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Strong
Kinds of Strong Terms modified by Strong Selected AbstractsRECOGNIZING STRONG AND WEAK OPINION CLAUSESCOMPUTATIONAL INTELLIGENCE, Issue 2 2006Theresa Wilson There has been a recent swell of interest in the automatic identification and extraction of opinions and emotions in text. In this paper, we present the first experimental results classifying the intensity of opinions and other types of subjectivity and classifying the subjectivity of deeply nested clauses. We use a wide range of features, including new syntactic features developed for opinion recognition. We vary the learning algorithm and the feature organization to explore the effect this has on the classification task. In 10-fold cross-validation experiments using support vector regression, we achieve improvements in mean-squared error over baseline ranging from 49% to 51%. Using boosting, we achieve improvements in accuracy ranging from 23% to 96%. [source] COMPARING STRENGTHS OF DIRECTIONAL SELECTION: HOW STRONG IS STRONG?EVOLUTION, Issue 10 2004Joe Hereford Abstract The fundamental equation in evolutionary quantitative genetics, the Lande equation, describes the response to directional selection as a product of the additive genetic variance and the selection gradient of trait value on relative fitness. Comparisons of both genetic variances and selection gradients across traits or populations require standardization, as both are scale dependent. The Lande equation can be standardized in two ways. Standardizing by the variance of the selected trait yields the response in units of standard deviation as the product of the heritability and the variance-standardized selection gradient. This standardization conflates selection and variation because the phenotypic variance is a function of the genetic variance. Alternatively, one can standardize the Lande equation using the trait mean, yielding the proportional response to selection as the product of the squared coefficient of additive genetic variance and the mean-standardized selection gradient. Mean-standardized selection gradients are particularly useful for summarizing the strength of selection because the mean-standardized gradient for fitness itself is one, a convenient benchmark for strong selection. We review published estimates of directional selection in natural populations using mean-standardized selection gradients. Only 38 published studies provided all the necessary information for calculation of mean-standardized gradients. The median absolute value of multivariate mean-standardized gradients shows that selection is on average 54% as strong as selection on fitness. Correcting for the upward bias introduced by taking absolute values lowers the median to 31%, still very strong selection. Such large estimates clearly cannot be representative of selection on all traits. Some possible sources of overestimation of the strength of selection include confounding environmental and genotypic effects on fitness, the use of fitness components as proxies for fitness, and biases in publication or choice of traits to study. [source] Prepulse inhibition of startle, intelligence and familial primary nocturnal enuresisACTA PAEDIATRICA, Issue 4 2000EM Ornitz Previous studies have shown a significant reduction of prepulse inhibition of startle in boys with primary nocturnal enuresis. Those enuretic boys who had higher IQs showed less prepulse inhibition. This study evaluates the association of prepulse inhibition and IQ in primary nocturnal enuresis in respect to family history of primary nocturnal enuresis. Prepulse inhibition of startle was studied in 83 boys with primary nocturnal enuresis and 57 non-enuretic boys using an interval of 120 ms between the onset of a 75 dB 1000 Hz tone and a 104 dB noise burst. Of the boys with primary nocturnal enuresis, 56 had a family history of primary nocturnal enuresis and 27 had no family history (no first-degree relative). Of the 57 non-enuretic boys, 42 also had no family history (no first-degree relative) of primary nocturnal enuresis, while 15 did have a positive family history. Associations between prepulse inhibition and IQ scores were compared among these four groups. Strong and significant associations between prepulse inhibition deficit and higher IQ scores in the enuretic group with familial primary nocturnal enuresis were unique in comparison to the other groups. Conclusions: The strong heritabilities of primary nocturnal enuresis, intelligence and prepulse inhibition suggest genetic mediation of the association of prepulse inhibition with intelligence in familial primary nocturnal enuresis. [source] (Pyrazole)silver(I) and -gold(I) Complexes with Strong and Weak Hydrogen-Bonding Interactions as the Basis of One- or Two-Dimensional StructuresEUROPEAN JOURNAL OF INORGANIC CHEMISTRY, Issue 15 2004M. Luz Gallego Abstract New AuI/AgI complexes containing one or two substituted pyrazole ligands [Au(Hpzbp2)(PPh3)](p -CH3C6H4SO3) [Hpzbp2 = 3,5-bis(4- n -butoxyphenyl)pyrazole] (1) and [M(HpzR2)2]nX [HpzR2 = Hpzbp2, M = Au, n = 1, X = p -CH3C6H4SO3 (2), NO3, (3); n = 2, X = 1,5-naphthalenedisulfonate (1,5nds) (4); HpzR2 = Hpzbp2, M = Ag, n = 1, X = BF4, (5), CF3SO3, (6); HpzR2 = HpzNO2 (3,5-dimethyl-4-nitropyrazole), M = Ag, n = 1, X = BF4, (7), CF3SO3, (8)], have been prepared and characterized. Compounds 1, 2, 5 and 8 have been proved to be useful for supramolecular assembly from their single X-ray diffraction analysis. In all cases strong hydrogen bonds maintain the cationic units bonded to their corresponding counterions. The crystal packing arrangement of 1, 2 and 5 is, however, determined by weak C,H···O/F hydrogen-bonding interactions involving the remaining O/F atoms of the counterion. By contrast, for 8 a two-dimensional layer-type polymeric network is formed by ,···, (NO2···NO2) and coordinative Ag···O interactions in which the NO2 substituent on the pyrazole is implicated. