term relief of pilonidal sinus disease was produced with as few as two treatments 2 months apart to as many as six treatments over a 2-year period. With each successive treatment, fewer pulses were needed and the interval between treatments increased. conclusion. The 800 nm diode laser may be an effective tool in the treatment of pilonidal sinus disease. By eliminating the source of hair and hair fragments that course along the surface of the lower back and buttocks, interruption of the etiologic source for pilonidal sinus disease can be accomplished. [source]

Isolation and structural characterization of an R-form lipopolysaccharide from Yersinia enterocolitica serotype O:8

FEBS JOURNAL, Issue 3 2001
Clemens Oertelt
The lipopolysaccharide (LPS) of strain 8081-c-R2, a spontaneous R-mutant of Yersinia enterocolitica serotype O:8, was isolated using extraction with phenol/chloroform/light petroleum. Its compositional analysis indicated the presence of d -GlcN, d -Glc, lglycerodmanno - and dglycerodmanno -heptose, 3-deoxy- dmanno -oct-2-ulosonic acid (Kdo) and phosphate. From deacylated LPS obtained after successive treatment with hydrazine and potassium hydroxide, three oligosaccharides (1,3) were isolated using high-performance anion-exchange chromatography, the structures of which were determined by compositional analysis and one- and two-dimensional NMR spectroscopy as in which all sugars are pyranoses, and R and R, represent ,- d -Glc (in 1 and 2) and ,- d -GlcN (in 1 only), respectively. d -,- d -Hep is dglycero -,- dmanno -heptose, l -,- d -Hep is lglycero -,- dmanno- heptose, Kdo is 3-deoxy- dmanno -oct-2-ulosonic acid, and P is phosphate. The liberated lipid A was analyzed by compositional analyses and MALDI-TOF MS. Its ,- d -GlcN4P-(1,6)-,- d -GlcN-1,P backbone is mainly tetra-acylated with two amide- and one ester-linked (at O3 of the reducing GlcN) (R)-3-hydroxytetradecanoic acid residues, and one tetradecanoic acid that is attached to the 3-OH group of the amide-linked (R)-3-hydroxytetradecanoic acid of the nonreducing GlcN. Additionally, small amounts of tri- and hexa-acylated lipid A species occur. [source]

An Iron(II) Carbonyl Thiolato Complex Bearing 2-Methoxy-Pyridine: A Structural Model of the Active Site of [Fe] Hydrogenase

CHEMISTRY - AN ASIAN JOURNAL, Issue 9 2010
Soichiro Tanino Dr.
Model complex: An FeII complex bearing a thiolate, 2-methoxy-pyridine, and three facially arranged CO ligands was synthesized as a structural analogue of the active site of a CO-inhibited form of [Fe] hydrogenase, from the reaction of [FeBr2(CO)4] with NaS{2,6-(mesityl)2C6H3} and the successive treatment with 2-methoxy-pyridine. [source]

Metallic Taste: An Unusual Reaction to Botulinum Toxin A

DERMATOLOGIC SURGERY, Issue 5 2003
Christian Murray MD
BACKGROUND Botulinum neurotoxin formulations are safe and effective agents for the treatment of facial rhytides. OBJECTIVES A patient is described who complained of metallic taste after each treatment with botulinum toxin A (BTX-A). RESULTS The sensation of metallic taste diminished after successive treatments with BTX-A, despite adequate dosing for cosmetic purposes. CONCLUSION Metallic taste is associated with the use of numerous medications; however, the pathogenesis remains unclear. Alteration in zinc metabolism, which may occur with BTX-A administration, has been suggested as a possible mechanism. Although this is the first known report of dysgeusia after BTX-A, physicians and patients may be reassured that the taste alteration was self-limited and was not significantly problematic for the patient in our case. [source]

Open comedones overlying granuloma annulare in a photoexposed area

PHOTODERMATOLOGY, PHOTOIMMUNOLOGY & PHOTOMEDICINE, Issue 5 2006
Emilio Sudy
A 57-year-old, fair-skinned female patient with lesions of granuloma annulare located on her forearms , with signs of actinic damage , is described. No response was observed after successive treatments with topical corticosteroids and oral pentoxifylline. Four years later, the patient developed open comedones on the rim of granuloma annulare lesions. The loss of elastic fibers seen in both granuloma annulare and solar elastosis is presumed to have induced the appearance of open comedones, because of a loss of supporting properties of the dermis inducing a distension of the infundibular canal of the sebaceous follicle, as seen in the Favre,Racouchot disease and actinic comedonal plaque. Concomitantly, the patient developed insulin-dependent diabetes mellitus. Treatment with insulin resulted in the disappearance of open comedones and notably regression of lesions of granuloma annulare. Response to insulin therapy in our case supports the hypothesis that insulinopenia could participate in the development of granuloma annulare in some cases. [source]