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Subcutaneous Fat Necrosis (subcutaneous + fat_necrosis)

Distribution by Scientific Domains
Medical Sciences100%

Selected Abstracts

Usefulness of Fine-Needle Aspiration in Subcutaneous Fat Necrosis of the Newborn Diagnosis

PEDIATRIC DERMATOLOGY, Issue 3 2010
Verónica López M.D.
No abstract is available for this article. [source]

Subcutaneous fat necrosis of the newborn associated with ventricular septal defect and patent ductus arteriosus

INTERNATIONAL JOURNAL OF DERMATOLOGY, Issue 9 2009
Jae Hwan Kim MD
No abstract is available for this article. [source]

Expression of 25-hydroxyvitamin D3 -1,-hydroxylase in subcutaneous fat necrosis

BRITISH JOURNAL OF DERMATOLOGY, Issue 2 2009
A. Farooque
Summary Background, The most serious complication of subcutaneous fat necrosis (SCFN), a rare condition of the newborn characterized by indurated purple nodules, is hypercalcaemia. However, the mechanism for this hypercalcaemia remains unclear. Objectives, To determine whether the hypercalcaemia associated with SCFN involves expression of the vitamin D-activating enzyme 25-hydroxyvitamin D3 -1,-hydroxylase (1,-hydroxylase) in affected tissue. Methods, Skin biopsies from two male patients with SCFN and hypercalcaemia were taken. The histological specimens were assessed using a polyclonal antibody against 1,-hydroxylase. Results, Histology in both cases showed strong expression of 1,-hydroxylase protein (brown staining) within the inflammatory infiltrate associated with SCFN. This was consistent with similar experiments in other granulomatous conditions. Conclusions, Hypercalcaemia in SCFN appears to be due to abundant levels of 1,-hydroxylase in immune infiltrates associated with tissue lesions. This is consistent with previous observations of extrarenal 1,-hydroxylase in skin from other granulomatous conditions such as sarcoidosis and slack skin disease. [source]