Home About us Contact
|
Home About us Contact | ||
|
|
||
Successful Method (successful + method)
Selected AbstractsSodium Hydroxide Chemical Matricectomy for the Treatment of Ingrown Toenails: Comparison of Three Different Application PeriodsDERMATOLOGIC SURGERY, Issue 7 2005Pelin Kocyigit MD Objective Sodium hydroxide matricectomy is a successful method for the treatment of ingrown toenails. This study was designed to evaluate the optimal sodium hydroxide application period providing high success rates with minimal postoperative morbidity. Materials and Methods Sixty-six patients with 225 ingrown nail edges were treated in three groups receiving 30-second, 1-minute, and 2-minute applications of sodium hydroxide. Each patient was reviewed postoperatively for pain, drainage, and tissue damage. The median long-term follow-up period was 14 months. Results The success rate of the therapy was 70.9% in the first group, 92.7% in the second group, and 94.4% in the third group. In all groups, about half of the patients experienced minimal pain within 48 hours following the operation, but only in the third group, 20% of the patients had minimal pain, which continued about 1 week. Drainage and tissue damage were minimal or mild in all groups and disappeared within 3 weeks in the first and second groups but were prolonged to 6 weeks in the third group. conclusion The success rate of 30-second application is significantly lower than 1-minute and 2-minute applications. Although the success rates of the latter two procedures are similar, the prolonged healing time is the disadvantage of the 2-minute application. We conclude that 1-minute application of 10% sodium hydroxide is simple, safe, and highly effective for the treatment of ingrown nails. [source] Minimizing Postoperative Drainage with 20% Ferric Chloride After Chemical Matricectomy with PhenolDERMATOLOGIC SURGERY, Issue 2 2001A. Burhan Aksakal MD Background. Phenol used in partial matricectomy shows its effects by denaturing matrix proteins. This highly successful method has the major problem of oozing which can continue for 5,6 weeks. Objective. The goal of this study was to determine the effect of 20% ferric chloride (FC) (FeCl3) on minimizing the oozing after chemical matricectomy with phenol. Methods. Sixty-seven patients with stage III onychocryptosis were treated by chemical matricectomy with 90% aqueous phenol. In 32 of these patients FC was applied to the nail bed after the phenolization procedure. Results. We found a statistically significant (P < .001) reduction of oozing in the FC-applied group of patients. Conclusion. We think that using FC after phenol chemical matricectomy results in a significant reduction in oozing from the operation site. [source] Microaffinity purification of proteins based on photolytic elution: Toward an efficient microbead affinity chromatography on a chipELECTROPHORESIS, Issue 3 2005Woo-Jae Chung Abstract A bead affinity chromatography system, which was based on the photolytic elution method, was integrated into a glass-silicon microchip to purify specific target proteins. CutiCore® beads, which were coupled with a photo-cleavable ligand, such as biotin and an RNA aptamer, were introduced into a filter chamber in the microchip. The protein mixture containing target protein labeled with fluorescein isothiocyanate (FITC) was then passed through the packed affinity beads in the microchamber by pressure-driven flow. During the process, the adsorbed protein on the bead was monitored by fluorescence. The concentrated target protein on the affinity bead was released by simple irradiation with UV light at a wavelength of 360 nm, and subsequently eluted with the phosphate buffer flow. The eluted target protein was quantitatively detected via the fluorescence intensity measurements at the downstream of the capillary connected to the outlet of the microchip. The microaffinity purification allowed for a successful method for the identification of specific target proteins from a protein mixture. In addition, the feasibility of this system for use as a diagnosis chip was demonstrated. [source] Rim versus sagittal mandibulectomy for the treatment of squamous cell carcinoma: Two types of mandibular preservationHEAD & NECK: JOURNAL FOR THE SCIENCES & SPECIALTIES OF THE HEAD AND NECK, Issue 12 2003Mario Fernando Muñoz Guerra MD Abstract Background. The role of conservative mandibulectomy for patients with bone invasion from squamous cell carcinoma remains poorly defined. However, marginal mandibular resection is biomechanically secure in its design while maintaining the mandibular continuity. This procedure has proven to be a successful method of treating squamous cell carcinoma with limited mandibular involvement. Purpose. The purpose of this study was to analyze our results after the use of a marginal technique for the treatment of oral and oropharyngeal cancer and to compare two types of mandibular conservative procedures: rim resection versus sagittal inner mandibulectomy. Methods. A retrospective review of a cohort of 50 patients (global group) who underwent mandibular conservative resection for previously untreated squamous cell carcinoma was performed. Two subgroups were considered: rim group (n = 37) and sagittal group (n = 13). Clinical evaluation and preoperative radiologic studies were the means used to evaluate bony invasion and to decide on the extent of mandibulectomy. The treatment outcome after these two types of mandibular resection was calculated and compared using analysis by the Pearson ,2 test, logistic regression model for multivariate analysis, and the Kaplan-Meier method to determine survival. Results. In the sagittal group, specimens from 2 patients (11.7%) demonstrated tumor invasion on decalcified histologic examination, whereas the rim group showed 11 cases (29.7%) with bone invasion. Local recurrence was observed in the follow-up of 10 patients. No statistical relationship was found between the presence of histologic bone invasion and the risk of local recurrence. The size of bone resection >4 cm (p = .002) and tumor invasion of surgical