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004) [source] LOCAL HETEROZYGOSITY-FITNESS CORRELATIONS WITH GLOBAL POSITIVE EFFECTS ON FITNESS IN THREESPINE STICKLEBACKEVOLUTION, Issue 8 2006Mélissa Lieutenant-Gosselin Abstract The complex interactions between genetic diversity and evolution have important implications in many biological areas including conservation, speciation, and mate choice. A common way to study these interactions is to look at heterozygosity-fitness correlations (HFCs). Until recently, HFCs based on noncoding markers were believed to result primarily from global inbreeding effects. However, accumulating theoretical and empirical evidence shows that HFCs may often result from genes being linked to the markers used (local effect). Moreover, local effect HFCs could differ from global inbreeding effects in their direction and occurrence. Consequently, the investigation of the structure and consequences of local HFCs is emerging as a new important goal in evolutionary biology. In this study of a wild threespine stickleback (Gasterosteus aculeatus) population, we first tested the presence of significant positive or negative local effects of heterozygosity at 30 microsatellites loci on five fitness components: survival, mating success, territoriality, length, and body condition. Then, we evaluated the direction and shape of total impact of local HFCs, and estimated the magnitude of the impacts on fitness using regression coefficients and selection differentials. We found that multilocus heterozygosity was not a reliable estimator of individual inbreeding coefficient, which supported the relevance of single-locus based analyses. Highly significant and temporally stable local HFCs were observed. These were mainly positive, but negative effects of heterozygosity were also found. Strong and opposite effects of heterozygosity are probably present in many populations, but may be blurred in HFC analyses looking for global effects only. In this population, both negative and positive HFCs are apparently driving mate preference by females, which is likely to contribute to the maintenance of both additive and nonadditive genetic variance. [source] SEXUAL DIMORPHISM IN RELATION TO CURRENT SELECTION IN THE HOUSE FINCHEVOLUTION, Issue 3 2000Alexander V. Badyaev Abstract., Sexual dimorphism is thought to have evolved in response to selection pressures that differ between males and females. Our aim in this study was to determine the role of current net selection in shaping and maintaining contemporary sexual dimorphism in a recently established population of the house finch (Carpodacus mexicanus) in Montana. We found strong differences between sexes in direction of selection on sexually dimorphic traits, significant heritabilities of these traits, and a close congruence between current selection and observed sexual dimorphism in Montana house finches. Strong directional selection on sexually dimorphic traits and similar intensities of selection in each sex suggested that sexual dimorphism arises from adaptive responses in males and females, with both sexes being far from their local fitness optimum. This pattern is expected when a recently established population experiences continuous immigration from ecologically distinct areas of a species range or as a result of widely fluctuating selection pressures, as found in our study. Strong and sexually dimorphic selection pressures on heritable morphological traits, in combination with low phenotypic and genetic covariation among these traits during growth, may have accounted for close congruence between current selection and observed sexual dimorphism in the house finch. This conclusion is consistent with the profound adaptive population divergence in sexual dimorphism that accompanied very successful colonization of most of the North America by the house finch over the last 50 years. [source] Corporate Bankruptcy in Korea: Only the Strong Survive?FINANCIAL REVIEW, Issue 4 2000Paola Bongini G30/G32/G33 Abstract We analyze whether the build-up of financial vulnerabilities led listed Korean companies to bankruptcy. We find that pre-crisis leverage is systematically high for both poor performing/slow growing firms and for profitable/fast-growing firms. Pre-crisis leverage raises the probability of bankruptcy, which is lower for firms: (1) relying more on (renegotiable) bank credit; (2) with less inter-firm debt; and (3) having higher interest coverage ratios. Finally, none of these liquidity variables help predict bankruptcies for chaebol-firms, suggesting that liquidity constraints are more stringent for non-chaebol. Thus, in a systemic crisis it is not only the strong/healthy that survive. [source] Strong and weak arbitrary discontinuities in spectral finite elementsINTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN ENGINEERING, Issue 