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Successful Expansion (successful + expansion)

Distribution by Scientific Domains
Humanities and Social Sciences50%

Selected Abstracts

Successful Expansion of the Living Donor Pool by Alternative Living Donation Programs

AMERICAN JOURNAL OF TRANSPLANTATION, Issue 9 2009
J. I. Roodnat
Between January 2000 and December 2007, 786 potential recipients and 1059 potential donors attended our pretransplant unit with the request for a living-donor renal transplant procedure. The recipients brought one potential donor in 77.2% and two or more donors in 22.8% of cases. In the regular living donor program, a compatible donor was found for 467 recipients. Without considering alternative donation, 579 donors would have been refused. Alternative living donation programs led to 114 compatible combinations: kidney-exchange program (35), ABO-incompatible donation (25), anonymous donation (37) and domino-paired anonymous donation (17). Together, the 114 alternative program donations and the 467 regular living donations led to 581 living donor transplantations (24.4% increase). Eventually for 54.9% (581/1059) of our donors, a compatible combination was found. Donor,recipient incompatibility comprised 19.4% (89/458) in the final refused population, which is 8.8% of the potential donor,recipient couples. Without considering alternative donation, 30.1% (174/579) of the refused donors would have been refused on incompatibility and 6.4% (37/579) because they were anonymous. This is 20% of the potential donor population (211/1059). The implementation of alternative living donation programs led to a significant increase in the number of transplantations, while transplantations via the direct donation program steadily increased. [source]

The Expansion of Global Governance into the Third World: Altruism, Realism, or Constructivism?

INTERNATIONAL STUDIES REVIEW, Issue 1 2004
Yakub Halabi
This essay examines the expansion of global governance into developing countries. Its central thesis is that in the present era of globalization, competitiveness has become a major concern for developed countries, in particular, those facing tough competition from the developing states that have improved their terms of trade through state-led development strategies and have become major exporters of manufactured products. Developed countries seek the expansion of global governance in order to regulate the behavior of these developing states, thereby opening their economies to foreign investment and augmenting their wealth. Yet, a successful expansion of global governance requires the creation of internal institutions in the developing countries that may alter their political cultures. Given the unique problems of the developing states, this task cannot be achieved simply by internationalizing the countries in the Global South. This essay relies on the theory of social constructivism and contends that the creation of internal institutions compatible with global governance has been achieved only when developing countries have become convinced that global regulations will benefit them, not just the more developed states. [source]

MICROFINANCE REVOLUTION: ITS EFFECTS, INNOVATIONS, AND CHALLENGES

THE DEVELOPING ECONOMIES, Issue 1 2010
Hisaki KONO
F35; O19 "Microfinance revolution" is the term often applied to the successful expansion of small-scale financial services to the poor with high repayment records in developing countries. The present paper investigates the extent to which the microfinance revolution is truly revolutionary. More specifically, it explores the impact of microfinance institutions on the poor, the mechanisms underlying high repayment rates and their innovations, and the new challenges microfinance institutions are currently facing. Different from the existing published survey literature, we focus on current topics and attempt to show recent theoretical developments in a comprehensive manner using simplified models with very similar settings. We contend that microfinance is developing in a promising direction but has yet to reach its full potential. [source]

Successful Immunotherapy of HCMV Disease Using Virus-Specific T Cells Expanded from an Allogeneic Stem Cell Transplant Recipient

AMERICAN JOURNAL OF TRANSPLANTATION, Issue 1 2010
G. R. Hill
Opportunistic infection remains the principal cause of mortality in allogeneic stem cell transplant recipients with active extensive chronic graft-versus-host disease. Human cytomegalovirus (HCMV) represents an important cause of disease in this setting and the toxicity of protracted and recurrent antiviral treatment together with eventual drug resistance represents a significant limitation to therapy. Although the expansion and adoptive transfer of HCMV-specific T cells from the healthy original donor can be an effective strategy to control viral replication, this is not possible when donors are seronegative or are subsequently inaccessible. Here we demonstrate for the first time, the successful expansion of HCMV-specific T cells from a seropositive transplant recipient of a seronegative graft with active HCMV disease and the long-term reconstitution of protective antiviral immunity following their adoptive transfer back into the patient. [source]