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Subtle Ways (subtle + way)
Selected AbstractsHas number of previous episodes any effect on response to group psychoeducation in bipolar patients?ACTA NEUROPSYCHIATRICA, Issue 2 2010A 5-year follow-up post hoc analysis Colom F, Reinares M, Pacchiarotti I, Popovic D, Mazzarini L, Martínez-Arán A, Torrent C, Rosa A, Palomino-Otiniano R, Franco C, Bonnin CM, Vieta E. Has number of previous episodes any effect on response to group psychoeducation in bipolar patients? A 5-year follow-up post hoc analysis. Objective: One of the main utilities of staging in bipolar disorder is enhancing the formulation of pharmacological and non-pharmacological treatment strategies. Hence, it is essential to ascertain whether the number of previous episodes influences treatment response. Hereby, we present a 5-year post hoc study on the efficacy of group psychoeducation for bipolar disorders according to the number of previous episodes. Methods: For this subanalysis, we have compared the 5-year outcome of 120 euthymic psychoeducated versus non-psychoeducated bipolar patients according to the number of previous episodes at study entry. Results: Patients with more than seven episodes at study entry did not show any significant improvement with psychoeducation according to time to recurrence. Patients with more than 14 episodes did not benefit from psychoeducation in terms of a reduction of time spent ill. Patients with 7 or 8 episodes showed a benefit in terms of fewer days spent in hypomania, depression, mixed episodes or any episodes but not mania, while patients with 9,14 episodes showed a benefit in terms of fewer days spent in hypomania and depression but not in mixed states or mania. Only patients who presented up to 6 episodes showed reduction in time spent in any episode polarity. Conclusion: The number of previous episodes clearly worsens response to psychoeducation, perhaps in a more subtle way than that observed with other psychological therapies. Psychoeducation should be delivered as soon as possible in the illness course, supporting the idea of early intervention. [source] Learning-by-Doing, Organizational Forgetting, and Industry DynamicsECONOMETRICA, Issue 2 2010David Besanko Learning-by-doing and organizational forgetting are empirically important in a variety of industrial settings. This paper provides a general model of dynamic competition that accounts for these fundamentals and shows how they shape industry structure and dynamics. We show that forgetting does not simply negate learning. Rather, they are distinct economic forces that interact in subtle ways to produce a great variety of pricing behaviors and industry dynamics. In particular, a model with learning and forgetting can give rise to aggressive pricing behavior, varying degrees of long-run industry concentration ranging from moderate leadership to absolute dominance, and multiple equilibria. [source] On the Application of Inductive Machine Learning Tools to Geographical AnalysisGEOGRAPHICAL ANALYSIS, Issue 2 2000Mark Gahegan Inductive machine learning tools, such as neural networks and decision trees, offer alternative methods for classification, clustering, and pattern recognition that can, in theory, extend to the complex or "deep" data sets that pervade geography. By contrast, traditional statistical approaches may fail, due to issues of scalability and flexibility. This paper discusses the role of inductive machine learning as it relates to geographical analysis. The discussion presented is not based on comparative results or on mathematical description, but instead focuses on the often subtle ways in which the various inductive learning approaches differ operationally, describing (1) the manner in which the feature space is partitioned or clustered, (2) the search mechanisms employed to identify good solutions, and (3) the different biases that each technique imposes. The consequences arising from these issues, when considering complex geographic feature spaces, are then described in detail. The overall aim is to provide a foundation upon which reliable inductive analysis methods can be constructed, instead of depending on piecemeal or haphazard experimentation with the various operational criteria that inductive learning tools call for. Often, it would appear that these criteria are not well understood by practitioners in the geographic sphere, which can lead to difficulties in configuration and operation, and ultimately to poor performance. [source] Deterministic fallacies and model validationJOURNAL OF CHEMOMETRICS, Issue 3-4 2010Douglas M. Hawkins Abstract Stochastic settings differ from deterministic ones in many subtle ways, making it easy to slip into errors through applying deterministic thinking inappropriately. We suspect this is the cause of much of the disagreement about model validation. A further technical issue is a common misapplication of cross-validation, in which it is applied only partially, leading to incorrect results. Statistical theory and empirical investigation verify the efficacy of cross-validation when it is applied correctly. In settings where data are relatively scarce, cross-validation is attractive in that it makes the maximum possible use of all available information, at the cost of potentially substantial computation. The bootstrap is another method that makes full use of all available data for both model fitting and model validation, at a cost of substantially increased computation, and it shares many of the broad philosophical background of cross-validation. Increasingly, the computational cost of these methods is not a major concern, leading to the recommendation, in most circumstances, to use cross-validation or bootstrapping rather than the earlier standard method of splitting the available data into a learning and a testing portion. Copyright © 2010 John Wiley & Sons, Ltd. [source] Capitalising the Value of Free Schools: The Impact of Supply Characteristics and Uncertainty,THE ECONOMIC JOURNAL, Issue 499 2004Paul Cheshire This paper explores the sources and impact of variations of a given school quality at either primary or secondary level as capitalised into the price of houses. The results provide new evidence on the complex and subtle ways in which housing