8 2005A. Legay Abstract Methods for constructing arbitrary discontinuities within spectral finite elements are described and studied. We use the concept of the eXtended Finite Element Method (XFEM), which introduces the discontinuity through a local partition of unity, so there is no requirement for the mesh to be aligned with the discontinuities. A key aspect of the implementation of this method is the treatment of the blending elements adjacent to the local partition of unity. We found that a partition constructed from spectral functions one order lower than the continuous approximation is optimal and no special treatment is needed for higher order elements. For the quadrature of the Galerkin weak form, since the integrand is discontinuous, we use a strategy of subdividing the discontinuous elements into 6- and 10-node triangles; the order of the element depends on the order of the spectral method for curved discontinuities. Several numerical examples are solved to examine the accuracy of the methods. For straight discontinuities, we achieved the optimal convergence rate of the spectral element. For the curved discontinuity, the convergence rate in the energy norm error is suboptimal. We attribute the suboptimality to the approximations in the quadrature scheme. We also found that modification of the adjacent elements is only needed for lower order spectral elements. Copyright © 2005 John Wiley & Sons, Ltd. [source] The normal circadian pattern of blood pressure: implications for treatmentINTERNATIONAL JOURNAL OF CLINICAL PRACTICE, Issue 2004J. Redon Summary Blood pressure fluctuates over 24 h following a circadian rhythm that reaches a peak in the morning shortly after awakening. The onset of many acute cardiovascular and cerebrovascular events shows a synchronous cyclical pattern, with the highest incidence of morbidity and mortality in the early morning hours. Strong, although circumstantial, evidence suggests that the early morning surge in blood pressure may contribute to the onset of acute cardiovascular episodes. Sustained blood pressure control that blunts the early morning blood pressure surge may help to reduce the incidence of these events. Antihypertensive agents are needed that provide smooth and sustained blood pressure control for the full 24 h, including the risky early morning hours. The angiotensin II receptor blocker telmisartan given once daily, because of its long half-life and mechanism of action, is likely to confer benefit in terms of 24-h blood pressure control and may reduce cardiovascular risk at the time of greatest patient vulnerability. [source] Late-glacial and Holocene palaeovegetation zonal reconstruction for central and north-central North AmericaJOURNAL OF BIOGEOGRAPHY, Issue 6 2005W. L Strong Abstract Aim, The purpose of this study is to develop palaeovegetation zonation models for central and north-central North America, based on late-Quaternary and Holocene pollen stratigraphic data (n = 246 sites). A secondary purpose was to evaluate an hypothesis (Strong & Hills, 2003) to explain the disjunct distribution of species in western Alberta. Location, Hudson Bay-Lake Michigan to the Rocky Mountains region, north of 36° N to the Arctic Ocean (c. 70° N). Methods, Pollen profiles spanning 40 years of palaeoecological research in North America were extracted from published and unpublished archival sources. Individual profiles were subdivided into 1000-year increments based on the assumption of a constant sedimentation rate between stratigraphic dates (e.g. surface sediments, radiocarbon 14C dates, tephra layers). The pollen composition among profiles was standardized to 54 commonly recognized taxa, with percentage composition within each stratigraphic sample prorated to 100% prior to analysis. Near-surface sediments from these profiles were included as analogues of modern vegetation. Cluster analysis was used as a guide to the classification of 2356 temporal stratigraphic samples, which resulted in the recognition of 16 pollen groups. These groups were summarized in terms of their pollen composition, mapped, and used in combination with terrain information and an ecological knowledge of the study area to construct six physiognomically-based palaeovegetation zonation models at 2000-year intervals from 14,000 to 4000 yr bp (radiocarbon years before present). Results, The 14,000 yr bp model placed Boreal and Cordilleran Forests proximal to the southern glacial front, whereas Arctic tundra dominated the Yukon Territory,Alaska ice-free zone. Pollen and macrofossil evidence suggests that this Boreal Forest zone contained a mixture of coniferous and deciduous tree species. Grassland was postulated immediately south of the forest zone, with its northern extreme near 49° N latitude in the Alberta,Montana border area. Separation of the Laurentide and Cordilleran glacial fronts about 12,000 yr bp initiated the northward advance of Boreal Forests into western Canada. By the end of the Hypsithermal at about 6000 yr bp, Boreal Forests occurred near the Arctic Ocean, and Grassland and Aspen Parkland zones may have extended to 54° N and 59° N latitude in Alberta, respectively. Between 6000 and 4000 yr bp, a 5° and 1° latitudinal southward shift of the northern Boreal Forest and Grassland/Aspen Parkland boundaries occurred, respectively, near their contemporary positions with corresponding expansions of the Subarctic