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Strong Preference (strong + preference)
Selected AbstractsSex Differentials in Childhood Feeding, Health Care, and Nutritional Status in IndiaPOPULATION AND DEVELOPMENT REVIEW, Issue 2 2004Vinod Mishra Strong preference for sons in South Asia is well documented, but evidence on female disadvantage in childhood feeding, health care, and nutritional status is inconclusive. This article examines sex differentials in indicators of childhood feeding, health care, and nutritional status of children under age 3 by birth order and sex composition of older living siblings. Data are from India's 1992,93 and 1998,99 National Family Health Surveys. The analysis finds three reasons for inconclusive evidence on female disadvantage in aggregate analyses. First, discrimination against girls is limited to the relatively small fraction of children of certain birth orders and sex compositions of older siblings. Second, discrimination against girls when boys are in short supply and discrimination against boys when girls are in short supply cancel each other to some extent. Third, some discrimination against girls (e.g., in exclusive breastfeeding at 6,9 months) is nutritionally beneficial to girls. Separate analyses for North and South India find that gender discrimination is as common in the South as in the North, where son preference is generally much stronger. [source] Environment and pollinator-mediated selection on parapatric floral races of Mimulus aurantiacusJOURNAL OF EVOLUTIONARY BIOLOGY, Issue 1 2007M. A. STREISFELD Abstract We tested whether selection by pollinators could explain the parapatric distribution of coastal red- and inland yellow-flowered races of Mimulus aurantiacus (Phrymaceae) by examining visitation to natural and experimental populations. As a first step in evaluating whether indirect selection might explain floral divergence, we also tested for local adaptation in early life stages using a reciprocal transplant experiment. Hummingbirds visited flowers of each race at similar rates in natural populations but showed strong (>95%) preference for red flowers in all habitats in experimental arrays. Hawkmoths demonstrated nearly exclusive (>99% of visits) preference for yellow flowers and only visited in inland regions. Strong preferences for alternative floral forms support a direct role for pollinators in floral divergence. Despite these preferences, measures of plant performance across environments showed that red-flowered plants consistently survived better, grew larger and received more overall pollinator visits than yellow-flowered plants. Unmeasured components of fitness may favour the yellow race in inland habitats. Alternatively, we document a marked recent increase in inland hummingbird density that may have caused a change in the selective environment, favouring the eastward advance of red-flowered plants. [source] Biological bases of face preference in 6-week-old infantsDEVELOPMENTAL SCIENCE, Issue 5 2003Elliott M. Blass Six-week-old infants (N =40) who started the experiment in either a calm or crying state, received sucrose from an experimenter, while in eye contact with her. Sucrose was delivered either by syringe or on a pacifier. After 3.5 min., the experimenter retired, the mother came into the test room and placed her infant over her shoulder en face with a video camera. The experimenter and a confederate, both dressed identically, sat in front of and slightly to either side of the infant and the infant could choose to look at either experimenter. To minimize position bias, experimenters switched sides every 30 sec. To maintain a stable level of infant attention, they simultaneously called the baby's name at 10 sec. intervals. When an infant looked at one or the other experimenters, she raised her thumb in camera view. Only crying infants who sucked a sweet pacifier showed a preference for their experimenter. As a group none of the other infants did so. However, there was a wide distribution of sucking times in calm week 6 infants. Choice was linearly related to sucking duration. Infants who sucked for substantial periods of time, showed a strong preference for the experimenter. Those who sucked for minimal periods of time strongly preferred the confederate. Based on these findings and ones from 9- and 12-week-old infants, a model is presented in which preference in this experimental paradigm is determined by idealized levels of central activation. These levels may be inferred from the normal crying function at a particular age. [source] Ground beetle species (Coleoptera, Carabidae) associations with land cover variables in northern England and southern ScotlandECOGRAPHY, Issue 4 2004M. D. Eyre Distribution data concerning 172 ground beetle species derived from 1145 pitfall trap sites in northern England and southern Scotland were used to assess the relationship between species distribution and 12 satellite-derived land cover variables at the regional scale. A number of species were strongly associated with one cover type and negatively with others. The major variation was for preferences for covers in upland or lowland parts of the region. Other distinct preferences for some species were covers such as those at the coast whilst a number of common species showed no strong preference for any cover variable. The synthesis of ground beetle species distribution and satellite-derived cover data is discussed in relation to environmental assessment and change. [source] Stability of preferences with regard to adjuvant chemotherapy: impact of treatment decision, experience and the passing of timeEUROPEAN JOURNAL OF CANCER CARE, Issue 1 2008S.J.T. JANSEN phd Research has shown that patients' preferences for adjuvant chemotherapy do not change as a result of experience. However, the preferences of experienced patients are usually more favourable than those of inexperienced patients. These results indicate a shift in preferences after the decision to proceed with adjuvant chemotherapy has been made, but before actual experience. We tested this assumption in early-stage breast and colorectal cancer patients. We asked patients to provide their preferences for chemotherapy before surgery and thus before they knew whether chemotherapy would be advised (T1), after surgery but before the start of chemotherapy (T2) and about 1 month after chemotherapy (T3). Patients who did not undergo chemotherapy co-operated at