markets capitalise the value of local public goods such as school quality and suggest that this is highly nonlinear. We expect variation in the capitalised price according to the elasticity of supply of ,school quality' in the local market, the certainty with which that quality can be expected to be maintained and the suitability of the dwelling to accommodate children. [source] A Multidisciplinary Approach to Describe Protists: Redescriptions of Novistrombidium testaceum Anigstein 1914 and Strombidium inclinatumMontagnes, Taylor, and Lynn 1990 (Ciliophora, Oligotrichia)THE JOURNAL OF EUKARYOTIC MICROBIOLOGY, Issue 3 2003LETIZIA MODEO ABSTRACT. We combined behavioral, morphological (live, stained, scanning and transmission electron-microscope), and molecular data to redescribe two common, intertidal oligotrich ciliates, Novistrombidium testaceum and Strombidium inclinatum. Both species were collected from a rocky shore near Leghorn, Ligurian Sea. A literature review revealed four morphotypes of Novistrombidium testaceum that differ in subtle ways, including oral morphology. These differences may be diagnostic, but we do not consider them sufficient to distinguish different taxa. Although other studies have synonymised Strombidium inclinatum and S. sulcatum, based on oral structures, size, and nuclear structure, there are morphological distinctions between them. In particular, the present study supports a lack of anterior protuberance in both live and preserved S. inclinatum, while S. sulcatum possesses a protuberance. The 18S rDNA molecular data, in accordance with morphological and ultrastructural observations, indicate that the Strombidiida (Oligotrichia) constitute a well-supported clade. The separation of the genera within this clade, even between Novistrombidium and Strombidium, remains unresolved, and the analysis of more species is required. Finally, we recommend that when possible, ecologists, morphological taxon-omists, and molecular biologists combine their expertise to provide comprehensive taxonomic descriptions. [source] The response of tree squirrels to fragmentation: a review and synthesisANIMAL CONSERVATION, Issue 4 2005John L. Koprowski Habitat fragmentation is often considered a major threat to biodiversity; however, our understanding of how fragmentation impacts populations is poor. Identifying appropriate models for such studies is difficult. Tree squirrels are dependent on mature forests for food, cover and nests; these are habitats that are being fragmented rapidly and that are easily defined by humans. Squirrels represent excellent models for study of fragmentation. The literature on tree squirrels was reviewed to glean data on density and home-range size in forest fragments. Sufficient data were available on four species (Sciurus carolinensis, S. niger, S. vulgaris, Tamiasciurus hudsonicus). Density was negatively related to fragment size for S. carolinensis and S. niger and marginally so for T. hudsonicus. Sciurus vulgaris did not exhibit this relationship. Home-range size was analysed for three species of Sciurus and was positively related to forest fragment size for S. carolinensis and S. niger. Again, only S. vulgaris did not to show this relationship. Sciurus vulgaris is rarely found in small forest fragments and is believed to be especially sensitive to fragmentation; other tree squirrels appear to be sensitive to fragmentation in more subtle ways. Home range compaction provides a mechanism by which densities may increase in small fragments. The demographic consequences resultant from the high densities of squirrels found in small woodlots are not known but may explain the forest damage, avian nest predation and reduced diversity often cited to occur in woodland fragments. [source] Youth Cosmopolitanism: Clothing, the City and Globalization in Dakar, SenegalCITY & SOCIETY, Issue 2 2007SUZANNE SCHELD Youth clothing and exchange shape cosmopolitan identities, the city, and global flows in Dakar, Senegal. How Dakarois youth use dress to shape the city and urban identity is puzzling. Despite the declining economy and for many, extreme poverty, youth dress up in stylish and provocative outfits. In Dakar, youth are increasingly entrepreneurial individuals who base the authenticity of their cosmopolitan identity on an ability to buy and sell (trade) in the urban/global informal economy. Because the informal economy is intensely competitive for both buyers and sellers, youth rely on social networks, various forms of reciprocity, and trust in order to perform their work. At times, youth engage in dishonest acts and banditry in order to sell and procure clothing. These strategies highlight the uncertainty of life in Dakar, the relativity of morality, and the creativity that youth employ to make their lives and a life for the city. In these often hidden and subtle ways, youth steer the economic cultural life of the city and keep it hooked in to the global economy. This research is based on fieldwork conducted in Dakar and New York City between 1996 and 2005. Research methods include interviews, participant observation, focus groups and engaging youth in authoring informal fashion magazines which feature their own photography and stories about contemporary clothing trends in Dakar. [source] Everything depends on everything elseCLINICAL MICROBIOLOGY AND INFECTION, Issue 2009J. Davies Abstract In physics the concept of entanglement is well established and it has become increasingly apparent that all levels of biological organization (communities, organisms, cells, metabolism) consist of mosaics of interactive networks. There is a universe of bioactive microbial chemicals that have so far only been considered for their therapeutic applications; for example, the environmental roles of antibiotics have been little investigated. At sub-inhibitory concentrations, so-called antibiotics have been shown to modulate bacterial functions in subtle ways; they behave more like signals than toxins. It is proposed that networks of microbial cell signalling are primarily based on the interactions of low molecular weight compounds with macromolecular receptors; studies of the nature of these signals will reveal important information on the functions of microbial communities. [source] | |||||||||||||||||||