and Arctic zones. Modern Canadian Cordilleran Forests along the eastern slopes of the Rocky Mountains were interpreted as originating from the north-central Montana,south-western Alberta area. Jack pine (Pinus banksiana Lamb.), a common Boreal Forest species, appears to have entered central Canada via the north side of Lake Superior after 11,000 yr bp. Main conclusions, Modern vegetation in central Canada evolved from biomes located in the northern USA during the late-Quaternary. The Boreal Forest biome contained the same arboreal taxa as the modern vegetation, except it lacked jack pine. The proposed regional palaeovegetation models support the hypothesis of Strong & Hills (2003), but new independent palaeoecological data will be needed for a proper evaluation. [source] ,-Amino-butyric acid immunoreactivity in intramucosal colonic tumorsJOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, Issue 9 2003KENTARO MAEMURA Abstract Background and Aim:, The level of ,-amino-butyric acid (GABA) is reported to be increased in colon cancer. Moreover, data suggests that GABA plays a role in the proliferation or maturation of some types of cells. We examined the expression of GABA in intramucosal colonic tumors to clarify the relation between GABA and the degree of atypia. Methods:, Paraffin sections were prepared from 56 protruded-type colonic neoplasms, which were classified as intramucosal adenocarcinoma (AC), adenoma with severe atypia (ASA), or adenoma with mild to moderate atypia (AMA). Expression of GABA was investigated immunohistochemically, and GABA immunoreactivity was compared to the staining patterns of carcinoembryonic antigen (CEA) and cancer-associated antigen (CA19-9) which were classified into three categories. Results:, Intense GABA immunoreactivity was observed in 73.7%, 54.6%, 13.3%, and 5.4% of AC, ASA, AMA, and normal mucosa specimens, respectively. Kendall's correlation coefficient between GABA immunoreactivity and the degree of atypia was 0.447. Strong, positive CEA staining (pattern 3) was observed in 57.9%, 36.3%, and 13.3% of AC, ASA, and AMA specimens, respectively. Strong, positive CA19-9 staining was observed: 26.3%, 9.1% and 0%, respectively. In AC and ASA, the proportion of glands with strong GABA immunoreactivity was greater than the proportion of glands that were strongly positive for CA19-9. Conclusion:, GABA may be useful as a tumor marker in combination with other tumor markers such as CEA and CA19-9. [source] Immunohistochemical study of syndecan-1 down-regulation and the expression of p53 protein or Ki-67 antigen in oral leukoplakia with or without epithelial dysplasiaJOURNAL OF ORAL PATHOLOGY & MEDICINE, Issue 9 2003Hideo Kurokawa Abstract Background:, Leukoplakia is an oral pre-cancerous lesion that sometimes develops into squamous cell carcinoma. Therefore, leukoplakia with epithelial dysplasia is useful for studying carcinogenesis at the cellular level. The purpose of this study was to evaluate a potential association between the loss of syndecan-1 expression and the expression of p53 protein and Ki-67 antigen, and to identify reliable markers for predicting malignant changes in oral leukoplakia with epithelial dysplasia. Methods:, Changes in the expression of syndecan-1, p53, and Ki-67 were examined immunohistochemically in 43 cases of oral leukoplakia with or without epithelial dysplasia. The subjects were categorized as: none, 13 cases; mild dysplasia, 5 cases; moderate dysplasia, 17 cases; and severe dysplasia, 8 cases. The expression of these molecules in normal oral epithelia (22 cases) was also investigated. Results:, Strong syndecan-1 expression was observed on the surface of keratinocytes in normal epithelium. Immunopositivity was lost gradually as the extent of epithelial dysplasia increased. In normal epithelium, p53 and Ki-67 appeared mainly in the basal cell layer, while they were more widely distributed in leukoplakia. Specifically, significant changes were observed in the labeling index of p53 and Ki-67 in leukoplakia as epithelial dysplasia progressed from mild to moderate or severe. Conclusion:, Our results reveal that overexpression of p53 protein and Ki-67 antigen, and down-regulation of syndecan-1 expression in the lower part of the epithelium, are associated with dysplastic changes. Therefore, the down-regulation of syndecan-1 expression may be the most important reliable marker for dysplastic changes. [source] Transforming growth factor ,1 (TGF,1) expression in head and neck squamous cell carcinoma patients as related to prognosisJOURNAL OF ORAL PATHOLOGY & MEDICINE, Issue 3 2003Angela F. Logullo Abstract Background:, Transforming growth factor ,1 (TGF,1) is a negative growth regulator in keratinocytes, and in vitro studies lead to the concept that loss of TGF,1 responsiveness is a critical step in epithelial carcinogenesis. Objective:, To investigate the prognostic relevance of TGF,1 expression in head and neck squamous cell carcinoma (HNSCC). Materials and methods:, TGF,1 distribution was determined by immunohistochemistry in oral cavity/oropharynx (n = 79), larynx (n = 36) and hypopharynx (n = 25) tumors and in matched normal adjacent mucosa. TGF,-type I and II receptors were determined in 20 cases of differentiated oral cavity/hypopharynx tumors. Cases were considered positive if displaying reactivity in >10% of the cells. Results:, TGF,1-positive expression was found