similar points in time. Preferences were measured on a nine-point scale, ranging from (1) ,very strong preference for no chemotherapy' to (9) ,very strong preference for chemotherapy'. As hypothesized, the preferences of patients who would be treated with chemotherapy became more favourable after the treatment decision had been made (n = 7, P = 0.06). The preferences of patients for whom chemotherapy was not part of the treatment plan showed the opposite effect (n = 38, P = 0.03). We did not find any effect of experiencing treatment (n = 22, P = 0.62) or the passing of time (n = 81, P = 0.25) on the stability of preferences. We conclude that the frequently observed discrepancy in treatment preferences between experienced and inexperienced patients seems to be an effect of the treatment decision and not of experience of the treatment. [source] Axon behaviour at Schwann cell , astrocyte boundaries: manipulation of axon signalling pathways and the neural adhesion molecule L1 can enable axons to crossEUROPEAN JOURNAL OF NEUROSCIENCE, Issue 6 2004Kathryn H. Adcock Abstract Axon regeneration in vivo is blocked at boundaries between Schwann cells and astrocytes, such as occur at the dorsal root entry zone and around peripheral nerve or Schwann cell grafts. We have created a tissue culture model of these boundaries in Schwann cell , astrocyte monolayer co-cultures. Axon behaviour resembles that in vivo, with axons showing a strong preference for Schwann cells over astrocytes. At boundaries between the two cell types, axons growing on astrocytes cross readily onto Schwann cells, but only 15% of axons growing on Schwann cells are able to cross onto astrocytes. Treatment with chondroitinase or chlorate to reduce inhibition by proteoglycans did not change this behaviour. The neural adhesion molecule L1 is present on Schwann cells and not astrocytes, and manipulation of L1 by application of an antibody, L1-Fc in solution, or adenoviral transduction of L1 into astrocytes increased the proportion of axons able to cross onto astrocytes to 40,50%. Elevating cAMP levels increased crossing from Schwann cells onto astrocytes in live and fixed cultures, and had a co-operative effect with NT-3 but not with NGF. Inactivation of Rho with a cell-permeant form of C3 exoenzyme also increased crossing from Schwann cells to astrocytes. Our experiments indicate that the preference of axons for Schwann cells is largely mediated by the presence of L1 on Schwann cells but not astrocytes, and that manipulation of growth cone signalling pathways can allow axons to disregard boundaries between the two cell types. [source] Characterization of the Saccharomyces cerevisiae galactose mutarotase/UDP-galactose 4-epimerase protein, Gal10pFEMS YEAST RESEARCH, Issue 3 2007Aaron Scott Abstract Saccharomyces cerevisiae and some related yeasts are unusual in that two of the enzyme activities (galactose mutarotase and UDP-galactose 4-epimerase) required for the Leloir pathway of d -galactose catabolism are contained within a single protein,Gal10p. The recently solved structure of the protein shows that the two domains are separate and have similar folds to the separate enzymes from other species. The biochemical properties of Gal10p have been investigated using recombinant protein expressed in, and purified from, Escherichia coli. Protein,protein crosslinking confirmed that Gal10p is a dimer in solution and this state is unaffected by the presence of substrates. The steady-state kinetic parameters of the epimerase reaction are similar to those of the human enzyme, and are not affected by simultaneous activity at the mutarotase active site. The mutarotase active site has a strong preference for galactose over glucose, and is not affected by simultaneous epimerase activity. This absence of reciprocal kinetic effects between the active sites suggests that they act independently and do not influence or regulate each other. [source] The energetic equivalence of changing salinity and temperature to juvenile salmonFUNCTIONAL ECOLOGY, Issue 4 2006S. J. WEBSTER Summary 1The influence of salinity, temperature and physiological development on habitat choice by juvenile salmon is poorly understood. We measured differences in the net energetic cost of habitats that differed in salinity or temperature using behavioural titration of juvenile salmon and correlated these costs with body size and osmoregulatory enzyme activity to quantify how costs change with physiological development. 2Juvenile salmon showed a strong preference for saline water (27 or 15 vs 0) and for cold water (9 °C vs 14 °C). It was estimated to be 0·15 W and 0·11 W more costly for salmon to forage in fresh water than in 15 and 27 salt water, respectively, and 0·09 W more costly to forage in warm than in cold water. 3We expected fish to prefer 15 salt water to fresh water regardless of enzyme activity because they are iso-osmotic with this salt concentration. In contrast, preference for higher salt concentrations should increase with enzyme activity. Consistent with our expectations, enzyme activity was not correlated with preference for 15 salt water, but was positively correlated with preference for 27 salt water. 4The cost of changing salinity vs changing temperature were very similar, indicating that knowledge of both of these costs are necessary to understand juvenile salmon habitat choice. [source] Quality of Life and the Migration of the College-Educated: A Life-Course ApproachGROWTH AND CHANGE, Issue 1 2008RONALD L. WHISLER ABSTRACT This paper examines how the college-educated population,segmented into selective demographic groups, from young adults to the elderly,differentially values quality-of-life (QOL) indicators of metropolitan areas in the United States. Using data from the 2000 Census and the 1997 Places Rated Almanac, out-migration patterns are shown to depend jointly upon stage in the life course, the spatial-demographic setting, and QOL characteristics. An abundance of cultural and recreational amenities lowers out-migration rates of young college-educated. For the older college-educated population, the revealed preferences shift toward concerns for safety and a strong preference for milder climates. The study also finds significantly lower out-migration rates for metropolitan areas with growing human capital. In light of shifting age distributions and rising educational attainment levels, the results have important implications for the emergence