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Successful Design (successful + design)
Selected AbstractsHospital Birthing Room Design: A Study Of Mothers' Perception Of HominessJOURNAL OF INTERIOR DESIGN, Issue 1 2004Jung-Hye Shin M.S. ABSTRACT The objective of this research is to examine a select set of interior design elements for their contribution to the perception of hominess in a birthing environment. Seven interior design elements were studied. Seven line drawings were generated to illustrate variability in the manipulation level of each design element, resulting in a total of 49 line drawings. Subjects were asked to rate each of the 49 drawings with three different outcome measures: the degree of hominess perceived, the likeliness of using the setting as their birthing place (preference), and the perception of personal control. Researchers employed multiple comparisons with analysis of variance to investigate the contribution of each interior design element to each of the three outcomes. Relationships among the three outcomes were then investigated through coefficient correlation analysis. Finally, a General Linear Model was utilized to further investigate degree of impact of each design element. The findings indicate that perceived hominess in the birthing place is important to women. Furthermore, there is agreement about the use and manipulation of interior design in enhancing the perception of hominess. Successful design in hospital birthing settings can contribute to women's feeling of hominess by providing personal control over visual access, patient exposure, family visitation, and the immediate environment. [source] Unexpected Novel Binding Mode of Pyrrolidine-Based Aspartyl Protease Inhibitors: Design, Synthesis and Crystal Structure in Complex with HIV ProteaseCHEMMEDCHEM, Issue 1 2006Edgar Specker Dr. Abstract At present nine FDA-approved HIV protease inhibitors have been launched to market, however rapid drug resistance arising under antiviral therapy calls upon novel concepts. Possible strategies are the development of ligands with less peptide-like character or the stabilization of a new and unexpected binding-competent conformation of the protein through a novel ligand-binding mode. Our rational design of pyrrolidinedimethylene diamines was inspired by the idea to incorporate key structural elements from classical peptidomimetics with a non-peptidic heterocyclic core comprising an endocyclic amino function to address the catalytic aspartic acid side chains of Asp,25 and 25,. The basic scaffolds were decorated by side chains already optimized for the recognition pockets of HIV protease or cathepsin,D. A multistep synthesis has been established to produce the central heterocycle and to give flexible access to side chain decorations. Depending on the substitution pattern of the pyrrolidine moiety, single-digit micromolar inhibition of HIV-1 protease and cathepsin,D has been achieved. Successful design is suggested in agreement with our modelling concepts. The subsequently determined crystal structure with HIV protease shows that the pyrrolidine moiety binds as expected to the pivotal position between both aspartic acid side chains. However, even though the inhibitors have been equipped symmetrically by polar acceptor groups to address the flap water molecule, it is repelled from the complex, and only one direct hydrogen bond is formed to the flap. A strong distortion of the flap region is detected, leading to a novel hydrogen bond which cross-links the flap loops. Furthermore, the inhibitor addresses only three of the four available recognition pockets. It achieves only an incomplete desolvation compared with the similarly decorated amprenavir. Taking these considerations into account it is surprising that the produced pyrrolidine derivatives achieve micromolar inhibition and it suggests extraordinary potency of the new compound class. Most likely, the protonated pyrrolidine moiety experiences strong enthalpic interactions with the enzyme through the formation of two salt bridges to the aspartic acid side chains. This might provide challenging opportunities to combat resistance of the rapidly mutating virus. [source] Ultra-wideband folded loop antenna fed by coplanar waveguideMICROWAVE AND OPTICAL TECHNOLOGY LETTERS, Issue 12 2008W. J. Lui Abstract In this article, a novel and successful design of ultra-wideband folded loop antenna is proposed and investigated. The antenna is fed by coplanar waveguide directly and can be fabricated easily by employing printed circuit board technology. It is studied both numerically and experimentally. From calculated and measured