in 47.2% of larynx, 36.7% of oral cavity/oropharynx and in 24% of the hypopharynx tumors. Reactivity in >60% of the cells was displayed only by 11.4% of HNSCC. All normal controls were positive. TGF,1-positive expression did not correlate with clinico pathological parameters. An association with differentiation was verified only in oral cavity/oropharynx tumors (P , 0.001). TGF,1 was also not related to 5 years survival (Kaplan,Meier). Strong and diffuse expression of TGF,-RII was identified in 19/20 cases regardless of TGF,1 immunoreactivity. Out of 17 TGF,1-positive oral cavity/oropharynx tumors, only nine expressed TGF,-RI suggesting a disruption of the TGF,1 pathway. We conclude that TGF,1 protein immunostaining is not a useful biomarker in assessment of prognosis in HNSCC. [source] Depression and diffuse physical symptoms in southern Chinese with temporomandibular disordersJOURNAL OF ORAL REHABILITATION, Issue 6 2009A. S. MCMILLAN Summary, The study investigated the experience of depressive symptoms and the relationship with diffuse physical symptoms reporting in southern Chinese seeking professional care for temporomandibular disorders (TMD) in Hong Kong. Eighty-seven new patients [77 females/10 males; mean age 39·3 years (SD 12·7)] referred to the specialist TMD clinic at the Prince Philip Dental Hospital, Hong Kong participated in this study. The Research Diagnostic Criteria (RDC)/TMD history questionnaire was used to derive Axis II psychological data. Psychological status was assessed through depression and non-specific physical symptoms (NPS) scores (pain items included and excluded) measured with RDC/TMD Axis II instruments; 42·5% of patients experienced moderate/severe depression symptoms; 59·8% and 57·5% had moderate/severe NPS scores when pain items were included and excluded, respectively. Strong, positive and statistically significant correlations were noted between depression scores and the NPS scores that included pain items (r = 0·80) and those that did not (r = 0·80). The correlations remained consistent and were of similar magnitude when male patients were excluded from the computation and also when the possible effect of patient age was controlled. While taking into account the modest patient sample which was related to a low rate of treatment seeking, depressive symptoms were common and similar to other western and Chinese patient groups. NPS reports were higher than in Singapore Chinese patients. There appeared to be a clear association between depression and diffuse physical symptoms. The findings should be considered in the holistic care of Chinese people with TMD. [source] Organosoluble and transparent polyimides derived from alicyclic dianhydride and aromatic diaminesJOURNAL OF POLYMER SCIENCE (IN TWO SECTIONS), Issue 1 2002J. G. Liu Abstract Organosoluble polyimides were synthesized with the alicyclic dianhydride 1,8-dimethylbicyclo[2,2,2]oct-7-ene-2,3,5,6-tetracarboxylic dianhydride and aromatic diamines. The polyimides possessed good solubility both in strong dipolar solvents and in common solvents; the thermal decomposition temperature of the polyimides exceeded 420 °C. Strong and flexible films of the polyimides, with the cutoff of ultraviolet,visible absorption lower than 310,320 nm, exhibited good features as the alignment layers for nematic liquid crystals with pretilt angles of 1.5,2.9°. © 2001 John Wiley & Sons, Inc. J Polym Sci Part A: Polym Chem 40: 110,119, 2002 [source] Evaluation of baking procedures for incorporation of barley roller milling fractions containing high levels of dietary fibre into breadJOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE, Issue 4 2008Morrison S Jacobs Abstract BACKGROUND: Roller milling of hull-less barley generates fibre-rich fractions (FRF) enriched in non-starch polysaccharides from the endosperm cell walls (,-glucans and arabinoxylans). This investigation was initiated to compare the suitability of different baking processes and to determine the optimal conditions for incorporation of barley FRF into pan bread. RESULTS: Addition of FRF from waxy and high-amylose starch hull-less barley genotypes was evaluated in pan bread prepared from Canada Western Red Spring (CWRS) and Canada Western Extra Strong (CWES) wheat flour. Three bread processes were used: Canadian short process (CSP), remix-to-peak, and sponge-and-dough. Addition of 20% FRF (equivalent to enrichment with 4.0 g of arabinoxylans and ,-glucans per 100 g of flour) disrupted dough properties and depressed loaf volume. CSP was not suitable for making FRF-enriched bread because dough could not be properly developed. FRF-enriched remix-to-peak bread was better, especially for the stronger CWES flour. The better bread quality compared to CSP was probably due to redistribution of water from non-starch polysaccharides to gluten during fermentation prior to remixing and final proof. The sponge-and-dough process produced the best FRF-enriched bread because of the positive effect of sponge fermentation on gluten development and hydration. FRF was added at the dough stage to fully developed dough. CONCLUSION: The method of bread production strongly influences bread quality. Pre-hydration of FRF improved bread quality. CWRS and CWES flour produced comparable FRF-enriched sponge-and-dough bread. Addition of xylanase to the sponge-and-dough formula improved the loaf volume, appearance, crumb structure and