of new migration patterns and the concentration of human capital. [source] Patient involvement in clinical decision making: the effect of GP attitude on patient satisfactionHEALTH EXPECTATIONS, Issue 2 2006Benedicte Carlsen Cand. Abstract Objective, This study investigates general practitioners' (GPs) and patients' attitudes to shared decision making, and how these attitudes affect patient satisfaction. Background, Sharing of information and decisions in the consultation is largely accepted as the ideal in general practice. Studies show that most patients prefer to be involved in decision making and shared decision making is associated with patient satisfaction, although preferences vary. Still we know little about how the interaction of GP and patients' attitudes affects patient satisfaction. One such study was conducted in the USA, but comparative studies are lacking. Design, Questionnaire survey distributed through GPs. Setting and participants, The results are based on the combined questionnaires of 41 GPs and 829 of their patients in the urban municipality of Bergen in the western part of Norway. Main variables studied, The data were collected using a nine-item survey instrument constructed to measure attitudes towards patient involvement in medical consultations. The patients were also asked to rate their satisfaction with their GP. Results and conclusions, The patients had a strong preference for shared decision making. The GPs also generally preferred shared decision making, but to a lesser degree than the patients, which is the opposite of the findings of the US study. There was a positive effect of the GP's attitude towards shared decision making on patient satisfaction, but no significant effect of congruence of attitudes between patient and GP on patient satisfaction. The suggested explanation is that GPs that are positive to sharing decisions are more responsive to patients' needs and therefore satisfy patients even when the patient's attitude differs from the GPs' attitude. Hence, although some patients do prefer a passive role, it is important to promote positive attitudes towards patient involvement in medical consultations. [source] , -Fluoro Thiafatty Acids: New Mechanistic Probes of Desaturase-Mediated ReactionsHELVETICA CHIMICA ACTA, Issue 11 2003Derek A series of 18-fluoro thiastearates were prepared and incubated with a yeast ,9-desaturating system. The relative efficiency of desaturase-mediated sulfoxidation was monitored via19F-NMR analysis of the sulfoxide products, and a strong preference for oxo transfer to the S-atom occupying the 9-position was confirmed. The oxidation profile obtained in this manner matched that of analogous experiments with non-fluorinated substrates. These results form the basis of a versatile 19F-NMR-based method for mapping the position of the putative diiron oxidant relative to substrate, and has potential application to the study of membrane-bound desaturases in vitro. [source] The role of the mother's voice in developing mother's face preference: Evidence for intermodal perception at birthINFANT AND CHILD DEVELOPMENT, Issue 1 2005F. Z. Sai Abstract Four experiments are described which investigated the role of the mother's voice in facilitating recognition of the mother's face at birth. Experiment 1 replicated our previous findings (Br. J. Dev. Psychol. 1989; 7: 3,15; The origins of human face perception by very young infants. Ph.D. Thesis, University of Glasgow, Scotland, UK, 1990) indicating a preference for the mother's face when a control for the mother's voice and odours was used only during the testing. A second experiment adopted the same procedures, but controlled for the mother's voice from birth through testing. The neonates were at no time exposed to their mother's voice. Under these conditions, no preference was found. Further, neonates showed only few head turns towards both the mother and the stranger during the testing. Experiment 3 looked at the number of head turns under conditions where the newborn infants were exposed to both the mother's voice and face from birth to 5 to 15 min prior to testing. Again, a strong preference for the mother's face was demonstrated. Such preference, however, vanished in Experiment 4, when neonates had no previous exposure to the mother's voice,face combination. The conclusion drawn is that a prior experience with both the mother's voice and face is necessary for the development of face recognition, and that intermodal perception is evident at birth. The neonates' ability to recognize the face of the mother is most likely to be rooted in prenatal learning of the mother's voice. Copyright © 2004 John Wiley & Sons, Ltd. [source] Sialic acid tissue distribution and influenza virus tropismINFLUENZA AND OTHER RESPIRATORY VIRUSES, Issue 5 2008Urban Kumlin Abstract, Avian influenza A viruses exhibit a strong preference for using ,2,3-linked sialic acid as a receptor. Until recently, the presumed lack of this receptor in human airways was believed to constitute an efficient barrier to avian influenza A virus infection of humans. Recent zoonotic outbreaks of avian influenza A virus have triggered researchers to analyse tissue distribution of sialic acid in further detail. Here, we review and extend the current knowledge about sialic acid distribution in human tissues, and discuss viruses with ocular tropism and their preference for ,2,3-linked sialic acid. [source] The role of trout in stream food webs: integrating evidence from field surveys and experimentsJOURNAL OF ANIMAL ECOLOGY, Issue 2 2006KRISTIAN MEISSNER Summary 1We evaluated the effects of brown trout on boreal stream food webs using field surveys and enclosure/exclosure experiments. Experimental results were related to prey preference of uncaged trout in the same stream, as well as to a survey of macroinvertebrate densities in streams with vs. without trout. Finally, we assessed the generality of our findings by examining salmonid predation on three groups of macroinvertebrate prey (chironomid midges, epibenthic grazers, invertebrate predators) in a meta-analysis. 