results, it may be observed that impedance bandwidth of over 130% for return loss lower than ,9.54 dB and good omnidirectional radiation performance is obtained. © 2008 Wiley Periodicals, Inc. Microwave Opt Technol Lett 50: 3075,3077, 2008; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.23890 [source] Compensating for die swell in the design of profile diesPOLYMER ENGINEERING & SCIENCE, Issue 10 2003W. A. Gifford Because of the effects of die swell, the final shape of an extrudate is often substantially different from that of the exit opening of the die. As a result, the design of profile dies producing complex shapes often involves more than just "balancing" the die but also compensating for the effects of die swell. Typically, a successful design of such dies is achieved only through much "cut and try," However, with the use of a fully three-dimensional finite element flow algorithm along with quick mesh generating capabilities, the usual cut and try involved in the design of many profile dies can be greatly reduced, if not eliminated. This paper demonstrates how the effects of die swell can be compensated for in the design of profile dies. For profiles with one plane of symmetry, this includes compensating for the sideways translation of the extrudate as well as the change in shape that the extrudate experiences. Completely asymmetric profiles undergo a "twisting" downstream of the die. This twisting, which appears not to have been reported in the literature (at least for isothermal extrusion), is also accounted for here, along with the change in shape that the extrudate undergoes. The translation or twisting of profiles downstream of a die is often attributed to non-Newtonian or non-isothermal effects. Only isothermal Newtonian examples are considered here. These results clearly show that asymmetry of the profile will result in a translation and twisting of the extrudate even in the isothermal Newtonian case. [source] Exchange traded contracts for difference: Design, pricing, and effects,THE JOURNAL OF FUTURES MARKETS, Issue 12 2010Christine Brown Contracts for Difference (CFDs) are a significant financial innovation in the design of futures contracts. Over-the-counter trading in the UK is significant and has created controversy, but there is no published academic research into the design, pricing, and effects of CFDs. This study analyzes CFD contract design and pricing. It uses a unique database of trades and quotes on exchange traded equity CFDs introduced by the Australian Securities Exchange to test theoretical pricing relationships, and draws out implications for successful design and trading arrangements for the introduction of new derivative contracts. © 2010 Wiley Periodicals, Inc. Jrl Fut Mark [source] Insights into drug metabolism by cytochromes P450 from modelling studies of CYP2D6-drug interactionsBRITISH JOURNAL OF PHARMACOLOGY, Issue S1 2008J-D Maréchal The cytochromes P450 (CYPs) comprise a vast superfamily of enzymes found in virtually all life forms. In mammals, xenobiotic metabolizing CYPs provide crucial protection from the effects of exposure to a wide variety of chemicals, including environmental toxins and therapeutic drugs. Ideally, the information on the possible metabolism by CYPs required during drug development would be obtained from crystal structures of all the CYPs of interest. For some years only crystal structures of distantly related bacterial CYPs were available and homology modelling techniques were used to bridge the gap and produce structural models of human CYPs, and thereby obtain useful functional information. A significant step forward in the reliability of these models came seven years ago with the first crystal structure of a mammalian CYP, rabbit CYP2C5, followed by the structures of six human enzymes, CYP1A2, CYP2A6, CYP2C8, CYP2C9, CYP2D6 and CYP3A4, and a second rabbit enzyme, CYP2B4. In this review we describe as a case study the evolution of a CYP2D6 model, leading to the validation of the model as an in silico tool for predicting binding and metabolism. This work has led directly to the successful design of CYP2D6 mutants with novel activity,including creating a testosterone hydroxylase, converting quinidine from inhibitor to substrate, creating a diclofenac hydroxylase and creating a dextromethorphan O -demethylase. Our modelling-derived hypothesis-driven integrated interdisciplinary studies have given key insight into the molecular determinants of CYP2D6 and other important drug metabolizing enzymes. British Journal of Pharmacology (2008) 153, S82,S89; doi:10.1038/sj.bjp.0707570; published online 19 November 2007 [source] | ||||||||||