margins (p = .039) were found to be associated with increased local recurrence rates. In multivariate analysis, lymph node affectation significantly correlated with histologic mandibular involvement (p = .02). In the global group, the 5-year observed survival rate was 56.97%. Overall survival and rate of recurrence were comparable in both groups. In the global group, tumor infiltration beyond the surgical margin was statistically related with poor survival (p = .01). Conclusions. Analysis of this series disclosed that marginal mandibulectomy is effective in the control of squamous cell carcinomas that are close to or involving the mandible. In carefully selected patients, sagittal bone resection seems to be as appropriate as rim resection in the local control of these tumors. © 2003 Wiley Periodicals, Inc. Head and Neck 25: 000,000, 2003 [source] Reconstructing the equilibrium Boltzmann distribution from well-tempered metadynamicsJOURNAL OF COMPUTATIONAL CHEMISTRY, Issue 11 2009M. Bonomi Abstract Metadynamics is a widely used and successful method for reconstructing the free-energy surface of complex systems as a function of a small number of suitably chosen collective variables. This is achieved by biasing the dynamics of the system. The bias acting on the collective variables distorts the probability distribution of the other variables. Here we present a simple reweighting algorithm for recovering the unbiased probability distribution of any variable from a well-tempered metadynamics simulation. We show the efficiency of the reweighting procedure by reconstructing the distribution of the four backbone dihedral angles of alanine dipeptide from two and even one dimensional metadynamics simulation. © 2009 Wiley Periodicals, Inc. J Comput Chem 2009 [source] Quantitative Trait Loci Affecting Ethanol Sensitivity in BXD Recombinant Inbred MiceALCOHOLISM, Issue 1 2000Kaitlin E. Browman Background: Genetic and environmental factors contribute to an individual's sensitivity to ethanol, although the exact genes underlying ethanol's effects are not known. Quantitative trait locus (QTL) mapping is one successful method for provisionally identifying genes participating in the mediation of a given behavior. QTL analyses seek to identify associations between a quantitative response and previously mapped marker genes across genetically diverse individuals. Many QTL analyses have been performed in BXD recombinant inbred (RI) strains of mice derived from a cross of C57BL/6J (B6) and DBA/2J (D2) progenitor strains. Methods: We conducted a QTL analysis of ethanol-induced loss of righting reflex and ataxia using a panel of 25 BXD RI strains and the progenitors B6 and D2. We measured the duration of loss of righting reflex after injection and blood ethanol concentrations upon regaining of righting reflex. Ataxia was measured as the latency to fall from a vertical screen. Results: Genome-wide QTL analyses correlating strain means with allelic status at >1500 markers identified several associations (p, 0.01). These provisional QTLs were on all chromosomes except 2,5,12,13, and X, and several map near potential candidate genes. Conclusions: These results suggest that ethanol sensitivity is determined by the actions of multiple genes and further suggest their general chromosomal map locations. These provisional linkages will now be confirmed or rejected using additional genetically segregating populations. [source] Successful Lecturing: Presenting Information in Ways That Engage Effective ProcessingNEW DIRECTIONS FOR TEACHING & LEARNING, Issue 89 2002Patricia Ann deWinstanley An effective lecture,one that induces effective processing in one's students,can be a successful method of teaching. [source] Algorithms for vector field generation in mass consistent modelsNUMERICAL METHODS FOR PARTIAL DIFFERENTIAL EQUATIONS, Issue 4 2010Ciro Flores Abstract Diagnostic models in meteorology are based on the fulfillment of some time independent physical constraints as, for instance, mass conservation. A successful method to generate an adjusted wind field, based on mass conservation equation, was proposed by Sasaki and leads to the solution of an elliptic problem for the multiplier. Here we study the problem of generating an adjusted wind field from given horizontal initial velocity data, by two ways. The first one is based on orthogonal projection in Hilbert spaces and leads to the same elliptic problem but with natural boundary conditions for the multiplier. We derive from this approach the so called E,algorithm. An innovative alternative proposal is obtained from a second approach where we consider the saddle,point formulation of the problem,avoiding boundary conditions for the multiplier, and solving this problem by iterative conjugate gradient methods. This leads to an algorithm that we call the CG,algorithm, which is inspired from Glowinsk's approach to solve Stokes,like problems in computational fluid dynamics. Finally, the introduction of new boundary conditions for the multiplier in the elliptic problem generates better adjusted fields than those obtained with the original boundary conditions. © 2009 Wiley Periodicals, Inc. Numer Methods Partial Differential Eq 2010 [source] Stimulation of investment in international energy through Nigerian tax exemption lawsOPEC ENERGY REVIEW, Issue 1 2002Uche Jack Osimiri This article assesses the impact of recent tax exemption legislation as a vehicle for the attraction of investment in the quest for the development of international energy in Nigeria, particularly oil and gas. It seeks to argue that generous tax incentives are the most successful method of inducement of foreign investors, judging from the rising profile in the expansion of investment in the gas sector and the attendant increase in world trade. It attempts to assert that tax incentives alone, without the combination of other favourable factors, like political stability, observance of the rule of law and deregulation or trade liberalisation, cannot produce the desired result of local industrialisation and integration into the world economy. [source] | ||||||||||