2In a preliminary experiment, invertebrate predators showed a strong negative response to trout, whereas chironomids benefited from trout presence. In the main experiment, trout impact increased with prey size. Trout had the strongest effect on invertebrate predators and cased caddis larvae, whereas Baetis mayfly and chironomid larvae were unaffected. Trout impact on the largest prey seemed mainly consumptive, because prey emigration rates were low and independent of fish presence. Despite strong effects on macroinvertebrates, trout did not induce a trophic cascade on periphyton. Uncaged trout showed a strong preference for the largest prey items (predatory invertebrates and aerial prey), whereas Baetis mayflies and chironomids were avoided by trout. 3Densities of invertebrate predators were significantly higher in troutless streams. Baetis mayflies also were less abundant in trout streams, whereas densities of chironomids were positively, although non-significantly, related to trout presence. Meta-analysis showed a strong negative impact of trout on invertebrate predators, a negative but variable impact on mobile grazers (mainly mayfly larvae) and a slightly positive impact on chironomid larvae. 4Being size-selective predators, salmonid fishes have a strong impact on the largest prey types available, and this effect spans several domains of scale. Discrepancies between our experimental findings and those from the field survey and meta-analysis show, however, that for most lotic prey, small-scale experiments do not reflect fish impact reliably at stream-wide scales. 5Our findings suggest that small-scale experiments will be useful only if the experimental results are evaluated carefully against natural history information about the experimental system and interacting species across a wide array of spatial scales. [source] Patterns of elephant impact on woody plants in the Hluhluwe-Imfolozi park, Kwazulu-Natal, South AfricaAFRICAN JOURNAL OF ECOLOGY, Issue 1 2010Roger Patrick Boundja Abstract This study identifies patterns of elephant Loxodonta africana africana impacts upon tree species and woody plant communities in Hluhluwe-Imfolozi Park, a South African savannahs/woodlands area. Elephants were reintroduced there from 1981, following more than 80 years of absence. Data were collected in 2003 on elephant impact on woodland in the Park. Different vegetation types were susceptible to different types and levels of damage by elephants, suggesting that elephants will not homogenize the vegetation. Elephants targeted larger stems for all types of damage, with a strong preference for some of the less abundant species such as Albizia versicolor (breaking and toppling) and Cordia caffra and Schotia brachypetala (debarking). Elephant impacts tended to be distributed evenly across the park landscape, irrespective of stem density or proximity to permanent water. Overall, elephants have little impact on slowing or reversing the spread of undesirable woody species, but are having a marked impact on certain less common tree species and larger tree size-classes in the Hluhluwe-Imfolozi Park. Résumé Cette étude identifie le schéma des impacts des éléphants Loxodonta africana africana sur des espèces d'arbres et sur des communautés végétales du Parc de Hluhluwe-Imfolozi, une zone de forêts et de savanes d'Afrique du Sud. Des éléphants y furent réintroduits à partir de 1981, après une absence de plus de 80 ans. En 2003, on a récolté des données sur l'impact des éléphants sur les forêts du parc. ON a vu que les différents types de végétation étaient sensibles à des types et à des niveaux différents de dommages causés par les éléphants, ce qui laisse entendre que les éléphants ne vont pas uniformiser la végétation. Les éléphants visaient les plus gros troncs pour tous les types de dommages, avec une préférence marquée pour certaines des espèces les moins abondantes, comme Albizia versicolor (cassés et renversés) et Cordia caffra and Schotia brachypetala (écorcés). Les impacts des éléphants avaient tendance àêtre répartis également dans tout le paysage du parc, quelles que soient la densité des troncs ou la proximité de points d'eau permanents. En général, les éléphants avaient peu d'impact sur le ralentissement ou l'inversion de la dispersion des espèces ligneuses indésirables, mais ils ont un impact réel sur certaines espèces d'arbres moins fréquentes et sur les arbres de classes de taille plus grandes dans le Parc de Hluhluwe-Imfolozi. [source] Quantum mechanical study of the conformational behavior of proline and 4R-hydroxyproline dipeptide analogues in vacuum and in aqueous solutionJOURNAL OF COMPUTATIONAL CHEMISTRY, Issue 3 2002Caterina Benzi The conformational behavior of the title compounds has been investigated by Hartree,Fock, MP2, and DFT computations on the most significant structures related to variations of the backbone dihedral angles, cis/trans isomerism around the peptide bond, and diastereoisomeric puckering of the pyrrolidine ring. In vacuum the reversed , turn (,l), characterized by an intramolecular hydrogen bridge, corresponds to the absolute energy minimum for both puckerings (up and down) of the pyrrolidine ring. An additional energy minimum is found in the helix region, but only for an up puckering of the pyrrolidine ring. When solvent effects are included by means of the polarizable continuum model the conformer observed experimentally in condensed phases becomes the absolute minimum. The down puckering is always favored over its up counterpart, albeit by different amounts (0.4,0.5 kcal/mol for helical structures and about 2 kcal/mol for ,l structures). In helical structures cis arrangements of the peptide bond are only slightly less stable than their trans counterparts. This is no longer true for ,l structures, because the formation of an intramolecular hydrogen bond is possible only for trans peptide bonds. In most cases, proline and hydroxyproline show the same general trends; however, the electronegative 4(R) substituent of hydroxyproline leads to a strong preference for up puckerings irrespective of the backbone conformation. © 2002 Wiley Periodicals, Inc. J Comput Chem 23: 341,350, 2002 [source] Loss of shoaling preference for familiar individuals in captive-reared crimson spotted rainbowfish Melanotaenia duboulayiJOURNAL OF FISH BIOLOGY, Issue 10 2009E. Kydd Captive-reared rainbowfish Melanotonia duboulayi showed no preference for familiar individuals in an experiment examining shoaling preferences. Fortnightly re-examination of the shoaling preferences of the captive-reared population showed that the lack of preference for familiar individuals did not alter over an 8 week period. The same experiment performed on laboratory-reared offspring raised in isolated groups for 8 months since hatching also showed no