firmness of FRF-enriched bread. Copyright © 2007 Society of Chemical Industry [source] Dynamic contrast-enhanced MRI of experimental spinal cord injury: In vivo serial studiesMAGNETIC RESONANCE IN MEDICINE, Issue 4 2001Mehmet Bilgen Abstract The progression of experimental spinal cord injury (SCI) was followed with in vivo dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and neurobehavioral studies on postinjury days 0, 2, 4, 7, 10, 14, 17, 21, 28, 35, and 42. Gadopentate dimeglumine (Gd) was administered IV and postcontrast, T1 -weighted, axial images were acquired repetitively for up to 60 min. Images were analyzed to determine the spatial and temporal evolution of the intensity enhancement. A statistical decision mechanism was developed to objectively detect the enhancement. Strong and rapid enhancement was observed at the epicenter of injury, indicating a significant compromise in blood spinal cord barrier. The enhanced regions in each slice were combined to estimate the area and volume of the lesion. On the day of injury, around 85% of the total cord area at the epicenter showed enhancement within the first 15 min of Gd administration. At the same time, the enhanced volumes attained nearly 40% of the total cord volume and extended axially over 8 mm along the cord. These quantities decreased steadily with time, with a concomitant improvement in the motor functions. The volume of enhancement correlated highly with the neurobehavioral tests (r = ,0.87). DCE-MRIs revealed small hyperintense regions distributed inside white matter about two weeks postinjury. Based on histology, these enhancements appear to represent new vessels with "leaky endothelium." Magn Reson Med 45:614,622, 2001. © 2001 Wiley-Liss, Inc. [source] Adaptationism for Human Cognition: Strong, Spurious or Weak?MIND & LANGUAGE, Issue 1 2005Scott Atran This strategy seems best when there is evidence of homology. Weak adaptationists don't assume that complex organic (including cognitive and linguistic) functioning necessarily or primarily represents task-specific adaptation. This approach to cognition resembles physicists' attempts to deductively explain the most facts with fewest hypotheses. For certain domain-specific competencies (folkbiology) strong adaptationism is useful but not necessary to research. With group-level belief systems (religion) strong adaptationism degenerates into spurious notions of social function and cultural selection. In other cases (language, especially universal grammar) weak adaptationism's ,minimalist' approach seems productive. [source] The State of Biological Anthropology in 2008: Is Our Discipline Strong and Our Cause Just?AMERICAN ANTHROPOLOGIST, Issue 2 2009Nicholas Malone ABSTRACT Biological anthropologists inform a largely professional discourse on the evolutionary history of our species. In addition, aspects of our biology, the ways in which we vary, and certain patterns of behavior are the subjects of a more public and popular conversation. The social contexts in which we work not only define our times but also produce the anthropologists that in turn construct an emergent understanding of our species' (and our societies') inner workings. In this review of scholarly production, I focus on developments within a selection of "sub-subdisciplines" that were particularly influential in bending the arc of biological anthropology in 2008, namely: evolutionary medical anthropology, anthropological neuroscience, forensic anthropology, primatology, and paleoanthropology. Ultimately, this review demonstrates, yet again, anthropology's great contribution: the ability to incorporate new technologies and research methodologies into a synthetic and integrative interdisciplinary approach toward the elucidation of human behavior, evolution, and biocultural engagements with the environment. [Keywords: biological anthropology, year in review, 2008, science and society] [source] Extragalactic MeV ,-ray emission from cocoons of young radio galaxiesMONTHLY NOTICES OF THE ROYAL ASTRONOMICAL SOCIETY, Issue 4 2007M. Kino ABSTRACT Strong ,-ray emission from cocoons of young radio galaxies is predicted for the first time. Considering the process of adiabatic injection of the shock dissipation energy and mass of the relativistic jet in active nuclei into the cocoon, while assuming thermalizing electron plasma interactions, we find that the thermal electron temperature of the cocoon is typically predicted to be of the order of , MeV, and is determined only by the bulk Lorentz factor of the relativistic jet. Together with the time-dependent dynamics of the cocoon expansion, we find that young cocoons can yield thermal bremsstrahlung emissions at energies ,MeV. [source] Strong and weak tests of macroecological theoryOIKOS, Issue 3 2003B. McGill First page of article [source] Immunohistochemical expression of 14-3-3 sigma protein in various histological subtypes of uterine cervical cancersPATHOLOGY INTERNATIONAL, Issue 10 2004Takaaki Sano 14-3-3 sigma (,) has been a major G2/M checkpoint control gene and has demonstrated that its inactivation in various cancers occurs mostly by epigenetic hypermethylation, not by genetic change. In order to confirm 14-3-3, protein expression together with p16 and p53 in cervical cancers, immunohistochemistry was performed using various histological subtypes of cervical cancers and dysplasia. Strong and diffuse immunoreactivity