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Selected AbstractsThe Effects of Ascorbic Acid on Penicillin-induced Epileptiform Activity in RatsEPILEPSIA, Issue 7 2007Mustafa Ayyildiz Summary:,Purpose: Epileptic seizure results from excessive discharge in a population of hyperexcitable neurons. A number of studies help to document the effects of active oxygen free radical scavengers such as ,-tocopherol or ascorbic acid (vitamin C). In the present study, we examined the effects of ascorbic acid, at the six different doses, on penicillin-induced epileptiform activity. Methods: A single microinjection of penicillin (2.5 ,l, 500 units, intracortically) into the left sensorimotor cortex induced epileptiform activity within 2,5 min, progressing to full seizure activity lasting ,3,5 h. In the first set of experiments, 30 min after penicillin injection, six different doses of ascorbic acid (25, 50, 100, 200, 400, or 800 mg/kg) were administered intraperitoneally (IP). The other group of animals received the effective dose of ascorbic acid (100 mg/kg, IP) for 7 days. Ascorbic acid administration was stopped 24 h before penicillin treatment. Another group of rats received the effective dose of ascorbic acid (100 mg/kg, IP) 30 min before penicillin treatment. In the second set of experiments, the lipid peroxidation (MDA) and reduced glutathione (GSH) levels of brain were measured in the control, control + ascorbic acid, penicillin, and penicillin + ascorbic acid groups. Results: Ascorbic acid, at the low dose (50, 100 mg/kg, 30 min after penicillin injection), decreased both the frequency and amplitude of penicillin-induced epileptiform activity in rats. Ascorbic acid, at intermediate doses (200, 400 mg/kg, 30 min after penicillin injection), decreased the frequency of epileptiform activity without changing the amplitude. Ascorbic acid, at the lowest dose (25 mg/kg) and highest dose (800 mg/kg) (30 min after penicillin injection), did not change either the frequency or amplitude of epileptiform activity. Ascorbic acid, at the low dose (100 mg/kg) was the most effective dose in changing the frequency and amplitude of penicillin-induced epileptiform activity. Pretreatment with ascorbic acid (100 mg/kg) 30 min before penicillin treatment caused a significant delay in the onset of penicillin-induced epileptiform activity. Pretreatment with ascorbic acid (100 mg/kg) for 7 days did not change the latency of epileptiform activity. The most effective dose of ascorbic acid (100 mg/kg) prevented both the decrease in GSH level and the increase in lipid peroxidation level (MDA) occurring after penicillin-induced epileptiform activity. Conclusions: These data indicate that ascorbic acid has neuroprotective activity against penicillin-induced epileptiform electrocorticogram activity. [source] Patients' and their parents' satisfaction levels about the treatment in a child and adolescent mental health inpatient unitJOURNAL OF PSYCHIATRIC & MENTAL HEALTH NURSING, Issue 9 2010F. VAROL TAS md Accessible summary ,,The views of patients and their relatives regarding the treatment are extremely important in mental health as well as in other medical disciplines. ,,In our study, consistent with the literature, the satisfaction levels of young people and their families regarding the service they got during their stay in the unit were determined to be high. ,,The questionnaire used in the survey was designed to allow for five domain-based subscales which were admission process, staff, environment/services, treatment interventions and treatment outcome. ,,The satisfaction level of young people and their families regarding the service they received during their stay in the unit were determined to be high. The results of the questionnaires completed by adolescents and parents showed that; the availability and the helpfulness of the staff, the admission process was given the highest satisfaction scores. ,,The results of such studies help to improve the quality of treatment and the mental health service that children and adolescents and their families receive. Abstract The aim of this study is to demonstrate the feedback and the satisfaction levels of the adolescents and their parents who received treatment in the newly opened inpatient unit. The results of the questionnaire evaluating the quality of the mental health service provided by the inpatient unit were examined retrospectively. The participants were the adolescents and their parents who received treatment and were discharged between January 2006 and May 2007. They were asked to give feedback on their observations and perceptions about the treatment they received, starting from the admission assessment until the time they were discharged. The satisfaction level of young people and their families regarding the service they received during their stay in the unit were determined to be high. The results of the questionnaires completed by adolescents and parents showed that the availability and the helpfulness of the staff, the admission process was given the highest satisfaction scores. Information about the adolescents' and their parents' experience of the treatment they received is essential and valuable in terms of promoting the quality of service and better treatment outcomes of an inpatient unit. [source] Organizational Learning and Productivity: State Structure and Foreign Investment in the Rise of the Chinese CorporationMANAGEMENT AND ORGANIZATION REVIEW, Issue 2 2005Doug Guthrie abstract Over the two and a half decades of economic reform in China, two types of Chinese firms have consistently outperformed their peers. In the 1980s, it was the firms at the lower levels of the industrial hierarchy, the township and village enterprises that were closely monitored by local governments. In the 1990s and beyond, the top performers have been those Chinese firms that have formal relationships with foreign investors. While many studies on the economic reforms in China have focused on the hardening of budget constraints and the transfer of technology from foreign to Chinese firms, I focus here on the stability created by relationships with local government offices and with powerful foreign investors. Where advocates of shock therapy have argued that a rapid transition to market institutions was the best path to building a market economy, I argue that the successful practices of the market are learned gradually over time, and the Chinese firms that are stabilized by attention from local government offices and relationships with foreign investors are well-positioned to successfully navigate China's emerging markets. A quantitative analysis of 81 firms in industrial Shanghai and three case studies help illuminate the mechanisms behind these relationships. [source] An extensive study of dynamical friction in dwarf galaxies: the role of stars, dark matter, halo profiles and MONDMONTHLY NOTICES OF THE ROYAL ASTRONOMICAL SOCIETY, Issue 4 2006F. J. Sánchez-Salcedo ABSTRACT We investigate the in-spiralling time-scales of globular clusters (GCs) in dwarf spheroidal (dSph) and dwarf elliptical (dE) galaxies, due to dynamical friction (DF). We address the problem of these time-scales having been variously estimated in the literature as much shorter than a Hubble time. Using self-consistent two-component (dark matter and stars) models, we explore mechanisms which may yield extended DF time-scales in such systems in order to explain why dwarf galaxies often show GC systems. As a general rule, dark matter and stars both give a comparable contribution to the dynamical drag. By exploring various possibilities for their gravitational make-up, it is shown that these studies help to constrain the parameters of the dark matter haloes in these galaxies, as well as to test alternatives to dark matter. Under the assumption of a dark halo having a central density core with a typical King core radius somewhat larger than the observed stellar core radius, DF time-scales are naturally extended upwards of a Hubble time. Cuspy dark haloes yield time-scales ,4.5 Gyr, for any dark halo parameters in accordance with observations of stellar line-of-sight velocity dispersion in dSph galaxies. We confirm, after a detailed formulation of the DF problem under the alternative hypothesis of modified Newtonian dynamics (MOND) and in the lack of any dark matter, that due to the enhanced dynamical drag of the stars, the DF time-scales in MOND would be extremely short. Taking the well-measured structural parameters of the Fornax dSph and its GC system as a case study, we conclude that requiring DF time-scales comparable to the Hubble time strongly favours dark haloes with a central core. [source] | ||||||||||