preference for shoals consisting of familiar individuals. In contrast, trials performed on a wild population of M. duboulayi found a strong preference for familiar shoalmates, a result that is consistent with previous studies. The lack of shoaling preferences in captive-reared populations is probably the result of relaxed selection and inbreeding in the captive environment. The consequences of captive breeding for fish social behaviour are discussed with particular reference to hatchery production. [source] Repetitive and ritualistic behaviour in children with Prader,Willi syndrome and children with autismJOURNAL OF INTELLECTUAL DISABILITY RESEARCH, Issue 2 2006N. Greaves Abstract Background Recent research has shown that the range of repetitive behaviour seen in individuals with Prader,Willi syndrome (PWS) extends beyond food-related behaviour. Methods The presence and intensity of repetitive, rigid and routinized behaviour in children with PWS was compared with that seen in children with another neurodevelopmental condition in which repetitive behaviour is common: children with autism. Parents completed the Childhood Routines Inventory (CRI). Results Contrary to our predictions, controlling for developmental level, children with PWS and children with autism showed similar levels of repetitive and ritualistic behaviour overall and on the two CRI factors measuring ,just right' and ,repetitive' behaviour. Indeed, the majority of the sample of parents of children with PWS endorsed most items on the CRI. However there was some specificity at the level of individual items with parents of children with PWS more frequently endorsing an item on ,collecting and storing objects' and parents of children with autism more frequently endorsing ,lining up objects', ,has a strong preference for certain foods' and ,seems aware of detail at home'. Conclusions These findings confirm the range of repetitive behaviours that form part of the behavioural phenotype of PWS, including insistence on sameness and ,just right' behaviours, and uncover a surprising overlap with those seen in children with autism. Clinical management for children with PWS should include advice and education regarding management of repetitive and rigid behaviour. Future research should investigate whether the repetitive behaviours that form part of the behavioural phenotype of both PWS and autism are associated with a common neuropsychological, neurotransmitter or genetic origin. [source] Opioids in the Hypothalamic Paraventricular Nucleus Stimulate Ethanol IntakeALCOHOLISM, Issue 2 2010Jessica R. Barson Background:, Specialized hypothalamic systems that increase food intake might also increase ethanol intake. To test this possibility, morphine and receptor-specific opioid agonists were microinjected in the paraventricular nucleus (PVN) of rats that had learned to drink ethanol. To cross-validate the results, naloxone methiodide (m-naloxone), an opioid antagonist, was microinjected with the expectation that it would have the opposite effect of morphine and the specific opioid agonists. Methods:, Sprague,Dawley rats were trained, without sugar, to drink 4 or 7% ethanol and were then implanted with chronic brain cannulas aimed at the PVN. After recovery, those drinking 7% ethanol, with food and water available, were injected with 2 doses each of morphine or m-naloxone. To test for receptor specificity, 2 doses each of the ,-receptor agonist [d -Ala2,N -Me-Phe4,Gly5 -ol]-Enkephalin (DAMGO), ,-receptor agonist d -Ala-Gly-Phe-Met-NH2 (DALA), or ,-receptor agonist U-50,488H were injected. DAMGO was also tested in rats drinking 4% ethanol without food or water available. As an anatomical control for drug reflux, injections were made 2 mm dorsal to the PVN. Results:, A main result was a significant increase in ethanol intake induced by PVN injection of morphine. The opposite effect was produced by m-naloxone. The effects of morphine and m-naloxone were exclusively on intake of ethanol, even though food and water were freely available. In the analysis with specific receptor agonists, PVN injection of the ,-agonist DALA significantly increased 7% ethanol intake without affecting food or water intake. This is in contrast to the ,-agonist U-50,488H, which decreased ethanol intake, and the ,-agonist DAMGO, which had no effect on ethanol intake in the presence or absence of food and water. In the anatomical control location 2 mm dorsal to the PVN, no drug caused any significant changes in ethanol, food, or water intake, providing evidence that the active site was close to the cannula tip. Conclusions:, The ,-opioid receptor agonist in the PVN increased ethanol intake in strong preference over food and water, while the ,-opioid agonist suppressed ethanol intake. Prior studies show that learning to drink ethanol stimulates PVN expression and production of the peptides enkephalin and dynorphin, which are endogenous agonists for the ,- and ,-receptors, respectively. These results suggest that enkephalin via the ,-opioid system can function locally within a positive feedback circuit to cause ethanol intake to escalate and ultimately contribute to the abuse of ethanol. This is in contrast to dynorphin via the ,-opioid system, which may act to counter this escalation. Naltrexone therapy for alcoholism may act, in part, by blocking the enkephalin-triggered positive feedback cycle. [source] User preference: A measure of query-term qualityJOURNAL OF THE AMERICAN SOCIETY FOR INFORMATION SCIENCE AND TECHNOLOGY, Issue 12 2006Nina Wacholder The goal of this research is to understand what characteristics, if any, lead users engaged in interactive information seeking to prefer certain sets of query terms. Underlying this work is the assumption that query terms that information seekers prefer induce a kind of cognitive efficiency: They require less mental effort to process and therefore reduce the energy required in the interactive information-seeking process. Conceptually, this work applies insights from linguistics and cognitive science to the study of query-term quality. We report on an experiment in which we compare user preference for three sets of terms; one had been preconstructed by a human indexer, and two were identified automatically. Twenty-four participants used a merged list of all terms to answer a carefully created set of questions. By design, the interface constrained users to access the text exclusively via the displayed list of