for 14-3-3, was uniformly observed in all the cervical dysplasia (17/17) and squamous cell carcinomas (29/29) including human papillomavirus (HPV)-negative cases. Even in adenosquamous carcinomas and adenocarcinomas of the cervix, immunohistochemical expression of 14-3-3, was shown with relatively high frequency (13/15, 87% and 22/27, 81%). In the in situ hybridization study, mRNA of 14-3-3, was expressed in six of eight immunohistochemical-negative cases. Therefore, the undetectable expression of 14-3-3, protein in cervical cancers might, at least in part, be due to a proteolysis not epigenetic hypermethylation. It is of interest that cancers without 14-3-3, expression were predominantly those lacking HPV DNA, and that there were no cases with concomitant inactivation of 14-3-3, and p16 in the present study. These observations are consistent with the hypothesis that inactivation of either 14-3-3, or p16 has an effect equivalent to the expression of E6 and E7 oncoproteins of HPV. [source] Growth of high-quality hexagonal InN on 3C-SiC (001) by molecular beam epitaxyPHYSICA STATUS SOLIDI (C) - CURRENT TOPICS IN SOLID STATE PHYSICS, Issue 7 2005Hiroyuki Yaguchi Abstract We have grown hexagonal InN (h-InN) films on 3C-SiC (001) substrates by RF-N2 plasma molecular beam epitaxy taking account of small lattice mismatch between h-InN (10-10) and 3C-SiC (110). It was found from X-ray diffraction (XRD) measurements that h-InN grows with h-InN (0001) || 3C-SiC (001) and h-InN (1-100) || 3C-SiC (110). XRD measurements also revealed that the h-InN epitaxial layers grown on 3C-SiC (001) are composed of single domain. Strong and sharp photoluminescence from the h-InN was clearly observed at around 0.69 eV. (© 2005 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim) [source] Association of Community Health Nursing Educators: Disaster Preparedness White Paper for Community/Public Health Nursing EducatorsPUBLIC HEALTH NURSING, Issue 4 2008Sandra W. Kuntz ABSTRACT The Association of Community Health Nursing Educators (ACHNE) has developed a number of documents designed to delineate the scope and function of community/public health nursing educators, researchers, and practitioners. In response to societal issues, increased emphasis on disaster preparedness in nursing and public health, and requests from partner organizations to contribute to curriculum development endeavors regarding disaster preparedness, the ACHNE Disaster Preparedness Task Force was appointed in spring 2007 for the purpose of developing this document. Task Force members developed a draft of the document in summer and fall 2007, input was solicited and received from ACHNE members in fall 2007, and the document was approved and published in January 2008. The members of ACHNE extend their appreciation to the members of the Emergency Preparedness Task Force for their efforts: Pam Frable, N.D., R.N.; Sandra Kuntz, Ph.D., C.N.S.-B.C. (Chair); Kristine Qureshi, D.N.Sc., C.E.N., R.N.; Linda Strong, Ed.D., R.N. This white paper is aimed at meeting the needs of community/public health nursing educators and clarifying issues for the nursing and public health communities. ACHNE is committed to promotion of the public's health through ensuring leadership and excellence in community and public health nursing education, research, and practice. [source] Development of the ways of helping questionnaire: A measure of preferred coping strategies for older African American cancer survivors,,RESEARCH IN NURSING & HEALTH, Issue 3 2009Jill B. Hamilton Abstract Although researchers have identified beneficial coping strategies for cancer patients, existing coping measures do not capture the preferred coping strategies of older African American cancer survivors. A new measure, the Ways of Helping Questionnaire (WHQ), was evaluated with 385 African American cancer survivors. Validity evidence from factor analysis resulted in 10 WHQ subscales (Others There for Me, Physical and Treatment Care Needs, Help from God, Church Family Support, Helping Others, Being Strong for Others, Encouraging My Healthy Behaviors, Others Distract Me, Learning about Cancer, and Distracting Myself). Reliability evidence was generally strong. Evidence regarding hypothesized relationships with measures of well-being and another coping measure was mixed. The WHQ's content coverage makes it especially relevant for older African American cancer survivors. © 2009 Wiley Periodicals, Inc. Res Nurs Health 32:243,259, 2009 [source] Androgen receptor expressing neurons that project to the paraventricular nucleus of the hypothalamus in the male ratTHE JOURNAL OF COMPARATIVE NEUROLOGY, Issue 6 2007Martin Williamson Abstract Androgen receptors are distributed throughout the central nervous system and are contained by a variety of nuclei that are known to project to or regulate the paraventricular nucleus (PVN) of the hypothalamus, the final common pathway by which the brain regulates the hypothalamic,pituitary,adrenal (HPA) response to homeostatic threat. Here we characterized androgen receptor staining within cells identified as projecting to the PVN in male rats bearing iontophoretic or crystalline injections of the retrograde tracer FluoroGold aimed at the caudal two-thirds of the nucleus, where corticotropin-releasing hormone-expressing neurons are amassed. Androgen receptor (AR) and FluoroGold (FG) double labeling was revealed throughout