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Subsequent Deprotection (subsequent + deprotection)

Distribution by Scientific Domains
Chemistry75%

Selected Abstracts

ChemInform Abstract: Indium- and Zinc-Mediated Barbier-Type Allylations of an N,N-(Dimethylsulfamoyl)-Protected Aldimine and Subsequent Deprotection.

CHEMINFORM, Issue 3 2008
Sara Kaellstroem
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source]

Polyhedral oligomeric silsesquioxane bound fulleropyrrolidines

APPLIED ORGANOMETALLIC CHEMISTRY, Issue 8 2008
David J. Clarke
Abstract The first reported examples of polyhedral oligomeric silsesquioxane (POSS) cages containing a fulleropyrrolidine species are reported herein. Monosubstituted POSS-dioxalane species were synthesized through the hydrosilylation of a silyl-dioxalane with mono-vinyl substituted POSS. Subsequent deprotection yielded the desired aldehyde functionality. An alternative synthetic pathway, involving the nucleophilic substitution of mono-benzyl chloride POSS with 4-hydroxybenzaldehyde yielded the desired aldehyde functionality. Each mono-aldehyde POSS was then reacted with N -methylglycine and C60 to yield the desired POSS fulleropyrrolidines. The prepared compounds were characterized by multinuclear NMR, electrospray mass spectrometry, elemental analysis, UV,vis, fluorescence and optical power limiting measurements. Copyright © 2008 John Wiley & Sons, Ltd. [source]

Molar Mass and Structural Characteristics of Poly[(lactide- co -(aspartic acid)] Block Copolymers

MACROMOLECULAR SYMPOSIA, Issue 1 2008
Ida Poljan
Abstract Summary: We report on various synthetic procedures for the preparation of biodegradable and biocompatible poly(lactide- co -aspartic acid) block copolymers based on natural monomeric units , lactic acid and aspartic acid. Multiblock poly(lactide- co -aspartic acid) copolymers of different comonomer composition were synthesized by heating a mixture of L-aspartic acid and L,L-lactide in melt without the addition of any catalyst or solvent and with further alkaline hydrolysis of the cyclic succinimide rings to aspartic acid units. Diblock poly(lactide- co -aspartic acid) copolymers with different block lengths were prepared by copolymerization of amino terminated poly(, -benzyl-L-aspartate) homopolymer and L,L-lactide with subsequent deprotection of the benzyl protected carboxyl group by hydrogenolysis. The differences in the structure, composition, molar mass characteristics, and water-solubility of the synthesized multiblock and diblock poly(lactide- co -aspartic acid) copolymers are discussed. [source]

Synthesis of Thia-Analogous Indirubin N -Glycosides and their Influence on Melanoma Cell Growth and Apoptosis

CHEMMEDCHEM, Issue 4 2010
Manfred Kunz Prof.
Stopping cancer in its tracks! Thia-analogues of indirubin- N -glycosides, prepared by condensation of N -glycosylisatines with thiaindane-3-one and subsequent deprotection, were tested for their activity against malignant melanoma cells. These indirubin- N -glycoside thia-analogues are active against melanoma cells, inducing growth arrest, apoptosis and inhibition of intracellular signal transduction. [source]