query terms. We found that participants displayed a preference for the human-constructed set of terms eight times greater than the preference for either set of automatically identified terms. We speculate about reasons for this strong preference and discuss the implications for information access. The primary contributions of this research are (a) explication of the concept of user preference as a measure of query-term quality and (b) identification of a replicable procedure for measuring preference for sets of query terms created by different methods, whether human or automatic. All other factors being equal, query terms that users prefer clearly are the best choice for real-world information-access systems. [source] The affinity of the FimH fimbrial adhesin is receptor-driven and quasi-independent of Escherichia coli pathotypesMOLECULAR MICROBIOLOGY, Issue 6 2006Julie Bouckaert Summary Type-1 fimbriae are important virulence factors for the establishment of Escherichia coli urinary tract infections. Bacterial adhesion to the high-mannosylated uroplakin Ia glycoprotein receptors of bladder epithelium is mediated by the FimH adhesin. Previous studies have attributed differences in mannose-sensitive adhesion phenotypes between faecal and uropathogenic E. coli to sequence variation in the FimH receptor-binding domain. We find that FimH variants from uropathogenic, faecal and enterohaemorrhagic isolates express the same specificities and affinities for high-mannose structures. The only exceptions are FimHs from O157 strains that carry a mutation (Asn135Lys) in the mannose-binding pocket that abolishes all binding. A high-mannose microarray shows that all substructures are bound by FimH and that the largest oligomannose is not necessarily the best binder. Affinity measurements demonstrate a strong preference towards oligomannosides exposing Man,1-3Man at their non-reducing end. Binding is further enhanced by the ,1-4-linkage to GlcNAc, where binding is 100-fold better than that of ,- d -mannose. Man,1-3Man,1-4GlcNAc, a major oligosaccharide present in the urine of ,-mannosidosis patients, thus constitutes a well-defined FimH epitope. Differences in affinities for high-mannose structures are at least 10-fold larger than differences in numbers of adherent bacteria between faecal and uropathogenic strains. Our results imply that the carbohydrate expression profile of targeted host tissues and of natural inhibitors in urine, such as Tamm-Horsfall protein, are stronger determinants of adhesion than FimH variation. [source] Variation in part-time job quality within the nonprofit human service sectorNONPROFIT MANAGEMENT & LEADERSHIP, Issue 4 2009Anna Haley-Lock This article extends the growing literature on the quality of part-time employment to the domain of nonprofit human services, specifically grassroots organizations in which paid work is itself a relatively new reality. It addresses three central questions: How do part-time and full-time workers differ in their personal and household characteristics? How do part-time jobs differ in access to employment benefits from their full-time counterparts; and finally, How does benefits access vary among part-time job titles? These lines of inquiry are examined using data from the populations of nonprofit domestic violence programs and their employees in a large midwestern metropolitan area. Analyses of worker-level data reveal that part-time workers in these settings disproportionately live with children, are in committed relationships, and report a strong preference for employment that facilitates work-life balance; they are also less likely to be primary household wage earners. Analyses at the level of jobs suggest that employment benefits extended to part-time jobs are minimal compared to their full-time equivalents, but there are also striking variations among different part-time titles. The results offer insights into the nature of part-time work in these nonprofit human service settings and potential challenges for effective management. [source] Users' subjective evaluation of electronic vision enhancement systemsOPHTHALMIC AND PHYSIOLOGICAL OPTICS, Issue 2 2009Louise E. Culham Abstract The aims of this study were (1) to elicit the users' responses to four electronic head-mounted devices (Jordy, Flipperport, Maxport and NuVision) and (2) to correlate users' opinion with performance. Ten patients with early onset macular disease (EOMD) and 10 with age-related macular disease (AMD) used these electronic vision enhancement systems (EVESs) for a variety of visual tasks. A questionnaire designed in-house and a modified VF-14 were used to evaluate the responses. Following initial experience of the devices in the laboratory, every patient took home two of the four devices for 1 week each. Responses were re-evaluated after this period of home loan. No single EVES stood out as the strong preference for all aspects evaluated. In the laboratory-based appraisal, Flipperport typically received the best overall ratings and highest score for image quality and ability to magnify, but after home loan there was no significant difference between devices. Comfort of device, although important, was not predictive of rating once magnification had been taken into account. For actual performance, a threshold effect was seen whereby ratings increased as reading speed improved up to 60 words per minute. Newly diagnosed patients responded most positively to EVESs, but otherwise users' opinion could not be predicted by age, gender, diagnosis or previous CCTV experience. User feedback is essential in our quest to understand the benefits and shortcoming of EVESs. Such information should help guide both prescribing and future development of low vision devices. [source] G.W. Bush and North Korea: A Levels of Analysis ViewPACIFIC FOCUS, Issue 1 2007Curtis H. Martin This study describes and evaluates, from the perspective of pertinent system, state, and individual level theory, the unfolding of the Bush administration's strategy for addressing the North Korea nuclear issue up to the February 2007 Beijing agreement on first steps toward denuclearization of the Korean peninsula. It will explore whether that policy has been "effective harmony of different goals," as the administration has claimed, or something far less coherent and effective. At its inception, the administration's policy was grounded in a strong, though by no means universally held,preference for "asphyxiation" rather than "oxygen," for pressure and isolation rather than for rewards. However, this default policy was constrained at almost every turn by system and state level realities that drove the United States to eschew forceful unilateral action and to pursue its objectives through multilateral regional diplomacy. And yet throughout the years of six-party talks, the strong preference of core decision makers for isolation continued,pending what they hoped would be a more propitious environment to pursue a forward leaning policy,to rein in U.S. negotiators. As a result, U.S. policy often appeared to exhibit characteristics of "temporary appeasement,""hawk engagement" and "malign neglect" in which negotiations assume a primarily tactical role rather than a wholehearted effort to engage the DPRK. The apparent success of financial sanctions, coupled with the international shock wave that followed North Korea's missile and nuclear tests, might have been expected to give administration hawks the long-awaited opportunity to pursue their default policy. Despite the successes enjoyed by new financial sanctions, however, U.S. policy remained as constrained as ever by the grave deterioration of the United States' position in the Middle East and the unanticipated shift of power in congress. These constraints may in part explain the dramatic about-face in the administration's position that led ultimately to the February 13, 2007 agreement to offer the DPRK an "early harvest" in exchange for initial steps toward denuclearization. [source] Bronchodilator effect of salbutamol from two different spacer devicesPEDIATRIC PULMONOLOGY, Issue 4 2006Albert M. Li MB Abstract Our aim was to compare the bronchodilator effect of salbutamol delivered via a new holding chamber (Volumatic Soft, VS) with that of an established device (Volumatic, V) in asthmatic children. Children with stable asthma were recruited. They inhaled 100 µg, and 10 min later, 300 µg of salbutamol aerosol delivered via VS or V on day 1, and vice versa on day 2. Spirometry was measured at baseline, 10 min after 100 µg, and 15 min after 300 µg of salbutamol were given. The preference for either device was assessed by visual analogue score. Forty-four children with a median age of 9.2 years (interquartile range, 8.0,10.7) completed the study. There were significant improvements in forced expired volume in 1 sec (FEV1) with time throughout the study period for both V and VS (linear and quadratic trend P,<,0.001). There was a statistically significant difference in postbronchodilator FEV1 between V and VS (P,=,0.013). VS gave an overall greater change in FEV1 than V, by 1.8%. The preference scores for V and VS were 7.0 (IQR 5.0,8.0) and 9.0 (IQR 8.0,10.0) (p,<,0.0005), respectively. In conclusion, comparable clinical efficacy was found for V and VS with respect to changes in FEV1 after salbutamol. Patients also showed a strong preference for the new device. Pediatr Pulmonol. © 2006 Wiley-Liss, Inc. [source] How pediatricians manage asthma in ThailandPEDIATRIC PULMONOLOGY, Issue 2 2001Pakit Vichyanond MD Abstract Currently, there is no existing information regarding prescribing practices for the management of childhood asthma among pediatricians in Thailand. In order to evaluate the management standards for childhood asthma in Thailand, 400 self-administered questionnaires were randomly mailed to nonacademic pediatricians throughout Thailand, asking questions about their preferences in the treatment of childhood asthma. One hundred and seventy-four of these 400 questionnaires were returned (a response rate of 43.5%). Data were analyzed using the descriptive module of the Epi-info 6 program. For acute asthma, 17% of the respondents used objective measures such as peak flow meters in assessing asthma severity and severity of acute asthma attacks. The drug of first choice for treating acute attacks was a nebulized beta-agonist q 20 min (81.8%). Although 93% indicated that they had used theophylline for treating acute attacks, most would reserve the drug for patients with severe symptoms. Corticosteroids were reserved for those with severe attacks (91.7% both for clinic and for in-hospital settings). Hydrocortisone was the most preferred corticosteroid preparation (59.8%). Ninety-seven percent used antibiotics in treating acute asthma, but only with appropriate indications. For chronic asthma, a strong preference was observed for oral beta-agonists as the bronchodilator of choice (88%). For moderately severe asthmatics, theophylline was still preferred by 41% of the responders. Among prophylactic agents, ketotifen was the most favored drug (90.4%), whereas inhaled steroids and cromolyn were chosen by 9.6% and 2.4%, respectively. Eighty-five percent indicated that they would prescribe prophylactic agents for 1 year or less. Forty-two percent never considered allergy evaluation as a part of a workup for childhood asthma. Certain prescribing practices of childhood asthma management in Thailand were observed among pediatricians, i.e., 1) low frequency of using objective measures in assessing asthma severity among pediatricians; 2) frequent use of theophylline and antibiotics in the treatment of acute asthma; 3) late introduction of corticosteroids in treating acute asthma; 4) preference for oral bronchodilators; and 5) preference of ketotifen as the prophylactic drug of choice. This survey provides baseline data and will aid in the evaluation of management guidelines for childhood asthma in Thailand. Pediatr Pulmonol. 