the limbic forebrain, including scattered numbers of cells within the anterior and posterior subdivisions of the bed nuclei of the stria terminalis; the medial zone of the hypothalamus, including large numbers of AR-FG-positive cells within the anteroventral periventricular and medial preoptic cell groups. Strong and consistent colabeling was also revealed throughout the hindbrain, predominantly within the periaqueductal gray and the lateral parabrachial nucleus, and within various medullary cell groups identified as catecholaminergic, predominantly C1 and A1 neurons of the ventral medulla. These connectional data predict that androgens can act on a large assortment of multimodal inputs to the PVN, including those involved with the processing of various types of sensory and limbic information, and provide an anatomical framework for understanding how gonadal status could contribute to individual differences in HPA function. J. Comp. Neurol. 503:717,740, 2007. © 2007 Wiley-Liss, Inc. [source] Turbulence energetics in stably stratified geophysical flows: Strong and weak mixing regimesTHE QUARTERLY JOURNAL OF THE ROYAL METEOROLOGICAL SOCIETY, Issue 633 2008S. S. Zilitinkevich Abstract Traditionally, turbulence energetics is characterised by turbulent kinetic energy (TKE) and modelled using solely the TKE budget equation. In stable stratification, TKE is generated by the velocity shear and expended through viscous dissipation and work against buoyancy forces. The effect of stratification is characterised by the ratio of the buoyancy gradient to squared shear, called the Richardson number, Ri. It is widely believed that at Ri exceeding a critical value, Ric, local shear cannot maintain turbulence, and the flow becomes laminar. We revise this concept by extending the energy analysis to turbulent potential and total energies (TPE, and TTE = TKE + TPE), consider their budget equations, and conclude that TTE is a conservative parameter maintained by shear in any stratification. Hence there is no ,energetics Ric', in contrast to the hydrodynamic-instability threshold, Ric,instability, whose typical values vary from 0.25 to 1. We demonstrate that this interval, 0.25 < Ri < 1, separates two different turbulent regimes: strong mixing and weak mixing rather than the turbulent and the laminar regimes, as the classical concept states. This explains persistent occurrence of turbulence in the free atmosphere and deep ocean at Ri , 1, clarifies the principal difference between turbulent boundary layers and free flows, and provides the basis for improving operational turbulence closure models. Copyright © 2008 Royal Meteorological Society [source] Biologically Inspired, Strong, Transparent, and Functional Layered Organic,Inorganic Hybrid Films,ANGEWANDTE CHEMIE, Issue 12 2010Hong-Bin Yao Wie Mutter Natur: Biologisch inspirierte organisch-anorganische Hybridfilme, in denen Schichten aus Chitosan und Mikro- und Nanoplättchen aus Doppelhydroxiden mit Schichtstruktur abwechseln, ahmen die einzigartigen Mikroschichtstrukturen von Perlmutt nach (siehe Bild) und weisen eine hohe Reißfestigkeit auf. Zudem können die Hybridfilme mit den optischen Eigenschaften der Plättchen versehen werden. [source] Leadership and management in the aged care sector: A narrative synthesisAUSTRALASIAN JOURNAL ON AGEING, Issue 2 2010Yun-Hee Jeon The aim of this study is to examine the issues and the progress being made in leadership and management with relevance for the residential aged care workforce. A systematic review was conducted using scientific journal databases, hand searching of specialist journals, Google, snowballing and suggestions from experts. After a seven-tiered culling process, we conducted a detailed review of 153 papers relevant to leadership and management development in aged care. Strong, effective leadership and management promotes staff job satisfaction and retention, high care quality and the well-being of care recipients, and reduces associated costs. Good leadership and effective management also play a key role in bringing about a successful change to a positive workplace culture through innovative programs and research projects. Organisational investment in improving leadership and management skills and capabilities can only improve outcomes for staff stability and productivity, care quality and budgets, and better prepare the aged care sector. [source] Strong and weak lifespan extension: what is most feasible and likely?AUSTRALASIAN JOURNAL ON AGEING, Issue 2 2006Jayne C Lucke Abstract Recent advances in biomedical science indicate that it may eventually be possible to intervene in the biological process of human ageing. This paper overviews the current state of the science of lifespan extension and promising future directions. It is uncertain whether ,strong' lifespan extension , the extension of human life beyond the maximum 122 years so far observed , will become a reality. It is more likely that cumulative effects of numerous scientific and biomedical advances in the treatment of common disease will produce ,weak' lifespan extension , the extension of average life expectancy. The practical application of molecular, genetic and nanomaterials research may also lead to advances in life expectancy. It is not too early to begin to consider the policy implications of either form of lifespan extension. [source] | ||||||||||||||||||||||||||||||||||||||||