2001; 32:109,114. © 2001 Wiley-Liss, Inc. [source] Fallback foods of temperate-living primates: A case study on snub-nosed monkeysAMERICAN JOURNAL OF PHYSICAL ANTHROPOLOGY, Issue 4 2009Cyril C. Grueter Abstract Only a few primate species thrive in temperate regions characterized by relatively low temperature, low rainfall, low species diversity, high elevation, and especially an extended season of food scarcity during which they suffer from dietary stress. We present data of a case study of dietary strategies and fallback foods in snub-nosed monkeys (Rhinopithecus bieti) in the Samage Forest, Northwest Yunnan, PRC. The snub-nosed monkeys adjusted intake of plant food items corresponding with changes in the phenology of deciduous trees in the forest and specifically showed a strong preference for young leaves in spring. A non-plant food, lichens (Parmeliaceae), featured prominently in the diet throughout the year (annual representation in the diet was about 67%) and became the dominant food item in winter when palatable plant resources were scarce. Additional highly sought winter foods were frost-resistant fruits and winter buds of deciduous hardwoods. The snub-nosed monkeys' choice of lichens as a staple fallback food is likely because of their spatiotemporal consistency in occurrence, nutritional and energetic properties, and the ease with which they can be harvested. Using lichens is a way to mediate effects of seasonal dearth in palatable plant foods and ultimately a key survival strategy. The snub-nosed monkeys' fallback strategy affects various aspects of their biology, e.g., two- and three-dimensional range use and social organization. The higher abundance of lichens at higher altitudes explains the monkeys' tendency to occupy relatively high altitudes in winter despite the prevailing cold. As to social organization, the wide temporal and spatial availability of lichens strongly reduces the ecological costs of grouping, thus allowing for the formation of "super-groups." Usnea lichens, the snub-nosed monkeys' primary dietary component, are known to be highly susceptible to human-induced environmental changes such as air pollution, and a decline of this critical resource base could have devastating effects on the last remaining populations. Within the order Primates, lichenivory is a rare strategy and only found in a few species or populations inhabiting montane areas, i.e., Macaca sylvanus, Colobus angolensis, and Rhinopithecus roxellana. Other temperate-dwelling primates rely mainly on buds and bark as winter fallback foods. Am J Phys Anthropol 140:700,715, 2009. © 2009 Wiley-Liss, Inc. [source] Fallback foods and dietary partitioning among Pan and gorillaAMERICAN JOURNAL OF PHYSICAL ANTHROPOLOGY, Issue 4 2009Juichi Yamagiwa Abstract Recent findings on the strong preference of gorillas for fruits and the large dietary overlap between sympatric gorillas and chimpanzees has led to a debate over the folivorous/frugivorous dichotomy and resource partitioning. To add insight to these arguments, we analyze the diets of sympatric gorillas and chimpanzees inhabiting the montane forest of Kahuzi-Biega National Park (DRC) using a new definition of fallback foods (Marshall and Wrangham: Int J Primatol 28 [2007] 1219,1235). We determined the preferred fruits of Kahuzi chimpanzees and gorillas from direct feeding observations and fecal analyses conducted over an 8-year period. Although there was extensive overlap in the preferred fruits of these two species, gorillas tended to consume fewer fruits with prolonged availability while chimpanzees consumed fruits with large seasonal fluctuations. Fig fruit was defined as a preferred food of chimpanzees, although it may also play a role as the staple fallback food. Animal foods, such as honey bees and ants, appear to constitute filler fallback foods of chimpanzees. Tool use allows chimpanzees to obtain such high-quality fallback foods during periods of fruit scarcity. Among filler fallback foods, terrestrial herbs may enable chimpanzees to live in small home ranges in the montane forest, whereas the availability of animal foods may permit them to expand their home range in arid areas. Staple fallback foods including barks enable gorillas to form cohesive groups with similar home range across habitats irrespective of fruit abundance. These differences in fallback strategies seem to have shaped different social features between sympatric gorillas and chimpanzees. Am J Phys Anthropol 140:739,750, 2009. © 2009 Wiley-Liss, Inc. [source] Optimal Asset Location and Allocation with Taxable and Tax-Deferred InvestingTHE JOURNAL OF FINANCE, Issue 3 2004Robert M. Dammon We investigate optimal intertemporal asset allocation and location decisions for investors making taxable and tax-deferred investments. We show a strong preference for holding taxable bonds in the tax-deferred account and equity in the taxable account, reflecting the higher tax burden on taxable bonds relative to equity. For most investors, the optimal asset location policy is robust to the introduction of tax-exempt bonds and liquidity shocks. Numerical results illustrate optimal portfolio decisions as a function of age and tax-deferred wealth. Interestingly, the proportion of total wealth allocated to equity is inversely related to the fraction of total wealth in tax-deferred accounts. [source] Environmental factors and population fluctuations of Akodon azarae (Muridae: Sigmodontinae) in central ArgentinaAUSTRAL ECOLOGY, Issue 2 2009VERÓNICA ANDREO Abstract The aim of this work was to explore the relationship between population density of Akodon azarae (Muridae: Sigmodontinae) and climatic and environmental variables, and determine which of them are associated to within and among-year changes in rodent abundance in agro-ecosystems from south Córdoba, Argentina. The study was carried out in a rural area of central Argentina, from 1983 to 2003. Density was estimated as a relative density index (RDI). Temperature, precipitation and humidity were obtained from records of the National University of Rio Cuarto. Normalized Difference Vegetation Index (NDVI) and Land Surface Temperature were recorded from National Oceanic and Atmospheric Administration (1983,1998) and Landsat (1998,2003) imagery data sets. We performed simple correlations, multiple regressions and distributed lag analysis. Direct association of climatic and environmental variables with RDI was in general, low. The amount of variability in seasonal changes in density explained by climatic and environmental variables altogether varied from 10% to 70%. Seasonal population fluctuations were influenced by NDVI and rainfall with one and two seasons of delay. Autumn maximum density of the species was also associated with vegetation and rainfall of previous seasons. There also seemed to be an indirect influence of rainfall through vegetation given that we found a positive correlation between them. Results were consistent with basic aspects of the ecology of the species, such as its strong preference for highly covered areas, which provide food and protection from predators, likely increasing its reproductive success. Therefore, in the rural area central Argentina, A. azarae showed seasonal fluctuations with delayed influence of rainfall and vegetation and indirect effects of rainfall. [source] | ||||||||||||||||||||||||||||||||||||||||